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1. 发明授权

US5981278A Chimeric monoclonal antibodies which neutralize HIV-1 infection and their applications in therapy and prevention for AIDS 失效
标题翻译：中和HIV-1感染的嵌合单克隆抗体及其在艾滋病治疗和预防中的应用
公开(公告)号：US5981278A
公开(公告)日：1999-11-09
申请号：US767533
申请日：1991-09-26
申请人： Tse-Wen Chang , Michael S. C. Fung , Nancy T. Chang , Bill N. C. Sun , Cecily R. Y. Sun
发明人： Tse-Wen Chang , Michael S. C. Fung , Nancy T. Chang , Bill N. C. Sun , Cecily R. Y. Sun
IPC分类号： A61K38/00 , A61K47/48 , C07K14/16 , C12N5/12 , C07K16/00
CPC分类号： C07K14/005 , A61K47/48523 , A61K38/00 , C07K2317/24 , C07K2319/02 , C12N2740/16122
摘要： Monoclonal antibodies are revealed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the rate of infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC.
摘要翻译：揭示单克隆抗体结合HIV-1包膜上的gp120蛋白。这些抗体中和HIV-1。它们抑制T细胞感染的速度，并且抑制合胞体的形成。此外，抗体是组特异性的，并且中和HIV-1的不同菌株和分离株。这些抗体具有各种用途，包括治疗和预防艾滋病和ARC。

2. 发明授权

US5834599A Immunoconjugates which neutralize HIV-1 infection 失效
标题翻译：中和HIV-1感染的免疫偶联物
公开(公告)号：US5834599A
公开(公告)日：1998-11-10
申请号：US26276
申请日：1993-03-04
申请人： Tse-Wen Chang , Sek C. Fung , Cecily Rou-Yun Sun , Bill Nai-Chau Sun , Nancy T. Chang , Young Woo Kim
发明人： Tse-Wen Chang , Sek C. Fung , Cecily Rou-Yun Sun , Bill Nai-Chau Sun , Nancy T. Chang , Young Woo Kim
IPC分类号： A61K38/00 , A61K47/48 , C07K16/00
CPC分类号： A61K47/48469 , A61K38/00 , C07K2317/24
摘要： Monoclonal antibodies are revealed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC. The antibodies are used in immunotoxins which are specifically toxic to HIV-1 infected T cells.
摘要翻译：揭示单克隆抗体结合HIV-1包膜上的gp120蛋白。这些抗体中和HIV-1。它们抑制T细胞的感染，并抑制合胞体的形成。此外，抗体是组特异性的，并且中和HIV-1的不同菌株和分离株。这些抗体具有各种用途，包括治疗和预防艾滋病和ARC。该抗体用于对HIV-1感染的T细胞特异性毒性的免疫毒素中。

3. 发明授权

US4596774A Method of preparing murine monoclonal antibodies against cell-free products of activated human T-lymphocytes 失效
标题翻译：制备针对活化的人T淋巴细胞的无细胞产物的鼠单克隆抗体的方法
公开(公告)号：US4596774A
公开(公告)日：1986-06-24
申请号：US547941
申请日：1983-11-02
申请人： Tse-Wen Chang , Nancy T. Chang
发明人： Tse-Wen Chang , Nancy T. Chang
IPC分类号： C07K16/18 , C12P21/08 , C12P21/00 , C12N5/00 , C12N5/02 , C12R1/91
CPC分类号： C07K16/18 , C07K2317/74 , Y10S530/806
摘要： A method of preparing simultaneously monoclonal antibodies specific for different cell-free products of activated human T lymphocytes is disclosed. Human T cells are activated in a medium supplemented with mouse serum rather than conventional calf serum. A supernatant prepared from the activated T cells is used to immunize mice. The dominant immunogens in the supernatant are the cell-free products of human T lymphocytes. The yield of hybrid cells which produce products reactive with cell-free products of human T lymphocytes is enhanced by injecting the immunized mice with a supernatant from mitogen-activated murine splenocytes. In addition, a novel radioimmunoadsorbent assay for screening hybrids to detect production of monoclonal antibodies reactive with cell-free products of human T lymphocytes is disclosed.
摘要翻译：公开了同时制备对活化的人T淋巴细胞的不同无细胞产物特异的单克隆抗体的方法。人T细胞在补充有小鼠血清而不是常规小牛血清的培养基中活化。使用从活化的T细胞制备的上清液来免疫小鼠。上清液中的主要免疫原是人T淋巴细胞的无细胞产物。通过从有丝分裂原激活的小鼠脾细胞中注射免疫小鼠来增强产生与人T淋巴细胞无细胞产物反应的产物的杂交细胞的产量。此外，公开了一种用于筛选杂交体以检测与人T淋巴细胞的无细胞产物反应的单克隆抗体的产生的新型放射免疫吸附测定法。

