专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5981278A Chimeric monoclonal antibodies which neutralize HIV-1 infection and their applications in therapy and prevention for AIDS 失效
标题翻译：中和HIV-1感染的嵌合单克隆抗体及其在艾滋病治疗和预防中的应用
公开(公告)号：US5981278A
公开(公告)日：1999-11-09
申请号：US767533
申请日：1991-09-26
申请人： Tse-Wen Chang , Michael S. C. Fung , Nancy T. Chang , Bill N. C. Sun , Cecily R. Y. Sun
发明人： Tse-Wen Chang , Michael S. C. Fung , Nancy T. Chang , Bill N. C. Sun , Cecily R. Y. Sun
IPC分类号： A61K38/00 , A61K47/48 , C07K14/16 , C12N5/12 , C07K16/00
CPC分类号： C07K14/005 , A61K47/48523 , A61K38/00 , C07K2317/24 , C07K2319/02 , C12N2740/16122
摘要： Monoclonal antibodies are revealed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the rate of infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC.
摘要翻译：揭示单克隆抗体结合HIV-1包膜上的gp120蛋白。这些抗体中和HIV-1。它们抑制T细胞感染的速度，并且抑制合胞体的形成。此外，抗体是组特异性的，并且中和HIV-1的不同菌株和分离株。这些抗体具有各种用途，包括治疗和预防艾滋病和ARC。

2. 发明授权

US06309880B1 Antibodies specific for CD4-binding domain of HIV-1 失效
标题翻译： HIV-1的CD4结合结构域特异性抗体
公开(公告)号：US06309880B1
公开(公告)日：2001-10-30
申请号：US08089990
申请日：1993-07-09
申请人： Tse Wen Chang , Michael S. C. Fung , Bill N. C. Sun , Cecily R. Y. Sun , Nancy T. Chang
发明人： Tse Wen Chang , Michael S. C. Fung , Bill N. C. Sun , Cecily R. Y. Sun , Nancy T. Chang
IPC分类号： C12N506
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K47/6425 , A61K47/6839 , C07K16/1063 , C07K2317/34 , C12N2740/16122
摘要： A particular epitope located within the CD4-binding region of gpl20 of HIV-1, and antibodies specific for the epitope which can inhibit HIV-1 infection of human cells by diverse strains and isolates of the virus, is disclosed. The antibodies are useful for a number of purposes, including diagnosis of HIV-1 infection.
摘要翻译：公开了位于HIV-1的gp120的CD4结合区域内的特定表位，以及能够通过多种毒株和病毒分离株抑制人细胞HIV-1感染的表位的特异抗体。抗体可用于许多目的，包括HIV-1感染的诊断。

3. 发明授权

US5834599A Immunoconjugates which neutralize HIV-1 infection 失效
标题翻译：中和HIV-1感染的免疫偶联物
公开(公告)号：US5834599A
公开(公告)日：1998-11-10
申请号：US26276
申请日：1993-03-04
申请人： Tse-Wen Chang , Sek C. Fung , Cecily Rou-Yun Sun , Bill Nai-Chau Sun , Nancy T. Chang , Young Woo Kim
发明人： Tse-Wen Chang , Sek C. Fung , Cecily Rou-Yun Sun , Bill Nai-Chau Sun , Nancy T. Chang , Young Woo Kim
IPC分类号： A61K38/00 , A61K47/48 , C07K16/00
CPC分类号： A61K47/48469 , A61K38/00 , C07K2317/24
摘要： Monoclonal antibodies are revealed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC. The antibodies are used in immunotoxins which are specifically toxic to HIV-1 infected T cells.
摘要翻译：揭示单克隆抗体结合HIV-1包膜上的gp120蛋白。这些抗体中和HIV-1。它们抑制T细胞的感染，并抑制合胞体的形成。此外，抗体是组特异性的，并且中和HIV-1的不同菌株和分离株。这些抗体具有各种用途，包括治疗和预防艾滋病和ARC。该抗体用于对HIV-1感染的T细胞特异性毒性的免疫毒素中。

