专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009000920A1 DEVICE AND METHOD FOR DETECTING A SUBSTANCE BY MEANS OF PARTICLE PLASMON RESONANCE (PPR) OR PARTICLE-MEDIATED FLUORESCENCE BASED ON CELL SURFACE POLARIZATIONS 审中-公开
标题翻译：设备和检测方法的物质通过粒子等离子体共振现象（PPR）或颗粒介导的基于荧光的细胞表面极化
公开(公告)号：WO2009000920A1
公开(公告)日：2008-12-31
申请号：PCT/EP2008058288
申请日：2008-06-27
申请人： UNIV DRESDEN TECH , OSTERMANN KAI , POMPE WOLFGANG , WERSING DAGMAR , LAKATOS MATHIAS , MERTIG MICHAEL , ROEDEL GERHARD , THIERFELDER SIMONE
发明人： OSTERMANN KAI , POMPE WOLFGANG , WERSING DAGMAR , LAKATOS MATHIAS , MERTIG MICHAEL , ROEDEL GERHARD , THIERFELDER SIMONE
IPC分类号： C12Q1/02 , G01N33/543 , G01N33/58
CPC分类号： G01N33/587 , G01N33/54373 , G01N2333/395
摘要： The invention relates to devices and methods for detecting a substance by cell surface polarizations and the detection thereof by means of PPR or particle-mediated fluorescence. The device for detecting a substance by cell surface polarization according to the invention has cells, wherein a gene the expression of which leads to the polarized presentation of a protein on the surface of the cell is placed under the control of a promotor which can be regulated by the substance to be detected, nanoparticles which are functionalized with a molecule which can bind specifically to the surface-exposed protein, and at least one optical measurement device, such that an accumulation of the nanoparticles on the surface of the cells can be detected by particle plasmon resonance or particle-mediated fluorescence.
摘要翻译：本发明涉及一种装置和用于其通过PPR的手段或颗粒介导的荧光检测由细胞表面极化及检测的物质的方法。本发明的用于通过细胞表面极化检测的物质的装置包括细胞，在其中一个基因，其表达导致细胞表面上的蛋白质的偏振呈现可调节的控制下被置于由待测物质启动子，与纳米颗粒是官能化能够特异性结合到所述表面暴露的蛋白质分子，和至少一个光学测量装置，以使由粒子等离子共振或颗粒介导的荧光可被检测的细胞的表面上的纳米颗粒的聚集。

2. 发明申请

WO2004096831A3 METHOD OF PRODUCING THREE-DIMENSIONAL STRUCTURES USING MOTOR PROTEINS 审中-公开
标题翻译：使用电机蛋白质生产三维结构的方法
公开(公告)号：WO2004096831A3
公开(公告)日：2005-03-03
申请号：PCT/EP2004004630
申请日：2004-04-30
申请人： MAX PLANCK GESELLSCHAFT , UNIV DRESDEN TECH , DIEZ STEFAN , REUTHER CORDULA , HOWARD JONATHON , SEIDEL RALF , MERTIG MICHAEL , POMPE WOLFGANG , BERGMANN MAX
发明人： DIEZ STEFAN , REUTHER CORDULA , HOWARD JONATHON , SEIDEL RALF , MERTIG MICHAEL , POMPE WOLFGANG , BERGMANN MAX
IPC分类号： C07K17/02 , C07K17/00
CPC分类号： B82Y30/00 , C07K17/02
摘要： The present invention relates to a method of producing a three-dimensional structure of a nanornaterial on a surface comprising the step of (a) contacting said polymer material affixed to (aa) biological filaments with biologically active motor proteins carried by said surface; or (ab) biologically active motor proteins with biological filaments carried by said surface in the presence of an energy source in a buffer having a pH value of 5 to 9 and containing monovalent or divalent cations. It is preferred that said nanomaterial is carbon nanotubes or DNA and that said biological filaments are actin filaments or microtubules. It is further preferred that said motor proteins are kinesin or myosin molecules. Also preferred is that said DNA carries metal ions. In particular, the metal ions can be attached to the DNA before or after structure formation. The invention additionally relates to a three-dimensional structure of nanornaterial obtainable by the method of the invention. Said three-dimensional structure preferably is a nanocircuit of metallized DNA.
摘要翻译：本发明涉及一种在表面上制造纳米材料的三维结构的方法，其包括以下步骤：（a）将附着于（aa）生物细丝的所述聚合物材料与由所述表面携带的生物活性运动蛋白接触; 或（ab）生物活性的运动蛋白，其具有在能量源存在下由所述表面承载的具有pH值为5至9并含有一价或二价阳离子的缓冲液中的生物细丝。所述纳米材料优选为碳纳米管或DNA，所述生物细丝为肌动蛋白丝或微管。更优选所述运动蛋白是驱动蛋白或肌球蛋白分子。所述DNA还优选携带金属离子。特别地，金属离子可以在结构形成之前或之后连接到DNA。本发明还涉及通过本发明的方法获得的纳米材料的三维结构。所述三维结构优选为金属化DNA的纳米电路。

