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    • 4. 发明授权
    • Optical waveguide circuit
    • 光波导电路
    • US06925228B2
    • 2005-08-02
    • US10320189
    • 2002-12-16
    • Shin KameiMotohaya IshiiAkihiro TakagiTakeshi Kitagawa
    • Shin KameiMotohaya IshiiAkihiro TakagiTakeshi Kitagawa
    • G02B6/12G02B6/122G02B6/125G02B6/34G02B6/26
    • G02B6/12019G02B6/1228G02B6/125G02B2006/121
    • A practical optical waveguide circuit is provided which includes many intersections but is low loss. The width of a waveguide core is w1 at input and output terminal sections and w2 at an intersecting section, where w2>w1. The core width of the intersecting section is made different from that of the input and output terminal sections, or the core height of the intersecting section is made different from that of the input and output terminal sections. The core width is smoothly varied between the intersecting section and the input and output terminal sections by a tapered section. When the number of the waveguides intersecting with the intersecting section is 100, the intersection loss is 5.8 dB for the conventional device where w2=w1=5 μm, but is 1.8 dB when w2=12 μm, thereby being able to reduce the intersection loss sharply.
    • 提供了一种实用的光波导电路,其包括许多交叉点,但是具有低损耗。 在输入和输出端子部分处的波导芯的宽度为w 1,在交叉部分处为w 2 2,其中w 2 2 < SUB> 1 。 使交叉部分的芯部宽度与输入和输出端子部分的芯宽不同,或者使交叉部分的芯高度与输入和输出端子部分的芯高度不同。 芯部宽度通过锥形部分在交叉部分和输入和输出端子部分之间平滑地变化。 当与交叉部分相交的波导的数量为100时,对于其中w 2 2 = w 1 = 5mum的常规装置,交叉损耗为5.8dB,但是 当w 2 2 = 12时为1.8dB,从而能够急剧减少交叉损失。
    • 10. 发明授权
    • Substrate for assaying β-glucan and/or endotoxin and assay method
    • 用于测定β-葡聚糖和/或内毒素的底物和测定方法
    • US08546072B2
    • 2013-10-01
    • US12918724
    • 2009-02-20
    • Takeshi KitagawaNaoyuki YamamotoMutsuhiro Date
    • Takeshi KitagawaNaoyuki YamamotoMutsuhiro Date
    • A61K38/00A61K38/04C07K2/00C07K4/00C07K5/00C07K7/00C07K14/00C07K16/00C07K17/00C12Q1/00G01N33/53
    • C07K5/1013C07K5/0606C07K5/06095C07K5/0808C07K5/081C07K5/101G01N33/5308G01N2400/24
    • An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A1-Gly-Arg-A2-E-D  [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A2-E-D  [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.
    • 本发明的目的是提供一种用于测定允许高灵敏度测定的β-葡聚糖或内毒素的肽衍生物,以及使用该衍生物测定β-葡聚糖和/或内毒素的方法。 本发明涉及(1)由以下通式[1]表示的肽衍生物:X-A1-Gly-Arg-A2-ED [1],(2)用于测定β-葡聚糖和/或内毒素的试剂 其包含上述肽衍生物,(3)β-葡聚糖和/或内毒素的测定方法,其特征在于,含有β-葡聚糖和/或内毒素的样品,马蹄蟹的血小板裂解物和上述肽 衍生物彼此反应,然后将由以下通式[2]表示的所得释放化合物:H-A2-ED [2]与未反应物质分离并定量,并基于该值进行测定,和(4 )用于测定β-葡聚糖和/或内毒素的试剂盒,其包含鲎的微血管裂解物和上述肽衍生物作为其组成。