4. 发明申请

US20080105942A1 Sensor-type semiconductor package and fabrication method thereof 有权
标题翻译：传感器型半导体封装及其制造方法
公开(公告)号：US20080105942A1
公开(公告)日：2008-05-08
申请号：US11982516
申请日：2007-11-02
申请人： Chien-Ping Huang , Tse-Wen Chang , Chang-Yueh Chan , Cheng-Yi Chang
发明人： Chien-Ping Huang , Tse-Wen Chang , Chang-Yueh Chan , Cheng-Yi Chang
IPC分类号： H01L31/0203 , H01L31/18
CPC分类号： H01L31/0203 , H01L23/3128 , H01L24/97 , H01L27/14618 , H01L27/14683 , H01L2224/48247 , H01L2924/16195 , H01L2924/16235 , H01L2924/181 , H01L2924/00012
摘要： A sensor-type semiconductor package and a fabrication method thereof are provided. The fabrication method of the sensor-type semiconductor package includes steps of: providing a wafer having sensor chips; attaching light-permeable bodies to the sensor chips, wherein each light-permeable body has a covering layer and an adhesive layer; singulating the wafer so as to obtain a plurality of separated sensor chips with the light-permeable bodies attached thereon; attaching and electrically connecting the separated sensor chips to a substrate module having substrates, forming an encapsulant encapsulating the sensor chips and the light-permeable bodies; cutting the encapsulant along edges of the light-permeable bodies to a depth at least corresponding the bottom edges of the covering layers; removing the covering layers with the encapsulant mounted thereon to expose the light-permeable bodies; and cutting between the substrates to obtain a plurality of sensor-type semiconductor packages.
摘要翻译：提供了一种传感器型半导体封装及其制造方法。传感器型半导体封装的制造方法包括以下步骤：提供具有传感器芯片的晶片; 将透光体附接到传感器芯片，其中每个透光体具有覆盖层和粘合剂层; 分离晶片，以便获得多个分离的传感器芯片，其上安装有透光体; 将分离的传感器芯片附接和电连接到具有基板的基板模块，形成封装传感器芯片和透光体的密封剂; 沿着透光体的边缘切割密封剂至少对应于覆盖层的底部边缘的深度; 用安装在其上的密封剂去除覆盖层以暴露透光体; 并且在基板之间切割以获得多个传感器型半导体封装。

