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1. 发明授权

US06187769B1 Benzoxazepine derivatives and their salts and medicaments containing the same 有权
标题翻译：苯并西泮衍生物及其盐及含有它们的药物
公开(公告)号：US06187769B1
公开(公告)日：2001-02-13
申请号：US09306995
申请日：1999-05-07
申请人： Toshio Tatsuoka , Katsuhide Kamei , Noriko Maeda , Teruyoshi Inoue , Mika Nakajima , Ichiro Hirotsu
发明人： Toshio Tatsuoka , Katsuhide Kamei , Noriko Maeda , Teruyoshi Inoue , Mika Nakajima , Ichiro Hirotsu
IPC分类号： C07D40114
CPC分类号： C07D401/04 , C07D267/14 , C07D401/14 , C07D413/12 , C07D413/14
摘要： A benzoxazepine derivative having the general formula (I) and its salts and medicaments containing the same as effective ingredients: wherein, n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxyalkyl group, C1 to C4 halogenoalkyl group, cyano group, or ester group, R2 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxy group, or hydroxy group, a dotted line indicates the presence or absence of a binding bond, W indicates C, CH, or CH2 or a nitrogen atom, provided that, when W is a nitrogen atom, Z is bonded to W and the dotted line indicates the absence of a bond, and Z indicates an unsubstituted or substituted aromatic hydrocarbon ring group or an unsubstituted or substituted heterocyclic group). This benzoxazepine derivative and its salts are useful as medicaments for the treatment of anxiety neurosis, phobias, obsessive-compulsive disorders, schizophrenia, post-cardiac trauma stress, depression, psychosomatic and other psychoneurotic disorders, eating disorders, menopausal disorders, infantile autism and also emesis or disorders involving the cerebral circulatory system accompanying cerebral infarction and cerebral hemorrhage.
摘要翻译：具有通式（I）的苯并氧氮杂衍生物及其盐和药物含有效成分：其中n为2〜5的整数，R1表示氢原子，卤素原子，C1〜C4低级烷基，C1 C4低级烷氧基烷基，C1〜C4卤代烷基，氰基或酯基，R2表示氢原子，卤素原子，C1〜C4低级烷基，C1〜C4低级烷氧基或羟基，虚线表示存在或不存在结合键，W表示C，CH或CH 2或氮原子，条件是当W为氮原子时，Z与W键合，虚线表示不存在键，并且Z 表示未取代或取代的芳族烃环基团或未取代或取代的杂环基团）。该苯并氧氮杂衍生物及其盐可用作治疗焦虑性神经症，恐怖症，强迫症，精神分裂症，心脏外伤后的药物精神分裂症，抑郁症，心身和其他精神神经性疾病，进食障碍，绝经障碍，婴儿自闭症以及涉及脑梗死和脑出血的脑循环系统的呕吐或紊乱。

2. 发明授权

US06337397B1 Pyrimidine derivatives and their salts, useful for making benzoxazepine derivatives 失效
标题翻译：嘧啶衍生物及其盐，可用于制备苯并氧氮杂衍生物
公开(公告)号：US06337397B1
公开(公告)日：2002-01-08
申请号：US09726481
申请日：2000-12-01
申请人： Toshio Tatsuoka , Katsuhide Kamei , Noriko Maeda , Teruyoshi Inoue
发明人： Toshio Tatsuoka , Katsuhide Kamei , Noriko Maeda , Teruyoshi Inoue
IPC分类号： C07D40104
CPC分类号： C07D401/04 , C07D267/14 , C07D401/14 , C07D413/12 , C07D413/14
摘要： A benzoxazepine derivative having the general formula (I) and its salts and medicaments containing the same as effective ingredients: wherein, n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxyalkyl group, C1 to C4 halogenoalkyl group, cyano group, or ester group, R2 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxy group, or hydroxy group, a dotted line indicates the presence or absence of a binding bond, W indicates C, CH, or CH2 or a nitrogen atom, provided that, when W is a nitrogen atom, Z is bonded to W and the dotted line indicates the absence of a bond, and Z indicates an unsubstituted or substituted aromatic hydrocarbon ring group or an unsubstituted or substituted heterocyclic group).
摘要翻译：具有通式（I）的苯并氧氮杂衍生物及其盐和药物含有效成分：其中n为2〜5的整数，R1表示氢原子，卤素原子，C1〜C4低级烷基，C1 C4低级烷氧基烷基，C1〜C4卤代烷基，氰基或酯基，R2表示氢原子，卤素原子，C1〜C4低级烷基，C1〜C4低级烷氧基或羟基，虚线表示存在或不存在结合键，W表示C，CH或CH 2或氮原子，条件是当W为氮原子时，Z与W键合，虚线表示不存在键，并且Z 表示未取代或取代的芳族烃环基团或未取代或取代的杂环基团）。

