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1. 发明申请

US20090291940A1 AMINOPYRROLIDINE COMPOUND 失效
标题翻译：氨基吡啶化合物
公开(公告)号：US20090291940A1
公开(公告)日：2009-11-26
申请号：US12296082
申请日：2007-03-30
申请人： Taketoshi Okubo , Toshihito Kumagai , Takaaki Ishii , Toshio Nakamura , Kumi Abe , Yuri Amada , Tomoko Ishizaka , Xiang-Min Sun , Yoshinori Sekiguchi , Shigetada Sasako , Takanori Shimizu , Takayuki Nagatsuka
发明人： Taketoshi Okubo , Toshihito Kumagai , Takaaki Ishii , Toshio Nakamura , Kumi Abe , Yuri Amada , Tomoko Ishizaka , Xiang-Min Sun , Yoshinori Sekiguchi , Shigetada Sasako , Takanori Shimizu , Takayuki Nagatsuka
IPC分类号： A61K31/553 , A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/517 , A61K31/4709 , C07D417/14 , C07D413/14 , C07D403/14 , C07D401/14
CPC分类号： C07D401/12
摘要： Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.
摘要翻译：公开了由式[I]表示的氨基吡咯烷化合物或其药学上可接受的盐。化合物或盐可用作模式障碍如抑郁症，焦虑障碍，厌食症，恶病质，疼痛和药物依赖性的预防/治疗剂，其作用依赖于MC4受体拮抗作用。

2. 发明授权

US08044068B2 Aminopyrrolidine compound 失效
标题翻译：氨基吡咯烷化合物
公开(公告)号：US08044068B2
公开(公告)日：2011-10-25
申请号：US12296082
申请日：2007-03-30
申请人： Taketoshi Okubo , Toshihito Kumagai , Takaaki Ishii , Toshio Nakamura , Kumi Abe , Yuri Amada , Tomoko Ishizaka , Xiang-Min Sun , Yoshinori Sekiguchi , Shigetada Sasako , Takanori Shimizu , Takayuki Nagatsuka
发明人： Taketoshi Okubo , Toshihito Kumagai , Takaaki Ishii , Toshio Nakamura , Kumi Abe , Yuri Amada , Tomoko Ishizaka , Xiang-Min Sun , Yoshinori Sekiguchi , Shigetada Sasako , Takanori Shimizu , Takayuki Nagatsuka
IPC分类号： A61K31/47 , C07D453/04
CPC分类号： C07D401/12
摘要： Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.
摘要翻译：公开了由式[I]表示的氨基吡咯烷化合物或其药学上可接受的盐。化合物或盐可用作模式障碍如抑郁症，焦虑障碍，厌食症，恶病质，疼痛和药物依赖性的预防/治疗剂，其作用依赖于MC4受体拮抗作用。

3. 发明授权

US07601734B2 Cyclic amine compound 失效
标题翻译：环胺化合物
公开(公告)号：US07601734B2
公开(公告)日：2009-10-13
申请号：US11578169
申请日：2005-04-08
申请人： Toshihito Kumagai , Toshio Nakamura , Yuri Amada , Yoshinori Sekiguchi
发明人： Toshihito Kumagai , Toshio Nakamura , Yuri Amada , Yoshinori Sekiguchi
IPC分类号： A61K31/44 , A61P25/18 , A61P25/24
CPC分类号： C07D491/048 , C07D471/04 , C07D495/04
摘要： An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of α2C-adrenoceptor and is useful in preventing and treating disorders attributable to α2C-adrenoceptor.The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.
摘要翻译：本发明的目的是提供对α2C-肾上腺素能受体的结合具有强效抑制作用的环胺化合物，可用于预防和治疗归因于α2C-肾上腺素受体的病症。上述目的通过以下环胺化合物等来解决，其中X是O，S，SO，SO 2或NR 2等; R1是氢原子，氰基，羧基，C2-C13烷氧基羰基，氨基甲酰基等; Ar 1和Ar 2相同或不同，各自表示可被1〜3个取代基等取代的芳基或杂芳基; 环B为苯环可被1〜3个取代基取代等; n是1至10的整数; p和q相同或不同，各自表示1或2的整数。

