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    • 9. 发明授权
    • 2-amino-bicyclo[3.1.0]hexane-2, 6-dicarboxylic ester derivative
    • 2-氨基 - 双环[3.1.0]己烷-2,6-二羧酸酯衍生物
    • US08258133B2
    • 2012-09-04
    • US13269242
    • 2011-10-07
    • Akito YasuharaKazunari SakagamiHiroshi OhtaAtsuro Nakazato
    • Akito YasuharaKazunari SakagamiHiroshi OhtaAtsuro Nakazato
    • A61K31/535
    • C07C229/50C07D307/88
    • A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administration. A 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative represented by formula [I] [wherein R1 and R2 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; X represents a hydrogen atom or a fluorine atom; Y represents —OCHR3R4 or the like (wherein R3 and R4 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; and n represents integer 1 or 2)], a pharmaceutically acceptable salt thereof or a hydrate thereof.
    • 一种有效治疗和预防精神疾病如精神分裂症,焦虑及其相关疾病,抑郁症,双相情感障碍和癫痫的药物。 该药物拮抗II型代谢型谷氨酸受体的作用,并且在口服给药中显示高活性。 由式[I]表示的2-氨基 - 双环[3.1.0]己烷-2,6-二羧酸酯衍生物[其中R 1和R 2相同或不同,各自表示氢原子,C 1-10烷基或 喜欢; X表示氢原子或氟原子; Y表示-OCHR 3 R 4等(其中R 3和R 4相同或不同,并且各自表示氢原子,C 1-10烷基等; n表示1或2的整数)],其药学上可接受的盐或 水合物。
    • 10. 发明授权
    • 2-amino-bicyclo(3.1.0) hexane-2,6-dicarboxylic ester derivative
    • 2-氨基 - 双环(3.1.0)己烷-2,6-二羧酸酯衍生物
    • US08076502B2
    • 2011-12-13
    • US12847392
    • 2010-07-30
    • Akito YasuharaKazunari SakagamiHiroshi OhtaAtsuro Nakazato
    • Akito YasuharaKazunari SakagamiHiroshi OhtaAtsuro Nakazato
    • C07C69/74C07C61/12
    • C07C229/50C07D307/88
    • A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administrationA 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative represented by formula [I] [wherein R1 and R2 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; X represents a hydrogen atom or a fluorine atom; Y represents —OCHR3R4 or the like (wherein R3 and R4 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; and n represents integer 1 or 2)], a pharmaceutically acceptable salt thereof or a hydrate thereof.
    • 一种有效治疗和预防精神疾病如精神分裂症,焦虑及其相关疾病,抑郁症,双相情感障碍和癫痫的药物。 该药物拮抗II型代谢型谷氨酸受体的作用,并且在口服给药中表现出高活性。由式[I]表示的2-氨基 - 双环[3.1.0]己烷-2,6-二羧酸酯衍生物[其中R1和R2为 相同或不同,并且各自表示氢原子,C 1-10烷基等; X表示氢原子或氟原子; Y表示-OCHR 3 R 4等(其中R 3和R 4相同或不同,并且各自表示氢原子,C 1-10烷基等; n表示1或2的整数)],其药学上可接受的盐或 水合物。