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1. 发明授权

US06489351B1 Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentation induction factor action 失效
标题翻译：缩合的4,5,6,7-四氢苯并[C]噻吩作为细胞分化诱导因子作用的增强剂
公开(公告)号：US06489351B1
公开(公告)日：2002-12-03
申请号：US10105333
申请日：2002-03-26
申请人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
发明人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
IPC分类号： A61K311424
CPC分类号： C07D495/04 , C07D513/04 , C07F9/6561
摘要： A compound represented by the formula: wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; R2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof. A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.
摘要翻译：由下式表示的化合物：其中X表示硫原子或氧原子; Y表示任选氧化的硫原子或氧原子; Z表示键或二价烃基; R1表示任选取代的烃基; R 2表示任选的酰胺化或酯化的羧基; 环A表示任选取代的芳族五元杂环; 或其盐。上述化合物具有细胞分化诱导因子作用增强活性和抗基质金属蛋白酶活性，并且其可用于预防和治疗骨疾病如骨质疏松症，骨折，骨关节炎和类风湿性关节炎，动脉硬化，癌转移以及基于神经变性的疾病。

2. 发明授权

US06391905B1 Condensed 4,5,6,7-tetrahydrobenzo[C]thiopenes as enhancer for cell differentiation induction factor action 失效
标题翻译：缩合的4,5,6,7-四氢苯并[C]噻吩作为细胞分化诱导因子作用的增强剂
公开(公告)号：US06391905B1
公开(公告)日：2002-05-21
申请号：US09847416
申请日：2001-05-03
申请人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
发明人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
IPC分类号： A61K314162
CPC分类号： C07D495/04 , C07D513/04 , C07F9/6561
摘要： A compound represented by the formula: wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; R2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof. A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.
摘要翻译：由下式表示的化合物：其中X表示硫原子或氧原子; Y表示任选氧化的硫原子或氧原子; Z表示键或二价烃基; R1表示任选取代的烃基; R 2表示任选的酰胺化或酯化的羧基; 环A表示任选取代的芳族5元杂环; 或其盐。上述化合物具有细胞分化诱导因子作用增强活性和抗基质金属蛋白酶活性，并且其可用于预防和治疗骨疾病如骨质疏松症，骨折，骨关节炎和类风湿性关节炎，动脉硬化，癌转移以及基于神经变性的疾病。

3. 发明授权

US6066658A Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentiation induction factor action 失效
标题翻译：缩合的4,5,6,7-四氢苯并[C]噻吩作为细胞分化诱导因子作用的增强子
公开(公告)号：US6066658A
公开(公告)日：2000-05-23
申请号：US252913
申请日：1999-02-19
申请人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
发明人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
IPC分类号： C07D495/04 , C07D498/04 , C07D513/04 , C07F9/6561 , A61K31/4439 , A61K31/429
CPC分类号： C07D495/04 , C07D513/04 , C07F9/6561
摘要： A compound represented by the formula: ##STR1## wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R.sup.1 represents an optionally substituted hydrocarbon group; R.sup.2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof. A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.
摘要翻译：由下式表示的化合物：其中X表示硫原子或氧原子; Y表示任选氧化的硫原子或氧原子; Z表示键或二价烃基; R1表示任选取代的烃基; R 2表示任选的酰胺化或酯化的羧基; 环A表示任选取代的芳族5元杂环; 或其盐。上述化合物具有细胞分化诱导因子作用增强活性和抗基质金属蛋白酶活性，可用于预防和治疗骨质疏松症，骨折，骨关节炎和类风湿性关节炎，动脉硬化，癌症转移等骨疾病，和基于神经变性的疾病。

4. 发明授权

US06242471B1 Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentiation induction factor action 失效
标题翻译：缩合的4,5,6,7-四氢苯并[C]噻吩作为细胞分化诱导因子作用的增强子
公开(公告)号：US06242471B1
公开(公告)日：2001-06-05
申请号：US09559453
申请日：2000-04-28
申请人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
发明人： Tsuneo Yasuma , Tsuneo Oda , Masatoshi Hazama , Shigehisa Taketomi
IPC分类号： A61K31424
CPC分类号： C07D495/04 , C07D513/04 , C07F9/6561
摘要： A compound represented by the formula: wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; R2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof. A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.
摘要翻译：由下式表示的化合物：其中X表示硫原子或氧原子; Y表示任选氧化的硫原子或氧原子; Z表示键或二价烃基; R1表示任选取代的烃基; R 2表示任选的酰胺化或酯化的羧基; 环A表示任选取代的芳族5元杂环; 或其盐。上述化合物具有细胞分化诱导因子作用增强活性和抗基质金属蛋白酶活性，并且其可用于预防和治疗骨疾病如骨质疏松症，骨折，骨关节炎和类风湿性关节炎，动脉硬化，癌转移以及基于神经变性的疾病。

