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1. 发明申请

WO2013087644A2 METHOD OF STRENGTHENING HAIR FIBRES 审中-公开
标题翻译：加强毛发纤维的方法
公开(公告)号：WO2013087644A2
公开(公告)日：2013-06-20
申请号：PCT/EP2012/075121
申请日：2012-12-11
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , CONOPCO, INC., d/b/a UNILEVER
发明人： BHOGAL, Ranjit, Kaur , CASEY, John , D'AGOSTINO, Eleanor, Margaret
IPC分类号： A61K8/49 , A61K8/66 , A61Q5/00
CPC分类号： A61K8/66 , A61K8/22 , A61K8/498 , A61Q5/002 , A61Q5/02 , A61Q5/10 , A61Q5/12
摘要： Hair can be damaged in a number of ways including exposure to heat, bleaching, use of shampoos and styling products, brushing and combing, and exposure to the environment, for example ultra-violet light. Existing treatments designed to repair damaged hair make use of surface active materials that mask the problem rather than actually repairing the hair. These materials modify fibre feel by changing consumer perceivable fibre sensory cues such as smoothness, may change some measureable physical properties such as hydrophobicity and hydrophilicity, but do not change other physical characteristics such as fibre stiffness, strength or structural integrity. The invention relates to a method of repairing hair fibres using flavonoids, hydrogen peroxide and a peroxidase enzyme.
摘要翻译：毛发可以以多种方式被损坏，包括暴露于热，漂白，使用洗发剂和造型产品，刷牙和梳理以及暴露在环境中，例如紫外光。设计用于修复受损毛发的现有治疗方法是利用表面活性物质掩盖问题而不是实际修复头发。这些材料通过改变消费者可感知的纤维感官线索如光滑度来改变纤维感觉，可以改变一些可测量的物理性质如疏水性和亲水性，但不改变其它物理特性，例如纤维刚度，强度或结构完整性。本发明涉及使用黄酮，过氧化氢和过氧化物酶修复毛发纤维的方法。

2. 发明申请

WO2013189964A3 HAIR COLOURING COMPOSITION COMPRISING GOSSYPETIN 审中-公开
公开(公告)号：WO2013189964A3
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062699
申请日：2013-06-19
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： BHOGAL, Ranjit, Kaur , CASEY, John , GANGULI, Shovan , HUNTER, Karl, John , KOEK, Jean, Hypolites , REDFERN, Sally, Pamela
IPC分类号： A61K8/49 , A61Q5/06 , A61Q5/10 , A61K8/97 , A61K8/22
摘要： Hair colourant formulations fall into three main categories designated permanent, semi-permanent and temporary. Permanent hair colourant formulations are oxidative dye systems and generally contain paraphenylene diamine (PPD) and resorcinol, both of which have been shown to cause sensitisation and mutagenicity. Furthermore, severe oxidising conditions are required which in themselves cause skin irritation and sensitization as well as hair fibre damage. The inventive composition addresses the aforementioned disadvantages by providing a hair colour composition comprising: (a) Gossypetin; and either (b1 ) A combination of a peroxidase with either a hydrogen peroxide generator or hydrogen peroxide, or (b2) a laccase; wherein the composition has a pH of 4.5 to 7.0, preferably less than or equal to 6.0.

3. 发明申请

WO2013189966A3 HAIR COLOURING COMPOSITION COMPRISING BUTEIN 审中-公开
公开(公告)号：WO2013189966A3
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062701
申请日：2013-06-19
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., d/b/a UNILEVER
发明人： BHOGAL, Ranjit, Kaur , CASEY, John , GANGULI, Shovan , HUNTER, Karl, John , KOEK, Jean, Hypolites , REDFERN, Sally, Pamela
IPC分类号： A61K8/35 , A61Q5/06 , A61Q5/10 , A61K8/97 , A61K8/22
摘要： Hair colourant formulations fall into three main categories designated permanent, semi-permanent and temporary. Permanent hair colourant formulations are oxidative dye systems and generally contain paraphenylene diamine (PPD) and resorcinol, both of which have been shown to cause sensitisation and mutagenicity. Furthermore, severe oxidising conditions are required which in themselves cause skin irritation and sensitization as well as hair fibre damage. The inventive composition addresses the aforementioned disadvantages by providing a hair colour composition comprising: (a) Butein; and either (b1 ) A combination of a peroxidase with either a hydrogen peroxide generator or hydrogen peroxide, or (b2) a laccase; wherein the composition has a pH of 4.5 to 7.0, preferably less than or equal to 6.0.

