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1. 发明授权

US09045436B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US09045436B2
公开(公告)日：2015-06-02
申请号：US13446408
申请日：2012-04-13
申请人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara
发明人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara
IPC分类号： A61K31/535 , C07D413/14 , C07D233/90 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04
CPC分类号： C07D401/12 , C07D233/90 , C07D401/14 , C07D405/14 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04
摘要： Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
摘要翻译：由式表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压，高血压等各种器官损害的药剂。

2. 发明授权

US07629472B2 Method for producing optically active compound 失效
标题翻译：光学活性化合物的制造方法
公开(公告)号：US07629472B2
公开(公告)日：2009-12-08
申请号：US11812052
申请日：2007-06-14
申请人： Toru Yamano , Naohiro Taya , Akio Ojida
发明人： Toru Yamano , Naohiro Taya , Akio Ojida
IPC分类号： C07D233/54 , C07D211/80
CPC分类号： C07D233/64 , C07D213/55
摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.
摘要翻译：本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2表示与R 1不同的含氮杂环基，其表示为通式：其中环可以被取代等，R 3表示任选取代的烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“* “表示光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上所定义，与通式表示的化合物反应：其中R 3，R 4和 R5如上所定义，X为卤素原子。

3. 发明授权

US08664380B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08664380B2
公开(公告)日：2014-03-04
申请号：US12457646
申请日：2009-06-17
申请人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara
发明人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara
IPC分类号： C07D413/14
CPC分类号： C07D401/12 , C07D233/90 , C07D401/14 , C07D405/14 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04
摘要： Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
摘要翻译：由式表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压，高血压等各种器官损害的药剂。

4. 发明授权

US08466282B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08466282B2
公开(公告)日：2013-06-18
申请号：US12999428
申请日：2009-06-17
申请人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara , Yoshiyuki Fukase
发明人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara , Yoshiyuki Fukase
IPC分类号： C07D413/00 , A61K31/535
CPC分类号： C07D401/12 , C07D233/90 , C07D401/14 , C07D405/14 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04
摘要： Compounds represented by the formulas (I) (II) wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
摘要翻译：由式（I）（II）表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压的药剂，可归因于高血压等。

5. 发明申请

US20110178057A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20110178057A1
公开(公告)日：2011-07-21
申请号：US12999428
申请日：2009-06-17
申请人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara , Yoshiyuki Fukase
发明人： Takanobu Kuroita , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara , Yoshiyuki Fukase
IPC分类号： A61K31/454 , C07D413/14 , C07D471/04 , C07D401/14 , C07D401/12 , A61K31/5377 , A61K31/4545 , A61P9/12 , A61P9/00
CPC分类号： C07D401/12 , C07D233/90 , C07D401/14 , C07D405/14 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04
摘要： Compounds represented by the formulas (I) (II) wherein each symbol is as defined in the specification, and a pro-drug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
摘要翻译：由式（I）（II）表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压，各种器官损伤的药剂归因于高血压等。

6. 发明申请

US20070276143A1 Method for producing optically active compound 失效
标题翻译：光学活性化合物的制造方法
公开(公告)号：US20070276143A1
公开(公告)日：2007-11-29
申请号：US11812052
申请日：2007-06-14
申请人： Toru Yamano , Naohiro Taya , Akio Ojida
发明人： Toru Yamano , Naohiro Taya , Akio Ojida
IPC分类号： C07D233/54 , C07D211/80
CPC分类号： C07D233/64 , C07D213/55
摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2are as defined above with a compound represented by the general formula: wherein R3, R4and R5 are as defined above, and X is a halogen atom.
摘要翻译：本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义与由下列通式表示的化合物：其中R 3，R 4和R 5如上定义，X是卤素原子。

7. 发明授权

US07247732B2 Method for producing optically active compound 有权
标题翻译：光学活性化合物的制造方法
公开(公告)号：US07247732B2
公开(公告)日：2007-07-24
申请号：US11451051
申请日：2006-06-12
申请人： Toru Yamano , Naohiro Taya , Akio Ojida
发明人： Toru Yamano , Naohiro Taya , Akio Ojida
IPC分类号： C07D213/46 , C07D233/60
CPC分类号： C07D233/64 , C07D213/55
摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like,R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like,R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like,the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.
摘要翻译：本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示光学活性中心，其包括在cinchona生物碱等存在下反应，由以下通式表示的化合物：其中R 1和R 2如上定义与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