5. 发明授权

US06632807B1 (2R,4S)-(−)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5- tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide 失效
标题翻译：（2R，4S） - （ - ） - [N-（4-二乙氧基磷酰基甲基）苯基] -1,2,4,5-四氢-4-甲基-7,8-亚甲二氧基-5-氧代-3-苯并噻吩并-2 甲酰胺
公开(公告)号：US06632807B1
公开(公告)日：2003-10-14
申请号：US09635067
申请日：2000-08-09
申请人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
发明人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
IPC分类号： A61K3167
CPC分类号： C07D495/04 , C07F9/6561 , C07F9/657181
摘要： This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.
摘要翻译：本发明涉及由下式表示的光学活性苯并硫代衍生物：其中R代表低级烷基; R <1 和R <2 独立地表示低级烷基，或者可以结合在一起形成环，其显示出优异的成骨促进作用并且可用作骨疾病的预防或治疗药物

6. 发明授权

US06346521B1 Optically active 2R, 4S benzothiepin isomer 失效
标题翻译：光学活性的2R，4S苯并硫代异构体
公开(公告)号：US06346521B1
公开(公告)日：2002-02-12
申请号：US08579731
申请日：1995-12-28
申请人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
发明人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
IPC分类号： A61K3167
CPC分类号： C07D495/04 , C07F9/6561 , C07F9/657181
摘要： This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.
摘要翻译：本发明涉及由下式表示的光学活性苯并硫代衍生物：其中R代表低级烷基; R1和R2独立地表示低级烷基，或者可以结合在一起形成环，其表现出优异的成骨促进作用，并且可用作骨疾病的预防或治疗药物。

7. 发明授权

US5716944A Phosphonic acid compounds, their production and use 失效
标题翻译：膦酸化合物，其生产和使用
公开(公告)号：US5716944A
公开(公告)日：1998-02-10
申请号：US501022
申请日：1995-08-11
申请人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
发明人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
IPC分类号： C07F9/38 , C07F9/40 , C07F9/60 , C07F9/655 , C07F9/6553 , C07F9/6561 , C07F9/6571 , A01N57/16 , A61K31/66 , C07F9/44
CPC分类号： C07F9/657181 , C07F9/3882 , C07F9/4056 , C07F9/60 , C07F9/65517 , C07F9/65522 , C07F9/655345 , C07F9/65539 , C07F9/6561
摘要： The present invention relates to a compound of the general formula (I): ##STR1## wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q.sub.1 is a group of the formula --X--P(O)(OR.sup.1)(OR.sup.2) wherein X is a bond or a divalent group; R.sup.1 and R.sup.2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q.sub.2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q.sub.1)(Q.sub.2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.
摘要翻译： PCT No.PCT / JP95 / 01328 Sec。 371日期：1995年8月11日 102（e）日期1995年8月11日PCT提交1995年7月3日PCT公布。出版物WO96 / 01267 日本1月18日，日本本发明涉及通式（I）的化合物：其中环A为可被取代的苯环; Y是作为形成5-至8-元环的环B的构成成员的二价基团; Q1是式-X-P（O）（OR1）（OR2）的基团，其中X是键或二价基团; R 1和R 2相同或不同，为氢或低级烷基，或可以组合在一起形成环; Q2是氢，可以被取代的烃基或可以被取代的杂环基; 并且式-CON（Q1）（Q2）的基团与a-或b-位碳原子或其盐连接，其可用作各种代谢骨疾病如骨质疏松症的预防和治疗剂。

