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1. 发明授权

US08140271B2 Least-square deconvolution (LSD): a method to resolve DNA mixtures 有权
标题翻译：最小二乘解卷积（LSD）：一种解决DNA混合物的方法
公开(公告)号：US08140271B2
公开(公告)日：2012-03-20
申请号：US12947063
申请日：2010-11-16
申请人： Tse-Wei Wang , John Douglas Birdwell , Xue Ning , Mark S. Rader , John Flaherty
发明人： Tse-Wei Wang , John Douglas Birdwell , Xue Ning , Mark S. Rader , John Flaherty
IPC分类号： G06F7/00
CPC分类号： G06F19/18 , G06F19/22 , G06F19/24 , Y10S707/99943
摘要： Least Square Deconvolution (LSD) uses quantitative allele peak data, for example, allele peak area, allele peak height and optical density, derived/obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.
摘要翻译：最小二乘解卷积（LSD）使用定量等位基因峰数据，例如从包含多于一个贡献者的DNA的样品得到/获得的等位基因峰面积，等位基因峰高度和光密度，以解决每一个的最佳拟合基因型谱贡献者。该分辨率基于找到每个轨迹处的质量比系数的最小二乘拟合最接近定量等位基因峰数据。可以汇集来自每个基因座的一致的顶级质量比组合，以在可用基因座的子集处形成至少一个复合DNA谱。排名最高的DNA谱可用于检查疑似病例的轮廓，或用于在DNA数据库中搜索匹配的分布。

2. 发明授权

US07860661B2 Least-square deconvolution (LSD): a method to resolve DNA mixtures 有权
标题翻译：最小二乘解卷积（LSD）：一种解决DNA混合物的方法
公开(公告)号：US07860661B2
公开(公告)日：2010-12-28
申请号：US12631032
申请日：2009-12-04
申请人： Tse-Wei Wang , Xue Ning , John Douglas Birdwell , Mark Rader , John Flaherty
发明人： Tse-Wei Wang , Xue Ning , John Douglas Birdwell , Mark Rader , John Flaherty
IPC分类号： G06F7/00
CPC分类号： G06F19/18 , G06F19/22 , G06F19/24 , Y10S707/99943
摘要： Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.
摘要翻译：最小二乘解卷积（LSD）使用从含有多个贡献者的DNA的样品获得的定量等位基因峰数据来解决每个贡献者的最佳拟合基因型谱。该分辨率基于找到每个轨迹处的质量比系数的最小二乘拟合最接近定量等位基因峰数据。可以汇集来自每个基因座的一致的顶级质量比组合，以在可用基因座的子集处形成至少一个复合DNA谱。排名最高的DNA谱可用于检查疑似病例的轮廓，或用于在DNA数据库中搜索匹配的分布。

3. 发明授权

US08429153B2 Method and apparatus for classifying known specimens and media using spectral properties and identifying unknown specimens and media 有权
标题翻译：使用光谱性质分类已知标本和培养基并识别未知标本和培养基的方法和设备
公开(公告)号：US08429153B2
公开(公告)日：2013-04-23
申请号：US13469320
申请日：2012-05-11
申请人： John Douglas Birdwell , Carl G. Sapp , Tse-wei Wang , David J. Icove , Roger Horn , Mark S. Rader , Dale V. Stansberry
发明人： John Douglas Birdwell , Carl G. Sapp , Tse-wei Wang , David J. Icove , Roger Horn , Mark S. Rader , Dale V. Stansberry
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06K9/6224 , G06F17/30539 , G06K9/6253
摘要： Method and apparatus for determining a metric for use in predicting properties of an unknown specimen belonging to a group of reference specimen electrical devices comprises application of a network analyzer for collecting impedance spectra for the reference specimens and determining centroids and thresholds for the group of reference specimens so that an unknown specimen may be confidently classified as a member of the reference group using the metric. If a trait is stored with the reference group of electrical device specimens, then, the trait may be predictably associated with the unknown specimen along with any traits identified with the unknown specimen associated with the reference group.
摘要翻译：用于确定用于预测属于一组参考样本电气设备的未知样本的属性的度量的方法和装置包括：应用网络分析仪来收集参考样本的阻抗谱，并确定参考样本组的质心和阈值使得使用度量可以自信地将未知标本分类为参考组的成员。如果一个特征与参考组的电器件标本一起存储，那么该特征可以与未知样本一起预测相关联，以及与参考组相关联的未知标本识别的任何性状。

