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1. 发明授权

US5039459A Method of forming shaped hydrogel articles including contact lenses 失效
标题翻译：形成包括隐形眼镜的成形水凝胶制品的方法
公开(公告)号：US5039459A
公开(公告)日：1991-08-13
申请号：US451077
申请日：1989-12-15
申请人： Ture Kindt-Larsen , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
发明人： Ture Kindt-Larsen , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
IPC分类号： G02C7/04 , A61F9/00 , B29D11/00 , C08F2/00 , C08F2/02 , C08F2/44 , C08F220/10 , C08F220/18 , C08F220/28 , C08J7/00 , C08K5/05 , G02B1/04
CPC分类号： G02B1/043 , B29D11/00038 , B29K2033/08 , B29K2033/12 , B29K2105/0002 , B29K2707/02 , B29K2995/0092 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by (1) molding or casting a polymerization mixture comprising: (a) a monomer mixture comprising a major proportion of a hydrophilic (meth)acrylate ester such as 2-hydroxyethyl methacrylate, an alkyl (meth)acrylate wherein the alkyl group contains at least four carbon atoms, and a cross-linking monomer; and (b) a water-displaceable diluent, wherein said diluent has a viscosity of at least 100 MPa Sec at 30.degree. C., and wherein said diluent consists essentially of a boric acid ester of certain dihydric alcohols, said dihydric alcohols having Hansen polar (w.sub.p) and Hansen hydrogen bonding (w.sub.h) cohesion parameters falling within the area of a circle defined as having a center at w.sub.h =20.5, w.sub.p =13, and a radius of 8.5, to produce a shaped gel of a copolymer of said monomers and said diluent, and (2) thereafter replacing said diluent with water.
摘要翻译：诸如软性隐形眼镜的成形水凝胶制品通过（1）模制或浇铸聚合混合物制备，所述聚合混合物包含：（a）包含主要比例的亲水性（甲基）丙烯酸酯如甲基丙烯酸2-羟乙酯，烷基（甲基）丙烯酸酯，其中烷基含有至少四个碳原子，和交联单体; 和（b）可水移动的稀释剂，其中所述稀释剂在30℃下具有至少100MPa Sec的粘度，并且其中所述稀释剂基本上由某些二元醇的硼酸酯组成，所述二元醇具有Hansen极性（wp）和Hansen氢键（wh）内聚参数落入限定为具有中心的圆的区域中，其中心为wh = 20.5，wp = 13，半径为8.5，以产生所述单体的共聚物的成形凝胶和所述稀释剂，和（2）此后用水代替所述稀释剂。

2. 发明授权

US5292350A Method for preparing tinted contact lens 失效
标题翻译：着色隐形眼镜的制备方法
公开(公告)号：US5292350A
公开(公告)日：1994-03-08
申请号：US873316
申请日：1992-04-24
申请人： Frank F. Molock , James D. Ford , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
发明人： Frank F. Molock , James D. Ford , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
IPC分类号： B29D11/00 , D06P1/382 , D06P1/52 , D06P3/34 , G02B1/04 , G02C7/02 , G02C7/04 , D06P5/00
CPC分类号： G02C7/021 , B29D11/00317 , D06P1/382 , D06P1/5257 , D06P3/348 , G02B1/043
摘要： An improved method is disclosed of imparting a tint or color to a soft, hydrogel contact lens by uniformly dispersing a dye throughout the lens. The dye is composed of a water-soluble compound essentially free of ethylenic unsaturation. A homogeneous solution of the dye in a hydrophilic monomer is prepared, the solution is subjected to polymerization conditions to yield a hydrophilic polymer from which the lens is formed, and the dye dispersed within the polymer is bonded to the polymer by contact with aqueous base prior to final hydration.The finished lens does not require soaking in an aqueous solution of the dye to impart the desired tint or color to the lens. Additionally, the dye uniformly dispersed throughout the lens according to the improved method does not leach out of the lens or migrate within the lens.
摘要翻译：公开了一种改进的方法，通过使染料均匀地分散在整个透镜中，将柔软的水凝胶隐形眼镜赋予着色或着色。染料由基本上不含烯属不饱和键的水溶性化合物组成。制备染料在亲水单体中的均匀溶液，使溶液经受聚合条件以产生形成透镜的亲水聚合物，并且分散在聚合物内的染料通过与碱水溶液接触而与聚合物结合最终水化。成品镜片不需要在染料的水溶液中浸泡以赋予镜片所需的色调或颜色。此外，根据改进的方法均匀分散在整个透镜中的染料不会从透镜中浸出或在透镜内迁移。