3. 发明申请

WO2007012333A2 SUBSTRATE WITH SPATIALLY SELECTIVE METAL COATING METHOD FOR PRODUCTION AND USE THEREOF 审中-公开
标题翻译：选择性RAÜMLICHMETALLBESCHICHTUNG，生产和及其使用方法衬底
公开(公告)号：WO2007012333A2
公开(公告)日：2007-02-01
申请号：PCT/DE2006001363
申请日：2006-07-29
申请人： HOFINGER JUERGEN , POMPE WOLFGANG , MERTIG MICHAEL , KIRCHNER ALEXANDER , SCHREIBER NINA , BLUEHER ANJA , ROOS STEFFEN , KECK DANIELA , KATZSCHNER BEATE
发明人： HOFINGER JUERGEN , POMPE WOLFGANG , MERTIG MICHAEL , KIRCHNER ALEXANDER , SCHREIBER NINA , BLUEHER ANJA , ROOS STEFFEN , KECK DANIELA , KATZSCHNER BEATE
CPC分类号： C23C18/1889 , C23C18/31 , Y10T428/31678 , Y10T428/31681
摘要： The invention relates to a substrate with spatially selective metal coating and method for production thereof wherein the regions of metal coating on the substrate can be influenced. The invention further relates to the use of such substrates for catalysts, solid body electrolyte sensors or optical, transparent conducting layers. Said substrate with spatially selective metal coating the surfaces of which partly comprise biological templates with a metallic coating may be obtained by carrying out the metallic coating after deposition of the biological templates on the substrate.
摘要翻译：本发明涉及用空间选择性金属涂覆到基材，其制备方法，其中所述金属涂层的位置可在衬底上的影响的方法。本发明进一步涉及使用这样的基底为催化剂，固体电解质的传感器或光学透明的导电层。本发明的具有空间选择性的金属涂层的底物，其表面具有金属涂层部分有机模板，是在基板上的生物模板沉积之后进行，所述金属涂层获得。

4. 发明申请

WO2007017401A3 METHOD FOR INTEGRATING FUNCTIONAL NANOSTRUCTURES INTO MICROELECTRIC AND NANOELECTRIC CIRCUITS 审中-公开
标题翻译：微纳米电路中功能纳米结构的集成工艺
公开(公告)号：WO2007017401A3
公开(公告)日：2007-04-19
申请号：PCT/EP2006064761
申请日：2006-07-27
申请人： SIEMENS AG , SICKERT DANIEL , ECKSTEIN GERALD , BENKE ANNEGRET , JOST OLIVER , MERTIG MICHAEL , TAEGER SEBASTIAN
发明人： SICKERT DANIEL , ECKSTEIN GERALD , BENKE ANNEGRET , JOST OLIVER , MERTIG MICHAEL , TAEGER SEBASTIAN
IPC分类号： B82B3/00 , H01L21/768 , H01L29/10
CPC分类号： H01L51/102 , B82Y10/00 , B82Y30/00 , H01L51/0048
摘要： The invention relates to a method for integrating functional nanostructures into microelectric and nanoelectric circuits and to a method for producing at least one nanostructure (9) on a substrate (17) consisting in forming at least one multi-electrode arrangement (11) on the substrate (17), wherein said electrodes comprise respective electrode areas projected with respect to the opposite electrode ends (5) which extend along a line in such a way that the adjacent ends (5) produce a respectively frequency time-variable potential difference, in producing a suspension comprising nano-object (3) such as nanotubes, nano-wires and/or carbon nanotubes, in transferring said suspension to the substrate (17) which is arranged between the adjacent ends (5), respectively, in dielectrophoreticly deposing the assembly of respective individual nano-objects (7) on the line between said adjacent ends (5) and in fusing the assembly of respective nano-objects in the area of the ends (5) in such a way that the nanostructure (9) is formed.
摘要翻译：功能纳米结构在微电路和纳电电路中的整合过程。本发明涉及用于在衬底（17）上制造至少一个纳米结构（9）的方法。该方法是通过在基板上区分（17）成功端形成至少一个多电极结构（11），其中，所述电极各自具有从电极的端部（5），其这样沿着相邻端部的线布置背向突出电极部分（ 5）各自产生具有频率的时变电位差; 产生纳米管，纳米线和/或碳纳米管的纳米物体（3），其分别悬浮并将悬浮液转移到相邻端部（5）之间的基底（17）; 沿着相邻端部（5）之间的线，独立纳米物体积聚物（7）的介电泳沉积; 为了形成纳米结构（9），纳米物体积聚物（7）分别在端部（5）的区域中一起生长。

