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1. 发明授权

US08097565B2 Silicone hydrogels having consistent concentrations of multi-functional polysiloxanes 有权
标题翻译：具有一致浓度的多官能聚硅氧烷的硅氧烷水凝胶
公开(公告)号：US08097565B2
公开(公告)日：2012-01-17
申请号：US10861798
申请日：2004-06-04
申请人： Gregory A. Hill , John C. Heaton , Michael R. Clark , Shivkumar Mahadevan , Carrie L Caison , Frank F. Molock
发明人： Gregory A. Hill , John C. Heaton , Michael R. Clark , Shivkumar Mahadevan , Carrie L Caison , Frank F. Molock
IPC分类号： C40B40/00
CPC分类号： G02B1/043 , C08F230/08 , C08G77/04 , C08L43/04 , C08L33/00
摘要： The present invention relates to a process comprising forming a monomer mixture comprising at least one monofunctional silicone containing component which comprises at least one difunctional byproduct and adding to said monomer mixture a normalizing amount of said at least one difunctional byproduct and curing said monomer mixture to form a biomedical device.
摘要翻译：本发明涉及一种方法，包括形成包含至少一种单官能含硅氧烷的组分的单体混合物，其包含至少一种双官能副产物，并向所述单体混合物中加入标准化量的所述至少一种双官能副产物并固化所述单体混合物以形成生物医学装置。

2. 发明授权

US5292350A Method for preparing tinted contact lens 失效
标题翻译：着色隐形眼镜的制备方法
公开(公告)号：US5292350A
公开(公告)日：1994-03-08
申请号：US873316
申请日：1992-04-24
申请人： Frank F. Molock , James D. Ford , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
发明人： Frank F. Molock , James D. Ford , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
IPC分类号： B29D11/00 , D06P1/382 , D06P1/52 , D06P3/34 , G02B1/04 , G02C7/02 , G02C7/04 , D06P5/00
CPC分类号： G02C7/021 , B29D11/00317 , D06P1/382 , D06P1/5257 , D06P3/348 , G02B1/043
摘要： An improved method is disclosed of imparting a tint or color to a soft, hydrogel contact lens by uniformly dispersing a dye throughout the lens. The dye is composed of a water-soluble compound essentially free of ethylenic unsaturation. A homogeneous solution of the dye in a hydrophilic monomer is prepared, the solution is subjected to polymerization conditions to yield a hydrophilic polymer from which the lens is formed, and the dye dispersed within the polymer is bonded to the polymer by contact with aqueous base prior to final hydration.The finished lens does not require soaking in an aqueous solution of the dye to impart the desired tint or color to the lens. Additionally, the dye uniformly dispersed throughout the lens according to the improved method does not leach out of the lens or migrate within the lens.
摘要翻译：公开了一种改进的方法，通过使染料均匀地分散在整个透镜中，将柔软的水凝胶隐形眼镜赋予着色或着色。染料由基本上不含烯属不饱和键的水溶性化合物组成。制备染料在亲水单体中的均匀溶液，使溶液经受聚合条件以产生形成透镜的亲水聚合物，并且分散在聚合物内的染料通过与碱水溶液接触而与聚合物结合最终水化。成品镜片不需要在染料的水溶液中浸泡以赋予镜片所需的色调或颜色。此外，根据改进的方法均匀分散在整个透镜中的染料不会从透镜中浸出或在透镜内迁移。