8. 发明申请

US20060229457A1 Method for producing optically active compound 有权
标题翻译：光学活性化合物的制造方法
公开(公告)号：US20060229457A1
公开(公告)日：2006-10-12
申请号：US11451051
申请日：2006-06-12
申请人： Toru Yamano , Naohiro Taya , Akio Ojida
发明人： Toru Yamano , Naohiro Taya , Akio Ojida
IPC分类号： C07D233/61
CPC分类号： C07D233/64 , C07D213/55
摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.
摘要翻译：本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

9. 发明授权

US06800778B1 Process for producing optically active naphthalene derivative and optical resolver therefor 失效
标题翻译：用于制备光学活性萘衍生物和光学旋光器的方法
公开(公告)号：US06800778B1
公开(公告)日：2004-10-05
申请号：US10111211
申请日：2002-04-22
申请人： Isao Aoki , Mari Adachi , Mitsuru Kawada , Toru Yamano , Naohiro Taya
发明人： Isao Aoki , Mari Adachi , Mitsuru Kawada , Toru Yamano , Naohiro Taya
IPC分类号： C07F906
CPC分类号： C07D233/64 , A61K31/4164 , C07B2200/07 , C07F9/5027 , C07F9/65744
摘要： The present invention provides a method of producing an optically active form of a compound represented by the formula (I) having a steroid C17,20-lyase inhibitory activity and is useful as an agent for the prophylaxis or treatment of prostatism, tumor such as breast cancer, and the like or a salt thereof, which method includes reacting a mixture of optically active compounds of a naphthalene derivative represented by the formula: wherein R is a nitrogen-containing heterocyclic group, R1 is a hydrogen atom, a hydrocarbon group or an aromatic heteromonocyclic group, R2 is a hydrogen atom or a lower alkyl group, * shows the position of an asymmetric carbon, R3, R4, R5, R6, R7, R8 and R9 are each independently a hydrogen atom, a hydrocarbon group, a hydroxy group, a thiol group, an amino group, a carbamoyl group, an acyl group or a halogen atom, and R7 is bonded with R6 or R8 to form, together with a carbon atom on a naphthalene ring, a 5 or 6-membered ring containing an oxygen atom, with an optically active form of a compound represented by the formula: wherein ring A is a benzene ring, R10 and R11 are the same or different and each is a hydrogen atom, a hydrocarbon group or a halogen atom, or R10 and R11 in combination show an alkylene group, * shows the position of an asymmetric carbon, and ring B and ring C are each an aromatic ring, separating the resulting salt, and isolating the optically active form, and a novel reagent for optical resolution.
摘要翻译：本发明提供了具有类固醇C17,20-裂解酶抑制活性的由式（I）表示的化合物的光学活性形式的方法，可用作预防或治疗前列腺症，肿瘤如乳腺癌癌症等或其盐，该方法包括使由下式表示的萘衍生物的光学活性化合物的混合物：其中R是含氮杂环基，R 1是氢原子，烃基团或芳族杂单环基团，R 2是氢原子或低级烷基，*表示不对称碳的位置，R 3，R 4，R 5，R 6， R 7，R 8和R 9各自独立地为氢原子，烃基，羟基，硫醇基，氨基，氨基甲酰基，酰基或卤素原子，以及 R 7与R 6或R 8键合，与萘环上的碳原子一起形成5或6元环，具有下式表示的化合物的光学活性形式的氧原子：其中环A是苯环，R 10和R 11相同或不同，各自为氢原子，烃基或卤素原子，或R 10和R 11组合表示亚烷基，*表示不对称碳的位置，环B和环C各自为芳环，分离所得盐，并分离光学活性形式和用于光学拆分的新型试剂。

10. 发明申请

US20120264733A1 HETEROCYCLIC COMPOUND AND USE THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：US20120264733A1
公开(公告)日：2012-10-18
申请号：US13446408
申请日：2012-04-13
申请人： Takanobu KUROITA , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara , Yoshiyuki Fukase
发明人： Takanobu KUROITA , Yasuhiro Imaeda , Kouichi Iwanaga , Naohiro Taya , Hidekazu Tokuhara , Yoshiyuki Fukase
IPC分类号： A61K31/454 , A61K31/5377 , C07D471/04 , C07D495/04 , C07D405/14 , A61P9/12 , A61K31/4545 , C07D401/14 , C07D487/08 , A61K31/553 , A61K31/538 , A61P9/00 , C07D413/14 , C07D401/12
CPC分类号： C07D401/12 , C07D233/90 , C07D401/14 , C07D405/14 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04
摘要： Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
摘要翻译：由式表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压，高血压等各种器官损害的药剂。

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