8. 发明授权

US5580863A Benzopyran derivatives and their use 失效
标题翻译：苯并吡喃衍生物及其用途
公开(公告)号：US5580863A
公开(公告)日：1996-12-03
申请号：US242638
申请日：1994-05-13
申请人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
发明人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
IPC分类号： C07F9/655 , C07F9/6558 , C07F9/6571 , A61K31/665 , A61K31/675 , C07D311/24 , C07F9/38
CPC分类号： C07F9/65586 , C07F9/65522 , C07F9/657181
摘要： This invention relates to a compound represented by the formula: ##STR1## wherein B represents a hydrogen atom or a lower alkyl group; ring A represents a benzene ring which may have one or more substituents; .multidot..multidot..multidot..multidot..multidot. represents a single or double bond; Q.sub.1 represents the group represented by the formula, ##STR2## or a hydrocarbon residue substituted with the group represented by the formula, ##STR3## wherein X represents a bond or a spacer having a chain length of 1 to 4 atoms as the linear moiety which may have one or more side chains; R.sup.1 and R.sup.2, whether identical or not, independently represent a hydrogen atom or a lower alkyl, or may bind together to form a ring; Q.sub.2 represents a hydrogen atom, a hydrocarbon residue which may be substituted or a heterocyclic ring residue which may be substituted; or a salt thereof.
摘要翻译：本发明涉及由下式表示的化合物：其中B代表氢原子或低级烷基; 环A表示可具有一个或多个取代基的苯环; + E，ovs xxxxx + EE表示单键或双键; Q1表示由下式表示的基团：或被下式表示的基团取代的烃基，其中X表示键或具有1-4个原子的链长的间隔基作为直链部分，可能有一个或多个侧链; 无论相同或不同，R 1和R 2独立地表示氢原子或低级烷基，或可以结合在一起形成环; Q2表示氢原子，可以被取代的烃残基或可被取代的杂环残基; 或其盐。

9. 发明授权

US5741784A Benzopyran derivatives and their use 失效
标题翻译：苯并吡喃衍生物及其用途
公开(公告)号：US5741784A
公开(公告)日：1998-04-21
申请号：US697862
申请日：1996-08-30
申请人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
发明人： Takashi Sohda , Shigehisa Taketomi , Tsuneo Oda
IPC分类号： C07F9/655 , C07F9/6558 , C07F9/6571 , A61K31/665 , A61K31/675
CPC分类号： C07F9/65586 , C07F9/65522 , C07F9/657181
摘要： This invention relates to a compound represented by the formula: ##STR1## wherein B represents a hydrogen atom or a lower alkyl group; ring A represents a benzene ring which may have one or more substituents; ....... represents a single or double bond; Q.sub.1 represents the group represented by the formula, ##STR2## ,or a hydrocarbon residue substituted with the group represented by the formula, ##STR3## wherein X represents a bond or a spacer having a chain length of 1 to 4 atoms as the linear moiety which may have one or more side chains; R.sup.1 and R.sup.2, whether identical or not, independently represent a hydrogen atom or a lower alkyl, or may bind together to form a ring; Q.sub.2 represents a hydrogen atom, a hydrocarbon residue which may be substituted or a heterocyclic ring residue which may be substituted; or a salt thereof.
摘要翻译：本发明涉及由下式表示的化合物：其中B代表氢原子或低级烷基; 环A表示可具有一个或多个取代基的苯环; + E，ovs ....... + EE表示单键或双键; Q1表示由式表示的基团，或被下式表示的基团取代的烃基，其中X表示键或具有1-4个原子的链长的间隔基作为直链部分其可以具有一个或多个侧链; 无论相同或不同，R 1和R 2独立地表示氢原子或低级烷基，或可以结合在一起形成环; Q2表示氢原子，可以被取代的烃残基或可被取代的杂环残基; 或其盐。

10. 发明申请

US20090227560A1 Substituted imidazole compound and use thereof 审中-公开
公开(公告)号：US20090227560A1
公开(公告)日：2009-09-10
申请号：US12216874
申请日：2008-07-11
申请人： Takanobu Kuroita , Tsuneo Oda , Yasutomi Asano , Naohiro Taya , Kouichi Iwanaga , Hidekazu Tokuhara , Yoshiyuki Fukase
发明人： Takanobu Kuroita , Tsuneo Oda , Yasutomi Asano , Naohiro Taya , Kouichi Iwanaga , Hidekazu Tokuhara , Yoshiyuki Fukase
IPC分类号： A61K31/496 , C07D403/06 , C07D403/14 , C07D413/14 , A61K31/5377 , A61P9/12
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof.The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

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