3. 发明申请

US20120108551A1 OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：眼科成分
公开(公告)号：US20120108551A1
公开(公告)日：2012-05-03
申请号：US12915548
申请日：2010-10-29
申请人： Frank F. Molock, JR. , John C. Heaton
发明人： Frank F. Molock, JR. , John C. Heaton
IPC分类号： A61K31/662 , C07C69/533 , C07C309/42 , C07F9/38 , C07C63/04 , A61P27/04 , C07C309/47 , A61K31/215 , A61K31/195 , A61K31/192 , A61K31/185 , A61P27/02 , C07C309/61 , C07C65/24
CPC分类号： A61K31/33
摘要： The present invention relates to compositions that may alleviate symptoms of ocular stress, as well as methods of their production, use, and storage compositions. The compositions comprise at least one ocular epithelial cell associating group and at least one hydrophilic group. In one embodiment the at least one ocular epithelial cell associating group and at least one hydrophilic group are substituents on a conjugated polyaromatic core.The compositions may be used in ophthalmic compositions and ophthalmic devices.
摘要翻译：本发明涉及可减轻眼部压力症状的组合物，以及其生产，使用和储存组合物的方法。组合物包含至少一个眼上皮细胞缔合基团和至少一个亲水基团。在一个实施方案中，至少一个眼上皮细胞缔合基团和至少一个亲水基团是共轭多芳香核心上的取代基。组合物可用于眼用组合物和眼科装置中。

4. 发明申请

US20080290535A1 REDUCTION OF EXCESS POLYMERIC FLASH RING 审中-公开
标题翻译：减少超高分子闪光环
公开(公告)号：US20080290535A1
公开(公告)日：2008-11-27
申请号：US11753076
申请日：2007-05-24
申请人： Frank F. Molock, JR. , Changhong Yin , Scott F. Ansell , Michael J. Strong , John C. Heaton , Eric Hammitt , William McKee , Jason Tokarski
发明人： Frank F. Molock, JR. , Changhong Yin , Scott F. Ansell , Michael J. Strong , John C. Heaton , Eric Hammitt , William McKee , Jason Tokarski
IPC分类号： B29D11/00
CPC分类号： B29D11/00192
摘要： The present invention includes methods and apparatus for forming a biomedical device, such as an ophthalmic lens, in a area defined by a first mold part and a second mold part wherein during the formation of the biomedical device a HEMA is formed and the HEMA ring and a greater adhesive force is generated on the HEMA ring by the second mold part than the first mold part.
摘要翻译：本发明包括在由第一模具部件和第二模具部件限定的区域中形成诸如眼镜片的生物医学装置的方法和装置，其中在形成生物医学装置期间形成HEMA，并且HEMA环和通过第二模具部件在HEMA环上产生比第一模具部件更大的粘附力。

5. 发明授权

US5039459A Method of forming shaped hydrogel articles including contact lenses 失效
标题翻译：形成包括隐形眼镜的成形水凝胶制品的方法
公开(公告)号：US5039459A
公开(公告)日：1991-08-13
申请号：US451077
申请日：1989-12-15
申请人： Ture Kindt-Larsen , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
发明人： Ture Kindt-Larsen , John C. Heaton , Edmund C. Rastrelli , Gregory A. Hill
IPC分类号： G02C7/04 , A61F9/00 , B29D11/00 , C08F2/00 , C08F2/02 , C08F2/44 , C08F220/10 , C08F220/18 , C08F220/28 , C08J7/00 , C08K5/05 , G02B1/04
CPC分类号： G02B1/043 , B29D11/00038 , B29K2033/08 , B29K2033/12 , B29K2105/0002 , B29K2707/02 , B29K2995/0092 , Y10S524/916
摘要： Shaped hydrogel articles such as soft contact lenses are prepared by (1) molding or casting a polymerization mixture comprising: (a) a monomer mixture comprising a major proportion of a hydrophilic (meth)acrylate ester such as 2-hydroxyethyl methacrylate, an alkyl (meth)acrylate wherein the alkyl group contains at least four carbon atoms, and a cross-linking monomer; and (b) a water-displaceable diluent, wherein said diluent has a viscosity of at least 100 MPa Sec at 30.degree. C., and wherein said diluent consists essentially of a boric acid ester of certain dihydric alcohols, said dihydric alcohols having Hansen polar (w.sub.p) and Hansen hydrogen bonding (w.sub.h) cohesion parameters falling within the area of a circle defined as having a center at w.sub.h =20.5, w.sub.p =13, and a radius of 8.5, to produce a shaped gel of a copolymer of said monomers and said diluent, and (2) thereafter replacing said diluent with water.
摘要翻译：诸如软性隐形眼镜的成形水凝胶制品通过（1）模制或浇铸聚合混合物制备，所述聚合混合物包含：（a）包含主要比例的亲水性（甲基）丙烯酸酯如甲基丙烯酸2-羟乙酯，烷基（甲基）丙烯酸酯，其中烷基含有至少四个碳原子，和交联单体; 和（b）可水移动的稀释剂，其中所述稀释剂在30℃下具有至少100MPa Sec的粘度，并且其中所述稀释剂基本上由某些二元醇的硼酸酯组成，所述二元醇具有Hansen极性（wp）和Hansen氢键（wh）内聚参数落入限定为具有中心的圆的区域中，其中心为wh = 20.5，wp = 13，半径为8.5，以产生所述单体的共聚物的成形凝胶和所述稀释剂，和（2）此后用水代替所述稀释剂。

