专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JPS59181217A Anticancer agent composition containing dammarane based compound 失效
标题翻译：含有DAMMARANE的化合物的反应剂组合物
公开(公告)号：JPS59181217A
公开(公告)日：1984-10-15
申请号：JP5467883
申请日：1983-03-30
申请人： Toshio Odajima , Rooto Seiyaku Kk , Tsunematsu Takemoto
发明人： TAKEMOTO TSUNEMATSU , ARIHARA SHIGENOBU , ODAJIMA TOSHIO , HAYASHI SHINICHI , NISHIMOTO KIJIYUU , TAKAGI NORIKO , WATANABE YOSHIE
IPC分类号： C07J17/00 , A61K31/58 , A61K31/704 , A61P35/00
摘要： PURPOSE: A low toxic anticancer agent composition, containing one or more specific dammarane based compounds, including novel compounds, and capable of inhibiting tumorous cells in a very small amount without damaging cells in the inhibitory concentration thereof.
CONSTITUTION: An anticancer agent composition containing one or more of compound expressed by formula I (glu is β-D-glucopyranosyl), formula II, III or IV. The compounds expressed by formulas I WIV are found to have powerful antitumor activity in prosapogenin and sapogenin obtained by hydrolyzing dammarane based sepogenin contained in Hydrangeae serrata Seringe var. thunbergii Sugimoto. The compounds expressed by formulas I WIV are capable of inhibiting remarkably the multiplication of uterine neck cancer calls or melanoma cells, etc. in an amount of ≤10μg/ml concentration and scarcely damaging the cell in the concentration. The agent is applicable to cancers in the skin, liver and stomach, etc. The compound of formula III is a novel compound and designated as Mh-2.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：一种低毒性抗癌剂组合物，其含有一种或多种特异性抗坏血酸基化合物，包括新型化合物，并且能够以非常少的量抑制肿瘤细胞，而不会以抑制浓度破坏细胞。构成：含有一种或多种由式I表示的化合物（glu是β-D-吡喃葡萄糖基），式II，III或IV的抗癌剂组合物。发现由式I -IV表达的化合物在通过水解包含在绣球花serrata Seringe var中的基于dammarane的sepogenin获得的促生长素和皂甙元中具有强大的抗肿瘤活性。杉木杉杉本由式I -IV表达的化合物能够显着地抑制子宫颈癌调用或黑素瘤细胞等的增殖，其量为<= 10mug / ml浓度，并且几乎不破坏浓度的细胞。该药剂适用于皮肤，肝，胃等癌症。式Ⅲ化合物为新化合物，称为Mh-2。

2. 发明专利

JPS6043359B2 JPS6043359B2 - 失效
公开(公告)号：JPS6043359B2
公开(公告)日：1985-09-27
申请号：JP3063680
申请日：1980-03-11
申请人： Tsunematsu Takemoto , Nippon Shoji Kk
发明人： TAKEMOTO TSUNEMATSU , ARIHARA SHIGENOBU , NAKAJIMA TADASHI , OKUDAIRA MEGUMI
IPC分类号： C07J17/00 , A61K31/58 , A61K36/42 , A61P3/06 , A61P3/08

