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1. 发明授权

US5155026A Method for determination of nagase and reagent therefor 失效
标题翻译：用于确定NAGASE及其试剂的方法
公开(公告)号：US5155026A
公开(公告)日：1992-10-13
申请号：US723652
申请日：1991-06-26
申请人： Akira Noto , Kunihiro Nakajima , Kazuyuki Sasakura , Tsutomu Sugasawa
发明人： Akira Noto , Kunihiro Nakajima , Kazuyuki Sasakura , Tsutomu Sugasawa
IPC分类号： G01N33/50 , C12Q1/34 , C12Q1/54
CPC分类号： C12Q1/34 , C12Q1/54 , C12Q2334/40 , G01N2333/924 , Y10S435/81
摘要： Highly sensitive reagent for colorimetrically determining N-acetyl-.beta.-D-glucosaminidase (NAGase) activity by the continuous method, comprising sodio-3,3'-dichlorophenolsulfonphthaleinyl N-acetyl-.beta.-D-glucosaminide and a buffer, with which renal dysfunction can be diagnosed precisely, quickly, and easily.

2. 发明授权

US4186144A Process for the production of cyanopinacolone 失效
标题翻译：氰考酚酸的生产工艺
公开(公告)号：US4186144A
公开(公告)日：1980-01-29
申请号：US897001
申请日：1978-04-17
申请人： Tsutomu Sugasawa , Tatsuo Toyoda , Kazuyuki Sasakura , Shiro Ueda , Akira Takase , Katsuto Okuno , Ichiro Ishizuka , Shinzaburo Sumimoto
发明人： Tsutomu Sugasawa , Tatsuo Toyoda , Kazuyuki Sasakura , Shiro Ueda , Akira Takase , Katsuto Okuno , Ichiro Ishizuka , Shinzaburo Sumimoto
IPC分类号： C07D261/14 , A01N43/80 , C07C45/00 , C07C45/63 , C07C49/16 , C07C67/00 , C07C253/00 , C07C253/16 , C07C255/17 , C07C121/34
CPC分类号： C07C255/00 , C07C45/63
摘要： Cyanopinacolone is produced by reacting pinacolone with about 1.0 to about 1.2 molar equivalents of chlorine in methanol and further reacting the resulting monochloropinacolone with about 1.0 to about 1.2 molar equivalents of an alkali metal cyanide in methanol.
摘要翻译：通过频哪酮与约1.0至约1.2摩尔当量的甲醇中的氯反应制备亚氨基乐康酮，并使所得一氯一可乐酮与约1.0至约1.2摩尔当量的碱金属氰化物在甲醇中反应。

3. 发明授权

US4160784A Process for the production of o-aminophenyl ketone derivatives 失效
标题翻译：制备邻氨基苯基酮衍生物的方法
公开(公告)号：US4160784A
公开(公告)日：1979-07-10
申请号：US770037
申请日：1977-02-18
申请人： Tsutomu Sugasawa , Tatsuo Toyoda , Makoto Adachi , Kazuyuki Sasakura
发明人： Tsutomu Sugasawa , Tatsuo Toyoda , Makoto Adachi , Kazuyuki Sasakura
IPC分类号： C07C225/22 , C07C67/00 , C07C241/00 , C07C251/24 , C07F5/02 , C07C85/18
CPC分类号： C07F5/022
摘要： O-Aminophenyl ketone derivatives are regio-specifically prepared by reacting an aniline unsubstituted in at least one ortho position with a nitrile in the presence of boron trihalogenide to introduce a substituted iminomethyl into the ortho position of said aniline and hydrolyzing the resulting iminomethyl compound.
摘要翻译：通过在三卤代硼存在下使至少一个邻位未取代的苯胺与腈反应来引入O-氨基苯基酮衍生物，以将取代的亚氨基甲基引入所述苯胺的邻位并水解所得的亚氨基甲基化合物。