4. 发明申请

WO2014095318A2 METHOD OF PREVENTING HAIR FIBRE DAMAGE 审中-公开
标题翻译：防止毛发纤维损伤的方法
公开(公告)号：WO2014095318A2
公开(公告)日：2014-06-26
申请号：PCT/EP2013/075202
申请日：2013-12-02
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., d/b/a UNILEVER
发明人： BHOGAL, Ranjit, Kaur , BONNIST, Eleanor, Yveline, Margaret , CASEY, John , D'AGOSTINO, Eleanor, Margaret , PUDNEY, Paul, David, Austin
CPC分类号： A61Q5/002 , A61K8/22 , A61K8/498 , A61K8/66 , A61Q5/02 , A61Q5/06
摘要： Hair can be damaged in a number of ways including exposure to heat, bleaching, use of shampoos and styling products, brushing and combing, and exposure to the environment, for example ultra-violet light. Existing treatments designed to repair damaged hair make use of surface active materials that mask the problem rather than actually repairing the hair. These materials modify fibre feel by changing consumer perceivable fibre sensory cues such as smoothness, may change some measureable physical properties such as hydrophobicity and hydrophilicity, but do not change other physical characteristics such as fibre stiffness, strength or structural integrity. The invention relates to a method of preventing hair fibre damage using flavonoids, hydrogen peroxide and a peroxidase enzyme.
摘要翻译：毛发可以以多种方式被损坏，包括暴露于热，漂白，使用洗发剂和造型产品，刷牙和梳理以及暴露在环境中，例如紫外光。设计用于修复受损毛发的现有治疗方法是利用表面活性物质掩盖问题而不是实际修复头发。这些材料通过改变消费者可感知的纤维感官线索如光滑度来改变纤维感觉，可以改变一些可测量的物理性质如疏水性和亲水性，但不改变其它物理特性，例如纤维刚度，强度或结构完整性。本发明涉及使用类黄酮，过氧化氢和过氧化物酶预防头发纤维损伤的方法。

5. 发明申请

WO2014095289A3 METHOD OF TREATING HAIR AGEING 审中-公开
公开(公告)号：WO2014095289A3
公开(公告)日：2014-06-26
申请号：PCT/EP2013/074936
申请日：2013-11-28
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., d/b/a UNILEVER
发明人： BHOGAL, Ranjit, Kaur , HASLAM, Iain, Stuart , JENKINS, Gail , PAUS, Ralf, Ludwig , SAWICKA, Magdalena , WAINWRIGHT, Linda, Jane
IPC分类号： A61Q7/00 , A61K8/46 , A61K8/49 , A61K8/63 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/34
摘要： Hair ageing is a major age-related consumer issue (hair loss, thinning hair, loss of shine, increased number of grey hairs, etc). Biological routes for hair growth or preventing hair greying provide effective opportunities to target consumer hair issues. Currently, Minoxidil ™ and Finasteride™ are the only clinically proven, mildly effective products available for hair growth and both are classified as medicines and therefore not suitable for cosmetic use. The identification of cosmetic ingredients which are able to boost hair growth, maintain anagen and/or prevent catagen may prove to be effective anti ageing treatments to prevent or attenuate some of the symptoms associated with hair ageing. This invention relates to a method of treating hair ageing. In particular the method relates to treating hair ageing through application to hair fibres of a composition comprising a nuclear factor erythroid-2 related factor 2 (also known as NFE2L2or Nrf2) agonist.

6. 发明申请

WO2013189965A2 HAIR COLOURING COMPOSITION 审中-公开
标题翻译：头发着色组合物
公开(公告)号：WO2013189965A2
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062700
申请日：2013-06-19
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., d/b/a UNILEVER
发明人： BHOGAL, Ranjit, Kaur , CASEY, John , GANGULI, Shovan , HUNTER, Karl, John , KOEK, Jean, Hypolites , REDFERN, Sally, Pamela
IPC分类号： A61K8/00
CPC分类号： A61K8/22 , A61K8/498 , A61K8/97 , A61K8/9706 , A61K2800/4322 , A61K2800/4324 , A61Q5/065 , A61Q5/10
摘要： Hair colourant formulations fall into three main categories designated permanent, semi-permanent and temporary. Permanent hair colourant formulations are oxidative dye systems and generally contain paraphenylene diamine (PPD) and resorcinol, both of which have been shown to cause sensitisation and mutagenicity. Furthermore, severe oxidising conditions are required which in themselves cause skin irritation and sensitization as well as hair fibre damage. The inventive composition addresses the aforementioned disadvantages by providing a hair colour composition comprising: (a) Taxifolin; and (b) A combination of a peroxidase with either a hydrogen peroxide generator or hydrogen peroxide; wherein the composition has a pH of 4.5 to 7.0, preferably less than or equal to 6.0.
摘要翻译：头发着色剂可分为永久性，半永久性和临时性三大类。永久性着色着色剂是氧化染料体系，通常含有对苯二胺（PPD）和间苯二酚，这两者都已被证明会引起致敏和致突变性。此外，需要严重的氧化条件，其本身会引起皮肤刺激和敏化以及头发纤维损伤。本发明的组合物通过提供一种头发颜色组合物来解决上述缺点，该组合物包含：（a）紫杉醇; 和（b）过氧化物酶与过氧化氢发生器或过氧化氢的组合; 其中所述组合物的pH为4.5至7.0，优选小于或等于6.0。