6. 发明授权

US5679385A Apparatus for treating an ophthalmic lens mold 失效
标题翻译：用于治疗眼科镜片模具的装置
公开(公告)号：US5679385A
公开(公告)日：1997-10-21
申请号：US534918
申请日：1995-09-28
申请人： Jonathan Patrick Adams , Edmund C. Rastrelli , John C. Heaton , Kenneth John Weber , Thomas John Wagner
发明人： Jonathan Patrick Adams , Edmund C. Rastrelli , John C. Heaton , Kenneth John Weber , Thomas John Wagner
IPC分类号： B29C39/02 , A61F2/16 , A61F9/00 , B29C33/00 , B29C33/06 , B29C33/44 , B29C37/00 , B29C39/22 , B29C39/26 , B29C39/36 , B29C59/10 , B29C59/12 , B29D11/00 , B29L11/00 , G02C7/04 , B29C33/58
CPC分类号： B29D11/00192 , B29C33/0055 , B29C37/0003 , B29C39/22 , B29C59/10 , B29C59/12 , B29D11/00057 , B29C2791/005 , B29C33/44 , B29K2033/12 , B29K2105/0002 , B29L2011/0016 , B29L2031/757 , Y10S425/806 , Y10S425/808
摘要： An apparatus for causing the polymerized excess monomer to separate from a molded lens by increasing the surface energy of the flange area of one mold piece, causing the polymerized excess monomer to stick thereto. Specifically when manufactured under inert atmosphere conditions, a particular manifold is needed to supply an oxygen bearing gas, air, to the area to be treated while preventing the oxygen from contaminating the lens manufacturing area of the molds or diluting the nitrogen atmosphere of other lens process areas. It has been found that generation of the ionized oxygen by means of a corona treatment electrode sufficiently increases the adherence of the polymer to the mold piece so treated. In the preferred embodiment, the flange around the convex, male piece of the lens mold is corona treated so that when the mold pieces are separated after lens polymerization, the flashing of excess polymerized material surrounding the lens cavity adheres to that male, convex piece flange while the lens is removed with the female, concave piece.
摘要翻译：通过增加一个模具的凸缘区域的表面能，使聚合的多余单体与模制的透镜分离，使聚合的多余的单体粘附到其上的装置。具体地，当在惰性气氛条件下制造时，需要特殊的歧管以将氧气承载气体，空气供应到待处理的区域，同时防止氧气污染模具的透镜制造区域或者稀释其它透镜工艺的氮气气氛地区已经发现，通过电晕处理电极产生电离氧充分地增加了聚合物对如此处理的模具的粘附性。在优选实施例中，透镜模具的凸形凸形件周围的凸缘进行电晕处理，使得当透镜聚合之后分离模具片时，围绕透镜腔的过量聚合材料的闪烁附着到凸形凸起凸缘而透镜与女性的凹形部件一起被去除。