4. 发明授权

US4579685A Process for preparing 1-substituted-1,4-benzodiazepine derivatives 失效
标题翻译： 1-取代-1,4-苯并二氮杂衍生物的制备方法
公开(公告)号：US4579685A
公开(公告)日：1986-04-01
申请号：US635128
申请日：1984-07-27
申请人： Makoto Adachi , Kazuyuki Sasakura , Tsutomu Sugasawa
发明人： Makoto Adachi , Kazuyuki Sasakura , Tsutomu Sugasawa
IPC分类号： C07D207/14 , C07D211/58 , C07D243/28 , C07D401/04 , C07D403/04
CPC分类号： C07D401/04 , C07D207/14 , C07D211/58 , C07D403/04
摘要： Improvement in the production of psychotropic 1-substituted-1,3-dihydro-1,4-benzodiazepin-2-ones starting from 2-(1-substituted)amino-benzophenonimines through novel intermediates of the formula: ##STR1## (wherein R is hydrogen, methyl or benzyl, R.sup.1 is C.sub.1 -C.sub.5 alkyl or phenyl-C.sub.1 -C.sub.5 alkyl, X and Y each is hydrogen or halogen and n is an integer of 1 to 2)with economical and industrial advantage.
摘要翻译：由2-（1-取代）氨基 - 二苯甲酮亚胺开始的精神药物1-取代-1,3-二氢-1,4-苯并二氮杂-2-酮的生产改进通过下式的新型中间体：其中R 是氢，甲基或苄基，R 1是C 1 -C 5烷基或苯基-C 1 -C 5烷基，X和Y各自是氢或卤素，n是1至2的整数），具有经济和工业上的优点。

5. 发明授权

US4560684A 1,4-Benzodiazepine derivatives 失效
标题翻译： 1,4-苯并二氮杂衍生物
公开(公告)号：US4560684A
公开(公告)日：1985-12-24
申请号：US560994
申请日：1983-12-13
申请人： Tsutomu Sugasawa , Makoto Adachi , Kazuyuki Sasakura , Akira Matsushita , Masami Eigyo
发明人： Tsutomu Sugasawa , Makoto Adachi , Kazuyuki Sasakura , Akira Matsushita , Masami Eigyo
IPC分类号： C07D243/14 , A61K31/55 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D207/12 , C07D207/14 , C07D209/00 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/72 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07F7/18
CPC分类号： C07D401/04 , C07D207/12 , C07D207/14 , C07D211/42 , C07D211/58 , C07D211/72 , C07D401/12 , C07D403/04 , C07D403/12
摘要： 1,4-Benzodiazepine derivatives of the formula: ##STR1## (in which R.sup.1 is pyrrolidinyl or piperidinyl each optionally substituted by C.sub.1-3 alkyl, phenyl-C.sub.1-3 alkyl, C.sub.1-5 alkanoyl, or C.sub.2-5 alkoxycarbonyl,R.sup.2 is hydrogen, hydroxy, or acetoxy,R.sup.3 is C.sub.1-3 alkyl, phenyl-C.sub.1-3 alkyl, or phenyl optionally substituted by one or two halogens,X is hydrogen, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro, trifluoromethyl, or di-C.sub.1-3 alkyl-amino, andn is 1 or 2)or pharmaceutically acceptable acid addition salts thereof, which are useful as a psychotropic agent such as anti-depressant or anxiolytic agent can be prepared from several routes.
摘要翻译：下式的1,4-苯并二氮杂衍生物（其中R 1为吡咯烷基或哌啶基，各自任选被C 1-3烷基，苯基-C 1-3烷基，C 1-5烷酰基或C 2-5烷氧基羰基取代，R 2为氢，羟基或乙酰氧基，R 3是C 1-3烷基，苯基-C 1-3烷基或任选被一个或两个卤素取代的苯基，X是氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基，三氟甲基，或二-C 1-3烷基 - 氨基，n为1或2）或其药学上可接受的酸加成盐，其可用作精神药物如抗抑郁药或抗焦虑剂，可以从多种途径制备。

