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1. 发明申请

WO2017080958A1 COMPOSITION FOR HAIR FOLLICLE GROWTH 审中-公开
标题翻译：毛发生长的组合物
公开(公告)号：WO2017080958A1
公开(公告)日：2017-05-18
申请号：PCT/EP2016/076858
申请日：2016-11-07
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., d/b/a UNILEVER
发明人： FOWLER, Mark, Ian , JENKINS, Gail , MESSENGER, David, James , RABBANI, Naila , THORNALLEY, Paul, John , XUE, Mingzhan
IPC分类号： A61K8/34 , A61K8/49 , A61Q7/00 , A61K31/05 , A61K31/09 , A61K31/352 , A61K31/353
CPC分类号： A61Q7/00 , A61K8/347 , A61K8/498 , A61K31/353 , A61K2300/00 , A61K31/05 , A61K31/09
摘要： The invention relates to a composition, in particular to an oral anti-ageing composition for treating hair ageing. This invention is based on the observation that the combination of hesperetin, a flavanone, derivable from a natural rutinoside hesperetin 7-rutinoside (also known as hesperidin) in citrus, e.g., in Citrus aurantium L, Citrus sinensis, Zanthozylum gilletti, leaves of Agathosma serratifolia, and trans-resveratrol synergistically up-regulates NQO-1 in a gene expression assay. The combination also induces Glo1, decreases MG and MG-protein glycation, decreases insulin resistance, decreases fasting plasma glucose, induces modest weight loss, improves renal function, decreases vascular inflammation marker slCAM-1, improves arterial dilatation and decreases the risk of cardiovascular disease. Thus is one aspect of the invention, a composition is provided, the composition comprising a combination of: (a) 30-10000, preferably 60-5000, most preferably 60-2500 mg in the form of an equivalent daily dose of flavanone of structure (I) wherein R is -H or -CH3, and mono-, di- and tri-acylated derivatives thereof; and (b) 20-1000, preferably 45-750, most preferably 45-500 mg in the form of an equivalent daily dose stilbenoid, wherein the composition comprises at least 0.5 % w/w flavanone of structure I.
摘要翻译：本发明涉及一种组合物，特别涉及一种用于治疗头发老化的口服抗衰老组合物。本发明基于如下观察结果：橙皮素，一种来自天然芦丁苷橙皮素7-芸香糖苷（也称为橙皮苷）的黄烷酮在柑橘中的组合，例如在柑橘中，例如在枳实，柑橘中，紫色榛子，Agathosma serratifolia和反式白藜芦醇在基因表达分析中协同上调NQO-1。该组合还诱导Glo1，降低MG和MG蛋白糖基化，降低胰岛素抵抗，降低空腹血糖，诱导适度体重减轻，改善肾功能，降低血管炎症标志物slCAM-1，改善动脉扩张并降低心血管疾病的风险。因此，本发明的一个方面是提供一种组合物，该组合物包含以下物质的组合：（a）30-10000，优选60-5000，最优选60-2500mg的组合物，其为等当量日剂量的结构黄烷酮（I）其中R为-H或-CH 3，及其单 - ，二 - 和三 - 酰化衍生物; 和（b）20-1000，优选45-750，最优选45-500mg以等当量日剂量苯乙烯类形式存在，其中所述组合物包含至少0.5％w / w结构I的黄烷酮。

2. 发明申请

WO2020058155A1 PREVENTION OF POLLUTION DAMAGE TO THE SKIN OF AN INDIVIDUAL 审中-公开
公开(公告)号：WO2020058155A1
公开(公告)日：2020-03-26
申请号：PCT/EP2019/074627
申请日：2019-09-16
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： BHOGAL, Ranjit, Kaur , GHOSH DASTIDAR, Sudipta , MESSENGER, David, James , MUSCAT, Joseph , YUAN, Caigen
IPC分类号： A61K8/891 , A61Q17/00
摘要： The invention provides the use of a resin-based film former for the prevention of lipoperoxidation-based damage to the skin.

3. 发明公开

EP3399959A1 COMPOSITION FOR HAIR FOLLICLE GROWTH 有权转让
公开(公告)号：EP3399959A1
公开(公告)日：2018-11-14
申请号：EP16794283.8
申请日：2016-11-07
申请人： Unilever PLC , Unilever NV
发明人： FOWLER, Mark, Ian , JENKINS, Gail , MESSENGER, David, James , RABBANI, Naila , THORNALLEY, Paul, John , XUE, Mingzhan
IPC分类号： A61K8/34 , A61K8/49 , A61Q7/00 , A61K31/05 , A61K31/09 , A61K31/352 , A61K31/353
CPC分类号： A61K8/498 , A61K8/347 , A61K31/05 , A61K31/09 , A61K31/353 , A61P9/00 , A61Q7/00 , A61K2300/00
摘要： The invention relates to a composition, in particular to an oral anti-ageing composition for treating hair ageing. This invention is based on the observation that the combination of hesperetin, a flavanone, derivable from a natural rutinoside hesperetin 7-rutinoside (also known as hesperidin) in citrus, e.g., in Citrus aurantium L, Citrus sinensis, Zanthozylum gilletti, leaves of Agathosma serratifolia, and trans-resveratrol synergistically up-regulates NQO-1 in a gene expression assay. The combination also induces Glo1, decreases MG and MG-protein glycation, decreases insulin resistance, decreases fasting plasma glucose, induces modest weight loss, improves renal function, decreases vascular inflammation marker slCAM-1, improves arterial dilatation and decreases the risk of cardiovascular disease. Thus is one aspect of the invention, a composition is provided, the composition comprising a combination of: (a) 30-10000, preferably 60-5000, most preferably 60-2500 mg in the form of an equivalent daily dose of flavanone of structure (I) wherein R is -H or -CH3, and mono-, di- and tri-acylated derivatives thereof; and (b) 20-1000, preferably 45-750, most preferably 45-500 mg in the form of an equivalent daily dose stilbenoid, wherein the composition comprises at least 0.5 % w/w flavanone of structure I.

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