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1. 发明申请

US20090292241A1 BALLOON CATHETER 审中-公开
标题翻译：气球导管
公开(公告)号：US20090292241A1
公开(公告)日：2009-11-26
申请号：US12506066
申请日：2009-07-20
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
IPC分类号： A61M25/10 , B29C41/00
CPC分类号： A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M29/02 , A61M2025/0183 , A61M2025/1056 , A61M2025/107
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译：描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。

2. 发明申请

US20080140174A1 Method of increasing balloon flexibility in a balloon catheter 审中-公开
标题翻译：球囊导管增加球囊柔韧性的方法
公开(公告)号：US20080140174A1
公开(公告)日：2008-06-12
申请号：US11506243
申请日：2006-08-17
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61M25/1027 , A61M2025/1031
摘要： A variety of methods are described that pre-condition a balloon used in a balloon catheter in order to increase its flexibility. Generally, the membrane that forms the balloon is crumpled in order to induce a large number of irregular crumples in the balloon. The crinkling of the balloon improves its flexibility and thus the flexibility of the catheter. Most typically, torsion and/or compression are applied to the balloon membrane in order to induce the crumpling. The described crumpling can be used to increase the flexibility of a balloon of a given strength in a variety of catheters, including angioplasty catheters and stent delivery catheters. In stent delivery catheters, the resulting crinkles also have the additional benefit of improving stent retention.
摘要翻译：描述了预先调节气球导管中使用的球囊以增加其灵活性的各种方法。通常，形成气囊的膜被弄皱，以便在气球中引起大量的不规则褶皱。气球的皱缩改善了其灵活性，从而提高了导管的灵活性。最典型地，将扭转和/或压缩施加到球囊膜以引起皱巴巴。所描述的皱巴巴可用于增加各种导管（包括血管成形术导管和支架输送导管）中给定强度的球囊的柔性。在支架输送导管中，所产生的皱纹还具有改善支架保留的额外益处。

3. 发明申请

US20080097404A1 Catheter having markers to indicate rotational orientation 审中-公开
标题翻译：导管具有指示旋转取向的标记
公开(公告)号：US20080097404A1
公开(公告)日：2008-04-24
申请号：US11505697
申请日：2006-08-16
申请人： Travis R. Yribarren , Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Arik Zucker
发明人： Travis R. Yribarren , Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Arik Zucker
IPC分类号： A61M25/098 , A61M29/00 , A61F2/06 , A61F2/00
CPC分类号： A61M25/0108 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2250/0098 , A61M2025/0008 , A61M2025/1079
摘要： Various improved catheter marking arrangements are described. In a first aspect of the invention, a first longitudinally extending radiopaque marker is positioned on the catheter. A second longitudinally extending radiopaque marker is positioned opposite the first marker at a rotational orientation that is approximately 180 degrees offset from the first marker. The second marker has a length that is sufficiently different from the first marker such that a surgeon utilizing the catheter in a surgical procedure would be able to readily differentiate the first and second markers in a fluoroscopic image based on their respective lengths in order to determine the rotational orientation of the catheter.In some embodiments, the catheter includes a lumen that has a side port that opens to a side of the catheter. The first marker is composed of a pair of axially aligned marker segments located on opposite ends of the side port. The length of the first longitudinal extending marker defined as an end-to-end length of the pair of axially aligned marker segments is longer than the length of the second marker. The markers may be formed from any suitable materials that can be clearly detected by an imaging system.
摘要翻译：描述了各种改进的导管标记装置。在本发明的第一方面，第一纵向延伸的不透射线的标记位于导管上。第二纵向延伸的不透射线标记物以与第一标记物大约180度偏离的旋转方向定位成与第一标记相对。第二标记具有与第一标记足够不同的长度，使得在外科手术中利用导管的外科医生能够根据它们各自的长度容易地区分荧光镜图像中的第一和第二标记，以便确定导管的旋转取向。在一些实施例中，导管包括具有向导管侧面开口的侧端口的内腔。第一标记由位于侧端口的相对端上的一对轴向对齐的标记段组成。被定义为一对轴向对准的标记段的端到端长度的第一纵向延伸标记的长度比第二标记的长度长。标记可以由能够被成像系统清楚地检测到的任何合适的材料形成。

4. 发明授权

US07578831B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US07578831B2
公开(公告)日：2009-08-25
申请号：US11474111
申请日：2006-06-23
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1045 , A61M2025/1056 , A61M2025/107 , A61M2029/025
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译：描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。

5. 发明申请

US20070016241A1 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US20070016241A1
公开(公告)日：2007-01-18
申请号：US11474111
申请日：2006-06-23
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis Yribarren , Arik Zucker
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1045 , A61M2025/1056 , A61M2025/107 , A61M2029/025
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译：描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。

6. 发明授权

US07862541B2 Catheter having a soft distal tip 有权
标题翻译：导管具有软的远端
公开(公告)号：US07862541B2
公开(公告)日：2011-01-04
申请号：US11766662
申请日：2007-06-21
申请人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
发明人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0069 , A61M25/1006 , A61M25/1027 , A61M25/104 , A61M2025/0081 , A61M2025/1093 , Y10T29/49826
摘要： The present invention relates to a catheter having a soft distal tip that can be manufactured at lower cost than catheters in the prior art. In one embodiment, the catheter is produced by coupling a soft sleeve to the distal end of a catheter tube. The sleeve may affixed to the catheter tube under temperature and pressure conditions that cause the proximal end of the sleeve to taper against the outer surface of the catheter tube, avoiding or minimizing discontinuities in the insertion profile of the catheter, and that also cause the inner wall of the sleeve to taper against the distal end of the catheter tube, avoiding or minimizing discontinuities in the lumen of the catheter.
摘要翻译：本发明涉及一种导管，其具有可以以比现有技术中的导管低的成本制造的软远侧末端。在一个实施例中，通过将软套管连接到导管管的远端来产生导管。套管可在温度和压力条件下固定到导管上，导致套筒的近端相对于导管的外表面逐渐变细，避免或最小化导管插入轮廓中的不连续性，并且还使得内套管的壁与导管管的远端成锥形，避免或最小化导管内腔的不连续性。

