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1. 发明申请

WO2012139817A2 OIL-IN-WATER EMULSIONS 审中-公开
标题翻译：水包油乳液
公开(公告)号：WO2012139817A2
公开(公告)日：2012-10-18
申请号：PCT/EP2012/053611
申请日：2012-03-02
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , SMITH, Christopher , UNALI, Giovanni, Francesco
发明人： SMITH, Christopher , UNALI, Giovanni, Francesco
IPC分类号： A61K8/06 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/73 , A61K8/86 , A61Q19/00
CPC分类号： A61K8/92 , A61K8/062 , A61K8/39 , A61K8/602 , A61K8/604 , A61K8/731 , A61Q19/00
摘要： The invention provides an oil-in-water emulsion suitable for cosmetic or personal care use, the emulsion comprising: a) a aqueous continuous phase; b) a dispersed oil phase, and c) optionally, a nonionic emulsifier; in which the aqueous continuous phase is structured by a dispersed modified cellulose biopolymer, wherein the modification consists of the cellulose having its C6 primary alcohols oxidised to carboxyl moieties (acid/COOH-) on 10 to 70% of the glucose units and substantially all the remainder of the C6 positions occupied by unmodified primary alcohols; and in which the emulsion comprises less than 0.2 wt% anionic surfactant (by total weight anionic surfactant based on the total weight of the emulsion).
摘要翻译：本发明提供了一种适用于化妆品或个人护理用途的水包油乳液，所述乳液包含：a）水性连续相; b）分散的油相，和c）任选的非离子乳化剂; 其中水性连续相由分散的改性纤维素生物聚合物构成，其中改性由在其10至70％葡萄糖单元氧化成羧基部分（酸/ COOH-）的C6伯醇的纤维素组成，基本上全部未修饰的伯醇占据的C6位置的剩余部分; 并且其中乳液包含小于0.2重量％的阴离子表面活性剂（基于乳液总重量的总重量阴离子表面活性剂）。

2. 发明申请

WO2012171725A2 AQUEOUS GELS 审中-公开
标题翻译：水凝胶
公开(公告)号：WO2012171725A2
公开(公告)日：2012-12-20
申请号：PCT/EP2012/058523
申请日：2012-05-09
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , SCOTT, Janet, Lesley , SMITH, Christopher , UNALI, Giovanni, Francesco
发明人： SCOTT, Janet, Lesley , SMITH, Christopher , UNALI, Giovanni, Francesco
IPC分类号： A61K8/04 , A61K8/34 , A61K8/60 , A61K8/73 , A61Q19/00 , A61Q17/00
CPC分类号： A61Q5/00 , A61K8/042 , A61K8/34 , A61K8/345 , A61K8/60 , A61K8/731 , A61K2800/33 , A61Q19/00
摘要： The invention provides an aqueous gel comprising: a) from 0.5 to 5 wt% dispersed modified cellulose biopolymer, wherein the modification consists of the cellulose having its C6 primary alcohols oxidised to carboxyl moieties (acid/COOH-) on 10 to 70% of the glucose units and substantially all the remainder of the C6 positions occupied by unmodified primary alcohols; b) a water-soluble or water-miscible organic non-solvent for the modified cellulose biopolymer; c) 0 to 10 wt% non-surfactant electrolyte, and d) water; in which the aqueous gel comprises less than 3 wt% oil phase ingredients. The aqueous gels of the invention offer excellent tactile properties, in particular superior skin feel and reduced stickiness. Furthermore, the gels have thixotropic properties, allowing their usage in pumpable or sprayable formats. They also provide sufficient structure for the suspension of a variety of particulate materials.
摘要翻译：本发明提供了一种水性凝胶，其包含：a）0.5至5重量％的分散改性纤维素生物聚合物，其中所述改性由在其氧化至羧基部分（酸/ COOH-）的C6伯醇的纤维素占10至70％葡萄糖单元和未修饰的伯醇占据的C6位置的基本上所有其余部分; b）用于改性纤维素生物聚合物的水溶性或水混溶性有机非溶剂; c）0-10wt％非表面活性剂电解质，和d）水; 其中水凝胶包含小于3重量％的油相成分。本发明的水性凝胶提供优异的触感性，特别是优异的皮肤感觉和降低的粘性。此外，凝胶具有触变性，允许它们以可泵送或可喷涂的形式使用。它们还为各种颗粒材料的悬浮提供足够的结构。