6. 发明授权

US4831132A Ortho-mono-substituted amino)phenylimines 失效
标题翻译：正单取代氨基）苯基亚胺
公开(公告)号：US4831132A
公开(公告)日：1989-05-16
申请号：US948119
申请日：1986-12-30
申请人： Tsutomu Sugasawa , Kazuyuki Sasakura
发明人： Tsutomu Sugasawa , Kazuyuki Sasakura
IPC分类号： B01J27/135 , B01J27/138 , B01J27/14 , B01J31/00 , B01J31/02 , C07B61/00 , C07C67/00 , C07C213/00 , C07C225/22 , C07C241/00 , C07C249/02 , C07C251/24 , C07D207/14 , C07D209/08 , C07D211/26 , C07D211/58
CPC分类号： C07D211/58 , C07D207/14 , C07D209/08
摘要： Novel ortho-(mono-substituted amino)phenylimines being intermediates to psychotropic drugs and other drugs are economically and industrially prepared by reacting anilines with nitriles in the presence of a boron trifluoride ether adduct and a halide-type Lewis acid, if necessary together with an organic base. Furthermore, the imines can be hydrolyzed with an acid to afford the corresponding ketones.
摘要翻译：作为精神药物和其他药物的中间体的新型邻位 - （单取代氨基）苯基亚胺是经济和工业上制备的，如果必要的话，苯偶姻与腈在三氟化硼醚加合物和卤化物型路易斯酸的存在下反应，有机基地。此外，亚胺可以用酸水解，得到相应的酮。

7. 发明授权

US4551554A Process for production of 2-haloacetylphenols 失效
标题翻译： 2-卤代乙酰苯酚的制备方法
公开(公告)号：US4551554A
公开(公告)日：1985-11-05
申请号：US305621
申请日：1981-09-23
申请人： Tsutomu Sugasawa , Tatsuo Toyoda , Kazuyuki Sasakura
发明人： Tsutomu Sugasawa , Tatsuo Toyoda , Kazuyuki Sasakura
IPC分类号： C07C49/825 , B01J27/00 , B01J27/08 , C07C45/00 , C07C45/42 , C07C45/46 , C07C49/84 , C07C67/00
CPC分类号： C07C45/42 , C07C45/00 , C07C45/008
摘要： A new process for production of 2-haloacetylphenols having the general formula ##STR1## (wherein, Y is halogen atom;m is an integer of 0-2,X and n have the same meaning as mentioned below),which comprises reacting phenols having the general formula ##STR2## (wherein, X is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.5 alkoxy or halogen atom;n is an integer of 0-2)with haloacetonitriles and boron halide compounds in the presence of condensing coagents.
摘要翻译： PCT No.PCT / JP81 / 00012 Sec。 371日期1981年9月23日 102（e）1981年9月23日PCT PCT 1月16日PCT PCT。公开号WO81 / 02157 日本1981年8月6日。具有通式为“IMAGE”的2-卤代乙酰基苯酚的新方法（其中，Y为卤素原子; m为0-2的整数，X和n具有与下述相同的含义）），其包括使具有通式“IMAGE”（其中X是氢，C 1 -C 5烷基，C 3 -C 6环烷基，C 1 -C 5烷氧基或卤原子; n是0-2的整数）的酚与卤代乙腈和卤化硼化合物反应在冷凝助剂的存在下。

