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1. 发明授权

US08795175B2 Biological measurement system measuring cerebral blood volume changes to find disease or danger 有权
标题翻译：生物测量系统测量脑血量变化发现疾病或危险
公开(公告)号：US08795175B2
公开(公告)日：2014-08-05
申请号：US12252809
申请日：2008-10-16
申请人： Tsukasa Funane , Naoki Tanaka , Hideaki Koizumi , Atsushi Maki
发明人： Tsukasa Funane , Naoki Tanaka , Hideaki Koizumi , Atsushi Maki
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/14553 , A61B5/02416
摘要： Cerebral blood volume changes are measured to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its change over time to thereby estimate and display diseased and dangerous portions based on the evaluation. This is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.
摘要翻译：测量脑血容量变化，从这些变化的低频成分的特性和通过分析计算出的心率变化的性质来评估脑血管硬度的分布及其随时间的变化，从而基于以下方式估计和显示患病和危险部分：评估。这是通过具有测量被检测体的局部脑血容量的脑血容量测量单元的生物测量系统，分析由脑血容量测量单元测量的信号的分析单元，提取单元，基于分析单元的输出，关于测试体的区域性脑血管状态的信息和显示脑血容量测量单元的测量结果的显示单元，分析器单元的分析结果或提取结果的提取单位。

2. 发明申请

US20090143654A1 BIOLOGICAL MEASUREMENT SYSTEM 有权
标题翻译：生物测量系统
公开(公告)号：US20090143654A1
公开(公告)日：2009-06-04
申请号：US12252809
申请日：2008-10-16
申请人： Tsukasa FUNANE , Naoki Tanaka , Hideaki Koizumi , Atsushi Maki
发明人： Tsukasa FUNANE , Naoki Tanaka , Hideaki Koizumi , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/02416
摘要： This invention measures cerebral blood volume changes to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its with-time change to thereby estimate and display diseased and dangerous portions based on the evaluation. Briefly, the above-noted object is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.
摘要翻译：本发明通过分析计算出的这种变化和心率变化的低频成分的特性，脑血管硬度的分布及其随时间的变化来测量脑血容量变化，从而评估和显示患病危险部位基于评估。简而言之，上述目的可通过具有测量被测体的局部脑血容量的脑血容量测量单元的生物测量系统，分析由脑血容量测量单元测量的信号的分析器单元来实现，提取单元，用于根据分析单元的输出提取关于测试体的区域性脑血管状态的信息;以及显示单元，显示脑血容量测量单元的测量结果，分析结果分析器单元或提取单元的提取结果。

3. 发明授权

US08050744B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US08050744B2
公开(公告)日：2011-11-01
申请号：US11037338
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

4. 发明申请

US20060184047A1 Optical measurement instrument for living body 审中-公开
标题翻译：生物体光学测量仪器
公开(公告)号：US20060184047A1
公开(公告)日：2006-08-17
申请号：US11371919
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B6/03
摘要： An input instrument for a living body, using an optical measurement system for the living body, includes first and second light incident units arranged on a head of a living body, and first and second light detectors which are paired with the first and the second light incident units respectively, and which are provided to collect light which passes through the living body based on the light irradiated onto the head of the living body by the light incident means. Measurement signals are obtained by measuring a plurality of regions of the living body by the first and the second light incident units, the first and the second light detectors, and characteristic parameters of the signals of an arbitrary time interval of the measured signals are calculated.
摘要翻译：使用生物体的光学测量系统的生物体的输入仪器具有设置在生物体的头部的第一和第二光入射单元，以及与第一和第二光线配对的第一和第二光检测器入射单元，其被设置成基于通过光入射装置照射到生物体的头部上的光来收集穿过生物体的光。通过第一和第二光入射单元，第一和第二光检测器测量生物体的多个区域以及测量信号的任意时间间隔的信号的特性参数来计算测量信号。

5. 发明授权

US06947779B2 Optical measurement device 失效
标题翻译：光学测量装置
公开(公告)号：US06947779B2
公开(公告)日：2005-09-20
申请号：US09873206
申请日：2001-06-05
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/17 , G01N21/31
CPC分类号： A61B5/7475 , A61B5/1455
摘要： Optical measurement that is optimum for improving spatial resolution is accomplished by making it possible to estimate a physical quantity of an object substance to be measured at any point on a subject. When any position to be evaluated, in an image shown in a window 1-1, is pointed and selected a mouse pointer 1-4, the value of the concentration or its change of the object substance at the point is displayed in the display area 1-7 of a window 1-3. The drawings represents an example in which one position is specified and there are two object substances to be measured. The value of the concentration or its change of each object substance to be measured is separately displayed.
摘要翻译：通过使得可以在对象的任何点估计待测物体的物理量来实现对于改善空间分辨率最佳的光学测量。当要评估的任何位置在窗口1至1所示的图像中被指向并选择了鼠标指针1-4时，该点处的物体的浓度值或其变化的值被显示在显示区域中 1 - 7的窗口1 - 3。附图表示其中指定了一个位置并且存在两个待测物体的示例。分别显示要测量的每种物质的浓度值或其变化值。