7. 发明申请

US20080004568A1 CATHETER HAVING A SOFT DISTAL TIP 有权
标题翻译：导管带有一个软的距离
公开(公告)号：US20080004568A1
公开(公告)日：2008-01-03
申请号：US11766662
申请日：2007-06-21
申请人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
发明人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0069 , A61M25/1006 , A61M25/1027 , A61M25/104 , A61M2025/0081 , A61M2025/1093 , Y10T29/49826
摘要： The present invention relates to a catheter having a soft distal tip that can be manufactured at lower cost than catheters in the prior art. In one embodiment, the catheter is produced by coupling a soft sleeve to the distal end of a catheter tube. The sleeve may affixed to the catheter tube under temperature and pressure conditions that cause the proximal end of the sleeve to taper against the outer surface of the catheter tube, avoiding or minimizing discontinuities in the insertion profile of the catheter, and that also cause the inner wall of the sleeve to taper against the distal end of the catheter tube, avoiding or minimizing discontinuities in the lumen of the catheter.
摘要翻译：本发明涉及一种导管，其具有可以以比现有技术中的导管低的成本制造的软远侧末端。在一个实施例中，通过将软套管连接到导管管的远端来产生导管。套管可在温度和压力条件下固定到导管上，导致套筒的近端相对于导管的外表面逐渐变细，避免或最小化导管插入轮廓中的不连续性，并且还使得内套管的壁与导管管的远端成锥形，避免或最小化导管内腔的不连续性。

8. 发明申请

US20110172696A1 CATHETER HAVING A SOFT DISTAL TIP 审中-公开
标题翻译：导管带有一个软的距离
公开(公告)号：US20110172696A1
公开(公告)日：2011-07-14
申请号：US12983504
申请日：2011-01-03
申请人： Andrew Jeffrey , Louise Corcoran , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
发明人： Andrew Jeffrey , Louise Corcoran , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
IPC分类号： A61B17/22 , B23P17/04
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0069 , A61M25/1006 , A61M25/1027 , A61M25/104 , A61M2025/0081 , A61M2025/1093 , Y10T29/49826
摘要： The present invention relates to a catheter having a soft distal tip that can be manufactured at lower cost than catheters in the prior art. In one embodiment, the catheter is produced by coupling a soft sleeve to the distal end of a catheter tube. The sleeve may affixed to the catheter tube under temperature and pressure conditions that cause the proximal end of the sleeve to taper against the outer surface of the catheter tube, avoiding or minimizing discontinuities in the insertion profile of the catheter, and that also cause the inner wall of the sleeve to taper against the distal end of the catheter tube, avoiding or minimizing discontinuities in the lumen of the catheter.
摘要翻译：本发明涉及一种导管，其具有可以以比现有技术中的导管低的成本制造的软远侧末端。在一个实施例中，通过将软套管连接到导管管的远端来产生导管。套管可在温度和压力条件下固定到导管上，导致套筒的近端相对于导管的外表面逐渐变细，避免或最小化导管插入轮廓中的不连续性，并且还使得内套管的壁与导管管的远端成锥形，避免或最小化导管内腔的不连续性。

9. 发明授权

US08900286B2 Medical device shield and methods for delivering a medical device 有权
标题翻译：医疗设备屏蔽和用于递送医疗设备的方法
公开(公告)号：US08900286B2
公开(公告)日：2014-12-02
申请号：US13037008
申请日：2011-02-28
申请人： Randolf von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
发明人： Randolf von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
IPC分类号： A61F2/06 , A61F2/00 , A61F2/958 , A61F2/966 , A61F2/95
CPC分类号： A61F2/0095 , A61F2002/9505 , A61F2002/9583 , A61F2002/9665
摘要： Device shields for packaging and protecting medical devices during storage and deployment. A device shield includes a housing configured to maintain a medical device and at least a portion of a medical device delivery apparatus within the housing, and a limit element having a first constraining position and a second open position.
摘要翻译：在存储和部署期间用于包装和保护医疗设备的设备屏蔽。设备屏蔽包括被配置为将医疗设备和医疗设备传送设备的至少一部分保持在壳体内的壳体，以及具有第一约束位置和第二打开位置的限制元件。

10. 发明申请

US20130006220A1 DRUG COATED BALLOON CATHETER 有权
标题翻译：药物涂层气囊导管
公开(公告)号：US20130006220A1
公开(公告)日：2013-01-03
申请号：US13616305
申请日：2012-09-14
申请人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, JR. , Richard R. Newhauser
发明人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, JR. , Richard R. Newhauser
IPC分类号： A61M25/10
CPC分类号： A61M25/1006 , A61F2/958 , A61M25/0119 , A61M2025/1015 , A61M2025/105 , A61M2025/1059 , A61M2025/1065 , A61M2025/1068
摘要： The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.
摘要翻译：本发明涉及用于治疗患者的管腔系统的气囊导管。具体地，本发明涉及具有位于导管的远端部分的柔性膜的导管，柔性膜在展开之前保持基本上未曝光的构象。优选地，当部署到暴露的构象时，柔性膜能够将治疗剂递送至局部环境。

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