3. 发明授权

US08097565B2 Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes 有权
标题翻译：具有一致浓度的多官能聚硅氧烷的硅氧烷水凝胶
公开(公告)号：US08097565B2
公开(公告)日：2012-01-17
申请号：US10861798
申请日：2004-06-04
申请人： Gregory A. Hill , John C. Heaton , Michael R. Clark , Shivkumar Mahadevan , Carrie L Caison , Frank F. Molock
发明人： Gregory A. Hill , John C. Heaton , Michael R. Clark , Shivkumar Mahadevan , Carrie L Caison , Frank F. Molock
IPC分类号： C40B40/00
CPC分类号： G02B1/043 , C08F230/08 , C08G77/04 , C08L43/04 , C08L33/00
摘要： The present invention relates to a process comprising forming a monomer mixture comprising at least one monofunctional silicone containing component which comprises at least one difunctional byproduct and adding to said monomer mixture a normalizing amount of said at least one difunctional byproduct and curing said monomer mixture to form a biomedical device.
摘要翻译：本发明涉及一种方法，包括形成包含至少一种单官能含硅氧烷的组分的单体混合物，其包含至少一种双官能副产物，并向所述单体混合物中加入标准化量的所述至少一种双官能副产物并固化所述单体混合物以形成生物医学装置。

4. 发明申请

US20110085937A1 Method and Apparatus of Sterilization Using Monochromatic UV Radiation Source 有权
标题翻译：使用单色紫外线辐射源灭菌的方法和装置
公开(公告)号：US20110085937A1
公开(公告)日：2011-04-14
申请号：US12971486
申请日：2010-12-17
申请人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
发明人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
IPC分类号： A61L2/10
CPC分类号： A61L12/063 , A61L2/10 , B65B25/008
摘要： This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2.This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device. This invention provides a process and apparatus in which sterilization can be achieved in less than 20 seconds, preferably less than 15 seconds, more preferably in less than 5 seconds. The process and apparatus are efficient and continuous.
摘要翻译：本发明提供了一种对医疗装置进行灭菌的方法，优选包括所述医疗装置的密封容器的内容物，其包括将所述医疗装置暴露于单色紫外线辐射的步骤，由此使嗜热脂肪芽孢杆菌（ATCC 7953）的D值至少为在257nm处的23.7mJ / cm 2单色紫外线辐射对孢子。此外，本发明提供一种消毒医疗装置的方法，包括以下步骤：对所述医疗装置进行单色紫外线辐射，其中到达所述医疗装置上存在的微生物的257nm处的所述单色紫外线辐射的最小总能量密度至少为 284mJ / cm 2。本发明还提供一种用于将UV辐射递送到用于灭菌的医疗装置的装置，包括用于激光的激光器和扫描仪，使得在257nm处的至少284mJ / cm 2施加到所述医疗装置的治疗区域。本发明提供一种方法和装置，其中可以在少于20秒，优选小于15秒，更优选在少于5秒内实现灭菌。该方法和设备是有效和连续的。

5. 发明授权

US07052131B2 Biomedical devices containing internal wetting agents 有权
公开(公告)号：US07052131B2
公开(公告)日：2006-05-30
申请号：US10236762
申请日：2002-09-06
申请人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , Kent A Young , James D. Ford
发明人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , Kent A Young , James D. Ford
IPC分类号： G02C7/04 , C06F230/08
CPC分类号： A61L27/52 , A61L27/18 , A61L27/26 , G02B1/043 , C08L83/04
摘要： This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

6. 发明授权

US08431669B2 Biomedical devices containing internal wetting agents 有权
公开(公告)号：US08431669B2
公开(公告)日：2013-04-30
申请号：US13430839
申请日：2012-03-27
申请人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
发明人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
IPC分类号： G02C7/04 , C08L1/00 , C08F8/00 , C08F226/10 , C08J3/28 , B29D11/00
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/52 , C08F251/00 , C08F265/04 , C08F271/00 , C08F271/02 , C08F283/06 , C08F283/12 , C08F290/06 , C08F291/00 , G02C7/022 , C08L83/04
摘要： This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