5. 发明申请

US20120165357A1 Compositions Containing Berberine or Analogs Thereof for Treating Rosacea or Red Face Related Skin Disorders 有权
标题翻译：包含小檗碱或类似物治疗红斑痤疮或红脸相关皮肤疾病的组合物
公开(公告)号：US20120165357A1
公开(公告)日：2012-06-28
申请号：US13379604
申请日：2010-06-30
申请人： Shuen-Iu Hung , Wen-Hung Chung , Tse-Wen Chang
发明人： Shuen-Iu Hung , Wen-Hung Chung , Tse-Wen Chang
IPC分类号： A61K31/4745 , A61P17/10 , A61P31/12 , A61P31/04 , A61P31/10 , A61P29/00 , A61P17/00 , A61P31/00
CPC分类号： A61K9/0014 , A61K31/4375 , A61K45/06
摘要： The invention pertains to topical pharmaceutical formulations of berberine and its biologically equivalent analogues, such as palmatine and coptisine, for the treatment of rosacea and other red face-related skin disorders. The topical pharmaceutical formulations of this invention contain purified berberine as the primary active drug ingredient at concentrations higher than 0.1%. The invention also pertains to methods of treating rosacea and other red face related skin disorders, such as steroid-induced rosacea-like dermatitis, comprising the administration of topical pharmaceutical formulations that contain berberine or its biologically equivalent analogues, such as palmatine.
摘要翻译：本发明涉及小檗碱及其生物等效类似物如巴马汀和黄连碱的局部药物制剂，用于治疗红斑痤疮和其他与红色面部相关的皮肤疾病。本发明的局部药物制剂含有浓度高于0.1％的纯化小檗碱作为主要活性药物成分。本发明还涉及治疗酒渣鼻和其他与红脸相关的皮肤病症如类固醇诱导的红斑痤疮样皮炎的方法，其包括施用含有小檗碱或其生物等效类似物如巴马汀的局部药物制剂。

6. 发明授权

US07858446B2 Sensor-type semiconductor package and fabrication method thereof 有权
标题翻译：传感器型半导体封装及其制造方法
公开(公告)号：US07858446B2
公开(公告)日：2010-12-28
申请号：US11982516
申请日：2007-11-02
申请人： Chien-Ping Huang , Tse-Wen Chang , Chang-Yueh Chan , Cheng-Yi Chang
发明人： Chien-Ping Huang , Tse-Wen Chang , Chang-Yueh Chan , Cheng-Yi Chang
IPC分类号： H01L21/48 , H01L21/50 , H01L21/78
CPC分类号： H01L31/0203 , H01L23/3128 , H01L24/97 , H01L27/14618 , H01L27/14683 , H01L2224/48247 , H01L2924/16195 , H01L2924/16235 , H01L2924/181 , H01L2924/00012
摘要： A sensor-type semiconductor package and a fabrication method thereof are provided. The fabrication method of the sensor-type semiconductor package includes steps of: providing a wafer having sensor chips; attaching light-permeable bodies to the sensor chips, wherein each light-permeable body has a covering layer and an adhesive layer; singulating the wafer so as to obtain a plurality of separated sensor chips with the light-permeable bodies attached thereon; attaching and electrically connecting the separated sensor chips to a substrate module having substrates, forming an encapsulant encapsulating the sensor chips and the light-permeable bodies; cutting the encapsulant along edges of the light-permeable bodies to a depth at least corresponding the bottom edges of the covering layers; removing the covering layers with the encapsulant mounted thereon to expose the light-permeable bodies; and cutting between the substrates to obtain a plurality of sensor-type semiconductor packages.
摘要翻译：提供了一种传感器型半导体封装及其制造方法。传感器型半导体封装的制造方法包括以下步骤：提供具有传感器芯片的晶片; 将透光体附接到传感器芯片，其中每个透光体具有覆盖层和粘合剂层; 分离晶片，以便获得多个分离的传感器芯片，其上安装有透光体; 将分离的传感器芯片附接和电连接到具有基板的基板模块，形成封装传感器芯片和透光体的密封剂; 沿着透光体的边缘切割密封剂至少对应于覆盖层的底部边缘的深度; 用安装在其上的密封剂去除覆盖层以暴露透光体; 并且在基板之间切割以获得多个传感器型半导体封装。