3. 发明授权

US06114522A Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine derivative and salts thereof 有权
标题翻译： 4-取代-3-卤代-1,4-苯并氧氮杂衍生物及其盐的制备方法
公开(公告)号：US06114522A
公开(公告)日：2000-09-05
申请号：US254719
申请日：1999-11-24
申请人： Kastuhide Kamei , Noriko Maeda , Toshio Tatsuoka
发明人： Kastuhide Kamei , Noriko Maeda , Toshio Tatsuoka
IPC分类号： C07D267/14 , C07D413/12 , C07D413/14 , C07F9/6527 , C07F9/6558
CPC分类号： C07D413/12 , C07D267/14 , C07D413/14 , C07F9/6527 , C07F9/65583
摘要： A process for producing 4-substituted-3-halogeno-1,4-benzoxazepin derivative or the salt thereof comprising: deprotonizing a benzoxazepine derivative having the formula (II): ##STR1## with a base; and then, reacting the deprotonized product with a phosphate halide to produce an intermediate having the formula (IV): ##STR2## and then, reacting the resultant intermediate (IV) with a reagent selected from (i) a complex of a phosphine with chlorine or bromine, (ii) a phosphine and a chlorine gas or liquid bromine, (iii) a phosphine and tetrachloromethane or tetrabromomethane, or (iv) a halogenated phosphite ester to produce a 4-substituted-3-halogeno-1,4-benzoxazepine derivative having the formula (I) ##STR3## wherein X indicates a chlorine atom or a bromine atom, or its salt.
摘要翻译： PCT No.PCT / JP98 / 03153 Sec。 371日期：1999年11月24日 102（e）1999年11月24日PCT PCT 1997年7月14日PCT公布。第WO99 / 03847号公报日本1999年1月28日制备4-取代-3-卤代-1,4-苯并氧杂吖庚因衍生物或其盐的方法，其中包括：使碱具有式（II）的苯并氧氮杂衍生物去质子化：然后使去质子化产物与磷酸盐卤化物反应，生成具有式（Ⅳ）的中间体：然后使所得中间体（Ⅳ）与选自（ⅰ）膦与氯或溴的络合物，（ii）膦和氯气或液体溴，（iii）膦和四氯甲烷或四溴甲烷，或（iv）卤代亚磷酸酯，以产生具有以下成分的4-取代-3-卤代-1,4-苯并氧氮杂衍生物：式（I）其中X表示氯原子或溴原子，或其盐。

4. 发明授权

US10052840B2 Laminated non-woven fabric, and manufactured article using the same 有权
公开(公告)号：US10052840B2
公开(公告)日：2018-08-21
申请号：US13877172
申请日：2011-10-03
申请人： Noriko Maeda , Junji Iwata , Yasushi Matsuda , Mitsuru Kojima
发明人： Noriko Maeda , Junji Iwata , Yasushi Matsuda , Mitsuru Kojima
IPC分类号： B32B5/02 , D04H1/559 , D04H1/541 , D04H3/14 , D04H5/06 , B32B5/26
CPC分类号： B32B5/022 , B32B5/26 , B32B2250/20 , B32B2260/021 , B32B2260/046 , B32B2262/0253 , B32B2262/0276 , B32B2262/04 , B32B2555/00 , D04H1/541 , D04H1/559 , D04H3/14 , D04H5/06 , Y10T428/24942
摘要： A laminated non-woven fabric and a manufactured article using the laminated non-woven fabric are provided. The laminated non-woven fabric is formed by clamping a fibrous layer B between two of fibrous layer A, wherein the fibrous layer B is obtained by using a fiber melting or softening at 120° C. or less, and fibrous layer A includes a fiber neither melting nor softening at 120° C. or less, in which the fibrous layer A and the fibrous layer B are integrated through point thermal compression bonding, and interlayer peeling strength between the fibrous layer A and the fibrous layer B ranges from 0.3 Newton (N)/25 millimeters (mm) to 4.0 N/25 mm.