8. 发明授权

US4076704A Dipeptide derivatives and their production 失效
标题翻译：二肽衍生物及其生产
公开(公告)号：US4076704A
公开(公告)日：1978-02-28
申请号：US716267
申请日：1976-08-20
申请人： Kentaro Hirai , Teruyuki Ishiba , Kazuyuki Sasakura , Hirohiko Sugimoto
发明人： Kentaro Hirai , Teruyuki Ishiba , Kazuyuki Sasakura , Hirohiko Sugimoto
IPC分类号： A61K38/00 , C07K5/06 , C07K5/065 , C07K5/10 , C07C103/52
CPC分类号： C07K5/1027 , C07K5/06026 , C07K5/06078 , C07K5/06191 , A61K38/00 , Y02P20/55
摘要： Dipeptide derivatives represented by the formula: ##STR1## wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.7 alkenyl group, C.sub.2 -C.sub.7 cyanoalkyl group, C.sub.2 -C.sub.7 carbamoylalkyl group, C.sub.3 -C.sub.10 dialkylaminoalkyl group or cyclopropylmethyl group, R.sup.1 represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.7 -C.sub.14 hydroxyaralkyl group, C.sub.6 -C.sub.12 aryl group, C.sub.2 -C.sub.7 carbamoylalkyl group, C.sub.2 -C.sub.7 carboxyalkyl group, C.sub.1 -C.sub.6 aminoalkyl group, C.sub.4 -C.sub.10 guanidylalkyl group, C.sub.1 -C.sub.6 mercaptoalkyl group, C.sub.2 -C.sub.7 alkylthioalkyl group, C.sub.9 -C.sub.15 indolylalkyl group or C.sub.4 -C.sub.9 imidazolylalkyl group, R.sup.2 represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.12 aryl group, glycyl group or glycyl-glycyl group, R.sup.3 represents hydrogen, C.sub.1 -C.sub.6 alkyl group or amino-protecting group, R.sup.1 and R.sup.2 optionally combine to from C.sub.2 -C.sub.4 alkylene group, group ##STR2## optionally represents phthalimido group, piperidino group, 4-hydroxy-4-(p-halogenophenyl)piperidino, morpholino, or piperazino group substituted by C.sub.1 -C.sub.6 alkyl group or phenyl group, A ring represents benzene ring or pyridine ring optionally substituted by halogen and B ring represents benzene ring or thiophene ring optionally substituted by halogen, trifluoromethyl group, methylsulfonyl group, nitro group or C.sub.1 -C.sub.6 alkyl group and their acid addition salts, being useful as anxiolytics, sedatives, anticonvulsants, hypnotics, muscle relaxants, or their synthetic intermediates, are prepared.
摘要翻译：由下式表示的二肽衍生物：其中R表示氢，C1-C6烷基，C2-C7链烯基，C2-C7氰基烷基，C2-C7氨基甲酰基烷基，C3-C10二烷基氨基烷基或环丙基甲基，R1表示氢，C1-C6烷基基团，C 7 -C 14芳烷基，C 7 -C 14羟基烷基，C 6 -C 12芳基，C 2 -C 7氨基甲酰基烷基，C 2 -C 7羧基烷基，C 1 -C 6氨基烷基，C 4 -C 10冠酰基烷基，C 1 -C 6巯基烷基，C 2 -C 7烷硫基烷基，C 9 -C 15吲哚基基团或C 4 -C 9咪唑基烷基，R 2表示氢，C 1 -C 6烷基，C 7 -C 14芳烷基，C 6 -C 12芳基，甘氨酰基或甘氨酰 - 甘氨酰基，R 3表示氢，C 1 -C 6烷基或氨基保护基，R 1和 R2任选地与C 2 -C 4亚烷基相结合，基团“任选地表示被C 1 -C 6烷基或苯基取代的邻苯二甲酰亚氨基，哌啶子基，4-羟基-4-（对卤代苯基）哌啶子基，吗啉代或哌嗪基，一个rin g表示任选被卤素取代的苯环或吡啶环，B环表示任选被卤素，三氟甲基，甲基磺酰基，硝基或C 1 -C 6烷基取代的苯环或噻吩环及其酸加成盐，可用作抗焦虑剂，镇静剂，抗惊厥药，催眠药，肌肉松弛剂或其合成中间体。