7. 发明申请

US20100084775A1 BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS 有权
公开(公告)号：US20100084775A1
公开(公告)日：2010-04-08
申请号：US12630219
申请日：2009-12-03
申请人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
发明人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
IPC分类号： B29D11/00 , C08F8/00 , C08J3/28 , C08F226/10
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/52 , C08F251/00 , C08F265/04 , C08F271/00 , C08F271/02 , C08F283/06 , C08F283/12 , C08F290/06 , C08F291/00 , G02C7/022 , C08L83/04
摘要： This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

8. 发明申请

US20080316424A1 Biomedical Devices Containing Internal Wetting Agents 审中-公开
标题翻译：包含内部润湿剂的生物医学装置
公开(公告)号：US20080316424A1
公开(公告)日：2008-12-25
申请号：US12197622
申请日：2008-08-25
申请人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
发明人： Kevin P. McCabe , Frank F. Molock , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
IPC分类号： G02C7/04
摘要： This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.
摘要翻译：本发明包括含有高分子量亲水聚合物和羟基官能化含硅氧烷单体的可湿性生物医学装置。

9. 发明授权

US07461937B2 Soft contact lenses displaying superior on-eye comfort 有权
标题翻译：柔软的隐形眼镜表现出优越的眼睛舒适度
公开(公告)号：US07461937B2
公开(公告)日：2008-12-09
申请号：US11036669
申请日：2005-01-14
申请人： Robert Steffen , Kevin McCabe , David Turner , Azaam Alli , Kent Young , Cristina Schnider , Gregory A. Hill
发明人： Robert Steffen , Kevin McCabe , David Turner , Azaam Alli , Kent Young , Cristina Schnider , Gregory A. Hill
IPC分类号： G02C7/04
CPC分类号： C08F226/10 , B29D11/00067 , C08F220/60
摘要： The present invention relates to soft contact lenses having an overall comfort preference of at least about 2 to 1 as compared to an Acuvue® contact lens and measured after one week of daily wear. The present invention further relates to a soft contact lens comprising an oxygen transmissibility greater than about 70 barrers/mm and physical properties suitable to provide wearer comfort over at least about 9 hours in at least about 80% of wearers, as measured in a randomized, double masked clinical study.
摘要翻译：本发明涉及与隐形眼镜相比具有至少约2至1的整体舒适偏好并且在每日磨损一周后测量的软性隐形眼镜。本发明还涉及一种软性隐形眼镜，其包含大于约70巴勒/毫米的透氧率和适于在至少约80％的佩戴者中在至少约9小时内提供佩戴者舒适度的物理性质，如随机，双重掩蔽临床研究。

10. 发明授权

US6088744A Multiport data buffer having multi level caching wherein each data port has a FIFO buffer coupled thereto 失效
标题翻译：具有多级缓存的多端口数据缓冲器，其中每个数据端口具有耦合到其上的FIFO缓冲器
公开(公告)号：US6088744A
公开(公告)日：2000-07-11
申请号：US23837
申请日：1998-02-13
申请人： Gregory A. Hill
发明人： Gregory A. Hill
IPC分类号： G06F13/38 , G06F5/06 , G06F5/10 , H04L12/40 , H04L12/64 , G06F13/00
CPC分类号： G06F5/10 , H04L12/40123
摘要： A three port FIFO buffer circuit uses off the shelf static RAM and dedicated shallow, e.g. 16 word, FIFOs in a multi-level caching scheme. The circuit results in multiple, reconfigurable, deep (e.g. up to 32k word) FIFO buffers. The preferred embodiment of the invention provides a buffer that comprises a bank of 32k word RAM, six dual port 16-word FIFOs, and associated sequencing logic. The sequencing logic includes RAM address registers/counter associated with each of the six FIFOs, and manages the movement of data into and out of the RAM.
摘要翻译：三端口FIFO缓冲电路使用现成的静态RAM和专用浅的，例如。 16字，多级缓存方案中的FIFO。该电路产生多个可重新配置的深（例如高达32k字）的FIFO缓冲器。本发明的优选实施例提供一种缓冲器，其包括一组32k字RAM，六个双端口16字FIFO和相关联的排序逻辑。排序逻辑包括与六个FIFO中的每一个相关联的RAM地址寄存器/计数器，并且管理数据进出RAM的数据。

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