3. 发明专利

JPS5758699A Gynosaponins and their preparations 失效
标题翻译：青蒿素及其制剂
公开(公告)号：JPS5758699A
公开(公告)日：1982-04-08
申请号：JP13468480
申请日：1980-09-27
申请人： Nippon Shoji Kk , Tsunematsu Takemoto
发明人： TAKEMOTO TSUNEMATSU , ARIHARA SHIGENOBU , NAKASHIMA TADASHI , OKUDAIRA MEGUMI
IPC分类号： C07J17/00 , A61K31/575 , A61K31/70 , A61K36/42 , A61P3/06 , C07J9/00
摘要： NEW MATERIAL:A gynosaponin shown by the formula[when R
3 is H, R
1 is β-D- xylopyranosyl(1→2)-β-D-glucopyranosyl and R
2 is β-D-xylopyranosyl(1→6)-β-D-glucopyranosyl, etc.; when R
3 is OH, R
1 is β-D-glucopyranosyl(1→2)-β-D-glycopyranosyl and R
2 is α-L-rhamnopyranosyl(1→6)-β-D-glucopyranosyl, etc.].
EXAMPLE: 20S, 26-Hydroxyprotopanaxadiol-3-0-[β-D-glucopyranosyl(1→2)-β-D- glucopyranoside]20-0-[α-L-rhamnopyranosy(1→6)-β-D-glucopyranoside]: gynosaponin P.
USE: A lipometabolism agent.
PROCESS: Gynostemma pentaphyllum Makino is extracted with water or water- containing alcohol, the extracted solution is treated with a nonionic adsorbing resin, eluted with a lower alcohol, absorbed on alumina, and eluted with a lower alcohol to give the titled compounds.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：由式[当R 3是H时，R 1是β-D-吡喃木糖基（12）-β-D-吡喃葡萄糖基并且R 2是β-D-吡喃木糖基（ 1 6）-β-D-吡喃葡萄糖基等; 当R 3为OH时，R 1为β-D-吡喃葡萄糖基（12）-β-D-吡喃葡萄糖基，R 2为α-L-鼠李糖吡喃糖基（16）-β-D-吡喃葡萄糖基，等等。]。实施例：20S，26-羟基新戊二醇-3-0- [β-D-吡喃葡萄糖基（12）-β-D-吡喃葡萄糖苷] 20-0- [α-L-鼠李糖吡喃糖（16）-β-D-吡喃葡萄糖苷] ：gynosaponin P.使用：脂代谢剂。方法：用水或含水醇提取绞股蓝绞肉提取液，用非离子吸附树脂处理提取液，用低级醇洗脱，吸附在氧化铝上，用低级醇洗脱，得到标题化合物。

4. 发明专利

JPH0368040B2 失效
公开(公告)号：JPH0368040B2
公开(公告)日：1991-10-25
申请号：JP22887987
申请日：1987-09-11
申请人： ROOTO SEIYAKU KK , TAKEMOTO TSUNEMATSU , ODAJIMA TOSHIO
发明人： TAKEMOTO TSUNEMATSU , ARIHARA SHIGENOBU , ODAJIMA TOSHIO , HAYASHI SHINICHI , NISHIMOTO KIJU , TAKAGI NORIKO , WATANABE YOSHE
IPC分类号： C07J17/00 , A61K31/704 , A61P35/00

5. 发明专利

JPS6312448B2 失效
公开(公告)号：JPS6312448B2
公开(公告)日：1988-03-18
申请号：JP5467883
申请日：1983-03-30
申请人： ROOTO SEIYAKU KK , TAKEMOTO TSUNEMATSU , ODAJIMA TOSHIO
发明人： TAKEMOTO TSUNEMATSU , ARIHARA SHIGENOBU , ODAJIMA TOSHIO , HAYASHI SHINICHI , NISHIMOTO KIJU , TAKAGI NORIKO , WATANABE YOSHE
IPC分类号： C07J17/00 , A61K31/58 , A61K31/704 , A61P35/00

6. 发明专利

JPS6312445B2 失效
公开(公告)号：JPS6312445B2
公开(公告)日：1988-03-18
申请号：JP15792581
申请日：1981-10-02
申请人： ROOTO SEIYAKU KK , TAKEMOTO TSUNEMATSU , ODAJIMA TOSHIO
发明人： TAKEMOTO TSUNEMATSU , ARIHARA SHIGENOBU , ODAJIMA TOSHIO , NISHIKAWA KATSUZO , HAYASHI SHINICHI , NISHIMOTO KIJU , TAKAGI NORIKO
IPC分类号： A61K31/575 , A61K31/704 , A61K36/42 , A61P35/00 , C07J9/00 , C07J17/00

7. 发明专利

JPS6114160B2 JPS6114160B2 - 失效
公开(公告)号：JPS6114160B2
公开(公告)日：1986-04-17
申请号：JP10849976
申请日：1976-09-09
申请人： Tsunematsu Takemoto , Nippon Shoji Kk
发明人： TAKEMOTO TSUNEMATSU , NAKAJIMA TADASHI , ARIHARA SHIGENOBU , OKUDAIRA MEGUMI
IPC分类号： A23L27/00 , C07H1/08 , C07H15/18 , C07H15/20 , C07J17/00

8. 发明专利

JPS597302B2 JPS597302B2 - 失效
公开(公告)号：JPS597302B2
公开(公告)日：1984-02-17
申请号：JP3502577
申请日：1977-03-28
申请人： Nippon Shoji Kk , Tsunematsu Takemoto
发明人： TAKEMOTO TSUNEMATSU , NAKAJIMA TADASHI , ARIHARA SHIGENOBU , OKUDAIRA MEGUMI
IPC分类号： A23L27/00 , C07G99/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式