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1. 发明专利

ES2384506T3 1-(3-Metil-2,4-dimetoxifenil)-3-(2',4'-dihidroxifenil)-propano como un potente inhibidor de tirosinasa 未知
公开(公告)号：ES2384506T3
公开(公告)日：2012-07-06
申请号：ES05762186
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI FU , UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00
摘要： El compuesto 1-(3-metil-2,4-dimetoxifenil)-3-(2',4'-dihidroxifenil)-propano.

2. 发明专利

AU2005249493A1 Diarylalkanes as potent inhibitors of binuclear enzymes 未知
公开(公告)号：AU2005249493A1
公开(公告)日：2005-12-15
申请号：AU2005249493
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI-FU
发明人： ZHAO JI-FU , JIA QI
IPC分类号： A61K31/015 , A61K31/05 , A61K31/704 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

3. 发明公开

EP1748767A4 DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES 有权转让
标题翻译：二芳基烷烃AS高效抑制剂双核的酶
公开(公告)号：EP1748767A4
公开(公告)日：2008-12-24
申请号：EP05762186
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00
CPC分类号： A61K8/347 , A61K8/31 , A61K8/4973 , A61K8/97 , A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61K2800/782 , A61Q19/02 , C07C39/15 , C07C39/367 , C07C41/26 , C07C41/32 , C07C43/23 , C07C45/673 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

4. 发明申请

WO2004069161A3 POLYCOSANOLS FROM ERICERUS PELA WAX 审中-公开
标题翻译：茜素皮蜡多元醇
公开(公告)号：WO2004069161A3
公开(公告)日：2004-12-02
申请号：PCT/US2004002273
申请日：2004-01-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI-FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/045 , A01N31/00
CPC分类号： A61K31/045 , Y10S514/925 , A61K2300/00
摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as "polycosanol" produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.
摘要翻译：本发明提供了一种由昆虫蜡蝉分泌的蜡制备具有24至30个碳原子的伯脂族醇的独特性质的新方法。包括在本发明中的是本发明方法生产的物质组合物，在此称为“聚葡萄糖醇”。多元醇组合物主要由四种伯脂族醇，二十四烷醇，二十六烷醇，二十八烷醇和三十烷醇组成。本发明还包括所述组合物用于预防和治疗肥胖症，X综合征，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。

5. 发明专利

PL1748767T3 1-(3-metylo-2,4-dimetoksyfenylo)-3-(2',4'-dihydroksyfenylo)-propan jako silny inhibitor tyrozynazy 未知
公开(公告)号：PL1748767T3
公开(公告)日：2012-08-31
申请号：PL05762186
申请日：2005-05-27
申请人： UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/05 , A61K31/015 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00

6. 发明专利

HK1095536A1 1-(3-METHYL-2,4-DIMETHOXYPHENYL)-3-(2',4'-DIHYDROXYPHENYL)-PROPANE AS A POTENT TYROSINASE INHIBITOR 未知
公开(公告)号：HK1095536A1
公开(公告)日：2007-06-29
申请号：HK07102730
申请日：2007-03-13
申请人： UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K20060101 , A61K31/015 , A61K31/05 , A61K31/704 , A61P20060101 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D20060101 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

7. 发明专利

AT538778T 未知
公开(公告)号：AT538778T
公开(公告)日：2012-01-15
申请号：AT05762186
申请日：2005-05-27
申请人： UNIGEN INC , JIA QI , ZHAO JI-FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

8. 发明申请

WO2005020932A3 FORMULATION OF A MIXTURE OF FREE-B-RING FLAVONOIDS AND FLAVANS FOR USE IN THE PREVENTION AND TREATMENT OF COGNITIVE DECLINE AND AGE-RELATED MEMORY IMPAIRMENTS 审中-公开
标题翻译：制备免费B环FLAVONOIDS和FLAVANS混合物用于预防和治疗认知衰退和与年龄相关的记忆障碍
公开(公告)号：WO2005020932A3
公开(公告)日：2005-07-28
申请号：PCT/US2004028639
申请日：2004-09-01
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , BURNETT BRUCE , ZHAO YUAN
发明人： JIA QI , BURNETT BRUCE , ZHAO YUAN
IPC分类号： A61K20060101 , A61K31/353 , A61K31/7048 , A61K35/78
CPC分类号： A61K36/539 , A61K31/35 , A61K36/48
摘要： The present invention provides a novel method for preventing and treating memory and cognitive impairment resulting from oxidative stress, inflammation and the process of aging, as well as, neurodegenerative conditions. The method is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants to a host in need thereof. The present also includes a novel method for simultaneously inhibiting expression of pro-inflammatory cytokines, preventing ROS generation and augmenting anti-oxidant defenses. The activity of this composition is conducive to ultimately preserving cognitive function and providing a level of neuroprotection.
摘要翻译：本发明提供了一种用于预防和治疗由氧化应激，炎症和衰老过程以及神经变性疾病引起的记忆和认知障碍的新方法。该方法包括施用包含游离B环类黄酮和从单一植物或多种植物合成和/或分离的黄烷的混合物到有需要的宿主的组合物。本发明还包括同时抑制促炎细胞因子表达，预防ROS产生和增强抗氧化防御的新方法。该组合物的活性有助于最终保持认知功能并提供一定程度的神经保护作用。