5. 发明专利

DE102004042286A1 Self-assembling proteins with altered electronic structure, useful in biomolecular engineering, e.g. for deposition of metal clusters, are modified by incorporation of electron donors 未知
公开(公告)号：DE102004042286A1
公开(公告)日：2006-03-02
申请号：DE102004042286
申请日：2004-08-25
申请人： UNIV DRESDEN TECH
发明人： MERTIG MICHAEL , KIRCHNER ALEXANDER , POMPE WOLFGANG , VYALIKH DENIS , DANZENBAECHER STEFFEN , DEDKOV YURIY , MOLODTSOV SERGUEI
IPC分类号： C07K1/107 , C07K14/195
摘要： Self-assembling proteins (I) with modified electronic structure in which the Fermi limit in this structure is shifted to higher energy so that states in the lowest unoccupied molecular orbital (LUMO) are occupied, are new. An independent claim is also included for several methods for preparing (I).

6. 发明专利

DE102008062620B4 Vorrichtung und Verfahren zur Detektion von in flüssigen Proben enthaltenen Analytmolekülen 未知
公开(公告)号：DE102008062620B4
公开(公告)日：2012-12-27
申请号：DE102008062620
申请日：2008-12-10
申请人： FRAUNHOFER GES FORSCHUNG , UNIV DRESDEN TECH
发明人： SONNTAG FRANK , KLOTZBACH UDO DR , GRUCHOW MATHIAS , MEHRINGER FLORIAN , MERTIG MICHAEL , ERLER CHRISTIAN
IPC分类号： G01N33/50 , G01N21/76
摘要： Vorrichtung zur Detektion von in flüssigen Proben enthaltenen Analytmolekülen, die an auf mindestens einer Messfläche immobilisierten Liganden anbinden, dabei die Probe durch einen Messkanal (2) strömt, an dem sich gegenüberliegend mindestens zwei Öffnungen (11, 12) für eine Zu- und eine Abfuhr von flüssiger Probe vorhanden sind, im Bereich des Messkanals (2) an einer Kanalwand zwischen den Öffnungen (11, 12) eine flächige metallische Dick- oder Dünnschicht als eine Elektrode (1), und der Elektrode (1) gegenüberliegend an einer weiteren Kanalwand mehrere elektrisch leitende streifenförmige Dünnschichten als weitere Elektroden (3) angeordnet sind, die an eine elektrische Wechselspannungsquelle angeschlossen sind, wobei an nebeneinander angeordneten Elektroden (3) jeweils ein anderes elektrisches Spannungspotential, zur Ausbildung inhomogener elektrischer Felder, eingehalten ist; dabei die Liganden oberhalb der einen Elektrode (1), mit Kontakt zur flüssigen Probe und in Kommunikation mit dem Messkanal (2) stehend, auf einer Messfläche (4) immobilisiert sind.

7. 发明专利

DE102004042286B4 未知
公开(公告)号：DE102004042286B4
公开(公告)日：2008-11-13
申请号：DE102004042286
申请日：2004-08-25
申请人： UNIV DRESDEN TECH
发明人： MERTIG MICHAEL , KIRCHNER ALEXANDER , POMPE WOLFGANG , VYALIKH DENIS , DANZENBAECHER STEFFEN , DEDKOV YURIY , MOLODTSOV SERGUEI
IPC分类号： C07K1/107 , C07K14/195

8. 发明专利

DE19831622B4 未知
公开(公告)号：DE19831622B4
公开(公告)日：2004-03-18
申请号：DE19831622
申请日：1998-07-15
申请人： UNIV DRESDEN TECH
发明人： LAMPENSCHERF STEFAN , MERTIG MICHAEL , POMPE WOLFGANG , TUCKERMANN MARTIN , GERBATSCH ANDRE , REICH GUENTER
IPC分类号： G01B7/16 , G01B11/06