6. 发明授权

US06657183B2 Amusement system using living body measurement by light, head setter for the amusement system, and program for use in the amusement system 有权
标题翻译：娱乐系统使用活体测量的乐器，娱乐系统的头枕，以及娱乐系统中使用的节目
公开(公告)号：US06657183B2
公开(公告)日：2003-12-02
申请号：US09939601
申请日：2001-08-28
申请人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
发明人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
IPC分类号： H01J4014
CPC分类号： A63F13/212 , A63F13/10 , A63F13/213 , A63F2300/1012 , A63F2300/807
摘要： Disclosed herein is an amusement system that can be used and enjoyed by different persons without using the brain continuously and with little feeling of fatigue and which permits setting a probe at any spot on the head of the subject. The amusement system includes irradiators for irradiating the subject with light, light detectors for detection of the light that has been emitted from said irradiator and which has propagated through the living body, signal processors for processing the signal of light intensity detected by said detector and display units that show the processing results from the signal processor. The range of display of a change in intensity of said transmitted light according to the results of a test task carried out on said living body.
摘要翻译：本文公开了一种娱乐系统，其可以由不同的人使用和享用，而不用连续地使用大脑并且几乎没有疲劳的感觉，并且允许在受试者头部的任何位置设置探针。娱乐系统包括用于用光照射对象的照射器，用于检测已经从所述照射器发射并已经通过生物体传播的光的光检测器，用于处理由所述检测器检测的光强度的信号的信号处理器和显示器显示信号处理器处理结果的单位。根据在所述活体上进行的测试任务的结果，显示所述透射光的强度变化的范围。

7. 发明授权

US5803909A Optical system for measuring metabolism in a body and imaging method 失效
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US5803909A
公开(公告)日：1998-09-08
申请号：US539871
申请日：1995-10-06
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055 , A61B5/18 , A61B6/00 , A61B6/03
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B2562/0219 , A61B2562/0233 , A61B2562/046 , A61B5/055 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface Changes in concentration values of absorbers are determined from the living body transmitting light intensity levels and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point to image a function of the living body. The measuring time is shortened by estimating fluctuation attributable to the living body, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by light detection at two different sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译：以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平波长和各个照射位置在表面上的不同位置被测量吸收体的浓度值的变化由生物体透射光强度水平确定，并且测量点设置在延伸穿过入射点和每个之间的中间点的垂直检测点成像生物体的功能。通过估计生物体的波动来缩短测量时间，并且可以通过在两个不同位置（等于光入射点的光检测）检测透射通过生物体内部的光线来测量血液动力学运动的局部变化），并且根据两个检测信号之间的对数差异仅分离血液动力学运动的局部变化与生物体中的血液动力学运动的总体变化。

8. 发明申请

US20050171440A1 Optical system for measuring metabolism in a body and imaging method 有权
公开(公告)号：US20050171440A1
公开(公告)日：2005-08-04
申请号：US11037338
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055 , A61B5/18 , A61B6/00 , A61B6/03
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

9. 发明授权

US06640133B2 Optical measurement instrument for living body 有权
标题翻译：生物体光学测量仪器
公开(公告)号：US06640133B2
公开(公告)日：2003-10-28
申请号：US09849409
申请日：2001-05-07
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B505
CPC分类号： A61B5/0059 , A61B5/055 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B6/03 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： A control device for a living body including an input device having a launcher for launching light into the living body from at least one light incident position on a surface of the living body, a collector for collecting light obtained by causing the light incident from the light incident position to pass through the living body, at at least one light detection position on the surface of the living body, a detector for detecting an intensity of the transmitted light collected by the collector, an operator for determining a type of output signal, based on the intensity of the transmitted light, which has been detected by the detector and pre-stored reference data and for outputting a signal indicative thereof. External equipment is provided for using the signal outputted as an input signal and for executing a functional operation according to a type of the input signal.
摘要翻译：一种生物体的控制装置，具有：输入装置，具有从生物体的表面上的至少一个光入射位置向所述生物体射出光的发射器，收集从所述光入射的光所得到的光的收集体在生物体的表面上的至少一个光检测位置通过活体的入射位置，用于检测由收集器收集的透射光的强度的检测器，用于确定输出信号的类型的操作者关于由检测器检测到的透射光的强度，以及预先存储的参考数据，并输出指示其的信号。提供外部设备，用于使用作为输入信号输出的信号，并根据输入信号的类型执行功能操作。

10. 发明授权

US06282438B1 Optical system for measuring metabolism in a body and imaging method 失效
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US06282438B1
公开(公告)日：2001-08-28
申请号：US09203610
申请日：1998-12-02
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译：以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平波长和各个照射位置在生物体的表面上的不同位置处被测量。在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在，并且可以通过检测设置在被摄体上不同的两个位置（等于光入射点的位置）的两个光检测器检测通过生物体的内部的光线，并且仅分离本地根据两个检测信号之间的对数差异，从生物体的血液动力学运动的总体变化中改变血流动力学运动。

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