9. 发明申请

WO2006122160A3 COMPOSITIONS OF BAKUCHIOL AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：硼酸钾的组合物及其制备方法
公开(公告)号：WO2006122160A3
公开(公告)日：2007-02-08
申请号：PCT/US2006018006
申请日：2006-05-09
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , HONG MEI-FENG
发明人： JIA QI , HONG MEI-FENG
IPC分类号： A61K36/00
CPC分类号： A61K31/05 , A61K9/0014 , A61K36/487
摘要： The present invention provides compositions of bakuchiol (UP246) having low levels of impurities, particularly furanocoumarin impurities. The present invention further provides improved methods for the isolation, purification and analysis of compositions of bakuchiol. Finally, the present invention provides methods for using the purified bakuchiol compositions and formulations thereof for the prevention and treatment of various diseases and conditions mediated by cyclooxygenase (COX), lipoxygenase (LOX), minor inflammatory conditions and various microbial infections. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.
摘要翻译：本发明提供具有低水平杂质，特别是呋喃香豆素杂质的组合酚（UP246）。本发明进一步提供了用于分离，纯化和分析bakuchiol组合物的改进方法。最后，本发明提供了使用纯化的bakuchiol组合物及其制剂用于预防和治疗由环氧合酶（COX），脂氧合酶（LOX），轻微炎性病症和各种微生物感染介导的各种疾病和病症的方法。本发明的方法包括向有需要的宿主施用有效量的本发明组合物和药学上可接受的载体。

10. 发明申请

WO2006099217A2 FORMULATION OF A MIXTURE OF FREE-B-RING FLAVONOIDS AND FLAVANS AS A THERAPEUTIC AGENT 审中-公开
标题翻译：作为治疗药物的免费B环黄酮和FLAVANS的混合物的配制
公开(公告)号：WO2006099217A2
公开(公告)日：2006-09-21
申请号：PCT/US2006008749
申请日：2006-03-10
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO YUAN
发明人： JIA QI , ZHAO YUAN
IPC分类号： A61K36/539 , A61K31/353 , A61K31/365 , A61K31/366 , A61K31/415 , A61K36/28 , A61K36/48 , A61K36/53
CPC分类号： A61K36/60 , A61K31/192 , A61K31/353 , A61K31/365 , A61K31/366 , A61K31/405 , A61K31/415 , A61K31/727 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/53 , A61K36/54 , A61K36/906 , A61K45/06 , A61K2300/00
摘要： The present invention provides a composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans- referred to herein as UP736 for use in the prevention and treatment of diseases and conditions related to platelet aggregation and platelet-induced thrombosis. The invention further provides a novel composition of matter comprised of UP736 in combination with injectable or oral anticoagulants, antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors and a method for using said composition in the prevention and treatment of diseases and conditions related to platelet aggregation and platelet-induced thrombosis. Finally, this invention provides a method for using UP736 in combination with anti-platelet, anti-coagulant, prophylaxis agents and NSAIDs as a means for reducing the dosage of these agents, decreasing the side effects associated with acute or chronic administration of these agents; counteracting or antagonizing the risks of acute or chronic administration of these agents and for achieving additional and/or multiple clinical benefits.
摘要翻译：本发明提供了由两种特定类别的化合物的混合物组成的物质组合物 - 用于预防和治疗与血小板聚集有关的疾病和病症的免费B环类黄酮和本文称为UP736的黄烷，血小板诱导血栓形成。本发明还提供了一种由UP736与可注射或口服抗凝剂，抗血小板剂，非甾体抗炎药（NSAID）和COX-2选择性抑制剂组合的新物质组合物，以及使用所述组合物在预防和/ 治疗与血小板聚集和血小板引起的血栓形成相关的疾病和病症。最后，本发明提供了一种使用UP736与抗血小板，抗凝血剂，预防剂和NSAID组合的方法，作为减少这些药物剂量的方法，减少与这些药物的急性或慢性给药有关的副作用; 抵制或拮抗这些药物的急性或慢性给药的风险以及获得额外和/或多种临床益处。

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