4. 发明申请

US20070244145A1 Cyclic Amine Compound 失效
标题翻译：环胺化合物
公开(公告)号：US20070244145A1
公开(公告)日：2007-10-18
申请号：US11578169
申请日：2005-04-08
申请人： Toshihito Kumagai , Toshio Nakamura , Yuri Amada , Yoshinori Sekiguchi
发明人： Toshihito Kumagai , Toshio Nakamura , Yuri Amada , Yoshinori Sekiguchi
IPC分类号： A61K31/44 , A61P25/18 , A61P25/24
CPC分类号： C07D491/048 , C07D471/04 , C07D495/04
摘要： An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of α2C-adrenoceptor and is useful in preventing and treating disorders attributable to α2C-adrenoceptor. The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.
摘要翻译：本发明的目的是提供对α2C-肾上腺素能受体的结合具有强效抑制作用的环胺化合物，可用于预防和治疗归因于α2C-肾上腺素受体的病症。上述目的通过以下环胺化合物等来解决，其中X是O，S，SO，SO 2或NR 2等; R 1是氢原子，氰基，羧基，C 1 -C 13烷氧基羰基，氨基甲酰基等。 Ar 1和Ar 2相同或不同，各自表示可被1至3个取代基等取代的芳基或杂芳基; 环B为苯环可被1〜3个取代基取代等; n是1至10的整数; p和q相同或不同，各自表示1或2的整数。

5. 发明授权

US08642626B2 Ethinyl-pyrazole derivative 失效
标题翻译：乙烯基 - 吡唑衍生物
公开(公告)号：US08642626B2
公开(公告)日：2014-02-04
申请号：US13812437
申请日：2011-07-29
申请人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto
发明人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto
IPC分类号： A61K31/4439 , A61K31/415 , C07D231/12 , C07D231/20 , C07D231/38 , C07D403/06 , C07D401/06
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04
摘要： Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like.
摘要翻译：本发明提供由式[I]表示的新化合物或其对II类代谢型谷氨酸（m-Glu）受体具有拮抗作用的药学上可接受的盐。化合物或其药学上可接受的盐可用作疾病的预防或治疗剂，例如新的情绪障碍（抑郁和双相性精神障碍），焦虑症（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤性应激障碍，特异性恐惧症和急性应激障碍），精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，药物依赖，惊厥，震颤，疼痛，睡眠障碍等。

6. 发明申请

US20130137865A1 HETEROARYL-PYRAZOLE DERIVATIVE 审中-公开
标题翻译：异丙基吡唑衍生物
公开(公告)号：US20130137865A1
公开(公告)日：2013-05-30
申请号：US13814869
申请日：2011-08-11
申请人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto , Hideaki Amada , Hiroki Urabe , Rie Nishikawa , Shuhei Kashiwa ASHIWA
发明人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto , Hideaki Amada , Hiroki Urabe , Rie Nishikawa , Shuhei Kashiwa ASHIWA
IPC分类号： C07D413/14 , C07D413/04 , C07D403/04 , C07D231/38
CPC分类号： C07D413/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D413/04
摘要： A compound represented by formula [I] and a pharmaceutically accepted salt of said compound are a novel compound and a pharmaceutically accepted salt thereof which exert antagonistic activity against group II metabotropic glutamate (mGlu) receptors, and are effective as a novel preventive or therapeutic agent for disorders such as mood disorders (depressive disorder, bipolar disorder, etc.), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, a specific phobic disorder, acute stress disorder, etc.), schizophrenia, Alzheimer's disease, cognitive impairment, dementia, drug dependence, convulsions, shivering, pain, sleep disorders, and the like.
摘要翻译：由式[I]表示的化合物和所述化合物的药学上可接受的盐是对II族代谢型谷氨酸（mGlu）受体具有拮抗作用的新化合物及其药学上可接受的盐，并且作为新的预防或治疗剂是有效的用于诸如情绪障碍（抑郁障碍，双相情感障碍等），焦虑障碍（广泛性焦虑症，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特异性恐怖症，急性应激障碍等），精神分裂症，阿尔茨海默病，认知障碍，痴呆，药物依赖，抽搐，发抖，疼痛，睡眠障碍等。

