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1. 发明专利

JP2009242421A Cancer therapy 审中-公开
标题翻译：癌症治疗
公开(公告)号：JP2009242421A
公开(公告)日：2009-10-22
申请号：JP2009162200
申请日：2009-07-08
申请人： Aeolus Sciences Inc , National Jewish Health , Univ Duke , アイオロス・サイエンシズ・インコーポレーテッドAeolus Sciences,Inc. , デュークユニバーシティ , ナショナルジュウィッシュヘルス
发明人： CRAPO JAMES D , DAY BRIAN J , BATINIC-HABERLE INES , GAMMANS RICHARD , VUJASKOVIC ZELJKO
IPC分类号： A61K45/00 , C07D487/22 , A61K31/409 , A61K31/555 , A61K41/00 , A61P35/00 , C07D207/44
CPC分类号： A61K31/555 , A61K31/409 , A61K41/00
摘要： PROBLEM TO BE SOLVED: To provide cancer therapy. SOLUTION: A method for preventing or treating cancer is provided. In the method, low molecular weight antioxidants [e.g., mimetics of superoxide dismutase (SOD)] are generally used in cancer therapy, especially as an active agent or as a chemo- and/or radio-protectant. Compounds and suitable compositions for such a method are also provided. In addition, agents including methine (i.e. meso) substituted porphyrin and tetrapyrrole and suitable for use in such a method are provided. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供癌症治疗。提供了一种预防或治疗癌症的方法。在该方法中，低分子量抗氧化剂[例如，超氧化物歧化酶（SOD）的模拟物]通常用于癌症治疗，特别是作为活性剂或作为化学和/或放射性保护剂。还提供了用于这种方法的化合物和合适的组合物。另外，提供了包括次甲基（即内消旋）取代的卟啉和四吡咯并适用于这种方法的试剂。版权所有（C）2010，JPO＆INPIT

2. 发明公开

EP0831891A4 OXIDANT SCAVENGERS 失效
标题翻译： FAENGER FUER OXIDANTIEN
公开(公告)号：EP0831891A4
公开(公告)日：1999-02-03
申请号：EP96923328
申请日：1996-06-07
申请人： UNIV DUKE , UNIV ALABAMA BIRMINGHAM RESEAR
发明人： TROVA MICHAEL P , CRAPO JAMES D , FRIDOVICH IRWIN , OURY TIM , DAY BRIAN J , FOLZ RODNEY J , FREEMAN BRUCE A , BATINIC-HABERLE INES
IPC分类号： A61K31/40 , A61K38/00 , A61K45/00 , A61K45/08 , A61P43/00 , C07D487/22 , C12N9/02 , A61K38/44 , A61K45/05 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07D487/22 , A61K38/00 , A61K47/546 , B82Y5/00 , C12N9/0089

3. 发明申请

WO0043395A8 SUBSTITUTED PORPHYRINS 审中-公开
标题翻译：取代的PORPHYRINS
公开(公告)号：WO0043395A8
公开(公告)日：2002-02-14
申请号：PCT/US0002062
申请日：2000-01-25
申请人： NAT JEWISH MED & RES CENTER , AEOLUS PHARMACEUTICALS INC , UNIV DUKE
发明人： CRAPO JAMES D , DAY BRIAN J , TROVA MICHAEL P , GAUUAN POLIVINI JOLICIA F , KITCHEN DOUGLAS B , FRIDOVICH IRWIN , BATINIC-HABERLE INES
IPC分类号： A61K31/409 , A61P7/02 , A61P11/00 , A61P11/06 , A61P29/00 , A61P39/06 , C07D487/22 , C09B47/00 , A61K51/02
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译：本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。本发明还涉及适用于这些方法的化合物和组合物。

4. 发明公开

EP2435387A4 METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS 审中-公开
标题翻译：一种用于提供神经保护免受卟啉的使用
公开(公告)号：EP2435387A4
公开(公告)日：2013-03-20
申请号：EP10781161
申请日：2010-05-26
申请人： UNIV DUKE
发明人： WARNER DAVID S , BATINIC-HABERLE INES , SHENG HUAXIN , SPASOJEVIC IVAN
IPC分类号： C07B47/00 , A61K31/409 , A61K31/4425 , C07D487/22
CPC分类号： C07D487/22 , A61K31/409 , A61K31/4425

5. 发明公开

EP1155019A4 SUBSTITUTED PORPHYRINS 有权
标题翻译：取代的卟啉
公开(公告)号：EP1155019A4
公开(公告)日：2002-07-03
申请号：EP00905776
申请日：2000-01-25
申请人： NAT JEWISH MED & RES CENTER , AEOLUS PHARMACEUTICALS INC , UNIV DUKE
发明人： CRAPO JAMES D , DAY BRIAN J , TROVA MICHAEL P , GAUUAN POLIVINI JOLICIA F , KITCHEN DOUGLAS B , FRIDOVICH IRWIN , BATINIC-HABERLE INES
IPC分类号： A61K31/409 , A61P7/02 , A61P11/00 , A61P11/06 , A61P29/00 , A61P39/06 , C07D487/22 , C09B47/00 , C07D487/02 , A61K51/02
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00