9. 发明专利

DE102006043386A1 Electrical features improvement method for nano-electronic structure, involves arranging nanoelectronic structure between two electrodes, applying metallic salt solution on nanowires and nanotubes 未知
公开(公告)号：DE102006043386A1
公开(公告)日：2008-03-27
申请号：DE102006043386
申请日：2006-09-11
申请人： UNIV DRESDEN TECH
发明人： MERTIG MICHAEL , TAEGER SEBASTIAN , RANJAN NITESH
IPC分类号： B82B3/00 , B82B1/00
摘要： The method involves arranging a nanoelectronic structure between two electrodes, applying a metallic salt solution on a nanowires (2) and nanotubes. An alternating voltage applying on the electrodes, so that electrical fields are formed at defects of the nanowires and nanotube and metal is separated at the defects. The method involves an electrically leading or semiconducting nanowires and nanotubes with a certain diameter. The nanowires and nanotubes is made of carbon. Independent claims are also included for the following: (1) an arrangement for improvement of the electrical features of an nanoelectronic structure, which has nanoelectronic structure with electrically leading or semi conducting nanowires and nanotube (2) an application of a dielectrophoresis cell, which has two electrodes and a metallic salt solution (3) a nanoelectronic structure, which has electrically leading or semi conducting nanowires and nanotubes (4) an application of a nanoelectronic structure as sensor for measuring string bowden cable (5) a method for measuring bowden cable, which involves arranging electrically leading or semi conducting nanowires and nanotubes with a diameter between two electrodes.

10. 发明专利

DE102006057975A1 Detection of microorganisms and/or their activity by biosensors, by immobilizing ligands for binding a receptor at a substrate surface or immobilizing the receptor for the ligands at the surface in chemical-, physical- or biological manner 未知
公开(公告)号：DE102006057975A1
公开(公告)日：2007-06-06
申请号：DE102006057975
申请日：2006-12-01
申请人： UNIV DRESDEN TECH
发明人： OSTERMANN KAI , POMPE WOLFGANG , WERSING DAGMAR , MERTIG MICHAEL , GOODING JUSTIN , ROEDEL GERHARD , IHLE KAROLINA
IPC分类号： C12Q1/02
摘要： The detection of microorganisms and/or their activity using biosensors, comprises area-wise immobilization of signal molecule ligands for binding a receptor at a surface of a substrate (1) or immobilizing the receptor for the ligands at the surface of the substrate in chemical-, physical- or biological manner. By the bonding of ligands, which are sent from the microorganisms into a process quorum of sensing, the caused physical- or physico-chemical changes detected by sensor are measurable at the receptors. The receptors are provided with a sort of- or different sorts of fluorescence markers. The detection of microorganisms and/or their activity using biosensors, comprises area-wise immobilization of signal molecule ligands for binding of a receptor at a surface of a substrate (1) or immobilizing the receptor for the ligands at the surface of the substrate in chemical-, physical- or biological manner. By the bonding of ligands, which are sent from the microorganisms into a process quorum of sensing, the caused physical- or physico-chemical changes detected by sensor are measurable at the receptors. For the production of fusion proteins or peptides by recombination techniques, amino acid sequences of receptors are changed in such a way that a change of charge, mass, light, conformation or enzymatic reaction takes place in chemical- or physical manner. The ligands are bound at the surface, the receptors are bound at the ligands and the receptors of microorganisms are delivered in the process quorum of the sensing. The receptors are separated with ligands of the medium, and the separation instrumentation is detected by the changes of the charge, mass, optical- and magnetic characteristic, charge distribution or enzymatic activity. The biosensor is calibrated by accumulation of particles at the ligands or receptors. The surface of the substrate bound with the single molecules and with the receptors, is regenerated by a repeated coating with the receptor. The fusion of proteins or the peptide is changed in such a way that the mass of the fusion protein significantly increases. The peptide is arginine, histidine or lysine for a positive net charge or the peptides contain asparagine acid or glutamine acid for a negative net charge. The receptors in their amino acid sequences are changed in such a way that an affinity between the signal molecule and the receptor is increased or decreased. The receptors are provided with a sort of- or different sorts of fluorescence markers, which are fluorescence proteins or quantum dots. The signal molecule is an autoinducer-1 (AI-1) and/or an autoinducer-2 (AI-2) and/or its combinations. The receptor is either autoinducer 2-binding periplasmic protein LuxP-molecule or a genetically produced derivative. The peptides exhibit a self-fluorescence or cause enzymatic light reaction by the addition of the substrate molecules. By the recombination techniques, an additional protein, which exhibits proteolytic-, lipolytic- or nucleolytic function, is added at the receptors to produce fusion proteins. An independent claim is included for biosensors for the detection of microorganisms and/or their activity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式