7. 发明授权

US08376934B2 Multijoint manipulator and endoscope system having the same 有权
标题翻译：具有相同的多节点机械手和内窥镜系统
公开(公告)号：US08376934B2
公开(公告)日：2013-02-19
申请号：US13092702
申请日：2011-04-22
申请人： Kazuhiko Takahashi , Toshio Nakamura
发明人： Kazuhiko Takahashi , Toshio Nakamura
IPC分类号： A61B1/00 , A61B1/04 , G06F3/033
CPC分类号： B25J9/06 , A61B1/00147 , A61B1/0052 , A61B1/0055 , A61B5/065 , A61B34/30 , A61B34/37 , A61B2034/2059 , A61B2034/306 , A61B2090/064
摘要： A multijoint manipulator apparatus includes a tubular-member, linear-motion-transmission-members, a drive-unit, a position-detector, a tension-detector, an operation-unit, and a movement-degree-calculation-unit. The linear-members are inserted in the tubular-member, one end and the other end of each of the linear-members being fixed to the vicinity of a joint of the tubular-member and the drive-unit, respectively. The drive-unit moves the linear-members. The position-detector and the tension-detector detect positions and tension of the linear-members, respectively. A desired position/posture of a point of interest is input to the operation-unit. The calculation-unit calculates a current position/posture of the point, a weighting factor serving to give priority to and move the linear-members the tension of which is relatively low among the linear-members, and movement degrees of the linear-members to move the point to the desired position/posture, and causes the drive-unit to pull the linear-members.
摘要翻译：多关节机械手装置包括管状构件，直线运动传递构件，驱动单元，位置检测器，张力检测器，操作单元和移动程度计算单元。线性构件插入管状构件中，每个线性构件的一端和另一端分别固定在管状构件和驱动单元的接头附近。驱动单元移动线性元件。位置检测器和张力检测器分别检测线性元件的位置和张力。将感兴趣点的期望位置/姿势输入到操作单元。计算单元计算点的当前位置/姿势，用于优先使线性构件中的线性构件的张力相对较低的直线构件的加权系数和线性构件的移动度向将点移动到期望的位置/姿势，并且使驱动单元拉动线性构件。

8. 发明授权

US08282543B2 Surgical instrument and endoscope surgical system having surgical instrument 有权
标题翻译：手术器械和内窥镜手术系统具有手术器械
公开(公告)号：US08282543B2
公开(公告)日：2012-10-09
申请号：US12573201
申请日：2009-10-05
申请人： Tsutomu Ishiguro , Toshio Nakamura , Jun Hasegawa
发明人： Tsutomu Ishiguro , Toshio Nakamura , Jun Hasegawa
IPC分类号： A61B1/00
CPC分类号： A61B17/29 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B34/70 , A61B34/71 , A61B34/74 , A61B2017/003 , A61B2017/00318 , A61B2017/0034 , A61B2017/00398 , A61B2017/2927 , A61B2017/2939 , A61B2017/320072 , A61B2018/1425 , A61B2018/1475 , A61B2034/742
摘要： A surgical instrument having a surgical unit which operates on an operating portion in a body cavity, an accommodation portion capable of accommodating the surgical unit. The surgical instrument having movement manipulation mechanism connected to the surgical unit for moving the surgical unit to a position at which the surgical unit is accommodated in the accommodation portion and to a position at which the surgical unit is exposed from the accommodation portion along the inside of the accommodation portion.
摘要翻译：一种具有在体腔内的操作部分上操作的手术单元的手术器械，能够容纳外科单元的容纳部分。该外科器具具有连接到外科单元的移动操作机构，用于将手术单元移动到手术单元容纳在容纳部分中的位置，以及外科单元沿着容纳部分沿着内窥镜住宿部分。

