专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5540935A Reactive vesicle and functional substance-fixed vesicle 失效
标题翻译：活性囊泡和功能物质固定囊泡
公开(公告)号：US5540935A
公开(公告)日：1996-07-30
申请号：US349362
申请日：1994-12-05
申请人： Tsuyoshi Miyazaki , Kazuo Maruyama , Motoharu Iwatsuru , Kouzoh Sanchika , Mitsuhiro Nishida , Tohru Yasukohchi , Shigeru Kitano , Akinori Suginaka , Yoshihito Kadoma
发明人： Tsuyoshi Miyazaki , Kazuo Maruyama , Motoharu Iwatsuru , Kouzoh Sanchika , Mitsuhiro Nishida , Tohru Yasukohchi , Shigeru Kitano , Akinori Suginaka , Yoshihito Kadoma
IPC分类号： A61K9/127 , A61K47/48 , C07F9/6506 , C08G65/332 , C08G65/335
CPC分类号： A61K9/1271 , A61K47/48823 , C07F9/65061 , C08G65/3328 , C08G65/335 , Y10T428/2984
摘要： A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.
摘要翻译： 1.一种活性囊泡，其特征在于，作为泡囊形成成分，含有由以下通式（1）表示的反应性磷脂衍生物和通过使所述活性囊泡与功能性物质反应制备的功能性物质固定的囊泡：其中R1C（= O）和R2C（= O）各自表示脂族酰基，R3表示氢原子或甲基，OA表示2-4个碳原子的氧化烯基，n表示加入的氧化烯基团的平均摩尔数并且为1-1,000，p为0或1，X表示，其中q和r各自为0至4或1至4的整数，M表示氢原子或烷基金属原子。

2. 发明授权

US5463066A Phospholipid derivative and reactive vesicle-forming agent 失效
标题翻译：磷脂衍生物和反应性囊泡形成剂
公开(公告)号：US5463066A
公开(公告)日：1995-10-31
申请号：US349368
申请日：1994-12-05
申请人： Tsuyoshi Miyazaki , Kouzoh Sanchika , Mitsuhiro Nishida , Tohru Yasukohchi , Shigeru Kitano , Akinori Suginaka , Yoshihito Kadoma
发明人： Tsuyoshi Miyazaki , Kouzoh Sanchika , Mitsuhiro Nishida , Tohru Yasukohchi , Shigeru Kitano , Akinori Suginaka , Yoshihito Kadoma
IPC分类号： A61K9/127 , A61K47/48 , C07D233/64 , C07F9/6506 , C08G65/332 , C08G65/335
CPC分类号： C08G65/3328 , A61K47/48238 , A61K47/48815 , A61K9/1271 , C07F9/65061 , C08G65/335
摘要： A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.
摘要翻译：用于反应性泡囊形成剂的新型有用的磷脂衍生物，其由以下通式（1）表示：各自为脂族酰基，R 3表示氢原子或甲基，OA表示氧化烯基 2-4个碳原子，n表示加成的氧化烯基的平均加成摩尔数，为1-1000，p为0或1，X为4或1〜4，M为氢原子或碱金属原子。

3. 发明授权

US06812367B2 Polyethylene glycol and process for producing the same 有权
标题翻译：聚乙二醇及其制造方法
公开(公告)号：US06812367B2
公开(公告)日：2004-11-02
申请号：US10463547
申请日：2003-06-18
申请人： Kenji Sakanoue , Kouzoh Sanchika , Tohru Yasukohchi
发明人： Kenji Sakanoue , Kouzoh Sanchika , Tohru Yasukohchi
IPC分类号： C07C4318
CPC分类号： C08G65/2609 , C08L2203/02
摘要： Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢ ⁢ of ⁢ ⁢ ethylene ⁢ ⁢ glycol ⁢ ⁢ and ⁢ ⁢ diethylene ⁢ ⁢ glycol ⁢ ⁢ contents ⁢ ⁢ ( ppm ) = 150 × 2900 × 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.
摘要翻译：聚乙二醇用于应用于生物体的领域，其中聚乙二醇中乙二醇和二甘醇的含量之和小于或等于下式[I]表示的含量：其中x表示平均分子量聚乙二醇的重量，聚乙二醇的平均分子量为190〜1050。

4. 发明授权

US06455639B1 Oxirane derivative and process for the preparation thereof 有权
标题翻译：环氧乙烷衍生物及其制备方法
公开(公告)号：US06455639B1
公开(公告)日：2002-09-24
申请号：US09367642
申请日：1999-08-19
申请人： Tohru Yasukohchi , Kouzoh Sanchika , Chika Itoh , Kei-ichi Maruyama
发明人： Tohru Yasukohchi , Kouzoh Sanchika , Chika Itoh , Kei-ichi Maruyama
IPC分类号： C08G6528
CPC分类号： C08G65/2609 , C08G65/30 , G01N30/90
摘要： An oxirane derivative and process for preparation of the same, having a high purity characterized in terms of gel permeation chromatography and thin layer chromatography. The oxirane derivative is useful as a starting material for medical purposes, and mainly drug delivery systems.
摘要翻译：一种环氧乙烷衍生物及其制备方法，具有以凝胶渗透色谱和薄层色谱为特征的高纯度。环氧乙烷衍生物可用作医疗用途的原料，主要用于药物输送系统。