4. 发明申请

US20100114809A1 Method of Organizing and Presenting Data in a Table 有权
标题翻译：组织和呈现数据在表中的方法
公开(公告)号：US20100114809A1
公开(公告)日：2010-05-06
申请号：US12618205
申请日：2009-11-13
申请人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
发明人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
IPC分类号： G06N5/02 , G06F17/00
CPC分类号： G06F17/246
摘要： Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted.
摘要翻译：提供数据分析方法。专家系统从至少第一源接收输入。数据由专家系统导入和分析，其中专家系统作出至少一个第一决定，其基于规则库来表征数据。所述至少一个第一决定是可由第一来源的第一输入显示和修改的。响应于来自第一源的第一输入，规则库可以被重新应用以做出至少一个第二决定，其中所述至少一个第二决定不同于所述至少一个第一决定，或者所述至少一个第一决定决定可能被接受。响应于来自第二源的第一输入，至少一个第一决定或至少一个第二决定然后可显示和修改。响应于来自第二来源的第一输入，规则库被重新应用以做出至少一个第三决定，其中第三决定不同于第二决定，或者接受第一或第二决定。

5. 发明授权

US07664719B2 Interaction method with an expert system that utilizes stutter peak rule 有权
标题翻译：与专家系统的交互方法，利用了口吃峰值规则
公开(公告)号：US07664719B2
公开(公告)日：2010-02-16
申请号：US11560601
申请日：2006-11-16
申请人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
发明人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
IPC分类号： G06N5/00
CPC分类号： G06N5/04
摘要： Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted.
摘要翻译：提供数据分析方法。专家系统从至少第一源接收输入。数据由专家系统导入和分析，其中专家系统作出至少一个第一决定，其基于规则库来表征数据。所述至少一个第一决定是可由第一来源的第一输入显示和修改的。响应于来自第一源的第一输入，规则库可以被重新应用以做出至少一个第二决定，其中所述至少一个第二决定不同于所述至少一个第一决定，或者所述至少一个第一决定决定可能被接受。响应于来自第二源的第一输入，至少一个第一决定或至少一个第二决定然后可显示和修改。响应于来自第二来源的第一输入，规则库被重新应用以做出至少一个第三决定，其中第三决定不同于第二决定，或者接受第一或第二决定。

6. 发明申请

US20080288428A1 Method of Interaction With an Automated System 有权
标题翻译：与自动化系统相互作用的方法
公开(公告)号：US20080288428A1
公开(公告)日：2008-11-20
申请号：US11560601
申请日：2006-11-16
申请人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
发明人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
IPC分类号： G06N5/02
CPC分类号： G06N5/04
摘要： Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted.
摘要翻译：提供数据分析方法。专家系统从至少第一源接收输入。数据由专家系统导入和分析，其中专家系统作出至少一个第一决定，其基于规则库来表征数据。所述至少一个第一决定是可由第一来源的第一输入显示和修改的。响应于来自第一源的第一输入，规则库可以被重新应用以做出至少一个第二决定，其中所述至少一个第二决定不同于所述至少一个第一决定，或者所述至少一个第一决定决定可能被接受。响应于来自第二源的第一输入，至少一个第一决定或至少一个第二决定然后可显示和修改。响应于来自第二来源的第一输入，规则库被重新应用以做出至少一个第三决定，其中第三决定不同于第二决定，或者接受第一或第二决定。

7. 发明申请

US20130030713A1 METHODS OF ASSOCIATING AN UNKOWN BIOLOGICAL SPECIMEN WITH A FAMILY 有权
标题翻译：与家族相关的未知生物样本的方法
公开(公告)号：US20130030713A1
公开(公告)日：2013-01-31
申请号：US13621311
申请日：2012-09-17
申请人： Ranajit Chakraborty , John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry
发明人： Ranajit Chakraborty , John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry
IPC分类号： G06F17/30 , G06F19/00
CPC分类号： G06F19/18
摘要： The present invention provides a method of predicting whether an unknown biological specimen originates from a member of a particular family. The method compares DNA profiles from at least one unknown biological specimen to DNA profiles of more than one family member, which significantly increases the methods' predictive ability. In particular, the invention describes a method of comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from biological specimens of family members. In one embodiment, a modified Elston Stewart algorithm is used to determine a probability that a genetic relationship exists between at least one unknown biological specimen and the family pedigree.
摘要翻译：本发明提供一种预测未知生物样品是否源自特定家族成员的方法。该方法将来自至少一个未知生物标本的DNA谱与多于一个家族成员的DNA谱进行比较，从而显着提高了方法的预测能力。特别地，本发明描述了将来自未知生物标本的测试DNA谱与家族谱系进行比较的方法，该方法包括从家族成员的生物标本获得的靶DNA谱。在一个实施例中，使用修改的Elston Stewart算法来确定在至少一个未知生物样本和家族血统之间存在遗传关系的概率。