5. 发明申请

US20130209763A1 LAMINATED NON-WOVEN FABRIC, AND MANUFACTURED ARTICLE USING THE SAME 审中-公开
标题翻译：层合非织造织物及其制造方法
公开(公告)号：US20130209763A1
公开(公告)日：2013-08-15
申请号：US13877172
申请日：2011-10-03
申请人： Noriko Maeda , Junji Iwata , Yasushi Matsuda , Mitsuru Kojima
发明人： Noriko Maeda , Junji Iwata , Yasushi Matsuda , Mitsuru Kojima
IPC分类号： B32B5/02
CPC分类号： B32B5/022 , B32B5/26 , B32B2250/20 , B32B2260/021 , B32B2260/046 , B32B2262/0253 , B32B2262/0276 , B32B2262/04 , B32B2555/00 , D04H1/541 , D04H1/559 , D04H3/14 , D04H5/06 , Y10T428/24942
摘要： A laminated non-woven fabric and a manufactured article using the laminated non-woven fabric are provided. The laminated non-woven fabric is formed by clamping a fibrous layer B between two of fibrous layer A, wherein the fibrous layer B is obtained by using a fiber melting or softening at 120° C. or less, and fibrous layer A includes a fiber neither melting nor softening at 120° C. or less, in which the fibrous layer A and the fibrous layer B are integrated through point thermal compression bonding, and interlayer peeling strength between the fibrous layer A and the fibrous layer B ranges from 0.3 Newton (N)/25 millimeters (mm) to 4.0 N/25 mm.
摘要翻译：提供层压无纺布和使用层压无纺布的制品。通过将纤维层B夹在纤维层A的两个之间来形成层压无纺布，其中纤维层B通过使用在120℃或更低温度下熔化或软化的纤维获得，纤维层A包括纤维在纤维层A和纤维层B通过点热压合结合在一起的120℃以下也不熔化或软化，纤维层A与纤维层B之间的层间剥离强度为0.3牛顿 N）/ 25毫米（mm）至4.0N / 25mm。

6. 发明授权

US08999240B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08999240B2
公开(公告)日：2015-04-07
申请号：US13546628
申请日：2012-07-11
申请人： Noriko Maeda , Kyoko Imai , Taku Sakazume , Yukie Tokiwa , Kantaro Suzuki
发明人： Noriko Maeda , Kyoko Imai , Taku Sakazume , Yukie Tokiwa , Kantaro Suzuki
IPC分类号： G01N35/00 , G01N35/10 , G06F17/00
CPC分类号： G06F17/00 , G01N35/00594 , G01N35/00603 , G01N35/00663 , G01N2035/00881 , G06F19/00 , Y10T436/11 , Y10T436/115831
摘要： An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.
摘要翻译：自动分析仪和自动分析系统，用于识别分析仪中使用的样品和试剂，以及用于测量至少两个共同物体的成员：系统试剂或缓冲溶液; 传感器部件; 探针喷嘴芯片分配杯; 管子 ISE电极; 探测器去离子水; 浪费，统一其识别信息的管理和测量结果。