4. 发明授权

US4596774A Method of preparing murine monoclonal antibodies against cell-free products of activated human T-lymphocytes 失效
标题翻译：制备针对活化的人T淋巴细胞的无细胞产物的鼠单克隆抗体的方法
公开(公告)号：US4596774A
公开(公告)日：1986-06-24
申请号：US547941
申请日：1983-11-02
申请人： Tse-Wen Chang , Nancy T. Chang
发明人： Tse-Wen Chang , Nancy T. Chang
IPC分类号： C07K16/18 , C12P21/08 , C12P21/00 , C12N5/00 , C12N5/02 , C12R1/91
CPC分类号： C07K16/18 , C07K2317/74 , Y10S530/806
摘要： A method of preparing simultaneously monoclonal antibodies specific for different cell-free products of activated human T lymphocytes is disclosed. Human T cells are activated in a medium supplemented with mouse serum rather than conventional calf serum. A supernatant prepared from the activated T cells is used to immunize mice. The dominant immunogens in the supernatant are the cell-free products of human T lymphocytes. The yield of hybrid cells which produce products reactive with cell-free products of human T lymphocytes is enhanced by injecting the immunized mice with a supernatant from mitogen-activated murine splenocytes. In addition, a novel radioimmunoadsorbent assay for screening hybrids to detect production of monoclonal antibodies reactive with cell-free products of human T lymphocytes is disclosed.
摘要翻译：公开了同时制备对活化的人T淋巴细胞的不同无细胞产物特异的单克隆抗体的方法。人T细胞在补充有小鼠血清而不是常规小牛血清的培养基中活化。使用从活化的T细胞制备的上清液来免疫小鼠。上清液中的主要免疫原是人T淋巴细胞的无细胞产物。通过从有丝分裂原激活的小鼠脾细胞中注射免疫小鼠来增强产生与人T淋巴细胞无细胞产物反应的产物的杂交细胞的产量。此外，公开了一种用于筛选杂交体以检测与人T淋巴细胞的无细胞产物反应的单克隆抗体的产生的新型放射免疫吸附测定法。

5. 发明授权

US06657050B1 Chimeric viral-neutralizing immunoglobulins 失效
标题翻译：嵌合病毒中和免疫球蛋白
公开(公告)号：US06657050B1
公开(公告)日：2003-12-02
申请号：US08015248
申请日：1993-02-05
申请人： Cecily R. Y. Sun , Bill N. C. Sun , Michael S. C. Fung , Tse Wen Chang , Nancy T. Chang
发明人： Cecily R. Y. Sun , Bill N. C. Sun , Michael S. C. Fung , Tse Wen Chang , Nancy T. Chang
IPC分类号： C07K128
CPC分类号： C07K14/005 , A61K47/6839 , C07K2317/24 , C07K2319/02 , C12N2740/16122
摘要： Chimeral viral-neutralizing, particularly HIV-neutralizing, immunoglobulins made up of a non-human antigen binding region and a human constant region are described.
摘要翻译：描述了由非人抗原结合区和人恒定区组成的中和性，特别是HIV-中和的免疫球蛋白。

6. 发明授权

US5866129A Method of producing an antibody with a peptide corresponding to membrane-bound IgA 失效
标题翻译：制备具有对应于膜结合的IgA的肽的抗体的方法
公开(公告)号：US5866129A
公开(公告)日：1999-02-02
申请号：US785565
申请日：1991-11-04
申请人： Tse Wen Chang , Nancy T. Chang
发明人： Tse Wen Chang , Nancy T. Chang
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61K47/48 , A61P37/04 , C07H21/04 , C07K7/08 , C07K16/00 , C07K16/28 , C07K16/42 , C07K17/02 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/04 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/4283 , A61K47/48284 , C07K16/00 , C07K16/4241 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S530/861 , Y10S530/866 , Y10S530/867 , Y10S530/868
摘要： The invention relates to a method of using a peptide which has the sequence of epitopes which are present on B cell-bound but not secreted IgA. This induces production of the antibody itself. These extracellular peptide segments form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA.
摘要翻译：本发明涉及使用具有存在于B细胞结合但不分泌的IgA上的表位序列的肽的方法。这诱导抗体本身的产生。这些细胞外肽段完全或部分地形成独特的膜结合但不分泌的IgA的抗原表位。

7. 发明授权

US5854400A Monoclonal antibodies which neutralize HIV-1 infection 失效
标题翻译：中和HIV-1感染的单克隆抗体
公开(公告)号：US5854400A
公开(公告)日：1998-12-29
申请号：US950571
申请日：1992-09-22
申请人： Tse Wen Chang , Michael S. C. Fung , Bill N. C. Sun , Cecily R. Y. Sun , Nancy T. Chang
发明人： Tse Wen Chang , Michael S. C. Fung , Bill N. C. Sun , Cecily R. Y. Sun , Nancy T. Chang
IPC分类号： A61K38/00 , C07K16/10 , C12N5/18 , C07K16/00
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： Murine monoclonal antibodies and related products such as antibody fragments, immunotoxins, human and humanized antibodies are disclosed, all of which bind to the gp120 protein on the envelope of HIV-1. These antibodies and related products neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are preferably group-specific and neutralize various strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment of AIDS and ARC, the prevention of HIV-1 infection, as well as a diagnostic application, in that they can be used for assaying of unknown fluid samples for HIV-1.
摘要翻译：公开了鼠单克隆抗体和相关产物，例如抗体片段，免疫毒素，人和人源化抗体，所有这些都与HIV-1包膜上的gp120蛋白结合。这些抗体和相关产品中和HIV-1。它们抑制T细胞的感染，并抑制合胞体的形成。此外，抗体优选为组特异性并中和HIV-1的各种菌株和分离物。这些抗体具有各种用途，包括治疗AIDS和ARC，预防HIV-1感染以及诊断应用，因为它们可用于检测HIV-1未知流体样品。