3. 发明申请

WO2011066356A1 METHODS OF INCREASING DIHYDROXY ACID DEHYDRATASE ACTIVITY TO IMPROVE PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 审中-公开
标题翻译：增加二羟酸脱水酶活性的方法，以提高燃料，化学品和氨基酸的生产
公开(公告)号：WO2011066356A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057957
申请日：2010-11-24
申请人： GEVO, INC. , URANO, Jun , DUNDON, Catherine Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , ALBERT, Lynne
发明人： URANO, Jun , DUNDON, Catherine Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , ALBERT, Lynne
IPC分类号： C12N1/00
CPC分类号： C12P7/16 , C07K14/395 , C12N9/88 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y402/01009 , Y02E50/10
摘要： The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本发明涉及包含一种或多种二羟基酸脱水酶（DHAD） - 生物合成途径的重组微生物，以及使用所述重组微生物产生源自所述DHAD需要生物合成途径的有益代谢物的方法。在本发明的各个方面，重组微生物可被工程化以过表达一种或多种编码一种或多种Aft蛋白或其同系物的多核苷酸。在一些实施方案中，重组微生物可以包含细胞溶质定位的DHAD酶。在另外的实施方案中，重组微生物可以包含线粒体定位的DHAD酶。在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物，和非发酵酵母微生物。

4. 发明申请

WO2011019894A1 CYTOSOLIC ISOBUTANOL PATHWAY LOCALIZATION FOR THE PRODUCTION OF ISOBUTANOL 审中-公开
标题翻译： CYPOSOLIC ISOBUTANOL路线本地化生产ISOBUTANOL
公开(公告)号：WO2011019894A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045295
申请日：2010-08-12
申请人： GEVO, INC. , URANO, Jun , DUNDON, Catherine, Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , BERRY, Ruth , KALRA, Ishmeet
发明人： URANO, Jun , DUNDON, Catherine, Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , BERRY, Ruth , KALRA, Ishmeet
IPC分类号： C12P7/16
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12P7/16 , Y02E50/10
摘要： The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本发明提供重组微生物，其包含产生异丁醇的代谢途径与位于细胞溶质中的至少一种异丁醇途径酶，其中所述重组微生物被选择以从碳源产生异丁醇。还提供了使用所述重组微生物产生异丁醇的方法。在本发明的各个方面，重组微生物可以包含胞质活性异丁醇途径酶。在一些实施方案中，本发明提供具有细胞溶质活性的突变，修饰和/或嵌合异丁醇途径酶。在本文所述的各种实施方案中，重组微生物可以是酵母进化枝的微生物，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，前-GGD（全基因组复制）酵母微生物，和非发酵酵母微生物。

5. 发明申请

WO2010151525A1 YEAST ORGANISMS FOR THE PRODUCTION OF ISOBUTANOL 审中-公开
标题翻译：用于生产ISOBUTANOL的YEAST有机体
公开(公告)号：WO2010151525A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/039447
申请日：2010-06-22
申请人： GEVO, INC. , FELDMAN, Reid M. Renny , GUNAWARDENA, Uvini , URANO, Jun , MEINHOLD, Peter , ARISTIDOU, Aristos , DUNDON, Catherine Asleson , SMITH, Christopher
发明人： FELDMAN, Reid M. Renny , GUNAWARDENA, Uvini , URANO, Jun , MEINHOLD, Peter , ARISTIDOU, Aristos , DUNDON, Catherine Asleson , SMITH, Christopher
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12N1/16 , Y02E50/10
摘要： The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本发明提供包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。在本发明的各个方面，重组微生物可以包含导致丙酮酸脱羧酶和/或甘油-3-磷酸脱氢酶活性降低的修饰。在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物，和非发酵酵母微生物。

6. 发明申请

WO2008007042A1 A FASTENER 审中-公开
标题翻译：紧固件
公开(公告)号：WO2008007042A1
公开(公告)日：2008-01-17
申请号：PCT/GB2006/050200
申请日：2006-07-13
申请人： SMITH, Christopher
发明人： SMITH, Christopher
IPC分类号： F16B12/22
CPC分类号： F16B12/22
摘要： A first furniture panel (16) is fastened to a second furniture panel (21) by engaging a shoulder bolt (10) which projects from a side edge of the first panel (16) into an aperture (22) formed in a major face of the second furniture panel (21). The first furniture panel (16) is then displaced to move the bolt (10) along a slot (23) which extends from the aperture (22) and into a position where it is captively retained. A locking element (30) is then inserted into the aperture (22) to constrain the first furniture panel (16). The arrangement is ideally suited for use in self assembly flat-pack furniture because it is strong and easy to use. Also, the panels (16, 21) can easily be disconnected to allow the furniture to be disassembled.
摘要翻译：第一家具面板（16）通过将从第一面板（16）的侧边缘突出的肩螺栓（10）接合到形成在主面板（22）的主面上的孔（22）中而紧固到第二家具面板（21）第二家具面板（21）。然后，第一家具面板（16）被移动以沿着从孔（22）延伸并且被自动保持的位置的狭槽（23）移动螺栓（10）。然后将锁定元件（30）插入孔（22）中以约束第一家具面板（16）。该装置非常适用于自组装平板包装家具，因为它坚固且易于使用。此外，面板（16,21）可以容易地断开以允许家具被拆卸。