9. 发明授权

US4240957A Dipeptide derivatives and their production 失效
标题翻译：二肽衍生物及其生产
公开(公告)号：US4240957A
公开(公告)日：1980-12-23
申请号：US775646
申请日：1977-03-07
申请人： Kentaro Hirai , Teruyuki Ishiba , Kazuyuki Sasakura , Hirohiko Sugimoto
发明人： Kentaro Hirai , Teruyuki Ishiba , Kazuyuki Sasakura , Hirohiko Sugimoto
IPC分类号： A61K38/00 , C07D233/90 , C07K5/06 , C07K5/065 , C07K5/10 , C07C103/52
CPC分类号： C07K5/1027 , C07K5/06026 , C07K5/06078 , C07K5/06191 , A61K38/00 , Y02P20/55
摘要： Dipeptide derivatives represented by the formula: ##STR1## wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.7 alkenyl group, C.sub.2 -C.sub.7 cyanoalkyl group, C.sub.2 -C.sub.7 carbamoylalkyl group, C.sub.3 -C.sub.10 dialkylaminoalkyl group or cyclopropylmethyl group, R.sup.1 represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.7 -C.sub.14 hydroxyaralkyl group, C.sub.6 -C.sub.12 aryl group, C.sub.2 -C.sub.7 carbamoylalkyl group, C.sub.2 -C.sub.7 carboxyalkyl group, C.sub.1 -C.sub.6 aminoalkyl group, C.sub.4 -C.sub.10 guanidylalkyl group, C.sub.1 -C.sub.6 mercaptoalkyl group, C.sub.2 -C.sub.7 alkylthioalkyl group, C.sub.9 -C.sub.15 indolylalkyl group or C.sub.4 -C.sub.9 imidazolylalkyl group, R.sup.2 represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.12 aryl group, glycyl group or glycyl-glycyl group, R.sup.3 represents hydrogen, C.sub.1 -C.sub.6 alkyl group or amino-protecting group, R.sup.1 and R.sup.2 optionally combine to from C.sub.2 -C.sub.4 alkylene group, group ##STR2## optionally represents phthalimido group, piperidino group, 4-hydroxy-4-(p-halogenophenyl)piperidino, morpholino, or piperazino group substituted by C.sub.1 -C.sub.6 alkyl group or phenyl group, A ring represents benzene ring or pyridine ring optionally substituted by halogen and B ring represents benzene ring or thiophene ring optionally substituted by halogen, trifluoromethyl group, methylsulfonyl group, nitro group or C.sub.1 -C.sub.6 alkyl group and their acid addition salts, being useful as anxiolytics, sedatives, anticonvulsants, hypnotics, muscle relaxants, or their synthetic intermediates, are prepared.
摘要翻译：由下式表示的二肽衍生物：其中R表示氢，C1-C6烷基，C2-C7链烯基，C2-C7氰基烷基，C2-C7氨基甲酰基烷基，C3-C10二烷基氨基烷基或环丙基甲基，R1表示氢，C1-C6烷基基团，C 7 -C 14芳烷基，C 7 -C 14羟基烷基，C 6 -C 12芳基，C 2 -C 7氨基甲酰基烷基，C 2 -C 7羧基烷基，C 1 -C 6氨基烷基，C 4 -C 10冠酰基烷基，C 1 -C 6巯基烷基，C 2 -C 7烷硫基烷基，C 9 -C 15吲哚基基团或C 4 -C 9咪唑基烷基，R 2表示氢，C 1 -C 6烷基，C 7 -C 14芳烷基，C 6 -C 12芳基，甘氨酰基或甘氨酰 - 甘氨酰基，R 3表示氢，C 1 -C 6烷基或氨基保护基，R 1和 R2任选地与C 2 -C 4亚烷基相结合，基团“任选地表示被C 1 -C 6烷基或苯基取代的邻苯二甲酰亚氨基，哌啶子基，4-羟基-4-（对卤代苯基）哌啶子基，吗啉代或哌嗪基，一个rin g表示任选被卤素取代的苯环或吡啶环，B环表示任选被卤素，三氟甲基，甲基磺酰基，硝基或C 1 -C 6烷基取代的苯环或噻吩环及其酸加成盐，可用作抗焦虑剂，镇静剂，抗惊厥药，催眠药，肌肉松弛剂或其合成中间体。