7. 发明授权

US07482006B2 Recombinant enterovirus 71 neutralizing antibodies and applications thereof 有权
标题翻译：重组肠病毒71中和抗体及其应用
公开(公告)号：US07482006B2
公开(公告)日：2009-01-27
申请号：US11404770
申请日：2006-04-17
申请人： Tse-Wen Chang , Jim Jinn-Chyuan Sheu , Lee-Hwa Lo , Nien-Yi Chen , Young-Sun Lin
发明人： Tse-Wen Chang , Jim Jinn-Chyuan Sheu , Lee-Hwa Lo , Nien-Yi Chen , Young-Sun Lin
IPC分类号： A61K39/42 , C12P21/08 , C12N15/13 , C07K16/10
CPC分类号： C07K16/1009 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2319/00
摘要： Provided is an antibody against enterovirus 71 comprising the amino acid sequence shown in SEQ ID NOS: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 or functionally active homologues thereof. Also provided are methods for obtaining the antibody comprising (a) selecting a yeast expressing such an antibody from a yeast library, (b) culturing the yeast under conditions that the antibody is expressed, and (c) recovering the antibody from the culture. Also provided is a process for producing the antibody comprising (a) culturing a host cell under conditions that the antibody is expressed, (b) recovering the antibody from the culture, wherein the host cells are transformed or transfected for expressing the antibody against enterovirus 71. Also provided are pharmaceutical compositions comprising an antibody against enterovirus 71 and a pharmaceutically acceptable carrier or diluent, wherein the antibody has an anti-virus agent or detectable label attached thereto.
摘要翻译：本发明提供了包含SEQ ID NO：14,15,16,17,18,19,20,21,22,23,24,25或26所示氨基酸序列的肠道病毒71抗体或其功能活性同系物。还提供了获得抗体的方法，其包括（a）从酵母文库中选择表达这种抗体的酵母，（b）在表达抗体的条件下培养酵母，和（c）从培养物中回收抗体。还提供了制备抗体的方法，其包括（a）在表达抗体的条件下培养宿主细胞，（b）从培养物中回收抗体，其中宿主细胞被转化或转染用于表达针对肠道病毒的抗体71 还提供了包含针对肠病毒71的抗体和药学上可接受的载体或稀释剂的药物组合物，其中所述抗体具有附着于其上的抗病毒剂或可检测标记。

8. 发明申请

US20080105941A1 Sensor-type semiconductor package and fabrication 审中-公开
标题翻译：传感器型半导体封装和制造
公开(公告)号：US20080105941A1
公开(公告)日：2008-05-08
申请号：US11982514
申请日：2007-11-02
申请人： Tse-Wen Chang , Chang-Yueh Chan , Chih-Ming Huang , Cheng-Hsu Hsiao
发明人： Tse-Wen Chang , Chang-Yueh Chan , Chih-Ming Huang , Cheng-Hsu Hsiao
IPC分类号： H01L31/0203 , H01L21/00
CPC分类号： H01L31/0203 , H01L23/3128 , H01L24/97 , H01L27/14618 , H01L27/14683 , H01L2224/48091 , H01L2224/48227 , H01L2224/49175 , H01L2224/97 , H01L2924/01005 , H01L2924/01006 , H01L2924/01033 , H01L2924/15311 , H01L2924/16235 , H01L2924/181 , H01L2924/1815 , H01L2224/85 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： The invention provides a sensor-type semiconductor package and fabrication method thereof. The fabrication method includes steps of: attaching a sensor chip to a chip carrier; electrically connecting the sensor chip and a chip carrier via a plurality of bonding wires; mounting a light-permeable body to the sensor chip with an adhesive layer as a partition therebetween, wherein the planar size of the light-permeable body is larger than a predefined planar size of the sensor-type semiconductor package to be formed; forming an encapsulant on the chip carrier for encapsulating the sensor chip and the bonding wires with the upper surface of the light-permeable body being exposed from the encapsulant; and cutting through the light-permeable body, the encapsulant and the chip carrier according to the predefined planar size. Accordingly the contacting area between the cut light-permeable body and the cut encapsulant increased and the bonding therebetween is reinforced.
摘要翻译：本发明提供一种传感器型半导体封装及其制造方法。该制造方法包括以下步骤：将传感器芯片附接到芯片载体; 经由多根接合线电连接传感器芯片和芯片载体; 将透光体安装到传感器芯片上，其中粘合剂层作为其间的隔板，其中透光体的平面尺寸大于要形成的传感器型半导体封装的预定平面尺寸; 在所述芯片载体上形成密封剂，用于封装所述传感器芯片，并且所述接合线与所述透光体的上表面暴露于所述密封剂; 并根据预定的平面尺寸切穿透光体，密封剂和芯片载体。因此，切割的透光体和切割的密封剂之间的接触面积增加，并且增强了它们之间的粘结。