7. 发明授权

US6071112A Automated method and apparatus for single sided hydration of soft contact lenses in package carriers 有权
公开(公告)号：US6071112A
公开(公告)日：2000-06-06
申请号：US363544
申请日：1999-07-29
申请人： Olin W. Calvin , Mark E. Schlagel , Darren S. Keene , Ture Kindt-Larsen , Craig W. Walker , Wallace A. Martin , John C. Heaton
发明人： Olin W. Calvin , Mark E. Schlagel , Darren S. Keene , Ture Kindt-Larsen , Craig W. Walker , Wallace A. Martin , John C. Heaton
IPC分类号： B29C39/36 , B29C31/00 , B29C33/04 , B29C33/34 , B29C39/44 , B29C43/02 , B29C43/50 , B29C71/00 , B29D11/00 , B29D11/02 , B29L11/00 , B65B25/00 , C08J7/00 , C08J7/02 , G02C7/04
CPC分类号： B29C31/00 , B29C31/006 , B29C43/021 , B29C43/50 , B29C71/0009 , B29D11/00067 , B29D11/00182 , B29D11/00221 , B65B25/008 , B29C2071/0027 , B29L2011/0016 , B29L2011/0041 , B65D2585/545 , Y10S134/901
摘要： An automated means for hydrating and packaging a molded hydrophilic contact lens in one of the mold parts used to mold the lens is provided in which a first robotic assembly removes a plurality of contact lens molds from a production line carrier, each of the lens molds having a contact lens adhered therein. The first robotic assembly transports the molds to a first staging area where the lens molds are sandwiched between a lens mold carrier and a top chamber plate to form a first hydration carrier. The hydration carrier is then transported through a plurality of flushing or extraction stations wherein fresh deionized water is introduced into the hydration chambers at each hydration station to flush leachable substances from the hydration chamber. At each flushing station, fresh deionized water is introduced into the hydration chamber to remove previously extracted impurities and the products of hydrolysis. A final robotic dis-assembly device separates the top chamber plate and lens molds in the mold carrier plate, to provide fully hydrated lenses in a concave lens mold ready for transfer to inspection and packaging stations. Following inspection of the lens, the concave lens mold is dosed with saline and used to form part of the package used to distribute the lens.

8. 发明授权

US5326505A Method for treating an ophthalmic lens mold 失效
标题翻译：眼用镜片模具的治疗方法
公开(公告)号：US5326505A
公开(公告)日：1994-07-05
申请号：US992884
申请日：1992-12-21
申请人： Jonathan P. Adams , Edmund C. Rastrelli , John C. Heaton
发明人： Jonathan P. Adams , Edmund C. Rastrelli , John C. Heaton
IPC分类号： B29C39/02 , B29C33/00 , B29C33/44 , B29C37/00 , B29C39/22 , B29C39/26 , B29C39/36 , B29C59/10 , B29C59/12 , B29D11/00 , B29L11/00 , G02C7/04
CPC分类号： B29D11/00192 , B29C33/0055 , B29C37/0003 , B29C39/22 , B29C59/10 , B29C59/12 , B29D11/00057 , B29C2791/005 , B29C33/44 , B29K2033/12 , B29K2105/0002 , B29L2011/0016 , B29L2031/757
摘要： An apparatus and method for directing accelerated electrons to at least part of one surface of one ophthalmic mold piece prior to filling with monomer and lens polymerization. In particular it has been found that generation of the ionized oxygen by means of a corona treatment electrode sufficiently increases the adherence of the polymer to the mold piece so treated. In the preferred embodiment, the flange around the convex, male piece of the lens mold is corona treated so that when the mold pieces are separated after lens polymerization, the flashing of excess polymerized material surrounding the lens cavity adheres to that male, convex piece flange while the lens is removed with the female, concave piece.
摘要翻译：一种用于在加入单体和透镜聚合之前将加速电子引导到一个眼用模具件的一个表面的至少一部分的装置和方法。特别地，已经发现通过电晕处理电极产生电离氧充分地增加了聚合物对如此处理的模具的粘附性。在优选实施例中，透镜模具的凸形凸形件周围的凸缘进行电晕处理，使得当透镜聚合之后分离模具片时，围绕透镜腔的过量聚合材料的闪烁附着到凸形凸起凸缘而透镜与女性的凹形部件一起被去除。