10. 发明授权

US4154727A Dipeptide derivatives and their production 失效
标题翻译：二肽衍生物及其生产
公开(公告)号：US4154727A
公开(公告)日：1979-05-15
申请号：US867605
申请日：1978-01-06
申请人： Kentaro Hirai , Teruyuki Ishiba , Kazuyuki Sasakura , Hirohiko Sugimoto
发明人： Kentaro Hirai , Teruyuki Ishiba , Kazuyuki Sasakura , Hirohiko Sugimoto
IPC分类号： A61K38/00 , C07K5/06 , C07K5/065 , C07K5/10 , C07C103/52
CPC分类号： C07K5/1027 , C07K5/06026 , C07K5/06078 , C07K5/06191 , A61K38/00 , Y02P20/55
摘要： Dipeptide derivatives represented by the formula: ##STR1## wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.7 alkenyl group, C.sub.2 -C.sub.7 cyanoalkyl group, C.sub.2 -C.sub.7 carbamoylalkyl group, C.sub.3 -C.sub.10 dialkylaminoalkyl group or cyclopropylmethyl group, R.sup.1 represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.7 -C.sub.14 hydroxyaralkyl group, C.sub.6 -C.sub.12 aryl group, C.sub.2 -C.sub.7 carbamoylalkyl group, C.sub.2 -C.sub.7 carboxyalkyl group, C.sub.1 -C.sub.6 aminoalkyl group, C.sub.4 -C.sub.10 guanidylalkyl group, C.sub.1 -C.sub.6 mercaptoalkyl group, C.sub.2 -C.sub.7 alkylthioalkyl group, C.sub.9 -C.sub.15 indolylalkyl group or C.sub.4 -C.sub.9 imidazolylalkyl group, R.sup.2 represents hydrogen, C.sub.1 -C.sub.6 alkyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.12 aryl group, glycyl group or glycyl-glycyl group, R.sup.3 represents hydrogen, C.sub.1 -C.sub.6 alkyl group or amino-protecting group, R.sup.1 and R.sup.2 optionally combine to form C.sub.2 -C.sub. 4 alkylene group, group ##STR2## optionally represents phthalimido group, piperidino group, 4-hydroxy-4-(p-halogenophenyl)piperidino, morpholino, or piperazino group each substituted by C.sub.1 -C.sub.6 alkyl group or phenyl group, A ring represents benzene ring or pyridine ring optionally substituted by halogen and B ring represents benzene ring or thiophene ring optionally substituted by halogen, trifluoromethyl group, methylsulfonyl group, nitro group or C.sub.1 -C.sub.6 alkyl group and their acid addition salts, being useful as anxiolytics, sedatives, anticonvulsants, hypnotics, muscle relaxants, or their synthetic intermediates, are prepared.
摘要翻译：由下式表示的二肽衍生物：其中R表示氢，C1-C6烷基，C2-C7链烯基，C2-C7氰基烷基，C2-C7氨基甲酰基烷基，C3-C10二烷基氨基烷基或环丙基甲基，R1表示氢，C1- C 6烷基，C 7 -C 14芳烷基，C 7 -C 14羟基烷基，C 6 -C 12芳基，C 2 -C 7氨基甲酰基烷基，C 2 -C 7羧基烷基，C 1 -C 6氨基烷基，C 4 -C 10冠酰基烷基，C 1 -C 6巯基烷基，C 2 -C 7烷硫基烷基， C 9 -C 15吲哚基烷基或C 4 -C 9咪唑基烷基，R 2表示氢，C 1 -C 6烷基，C 7 -C 14芳烷基，C 6 -C 12芳基，甘氨酰基或甘氨酰 - 甘氨酰基，R 3表示氢，C 1 -C 6烷基或氨基 - 保护基，R1和R2任选地结合形成C 2 -C 4亚烷基，基团可以任选地代表邻苯二甲酰亚氨基，哌啶子基，4-羟基-4-（对卤代苯基）哌啶子基，吗啉代或哌嗪基，各自被 C1-C6烷基或苯基 A环表示苯环或任选被卤素取代的吡啶环，B环表示任选被卤素，三氟甲基，甲基磺酰基，硝基或C 1 -C 6烷基取代的苯环或噻吩环及其酸加成盐，可用作抗焦虑药，镇静剂，抗惊厥药，催眠药，肌肉松弛剂或其合成中间体。

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