9. 发明授权

US4591570A Matrix of antibody-coated spots for determination of antigens 失效
标题翻译：用于测定抗原的抗体包被点的基质
公开(公告)号：US4591570A
公开(公告)日：1986-05-27
申请号：US463188
申请日：1983-02-02
申请人： Tse-Wen Chang
发明人： Tse-Wen Chang
IPC分类号： A61K39/00 , C40B60/14 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/569
CPC分类号： G01N33/543 , G01N33/54366 , G01N33/545 , G01N33/552 , G01N33/569 , G01N33/56977 , B01J2219/00367 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00659 , C40B60/14 , Y10S435/965 , Y10S435/975 , Y10S436/809 , Y10S436/815
摘要： This invention relates to a novel immunoassay device and method for the determination of antigenic substances. The device essentially comprises a pattern or array of minute antibody-coated spots on the surface of a support. The array of antibody-coated spots is preferably in the form of a rectangular matrix. Each antibody-coated spot is made up of antibodies of a different and distinct specificity. A large number of different antibody-coated spots can be assembled on a very small portion of the surface of the support. The spots serve as tiny, specific immunoadsorbents of cells. The expression of particular surface antigen by cells may be detected by determining to which antibody-coated spot the cells bind.
摘要翻译：本发明涉及用于测定抗原物质的新型免疫测定装置和方法。该装置基本上包括在载体表面上的微小抗体包被点的图案或阵列。抗体包被斑点的阵列优选为矩形矩阵的形式。每个抗体包被的斑点由不同和不同特异性的抗体组成。可以在载体表面的非常小的一部分上组装大量不同的抗体包被的斑点。这些斑点作为细胞的特异性免疫吸附剂。可以通过确定细胞结合于哪个抗体包被的位点来检测细胞对特定表面抗原的表达。

10. 发明授权

US09486402B2 Compositions containing berberine or analogs thereof for treating rosacea or red face related skin disorders 有权
标题翻译：含有小檗碱或其类似物用于治疗红斑痤疮或红脸相关皮肤病的组合物
公开(公告)号：US09486402B2
公开(公告)日：2016-11-08
申请号：US13379604
申请日：2010-06-30
申请人： Shuen-Iu Hung , Wen-Hung Chung , Tse-Wen Chang
发明人： Shuen-Iu Hung , Wen-Hung Chung , Tse-Wen Chang
IPC分类号： A61K9/14 , A61K31/4375 , A61K45/06 , A61K9/00
CPC分类号： A61K9/0014 , A61K31/4375 , A61K45/06
摘要： The invention pertains to topical pharmaceutical formulations of berberine and its biologically equivalent analogs, such as palmatine and coptisine, for the treatment of rosacea and other red face-related skin disorders. The topical pharmaceutical formulations of this invention contain purified berberine as the primary active drug ingredient at concentrations higher than 0.1%. The invention also pertains to methods of treating rosacea and other red face related skin disorders, such as steroid-induced rosacea-like dermatitis, comprising the administration of topical pharmaceutical formulations that contain berberine or its biologically equivalent analogs, such as palmatine.
摘要翻译：本发明涉及小檗碱及其生物等效类似物如巴马汀和黄连碱的局部药物制剂，用于治疗酒渣鼻和其他与红脸相关的皮肤疾病。本发明的局部药物制剂含有浓度高于0.1％的纯化小檗碱作为主要活性药物成分。本发明还涉及治疗酒渣鼻和其它与红脸相关的皮肤病症如类固醇诱导的红斑痤疮样皮炎的方法，其包括施用含有小檗碱或其生物等效类似物如巴马汀的局部药物制剂。

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