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1. 发明申请

WO2014060360A1 EMBRYO INCUBATOR INCORPORATING GAS CONTROL 审中-公开
公开(公告)号：WO2014060360A1
公开(公告)日：2014-04-24
申请号：PCT/EP2013/071433
申请日：2013-10-14
申请人： UNISENSE FERTILITECH A/S
发明人： PEDERSEN, Thomas William , PLOUGSGAARD, Holger Søe , RAMSING, Niels B
IPC分类号： C12M3/00 , C12M1/00 , C12M1/34
CPC分类号： C12M21/06 , C12M41/14 , C12M41/34
摘要： The invention relates to an incubator having a chamber for cultivating embryos and a gas control system for maintaining a constant atmosphere in the incubating chamber. In a first aspect the invention relates to an incubator for incubating embryos, comprising an incubating chamber adapted to contain the embryos, and a gas unitary module in fluid communication with the incubating chamber comprising at least two proportional valves, a CO 2 gas sensor and an O 2 gas sensor, wherein the gas unitary module is adapted to receive a gas supply of N 2 at one of said proportional valves and CO 2 at another of said proportional valves, and control the proportional valves based on feedback from the gas sensors such that supply of N 2 and CO 2 to the incubation chamber is regulated to sustain a predefined level of O 2 and/or CO 2 in said incubating chamber.
摘要翻译：本发明涉及具有培养胚胎的培养箱和用于在孵化室中保持恒定气氛的气体控制系统。在第一方面，本发明涉及用于孵育胚胎的培养箱，其包括适于容纳胚胎的孵化室，以及与所述孵育室流体连通的气体整体模块，所述孵育室包括至少两个比例阀，CO 2气体传感器和O2 气体传感器，其中气体单一模块适于在所述比例阀中的一个比例阀和另一个所述比例阀处接收CO 2的气体供应，并且基于来自气体传感器的反馈来控制比例阀，使得供应N2和调节孵化室的CO 2以维持所述孵育室中的预定水平的O 2和/或CO 2。

2. 发明申请

WO2010003423A2 ONE TO ONE IDENTIFICATION SYSTEM 审中-公开
标题翻译：一对一识别系统
公开(公告)号：WO2010003423A2
公开(公告)日：2010-01-14
申请号：PCT/DK2009/050162
申请日：2009-07-03
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels, B. , BERNTSEN, Jørgen , GUNDERSEN, Jens, K. , PLOUGSGAARD, Holger Søe
发明人： RAMSING, Niels, B. , BERNTSEN, Jørgen , GUNDERSEN, Jens, K. , PLOUGSGAARD, Holger Søe
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/12 , C12M41/12 , C12M41/26 , C12M41/36 , C12M41/46
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.
摘要翻译：本发明涉及一种用于辅助细胞的安全处理的系统，以便最小化处理导致细胞样品混合的错误的风险。该系统允许在整个培养期间对细胞进行一对一鉴定。这是通过为培养系统提供装载/出口控制装置获得的，其确保每次只能装载/移除一个装置。

3. 发明申请

WO2014140181A1 A TRAY, A SYSTEM AND A METHOD FOR MONITORING AND CULTURING OF A CELL CULTURE 审中-公开
标题翻译：用于监测和培养细胞培养物的托盘，系统和方法
公开(公告)号：WO2014140181A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054968
申请日：2014-03-13
申请人： UNISENSE FERTILITECH A/S
发明人： HANSEN, Jonas Lerche , RAMSING, Niels B. , PORSGAARD, Søren , PLOUGSGAARD, Holger Søe , ISAKSEN, Mai Faurschou
IPC分类号： C12M3/00 , C12M1/32 , C12M1/00 , C12M1/34 , B01L3/00
CPC分类号： C12M23/12 , B01L3/5085 , B01L2200/0668 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , C12M21/06 , C12M23/02 , C12M41/36 , G01N33/5005
摘要： A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally moulded with the carrier structure from a thermoplastic material.
摘要翻译：一种用于容纳诸如胚胎的细胞培养物（101）的托盘（100; 400; 500; 600），用于在培养期间使用并用于细胞培养物的光学监测。在体外受精期间包括限定用于容纳细胞培养物的至少一个容纳区（102; 402; 502; 602）的载体结构（104; 404; 504; 604）。与载体结构一体地形成至少一个聚焦透镜（110; 410; 510; 610），特别是数字孔径增加透镜，以便于通过载体结构监测细胞培养。焦点透镜的直径可以超过至少一个容纳区的直径。聚焦透镜可以与热塑性材料与载体结构一体地模制。