8. 发明授权

US07624087B2 Method of expert system analysis of DNA electrophoresis data 有权
标题翻译： DNA电泳数据专家系统分析方法
公开(公告)号：US07624087B2
公开(公告)日：2009-11-24
申请号：US11560580
申请日：2006-11-16
申请人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
发明人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
IPC分类号： G06N5/00
CPC分类号： G06N5/04
摘要： Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted.
摘要翻译：提供数据分析方法。专家系统从至少第一源接收输入。数据由专家系统导入和分析，其中专家系统作出至少一个第一决定，其基于规则库来表征数据。所述至少一个第一决定是可由第一来源的第一输入显示和修改的。响应于来自第一源的第一输入，规则库可以被重新应用以做出至少一个第二决定，其中所述至少一个第二决定不同于所述至少一个第一决定，或者所述至少一个第一决定决定可能被接受。响应于来自第二源的第一输入，至少一个第一决定或至少一个第二决定然后可显示和修改。响应于来自第二来源的第一输入，规则库被重新应用以做出至少一个第三决定，其中第三决定不同于第二决定，或者接受第一或第二决定。

9. 发明申请

US20090150318A1 Method of Enhancing Expert System Decision Making 有权
标题翻译：加强专家系统决策的方法
公开(公告)号：US20090150318A1
公开(公告)日：2009-06-11
申请号：US11560580
申请日：2006-11-16
申请人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
发明人： John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry , Jared Pendleton
IPC分类号： G06N5/02 , G06F17/00 , G06F3/048
CPC分类号： G06N5/04
摘要： Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted.
摘要翻译：提供数据分析方法。专家系统从至少第一源接收输入。数据由专家系统导入和分析，其中专家系统作出至少一个第一决定，其基于规则库来表征数据。所述至少一个第一决定是可由第一来源的第一输入显示和修改的。响应于来自第一源的第一输入，规则库可以被重新应用以做出至少一个第二决定，其中所述至少一个第二决定不同于所述至少一个第一决定，或者所述至少一个第一决定决定可能被接受。响应于来自第二源的第一输入，至少一个第一决定或至少一个第二决定然后可显示和修改。响应于来自第二来源的第一输入，规则库被重新应用以做出至少一个第三决定，其中第三决定不同于第二决定，或者接受第一或第二决定。

10. 发明授权

US08645073B2 Method and apparatus for allele peak fitting and attribute extraction from DNA sample data 有权
标题翻译：从DNA样本数据等位基因峰拟合和属性提取的方法和装置
公开(公告)号：US08645073B2
公开(公告)日：2014-02-04
申请号：US11913098
申请日：2006-07-28
申请人： Kenneth H. Gilbert , John Douglas Birdwell , Tse-Wei Wang , Dale V. Stransberry
发明人： Kenneth H. Gilbert , John Douglas Birdwell , Tse-Wei Wang , Dale V. Stransberry
IPC分类号： G01N33/48 , C12Q1/68
CPC分类号： G01N30/8624
摘要： Analysis of DNA is critical to many applications including identifying perpetrators of crimes based on genetic evidence left at crime scenes. An initial step to analyzing DNA data is detection, identification, and quantization of allele peaks in the DNA data. The invention provides a method and apparatus for accurately and expeditiously performing this initial step by sequentially checking unfitted peaks against various models including a default model, a hybrid peak model, a dual fit model and, in special situations, a narrow fit function and a saturated fit function.
摘要翻译： DNA分析对许多应用至关重要，包括根据犯罪现场留下的遗传证据确定犯罪者。分析DNA数据的初步步骤是DNA数据中等位基因峰的检测，鉴定和量化。本发明提供了一种方法和装置，用于通过对包括默认模型，混合峰值模型，双拟合模型在内的各种模型顺序检查未匹配的峰值来准确且快速地执行该初始步骤，并且在特殊情况下，窄拟合函数和饱和适合功能。

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