7. 发明申请

WO2022146820A1 COOKING DEVICE AND COMPONENTS THEREOF 审中-公开
公开(公告)号：WO2022146820A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/064836
申请日：2021-12-22
申请人： SHARKNINJA OPERATING LLC , RAPOSO, Danny, Martins , JACKSON, Roger, Neil , SMITH, Christopher
发明人： RAPOSO, Danny, Martins , JACKSON, Roger, Neil , SMITH, Christopher
IPC分类号： A47J27/086 , A47J27/08
摘要： A cooking system for cooking food includes a housing defining a hollow chamber configured to receive the food, a lid movable relative to said housing between an open position and a closed position to form a pressure-tight cooking volume between said hollow chamber and said lid, at least one heating element associated with at least one of said housing and said lid, and a temperature probe positionable within said pressure-tight cooking volume. The cooking system is operable in a pressure cooking mode and during said pressure cooking mode. The temperature probe is operable to detect a temperature of the food in said pressure- tight cooking volume.

8. 发明申请

WO2015048687A1 THREAT INTELLIGENCE ON A DATA EXCHANGE LAYER 审中-公开
标题翻译：数据交换层的智能智能
公开(公告)号：WO2015048687A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/058130
申请日：2014-09-29
申请人： MCAFEE INC. , SMITH, Christopher , MCDONALD, Edward T. , HANSON II, Don R.
发明人： SMITH, Christopher , MCDONALD, Edward T. , HANSON II, Don R.
IPC分类号： H04L12/22 , H04L29/02
CPC分类号： H04L63/1408 , H04L63/168
摘要： In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.
摘要翻译：在一个示例中，威胁情报控制器被配置为在数据交换层（DXL）上操作。威胁情报控制器作为网络对象的信誉数据的DXL消费者，可以以各种不同的类型和不同的来源报告。在授权作为声誉数据生产者的设备中，每个设备可能具有自己的信任级别。随着威胁情报控制器对来自不同提供商的数据进行聚合，可以根据信任级别对信誉报告进行加权。因此，威胁情报引擎为对象建立了复合信誉。当它接收到请求对象的信誉的DXL消息时，它会在DXL总线上发布复合信誉。

9. 发明申请

WO2015047436A1 EFFICIENT REQUEST-RESPONSE ROUTING OVER A DATA EXCHANGE LAYER 审中-公开
标题翻译：在数据交换层上有效的请求响应路由
公开(公告)号：WO2015047436A1
公开(公告)日：2015-04-02
申请号：PCT/US2013/076621
申请日：2013-12-19
申请人： MCAFEE, INC. , SMITH, Christopher , FARRENKOPF, Edward A.
发明人： SMITH, Christopher , FARRENKOPF, Edward A.
IPC分类号： G06F21/50 , G06F15/16
CPC分类号： H04L67/16 , H04L63/145 , H04L67/42
摘要： In an example, there is disclosed an efficient request/response routing over a publish/subscribe messaging framework. Upon receiving a request for a service, a DXL broker may identify zero or more DXL domain masters providing the service. If no DXL domain masters are available to provide the service, the DXL broker may send a response message, or publish a DXL message, indicating that the service is not available. If more than one DXL domain master provides the service, then the DXL broker may identify the best DXL domain master to service the request, and forward the request to that DXL domain master.
摘要翻译：在一个示例中，公开了通过发布/订阅消息传递框架的有效的请求/响应路由。在接收到服务请求时，DXL代理可识别提供该服务的零个或多个DXL域主。如果没有DXL域主机可用于提供服务，则DXL代理可以发送响应消息或发布DXL消息，指示该服务不可用。如果一个以上的DXL域主服务器提供服务，那么DXL代理可能会识别最佳的DXL域主服务器来处理该请求，并将该请求转发给该DXL域主服务器。

10. 发明申请

WO2013048599A2 KETOL-ACID REDUCTOISOMERASES WITH IMPROVED PERFORMANCE PROPERTIES 审中-公开
标题翻译：具有改进性能特性的酮酸降低脂肪酸
公开(公告)号：WO2013048599A2
公开(公告)日：2013-04-04
申请号：PCT/US2012/042624
申请日：2012-06-15
申请人： GEVO, INC. , CALIFORNIA INSTITUTE OF TECHNOLOGY , BUELTER, Thomas , LIES, Douglas , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , MEINHOLD, Peter , BERRY, Ruth , SNOW, Christopher , BASTIAN, Sabine
发明人： BUELTER, Thomas , LIES, Douglas , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , MEINHOLD, Peter , BERRY, Ruth , SNOW, Christopher
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12N9/0006 , C12N15/52 , C12Y101/01086 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.
摘要翻译：本发明涉及包含编码酮酸酸还原异构酶（KARI）或其修饰的NADH依赖性变体的至少一种核酸分子的重组微生物，其中所述KARI与SEQ ID NO：2至少约60％相同。本发明的方面，重组微生物可包含产生异丁醇的代谢途径，可用于制备异丁醇的方法。

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