4. 发明申请

WO2009003487A2 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 审中-公开
标题翻译：用于监视和/或培养微观物体的装置，系统和方法
公开(公告)号：WO2009003487A2
公开(公告)日：2009-01-08
申请号：PCT/DK2008/050162
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/20 , C12M1/22
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.
摘要翻译：用于执行微观物体的监测和/或培养的装置，系统和方法技术领域本发明涉及用于执行微观物体的监测和/或培养的装置，系统和方法。微观物体特别是微生物，如细菌和细胞培养物，如组织样品和胚胎等培养物，为胚胎发育期间的孵化提供最佳和安全的培养条件，并促进选择最佳胚胎用于体外受精（ IVF）通过促进自动化数字成像和时间推移显微镜的胚胎处理。

5. 发明公开

EP2315823A2 ONE TO ONE IDENTIFICATION SYSTEM 有权转让
标题翻译： EINS-ZU-EINS-IDENTIFIZIERUNGSSYSTEM
公开(公告)号：EP2315823A2
公开(公告)日：2011-05-04
申请号：EP09776231.4
申请日：2009-07-03
申请人： UNISENSE FERTILITECH A/S
发明人： RAMSING, Niels, B. , BERNTSEN, Jørgen , GUNDERSEN, Jens, K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/18
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/12 , C12M41/12 , C12M41/26 , C12M41/36 , C12M41/46
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.
摘要翻译：本发明涉及一种用于辅助细胞的安全处理的系统，以便最小化处理导致细胞样品混合的错误的风险。该系统允许在整个培养期间对细胞进行一对一鉴定。这是通过为培养系统提供装载/出口控制装置获得的，其确保每次只能够装载/移除一个装置。

6. 发明授权

EP2173853B1 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 有权转让
标题翻译：设备，系统和方法监测和/或栽培微观对象
公开(公告)号：EP2173853B1
公开(公告)日：2011-03-23
申请号：EP08758299.5
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/34
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.

7. 发明公开

EP2173853A2 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 有权转让
标题翻译：设备，系统和方法监测和/或栽培微观对象
公开(公告)号：EP2173853A2
公开(公告)日：2010-04-14
申请号：EP08758299.5
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M3/00
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.

8. 发明公开

EP2906680A1 EMBRYO INCUBATOR INCORPORATING GAS CONTROL 无效
标题翻译：胚胎孵化MIT GASREGELUNG
公开(公告)号：EP2906680A1
公开(公告)日：2015-08-19
申请号：EP13776801.6
申请日：2013-10-14
申请人： Unisense FertiliTech A/S
发明人： PEDERSEN, Thomas William , PLOUGSGAARD, Holger Søe , RAMSING, Niels B
IPC分类号： C12M3/00 , C12M1/00 , C12M1/34
CPC分类号： C12M21/06 , C12M41/14 , C12M41/34
摘要： The invention relates to an incubator having a chamber for cultivating embryos and a gas control system for maintaining a constant atmosphere in the incubating chamber. In a first aspect the invention relates to an incubator for incubating embryos, comprising an incubating chamber adapted to contain the embryos, and a gas unitary module in fluid communication with the incubating chamber comprising at least two proportional valves, a CO
2 gas sensor and an O
2 gas sensor, wherein the gas unitary module is adapted to receive a gas supply of N
2 at one of said proportional valves and CO
2 at another of said proportional valves, and control the proportional valves based on feedback from the gas sensors such that supply of N
2 and CO
2 to the incubation chamber is regulated to sustain a predefined level of O
2 and/or CO
2 in said incubating chamber.

9. 发明授权

EP2315823B1 ONE TO ONE IDENTIFICATION SYSTEM 有权转让
标题翻译：一对一的身份识别系统
公开(公告)号：EP2315823B1
公开(公告)日：2018-03-07
申请号：EP09776231.4
申请日：2009-07-03
申请人： Unisense FertiliTech A/S
发明人： RAMSING, Niels, B. , BERNTSEN, Jørgen , GUNDERSEN, Jens, K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/18
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/12 , C12M41/12 , C12M41/26 , C12M41/36 , C12M41/46
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.

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