7. 发明申请

WO2020058155A1 PREVENTION OF POLLUTION DAMAGE TO THE SKIN OF AN INDIVIDUAL 审中-公开
公开(公告)号：WO2020058155A1
公开(公告)日：2020-03-26
申请号：PCT/EP2019/074627
申请日：2019-09-16
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： BHOGAL, Ranjit, Kaur , GHOSH DASTIDAR, Sudipta , MESSENGER, David, James , MUSCAT, Joseph , YUAN, Caigen
IPC分类号： A61K8/891 , A61Q17/00
摘要： The invention provides the use of a resin-based film former for the prevention of lipoperoxidation-based damage to the skin.

8. 发明申请

WO2016102177A1 HAIR COMPOSITION 审中-公开
标题翻译：头发组成
公开(公告)号：WO2016102177A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/078709
申请日：2015-12-04
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： BHOGAL, Ranjit, Kaur , JENKINS, Gail , SAWICKA, Magdalena , WAINWRIGHT, Linda, Jane
IPC分类号： A61K8/49 , A61K36/88 , A61K8/63 , A61Q17/00 , A61K8/97 , A61K31/56 , A61K31/575 , A61K36/04 , A61K36/15 , A61K36/185 , A61K36/324 , A61K36/328 , A61K36/68 , A61K36/73 , A61P17/14
CPC分类号： A61K8/63 , A61K8/42 , A61K8/46 , A61K8/4973 , A61K8/498 , A61K8/97 , A61K31/56 , A61K31/575 , A61K36/04 , A61K36/15 , A61K36/185 , A61K36/324 , A61K36/328 , A61K36/68 , A61K36/73 , A61K36/88 , A61K2800/592 , A61K2800/70 , A61Q7/00 , A61Q17/00 , A61K2300/00
摘要： Disclosed is an oral or topical composition comprising a nuclear factor erythroid-2 related factor 2 agonist and a liver X receptor agonist, wherein the amounts of each of the nuclear factor erythroid-2 related factor 2 agonist and the liver X receptor agonist produce a synergistic benefit of hair fibre growth, wherein the oral or topical composition comprises ≤ 9, preferably ≤ 8 % w/w β-sitosterol, wherein when the oral or topical composition comprises a catechin, the oral or topical composition comprises 0.001 to 90, preferably 0.005 to 70, most preferably 0.01 to 50 % w/w catechins, wherein the oral or topical composition excludes pregnenolone, 4, 5-dihydrofuranodiene-6-one, epoxy santamarin, hydroquinone, longistyline, monacolin K, protoanemonin, N-(2,2,2-trifluoro-ethyl)-N-[4-(2,2,2-tri-fluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-benzenesulfonamide, dihydronepetalactone, iridomyrmecin, and dihydroactinidiolide, wherein when the oral or topical composition comprises guggelsterone and epigallocatechin gallate, the oral or topical composition excludes a guggelsterone to epigallocatechin gallate weight ratio of 1 to 28, and wherein when the oral or topical composition comprises sodium dilauramide glutamide lysine, the oral or topical composition excludes 0.3 % w/w sodium dilauramide glutamide lysine.
摘要翻译：公开了包含核因子红细胞-2相关因子2激动剂和肝X受体激动剂的口服或局部组合物，其中每个核因子红系2相关因子2激动剂和肝X受体激动剂的量产生协同作用毛发纤维生长的益处，其中口服或局部组合物包含≤9，优选≤8％w / wβ-谷甾醇，其中当口服或局部组合物包含儿茶素时，口服或局部组合物包含0.001至90，优选0.005 其中口服或局部组合物不包括孕烯醇酮，4,5-二氢呋喃二酮-6-酮，环氧硫胺素，氢醌，长丝氨酸，莫纳可林K，原胰岛素，N-（2， 2,2-二氟乙基）-N- [4-（2,2,2-三氟-1-羟基-1-三氟甲基 - 乙基） - 苯基] - 苯磺酰胺，二氢荆芥内酯，伊立替康和二氢肉豆蔻酸，其中当口服或局部组合物包括gugg 槲皮素和表没食子儿茶素没食子酸酯，口服或局部组合物不包括凝胶剂至表没食子儿茶素没食子酸酯的重量比为1至28，并且其中当口服或局部组合物包含二月桂酰胺谷氨酰胺赖氨酸钠时，口服或局部组合物不包括0.3％w / w的二月桂酰胺钠谷氨酰胺赖氨酸。