9. 发明申请

US20090227834A1 ENERGY SURGICAL DEVICE 审中-公开
标题翻译：能量手术器械
公开(公告)号：US20090227834A1
公开(公告)日：2009-09-10
申请号：US12400917
申请日：2009-03-10
申请人： Koji Nakamoto , Toshio Nakamura , Kazuhiko Takahashi , Michifumi Yoshie
发明人： Koji Nakamoto , Toshio Nakamura , Kazuhiko Takahashi , Michifumi Yoshie
IPC分类号： A61B18/14 , A61B1/012
CPC分类号： A61B18/148 , A61B18/1402 , A61B18/1492 , A61B34/30 , A61B2018/00595 , A61B2018/00642 , A61B2018/00982 , A61B2018/1412 , A61B2090/064 , A61B2090/065
摘要： An energy surgical device is provided with a treatment section which treats a subject, an energy supply section which supplies energy to the treatment section, a state-change detecting section which detects a state change of the treatment section, an energy instruction input section which inputs an instruction for the energy supply, and a regulation section which regulates the energy supply by the energy supply section based on the input of the energy supply instruction through the energy instruction input section and a result of detection in the state-change detecting section.
摘要翻译：能量手术装置具有处理对象的治疗部，向治疗部供给能量的能量供给部，检测治疗部的状态变化的状态变化检测部，能够进行输入的能量指示输入部能量供给指令，以及调节部，其基于通过能量指示输入部的能量供给指示的输入和状态变化检测部的检测结果来调节能量供给部的能量供给。

10. 发明申请

US20060204158A1 Method of manufacturing cage for roller bearing and cage for roller bearing 有权
标题翻译：滚子轴承和滚子轴承保持架的制造方法
公开(公告)号：US20060204158A1
公开(公告)日：2006-09-14
申请号：US10567568
申请日：2004-08-06
申请人： Kazuto Kobayashi , Toshio Nakamura , Keiichi Horino , Yoshiro Ide
发明人： Kazuto Kobayashi , Toshio Nakamura , Keiichi Horino , Yoshiro Ide
IPC分类号： F16C33/52
CPC分类号： F16C33/4682 , B21D53/12 , F16C19/38 , F16C23/086 , F16C33/543 , Y10T29/49686 , Y10T29/49687 , Y10T29/49691
摘要： A method of manufacturing a retainer for a roller bearing made of a metal plate and has a tubular main portion, pockets formed in the main portion intermittently concerning a circumferential direction and capable of retaining rollers rollably, and an outwardly oriented flange-like collar portion. An annular intermediate material is formed by die cutting the metal plate, and after a second intermediate material is formed by forming through holes in the intermediate material intermittently, a portion of the second intermediate material excluding a radially outer end portion is plastically deformed into a tubular shape. The portion plastically deformed tubular shape is formed as the main portion, a portion corresponding to the radially outer end portion of the second intermediate material is formed as the collar portion or a collar portion element for forming the collar portion, and portions corresponding to the through holes are formed as the pockets.
摘要翻译：一种制造用于由金属板制成的滚子轴承的保持器的方法，并且具有管状主体部分，在主体部分中间歇地形成有围绕圆周方向并且能够滚动地保持辊的口袋和向外定向的凸缘状套环部分。通过对金属板进行模切而形成环状的中间材料，在间歇地形成中间材料的贯通孔而形成第二中间材料之后，除了径向外端部以外的部分第二中间材料塑性地变形为管状形状。形成塑性变形管状的部分形成为主要部分，对应于第二中间材料的径向外端部的部分形成为套环部分或用于形成套环部分的套环部分元件，以及对应于贯穿孔形成为袋。

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