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1. 发明申请

WO2009003487A2 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 审中-公开
标题翻译：用于监视和/或培养微观物体的装置，系统和方法
公开(公告)号：WO2009003487A2
公开(公告)日：2009-01-08
申请号：PCT/DK2008/050162
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/20 , C12M1/22
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.
摘要翻译：用于执行微观物体的监测和/或培养的装置，系统和方法技术领域本发明涉及用于执行微观物体的监测和/或培养的装置，系统和方法。微观物体特别是微生物，如细菌和细胞培养物，如组织样品和胚胎等培养物，为胚胎发育期间的孵化提供最佳和安全的培养条件，并促进选择最佳胚胎用于体外受精（ IVF）通过促进自动化数字成像和时间推移显微镜的胚胎处理。

2. 发明申请

WO2013029625A1 APPARATUS FOR MEASURING THE METABOLIC RATE OF MOTILE ORGANISMS 审中-公开
标题翻译：用于测量机体代谢率的装置
公开(公告)号：WO2013029625A1
公开(公告)日：2013-03-07
申请号：PCT/DK2012/050318
申请日：2012-08-29
申请人： UNISENSE RESPIROMETRY A/S , RAMSING, Niels B. , GUNDERSEN, Jens K. , PETERSEN, Bjørn Molt
发明人： RAMSING, Niels B. , GUNDERSEN, Jens K. , PETERSEN, Bjørn Molt
IPC分类号： G01N33/48 , C12M1/34 , C12Q1/02 , A61B10/00
CPC分类号： G01N33/5097 , G01N33/5005
摘要： The present invention relates to an apparatus and a method for measuring the metabolic rate of motile organisms, such as sperm cells or some forms of plankton. One embodiment of the invention discloses an apparatus for measurement of the metabolic rate of motile organisms in a medium comprising at least one compartment capable of accommodating at least a part of the medium, one or more capillary tubes in fluid communication with said compartment, and at least one metabolite detector for measuring the concentration of metabolite inside the compartment. One embodiment of the invention relates to measurement of the oxygen consumption of sperm cells, thereby obtaining a semen quality parameter.
摘要翻译：本发明涉及一种用于测量运动生物体如精子细胞或某些形式的浮游生物的代谢率的装置和方法。本发明的一个实施方案公开了一种用于测量培养基中活动生物体的代谢率的装置，包括至少一个能容纳介质的至少一部分的隔室，一个或多个与所述室流体连通的毛细管，以及至少一种用于测量隔室内代谢物浓度的代谢物检测器。本发明的一个实施方案涉及测量精子细胞的耗氧量，从而获得精液质量参数。

3. 发明申请

WO2014033210A1 AUTOMATIC SURVEILLANCE OF IN VITRO INCUBATING EMBRYOS 审中-公开
标题翻译：自动监测在体外监测EMBRYOS
公开(公告)号：WO2014033210A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067888
申请日：2013-08-29
申请人： UNISENSE FERTILITECH A/S
发明人： RAMSING, Niels B. , LÆGDSMAND, Mette , GUNDERSEN, Jens K. , PORSGAARD, Søren , AGERHOLM, Inge Errebo
IPC分类号： C12N5/073 , G06K9/00 , C12N5/02
CPC分类号： C12M21/06 , C12M41/36 , C12M41/46 , C12M41/48 , G06K9/00147
摘要： A computer implemented method for automatically detecting variations and/or abnormalities in the developmental conditions of in vitro incubating embryos, the method comprising the steps of: a) obtaining a first dataset comprising morphokinetic parameters relating to the development of a first group of embryos, b) obtaining a second dataset comprising morphokinetic parameters relating to the development of a second group of embryos, c) modifying the first and second datasets by extracting morphokinetic parameter outliers from the first dataset and or the second datasets, d) calculating the difference between specific morphokinetic parameters from the modified first dataset and the corresponding morphokinetic parameters from the modified second dataset, and monitoring said morphokinetic difference thereby detecting variations in the developmental conditions of the first and second group of embryos.
摘要翻译：一种计算机实现的方法，用于自动检测体外孵育胚胎的发育条件中的变异和/或异常，所述方法包括以下步骤：a）获得包含与第一组胚胎发育有关的形态动力学参数的第一数据集，b 获得第二数据集，其包括与第二组胚胎发育有关的形态动力学参数，c）通过从第一数据集和第二数据集提取形态动力学参数异常值来修改第一和第二数据集，d）计算特定形态动力学来自修改的第一数据集的参数和来自修改的第二数据集的相应的形态运动参数，以及监测所述形态运动差异，从而检测第一组和第二组胚胎的发育条件的变化。

4. 发明公开

EP2890781A1 AUTOMATIC SURVEILLANCE OF IN VITRO INCUBATING EMBRYOS 有权
标题翻译：体外自动监测胚胎培养
公开(公告)号：EP2890781A1
公开(公告)日：2015-07-08
申请号：EP13756438.1
申请日：2013-08-29
申请人： Unisense FertiliTech A/S
发明人： RAMSING, Niels B. , LÆGDSMAND, Mette , GUNDERSEN, Jens K. , PORSGAARD, Søren , AGERHOLM, Inge Errebo
IPC分类号： C12N5/073 , G06K9/00 , C12N5/02
摘要： A computer implemented method for automatically detecting variations and/or abnormalities in the developmental conditions of in vitro incubating embryos, the method comprising the steps of: a) obtaining a first dataset comprising morphokinetic parameters relating to the development of a first group of embryos, b) obtaining a second dataset comprising morphokinetic parameters relating to the development of a second group of embryos, c) modifying the first and second datasets by extracting morphokinetic parameter outliers from the first dataset and or the second datasets, d) calculating the difference between specific morphokinetic parameters from the modified first dataset and the corresponding morphokinetic parameters from the modified second dataset, and monitoring said morphokinetic difference thereby detecting variations in the developmental conditions of the first and second group of embryos.

5. 发明授权

EP2173853B1 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 有权转让
标题翻译：设备，系统和方法监测和/或栽培微观对象
公开(公告)号：EP2173853B1
公开(公告)日：2011-03-23
申请号：EP08758299.5
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/34
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.

6. 发明公开

EP2173853A2 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 有权转让
标题翻译：设备，系统和方法监测和/或栽培微观对象
公开(公告)号：EP2173853A2
公开(公告)日：2010-04-14
申请号：EP08758299.5
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M3/00
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.

7. 发明授权

EP2890781B1 AUTOMATIC SURVEILLANCE OF IN VITRO INCUBATING EMBRYOS 有权
公开(公告)号：EP2890781B1
公开(公告)日：2020-09-23
申请号：EP13756438.1
申请日：2013-08-29
申请人： Unisense FertiliTech A/S
发明人： RAMSING, Niels B. , LÆGDSMAND, Mette , GUNDERSEN, Jens K. , PORSGAARD, Søren , AGERHOLM, Inge Errebo
IPC分类号： C12N5/073 , G06K9/00 , C12N5/02

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