7. 发明授权

US08246907B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08246907B2
公开(公告)日：2012-08-21
申请号：US11514185
申请日：2006-09-01
申请人： Noriko Maeda , Kyoko Imai , Taku Sakazume , Yukie Tokiwa , Kantaro Suzuki
发明人： Noriko Maeda , Kyoko Imai , Taku Sakazume , Yukie Tokiwa , Kantaro Suzuki
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G06F17/00 , G01N35/00594 , G01N35/00603 , G01N35/00663 , G01N2035/00881 , G06F19/00 , Y10T436/11 , Y10T436/115831
摘要： An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.
摘要翻译：自动分析仪和自动分析系统，用于识别分析仪中使用的样品和试剂，以及用于测量至少两个共同物体的成员：系统试剂或缓冲溶液; 传感器部件; 探针喷嘴芯片分配杯; 管子 ISE电极; 探测器去离子水; 浪费，统一其识别信息的管理和测量结果。

8. 发明申请

US20070155627A1 Rice seed coated with an agricultural chemical 审中-公开
标题翻译：水稻种子涂上农药
公开(公告)号：US20070155627A1
公开(公告)日：2007-07-05
申请号：US11712014
申请日：2007-02-28
申请人： Naoki Harada , Noriko Maeda
发明人： Naoki Harada , Noriko Maeda
IPC分类号： A01N25/26
CPC分类号： A01N25/10 , A01C1/06 , A01N51/00 , Y10S47/09 , A01N47/38 , A01N43/36 , A01N2300/00
摘要： The invention provides a rice seed coated with an agricultural chemical, characterized in that a rice seed is deprived of husk and the surface of said rice seed is coated with a binder containing an agricultural chemical. The rice seed is suitable to be germinated by maintaining the seed for at least three days at 20 to 40 degrees C.
摘要翻译：本发明提供一种涂有农药的水稻种子，其特征在于，水稻种子被剥离，并且用含有农药的粘合剂包覆所述水稻种子的表面。水稻种子适宜于20至40摄氏度保持种子至少3天才能发芽。

9. 发明授权

US07189677B2 Rice seed coated with an agriculture chemical 失效
标题翻译：水稻种子涂上农药
公开(公告)号：US07189677B2
公开(公告)日：2007-03-13
申请号：US10258327
申请日：2001-04-18
申请人： Naoki Harada , Noriko Maeda
发明人： Naoki Harada , Noriko Maeda
IPC分类号： A01N25/26 , A01P3/00 , A01P7/04 , A01P1/00
CPC分类号： A01N25/10 , A01C1/06 , A01C1/08 , A01N51/00 , Y10S47/09 , A01N47/38 , A01N43/36 , A01N2300/00
摘要： The invention provides a rice seed coated with an agricultural chemical, characterized in that a rice seed is deprived of husk and the surface of said rice seed is coated with a binder containing an agricultural chemical. The rice seed is suitable to be germinated by maintaining the seed for at least three days at 20 to 40 degrees C.
摘要翻译：本发明提供一种涂有农药的水稻种子，其特征在于，水稻种子被剥离，并且用含有农药的粘合剂包覆所述水稻种子的表面。水稻种子适宜于20至40摄氏度保持种子至少3天才能发芽。

10. 发明申请

US20070053793A1 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US20070053793A1
公开(公告)日：2007-03-08
申请号：US11514185
申请日：2006-09-01
申请人： Noriko Maeda , Kyoko Imai , Taku Sakazume , Yukie Tokiwa , Kantaro Suzuki
发明人： Noriko Maeda , Kyoko Imai , Taku Sakazume , Yukie Tokiwa , Kantaro Suzuki
IPC分类号： G01N35/00
CPC分类号： G06F17/00 , G01N35/00594 , G01N35/00603 , G01N35/00663 , G01N2035/00881 , G06F19/00 , Y10T436/11 , Y10T436/115831
摘要： An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.
摘要翻译：一种自动分析仪和自动分析系统，用于识别分析仪中使用的样品和试剂，以及用于测量至少两个共同物体的成员：系统试剂或缓冲溶液; 传感器部件; 探针喷嘴芯片分配杯; 管子 ISE电极; 探测器去离子水; 浪费，统一其识别信息的管理和测量结果。

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