9. 发明申请

WO2014122132A1 TOPICAL COLOURING COMPOSITION 审中-公开
标题翻译：主题色彩组成
公开(公告)号：WO2014122132A1
公开(公告)日：2014-08-14
申请号：PCT/EP2014/052166
申请日：2014-02-04
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： BHOGAL, Ranjit, Kaur , CASEY, John , GANGULI, Shovan , HUNTER, Karl, John , KOEK, Jean, Hypolites , REDFERN, Sally, Pamela
IPC分类号： A61Q5/10 , A61K8/49 , A61K8/66 , A61Q1/02 , A61Q1/12
CPC分类号： A61Q1/02 , A61K8/498 , A61K8/66 , A61Q5/065
摘要： Hair colourant formulations fall into three main categories designated permanent, semi-permanent and temporary. Permanent hair colourant formulations are oxidative dye systems and generally contain paraphenylene diamine (PPD) and resorcinol, both of which have been shown to cause sensitisation and mutagenicity. Furthermore,severe oxidising conditions are required which in themselves cause skin irritation and sensitization as well as hair fibre damage. The inventive composition addresses the aforementioned disadvantages by providing a topical colour composition comprising: (a) Quercetin; and (b) A laccase, wherein the composition has a pH of 4.5 to 7.0, preferably less than or equal to 6.0.
摘要翻译：头发着色剂可分为永久性，半永久性和临时性三大类。永久性毛发着色剂配方是氧化染料体系，通常含有对苯二胺（PPD）和间苯二酚，这两者都已显示引起致敏和致突变性。此外，需要严重的氧化条件，其本身会引起皮肤刺激和敏化以及头发纤维损伤。本发明的组合物通过提供一种局部颜色组合物来解决上述缺点，包括：（a）槲皮素; 和（b）漆酶，其中所述组合物的pH为4.5至7.0，优选小于或等于6.0。

10. 发明申请

WO2012004228A1 USE OF GLABRANIN FOR STIMULATING HAIR GROWTH 审中-公开
标题翻译：使用GLABRANIN刺激头发生长
公开(公告)号：WO2012004228A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/061243
申请日：2011-07-04
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , BHOGAL, Ranjit, Kaur , ROGERS, Julia, Sarah
发明人： BHOGAL, Ranjit, Kaur , ROGERS, Julia, Sarah
IPC分类号： A61K8/97 , A61Q7/00 , A61K31/352 , A61P9/12
CPC分类号： A61K8/498 , A61K8/97 , A61K31/353 , A61Q5/02 , A61Q5/12 , A61Q7/00
摘要： One of the major hair concerns for both men and women is that of hair loss. For men the most obvious manifestation of this is male pattern baldness known as alopecia areata. However hair shedding resulting in hair thinning is also a concern for both men and women. Individuals suffering hair loss often experience psychological disadvantages, for example social phobia, anxiety, and depression, due to their change in appearance. This invention relates to a hair care composition comprising glabranin or a derivative thereof. The invention also relates to a cosmetic method for increasing hair fibre diameter, stimulating hair growth, retaining hair or reducing hair loss, stimulating hair follicle growth in anagen or telogen phases, increasing hair fibre density and preventing or treating alopecia.
摘要翻译：男性和女性的主要头发之一是脱发。对于男性来说，最明显的表现是男性型秃发被称为斑秃。然而，头发脱落导致头发变薄也是男性和女性的关注。脱发的人经常会因心理上的不利因素而出现社会恐惧症，焦虑症和抑郁症。本发明涉及一种包含格拉布林或其衍生物的护发组合物。本发明还涉及一种用于增加头发纤维直径，刺激毛发生长，保持毛发或减少脱发，刺激毛发生长或后期阶段的毛囊生长，增加毛发纤维密度和预防或治疗脱发的美容方法。

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