5. 发明授权

US5767284A Process for producing a polyoxyalkylene derivative substituted with succinimidyl group 失效
标题翻译：用琥珀酰亚胺基取代的聚氧化烯衍生物的制造方法
公开(公告)号：US5767284A
公开(公告)日：1998-06-16
申请号：US868261
申请日：1997-06-03
申请人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
发明人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
IPC分类号： C08G65/32 , A61K47/48 , C07D207/46 , C08G65/30 , C08G65/329 , C08G65/332 , C08G65/333 , C07D207/12
CPC分类号： A61K47/48215 , C08G65/30 , C08G65/329 , C08G65/33337
摘要： A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; filtering an obtained reaction product; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding isopropyl alcohol to a filtrate obtained by the filtration, an amount by weight of isopropyl alcohol being 1 to 100 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends. Materials can be handled with safety in the process of the present invention, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.
摘要翻译：一种制备被琥珀酰亚胺基取代的聚氧化烯衍生物的方法，包括在二环己基碳二亚胺的存在下，在惰性溶剂中使具有羧基的聚氧化烯化合物与N-羟基琥珀酰亚胺反应; 过滤得到的反应产物; 并将通过过滤得到的滤液中加入异丙醇使用琥珀酰亚胺基取代的聚氧化烯衍生物结晶，异丙醇的重量比在末端具有羧基的聚氧化烯化合物的重量的1〜100倍。可以在本发明的方法中安全地处理材料，并且可以制备用琥珀酰亚胺基取代的高纯度聚氧化烯衍生物，其不会在水溶液中引起浊度并且具有作为药物的材料的优良品质。

6. 发明授权

US06620976B2 Polyethylene glycol and process for producing the same 有权
标题翻译：聚乙二醇及其制造方法
公开(公告)号：US06620976B2
公开(公告)日：2003-09-16
申请号：US10106219
申请日：2002-03-27
申请人： Kenji Sakanoue , Kouzoh Sanchika , Tohru Yasukohchi
发明人： Kenji Sakanoue , Kouzoh Sanchika , Tohru Yasukohchi
IPC分类号： C07C4311
CPC分类号： C08G65/2609 , C08L2203/02
摘要： Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢ ⁢ of ⁢ ⁢ ethylene ⁢ ⁢ glycol ⁢ ⁢ and ⁢ ⁢ diethylene ⁢ ⁢ glycol ⁢ ⁢ contents ⁢ ⁢ ( ppm ) = 150 × 2900 × 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.
摘要翻译：聚乙二醇用于应用于生物体的领域，其中聚乙二醇中乙二醇和二甘醇的含量之和小于或等于下式[I]表示：其中x表示平均分子量聚乙二醇的重量，聚乙二醇的平均分子量为190〜1050。

7. 发明授权

US5872191A Process for producing a polyoxyalkylene derivatives substituted with succinimidyl group 失效
标题翻译：用琥珀酰亚胺基取代的聚氧化烯衍生物的制造方法
公开(公告)号：US5872191A
公开(公告)日：1999-02-16
申请号：US867985
申请日：1997-06-03
申请人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
发明人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
IPC分类号： C07D207/46 , C08G65/32 , C08G65/329 , C08G65/332 , C08G65/333 , C08L71/02
CPC分类号： C08G65/329 , C08G65/33337
摘要： A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; dissolving an obtained reaction product into chloroform, an amount by weight of chloroform being 0.5 to 10 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding an aliphatic hydrocarbon having 5 to 8 carbon atoms to a resultant solution, an amount by weight of the aliphatic hydrocarbon being 2 to 10 times as much as an amount by weight of chloroform. Materials can be handled with safety, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.
摘要翻译：一种制备被琥珀酰亚胺基取代的聚氧化烯衍生物的方法，包括在二环己基碳二亚胺的存在下，在惰性溶剂中使具有羧基的聚氧化烯化合物与N-羟基琥珀酰亚胺反应; 将得到的反应产物溶解在氯仿中，氯仿的重量为末端具有羧基的聚氧化烯化合物的重量的0.5〜10倍; 并通过向所得溶液中加入碳原子数为5〜8的脂肪族烃而使被琥珀酰亚胺基取代的聚氧化烯衍生物结晶化，所述脂肪族烃的重量比为氯仿的2〜10倍。可以安全地处理材料，并且可以制备用琥珀酰亚胺基取代的高纯度聚氧化烯衍生物，其不会在水溶液中引起浊度并且具有作为药物的材料的优良品质。

8. 发明授权

US08828373B2 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US08828373B2
公开(公告)日：2014-09-09
申请号：US11142683
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08F283/00 , C08G65/329 , C08G65/333 , C08G65/26 , A61K47/48
CPC分类号： C08G65/2609 , A61K47/48215 , A61K47/60 , C08G65/329 , C08G65/333
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA1和OA2分别为碳原子数2〜4的氧化烯基，由R表示的基团相同或在一个分子中彼此不同，在一个分子中由OA2表示的基团相同或不同，m为上述加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示官能团能够与生物相关物质进行化学反应的基团，Y为连接基，表示醚键，酰胺键，氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些基团的亚烷基键，多分散性上述聚亚烷基二醇衍生物的Mw / Mn满足以下关系式：Mw / Mn＆nlE 1.08其中Mw表示重均分子量，Mn表示数均mol 精神重量

9. 发明申请

US20090192320A1 MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 有权
标题翻译：改良的生物相关物质，其生产方法和中间体
公开(公告)号：US20090192320A1
公开(公告)日：2009-07-30
申请号：US12399249
申请日：2009-03-06
申请人： Ken-ichiro NAKAMOTO , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro NAKAMOTO , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C07D207/404 , C07C43/13 , C07C309/68
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

10. 发明授权

US07399877B2 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US07399877B2
公开(公告)日：2008-07-15
申请号：US10549630
申请日：2004-03-19
申请人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： C07F9/02
CPC分类号： A61K9/127 , C07F9/10 , C11D1/345
摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome
摘要翻译：由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数，符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性的脂质体

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式