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1. 发明专利

ES2384506T3 1-(3-Metil-2,4-dimetoxifenil)-3-(2',4'-dihidroxifenil)-propano como un potente inhibidor de tirosinasa 未知
公开(公告)号：ES2384506T3
公开(公告)日：2012-07-06
申请号：ES05762186
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI FU , UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00
摘要： El compuesto 1-(3-metil-2,4-dimetoxifenil)-3-(2',4'-dihidroxifenil)-propano.

2. 发明专利

AU2005249493A1 Diarylalkanes as potent inhibitors of binuclear enzymes 未知
公开(公告)号：AU2005249493A1
公开(公告)日：2005-12-15
申请号：AU2005249493
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI-FU
发明人： ZHAO JI-FU , JIA QI
IPC分类号： A61K31/015 , A61K31/05 , A61K31/704 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

3. 发明公开

EP1748767A4 DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES 有权转让
标题翻译：二芳基烷烃AS高效抑制剂双核的酶
公开(公告)号：EP1748767A4
公开(公告)日：2008-12-24
申请号：EP05762186
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00
CPC分类号： A61K8/347 , A61K8/31 , A61K8/4973 , A61K8/97 , A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61K2800/782 , A61Q19/02 , C07C39/15 , C07C39/367 , C07C41/26 , C07C41/32 , C07C43/23 , C07C45/673 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

4. 发明申请

WO2004069161A3 POLYCOSANOLS FROM ERICERUS PELA WAX 审中-公开
标题翻译：茜素皮蜡多元醇
公开(公告)号：WO2004069161A3
公开(公告)日：2004-12-02
申请号：PCT/US2004002273
申请日：2004-01-27
申请人： UNIGEN PHARMACEUTICALS INC , JIA QI , ZHAO JI-FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/045 , A01N31/00
CPC分类号： A61K31/045 , Y10S514/925 , A61K2300/00
摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as "polycosanol" produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.
摘要翻译：本发明提供了一种由昆虫蜡蝉分泌的蜡制备具有24至30个碳原子的伯脂族醇的独特性质的新方法。包括在本发明中的是本发明方法生产的物质组合物，在此称为“聚葡萄糖醇”。多元醇组合物主要由四种伯脂族醇，二十四烷醇，二十六烷醇，二十八烷醇和三十烷醇组成。本发明还包括所述组合物用于预防和治疗肥胖症，X综合征，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。

5. 发明专利

AT538778T 未知
公开(公告)号：AT538778T
公开(公告)日：2012-01-15
申请号：AT05762186
申请日：2005-05-27
申请人： UNIGEN INC , JIA QI , ZHAO JI-FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

6. 发明专利

HK1095536A1 1-(3-METHYL-2,4-DIMETHOXYPHENYL)-3-(2',4'-DIHYDROXYPHENYL)-PROPANE AS A POTENT TYROSINASE INHIBITOR 未知
公开(公告)号：HK1095536A1
公开(公告)日：2007-06-29
申请号：HK07102730
申请日：2007-03-13
申请人： UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K20060101 , A61K31/015 , A61K31/05 , A61K31/704 , A61P20060101 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D20060101 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

7. 发明专利

PL1748767T3 1-(3-metylo-2,4-dimetoksyfenylo)-3-(2',4'-dihydroksyfenylo)-propan jako silny inhibitor tyrozynazy 未知
公开(公告)号：PL1748767T3
公开(公告)日：2012-08-31
申请号：PL05762186
申请日：2005-05-27
申请人： UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/05 , A61K31/015 , A61K31/085 , A61K31/09 , A61K31/357 , A61K31/40 , A61K31/704 , A61P17/00 , A61P35/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D233/02 , C07D321/12 , C07D323/00

8. 发明专利

BRPI0510415A 未知
公开(公告)号：BRPI0510415A
公开(公告)日：2007-10-23
申请号：BRPI0510415
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K31/015 , A61K31/05 , A61K31/704 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

9. 发明专利

CA2567801C DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES 未知
公开(公告)号：CA2567801C
公开(公告)日：2013-12-03
申请号：CA2567801
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC
发明人： JIA QI , ZHAO JI-FU
IPC分类号： C07C43/295 , A61K31/015 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/704 , A61K36/00 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds - diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

10. 发明专利

CA2567801A1 DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES 未知
公开(公告)号：CA2567801A1
公开(公告)日：2005-12-15
申请号：CA2567801
申请日：2005-05-27
申请人： UNIGEN PHARMACEUTICALS INC
发明人： ZHAO JI-FU , JIA QI
IPC分类号： A61K31/015 , A61K31/05 , A61K31/704 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

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