9. 发明授权

US4871886A Electronic key and receptacle therefor 失效
标题翻译：电子钥匙及插座
公开(公告)号：US4871886A
公开(公告)日：1989-10-03
申请号：US061372
申请日：1987-06-15
申请人： John E. Vaughan , David R. Smale , Bernard Patry , John C. Heaton
发明人： John E. Vaughan , David R. Smale , Bernard Patry , John C. Heaton
IPC分类号： G07C9/00 , G07F7/00 , G07F7/08 , G07F15/00
CPC分类号： G06Q20/127 , G06Q20/3433 , G07C9/00944 , G07F15/003 , G07F17/0014 , G07F7/02 , G07F7/0866
摘要： An electronic token for use with a prepayment commodity meter such as an electricity meter comprises a key-like device 10 having a head 12 containing an electronic circuit and a body portion 14 for insertion into a keyway in a receptable 40 in the meter. The body portion 14 has grooves 24 which serve to guide the body portion into the keyway, and which contain electrical contacts 28, 30 connected within the device 10 to the electronic circuit. Between the body portion 14 and the head 12, the device 10 is provided with a locating recess 27, which engages a projection 78 in the receptacle 40 when the body portion is fully inserted into the keyway. The receptacle 40 incorporates a combined shutter 98 and spring 102, which serve to close the keyway in the absence of the device 10, and to urge the body portion 12 to one side of the keyway during insertion, such that the recess 27 engages the projection 78 and the contacts 28, 30 engage contacts 68, 72 in the receptacle.
摘要翻译：与诸如电表之类的预付费商品计量表一起使用的电子令牌包括具有包含电子电路的头部12的键状装置10和用于插入仪表中的可接收的40中的键槽中的主体部分14。主体部分14具有凹槽24，其用于将主体部分引导到键槽中，并且包含连接在装置10内的电触点28,30与电子电路。在主体部分14和头部12之间，装置10设置有定位凹槽27，当主体部分完全插入键槽时，定位凹槽27与插座40中的突起78接合。插座40包括组合的快门98和弹簧102，其用于在不存在装置10的情况下关闭键槽，并且在插入期间将主体部分12推动到键槽的一侧，使得凹部27接合突起 78和触头28,30接合插座中的接触件68,72。

10. 发明授权

US06478423B1 Contact lens coating selection and manufacturing process 有权
标题翻译：隐形眼镜涂层选择和制造工艺
公开(公告)号：US06478423B1
公开(公告)日：2002-11-12
申请号：US09663437
申请日：2000-09-16
申请人： David C. Turner , John C. Heaton , Douglas G. Vanderlaan , Robert B. Steffen , Joe M. Wood , Lenora L. Copper , James S. Jen
发明人： David C. Turner , John C. Heaton , Douglas G. Vanderlaan , Robert B. Steffen , Joe M. Wood , Lenora L. Copper , James S. Jen
IPC分类号： G02C704
CPC分类号： G02B1/10 , G02B1/043
摘要： The invention is a method of making a coated contact lens with desirable physiological performance. Preferably, the lenses are made from hydrophobic contact lens substrate with a hydrophilic coating material. The hydrophobic lens substrate is coated with a hydrophilic material having an expansion factor greater than one. The coated lenses have low physical defect and surface roughness profiles.
摘要翻译：本发明是制备具有理想生理性能的涂覆隐形眼镜的方法。优选地，透镜由具有亲水涂层材料的疏水性隐形眼镜基底制成。疏水性透镜基材用膨胀系数大于1的亲水材料涂覆。涂层透镜具有低物理缺陷和表面粗糙度轮廓。

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