8. 发明授权

US5690934A Peptides relating to the extracellular membrane-bound segment of human alpha chain 失效
标题翻译：与人α链细胞外膜结合片段有关的肽
公开(公告)号：US5690934A
公开(公告)日：1997-11-25
申请号：US619790
申请日：1996-03-20
申请人： Tse Wen Chang , Nancy T. Chang
发明人： Tse Wen Chang , Nancy T. Chang
IPC分类号： A61K39/00 , A61K47/48 , C07K14/705 , C07K16/00 , C07K16/42 , A61K39/395
CPC分类号： A61K47/48284 , C07K14/705 , C07K16/00 , C07K16/4283 , A61K39/00 , C07K2319/00 , C07K2319/30 , C07K2319/33
摘要： The invention relates to unique extracellular peptide segments present on B cell-bound but not secreted IgA. These extracellular peptide segments form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA, and thereby provide a unique epitope on the IgA-bearing B cells to which membrane-bound IgA is attached. These peptide segments can be used as immunogens to generate antibodies which specifically target membrane-bound IgA and IgA-bearing B cells.
摘要翻译：本发明涉及存在于B细胞结合但不分泌的IgA上的独特的细胞外肽区段。这些细胞外肽段完全或部分地形成对于膜结合但不分泌的IgA是独特的抗原表位，从而在附着有膜结合IgA的IgA携带B细胞上提供独特的表位。这些肽段可用作免疫原产生特异性靶向具有膜结合IgA和携带IgA的B细胞的抗体。

9. 发明授权

US5089603A Antigenic epitopes present on membrane-bound but not secreted IgA 失效
标题翻译：抗原蛋白在膜上存在但不分泌IGA
公开(公告)号：US5089603A
公开(公告)日：1992-02-18
申请号：US455080
申请日：1989-12-22
申请人： Tse-wen Chang , Nancy T. Chang
发明人： Tse-wen Chang , Nancy T. Chang
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61K47/48 , A61P37/04 , C07H21/04 , C07K7/08 , C07K16/00 , C07K16/28 , C07K16/42 , C07K17/02 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/04 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/4283 , A61K47/48284 , C07K16/00 , C07K16/4241 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S530/861 , Y10S530/866 , Y10S530/867 , Y10S530/868
摘要： Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgA, the epitopes are present on IgA-bearing B cells but not the secreted, soluble form of IgA. The epitopes can be exploited for therapy and prophylaxis. For example, antibodies specific for the epitopes associated with the anchor and peptide encompassing the epitope domain of IgA can be used to increase secretory IgA production for the purposes of treating patients with infectious diseases and IgE-mediated allergic diseases.
摘要翻译：公开了将免疫球蛋白锚定到B细胞膜的结构域的细胞外区段相关的抗原表位。对于IgA，表位存在于携带IgA的B细胞上，但不存在分泌的可溶形式的IgA。表位可以用于治疗和预防。例如，为了治疗感染性疾病和IgE介导的过敏性疾病的患者的目的，可以使用与包含IgA的表位结构域的锚和肽相关的表位特异性抗体来增加分泌型IgA产生。

10. 发明授权

US4808536A Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein 失效
标题翻译：基于重组HTLV-III gag基因编码蛋白检测针对HTLV-III核心蛋白的抗体的免疫化学方法
公开(公告)号：US4808536A
公开(公告)日：1989-02-28
申请号：US834212
申请日：1986-02-27
申请人： Nancy T. Chang , John Ghrayeb
发明人： Nancy T. Chang , John Ghrayeb
IPC分类号： A61K38/00 , A61K39/00 , A61K39/21 , C07K14/00 , C07K14/005 , C07K14/16 , C07K14/195 , C07K16/00 , C07K19/00 , C12N15/09 , C12P21/00 , C12R1/19 , G01N33/569 , G01N33/545 , B65D69/00 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/56988 , A61K38/00 , C12N2740/16222 , Y10S435/81 , Y10S435/974 , Y10S436/808 , Y10S436/811 , Y10S530/826 , Y10S930/221
摘要： Immunochemical assays for detection of antibodies against HTLV-III core proteins are described. The assays are based upon recombinant HTLV-III core proteins expressed by cloned DNA segments of the gag region of the HTLV-III genome. Immunoreactive, chimeric HTLV-III core proteins and methods of producing these proteins are also described.
摘要翻译：描述了用于检测针对HTLV-III核心蛋白的抗体的免疫化学测定。该测定基于由HTLV-III基因组的gag区域的克隆DNA片段表达的重组HTLV-III核心蛋白。还描述了免疫反应性，嵌合HTLV-III核心蛋白质和产生这些蛋白质的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式