6. 发明申请

WO02060383A2 CANCER THERAPY 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO02060383A2
公开(公告)日：2002-08-08
申请号：PCT/US0201507
申请日：2002-01-22
申请人： NAT JEWISH MED & RES CENTER , AEOLUS PHARMACEUTICALS INC , UNIV DUKE
发明人： CRAPO JAMES D , DAY BRIAN J , BATINIC-HABERLE INES , GAMMANS RICHARD , VUJASKOVIC ZELJKO
IPC分类号： C07D487/22 , A61K31/409 , A61K31/555 , A61K41/00 , A61K45/00 , A61P35/00 , C07D207/44 , A61K
CPC分类号： A61K31/555 , A61K31/409 , A61K41/00
摘要： The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo-and/or radio protectant. The invention also relates to compounds and compositions suitable for use in such a method.
摘要翻译：本发明一般涉及癌症治疗，特别涉及使用低分子量抗氧化剂（例如超氧化物歧化酶（SOD）的模拟物）作为活性剂或作为化学治疗剂的预防或治疗癌症的方法，和/或无线电保护。本发明还涉及适用于这种方法的化合物和组合物。

7. 发明申请

WO2008073195A2 METHOD FOR ACTIVATION OF OXAZAPHOSPHORINES 审中-公开
标题翻译：激活氧化氮的方法
公开(公告)号：WO2008073195A2
公开(公告)日：2008-06-19
申请号：PCT/US2007023359
申请日：2007-11-06
申请人： UNIV DUKE , SPASOJEVIC IVAN , COLVIN MICHAEL O , BATINIC-HABERLE INES , LUDEMAN SUSAN M , GAMCSIK MICHAEL P
发明人： SPASOJEVIC IVAN , COLVIN MICHAEL O , BATINIC-HABERLE INES , LUDEMAN SUSAN M , GAMCSIK MICHAEL P
IPC分类号： A61K33/24
CPC分类号： A61K31/555 , A61K31/675 , A61K2300/00
摘要： The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
摘要翻译：本发明提供了通过将目的化合物施用于受试者来羟化或氧化受试者中的目标化合物（例如细胞毒性恶唑磷酸前药）的方法; 并且同时给予受试者金属卟啉，所述金属卟啉有效地羟化或氧化受试者中目标化合物。

8. 发明公开

EP1718201A4 SUBSTITUTED PORPHYRINS 有权
标题翻译：取代卟啉
公开(公告)号：EP1718201A4
公开(公告)日：2010-06-16
申请号：EP05712218
申请日：2005-02-01
申请人： UNIV DUKE
发明人： BATINIC-HABERLE INES , FRIDOVICH IRWIN , SPASOJEVIC IVAN
IPC分类号： A61B5/055 , A61B10/00 , A61K31/40 , A61K31/4188 , A61K31/444 , A61K31/555 , C07B47/00 , C07D487/22
CPC分类号： C07F13/005 , C07D401/14 , C07D403/14 , C07D487/22

9. 发明公开

EP1513537A4 SUBSTITUTED PORPHYRINS 审中-公开
标题翻译：取代卟啉
公开(公告)号：EP1513537A4
公开(公告)日：2006-09-06
申请号：EP03736949
申请日：2003-06-09
申请人： UNIV DUKE
发明人： BATINIC-HABERLE INES , SPASOJEVIC IVAN , FRIDOVICH IRWIN
IPC分类号： C07D487/22 , A61K31/409 , A61K31/555 , A61P11/00
CPC分类号： C07D487/22
摘要： A series of ortho isomers of meso tetrakis N-alkylpyridylporphyrins (alkyl being methyl, ethyl, n-propyl, n-butyl, n-hexyl, and n-octyl) and their Mn(III) complexes were synthesized and characterized by elemental analysis, uv/vis spectroscopy, electrospray ionization mass spectrometry and electrochemistry. An increase in the number of carbon atoms in the alkyl chains from 1 to 8 is accompanied by an increase in: (a) lipophilicity measured by the chromatographic retention factor, Rf; (b) metal-centered redox potential, E1/2 from +220 to +367 mV vs NHE, and (c) proton dissociation constant, pKa2 from 10.9 to 13.2. A linear correlation was found between E1/2 and Rf of the Mn(III) porphyrins and between the pKa2 and Rf of the metal-free compounds. As the porphyrins become increasingly more lipophilic, the decrease in hydration disfavors the separation of charges, while enhancing the electron-withdrawing effect of the positively charged pyridyl nitrogen atoms. Consequently, the E1/2 increases linearly with the increase in pKa2, a trend in porphyrin basicity opposite from the one we previously reported for other water-soluble Mn(III) porphyrins. All of these Mn(III) porphyrins are potent catalysts for superoxide dismutation (disproportionation). Despite the favorable increase of E1/2 with the increase in chain length, the catalytic rate constant decreases from methyl (log kcat = 7.79) to n-butyl, and then increases such that the n-octyl is as potent an SOD mimic as are the methyl and ethyl compounds. The observed behavior originates from an interplay of hydration and steric effects that modulate electronic effects.

10. 发明公开

EP1392328A4 CANCER THERAPY 有权
标题翻译：癌症治疗
公开(公告)号：EP1392328A4
公开(公告)日：2004-11-17
申请号：EP02717355
申请日：2002-01-22
申请人： NAT JEWISH MED & RES CENTER , AEOLUS SCIENCES INC , UNIV DUKE
发明人： CRAPO J D , DAY BRIAN J , BATINIC-HABERLE INES , GAMMANS RICHARD , VUJASKOVIC ZELJKO
IPC分类号： C07D487/22 , A61K31/409 , A61K31/555 , A61K41/00 , A61K45/00 , A61P35/00 , C07D207/44 , A61P39/06
CPC分类号： A61K31/555 , A61K31/409 , A61K41/00

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