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1. 发明授权

US06482640B1 Hybridization device, case, support, and label agent 失效
标题翻译：杂交装置，病例，支架和贴标试剂
公开(公告)号：US06482640B1
公开(公告)日：2002-11-19
申请号：US09889990
申请日：2001-12-31
申请人： Toshiaki Tanaka , Kenji Yamamoto , Koichiro Hatano , Katsuya Mizuno
发明人： Toshiaki Tanaka , Kenji Yamamoto , Koichiro Hatano , Katsuya Mizuno
IPC分类号： C12M134
CPC分类号： G01N21/76 , G01N21/67 , G01N21/69
摘要： The present invention provides a hybridization device, case, support and labeling reagent which can enhance the efficiency of the hybridization reaction, save more time for the reaction and improve the detection sensitivity. A case (1) comprises: a metal support (2) made of platinum-covered titanium and having probe DNA immobilized thereon; counter electrodes (2a) and (2b) for applying a voltage between the metal support (2); a cap (3); and a filler port (23). As a result, a hybridization reaction can be performed in an efficient manner in a short time. In addition an electrogenerated chemiluminescent substance may be used for detection.
摘要翻译：本发明提供了一种杂交装置，病例，载体和标记试剂，可提高杂交反应的效率，节省更多的反应时间，提高检测灵敏度。一种情况（1）包括：金属载体（2）的铂覆盖的钛并且其上固定有探针DNA; 用于在金属支撑件（2）之间施加电压的对置电极（2a）和（2b）; 帽（3）; 和填充口（23）。结果，可以在短时间内以有效的方式进行杂交反应。此外，电生化的化学发光物质可用于检测。

2. 发明授权

US06787349B1 Biochip reader and labeling reagent 失效
标题翻译：生物芯片阅读器和贴标试剂
公开(公告)号：US06787349B1
公开(公告)日：2004-09-07
申请号：US09889747
申请日：2001-07-19
申请人： Kenji Yamamoto , Mitsuhiro Tachibana , Katsuya Mizuno
发明人： Kenji Yamamoto , Mitsuhiro Tachibana , Katsuya Mizuno
IPC分类号： C12M100
CPC分类号： G01N33/543 , B01J2219/00536 , Y10T436/13
摘要： The present invention provides a high-sensitive, inexpensive biochip reader for reading a biochip as compared to a fluorescence method. The biochip reader is provided with an X-Y stage (3) for mounting a biochip (6) and scanning the biochip (6) in a two-dimensional manner, a controller (4) for the X-Y stage, a magnetic sensor (1) for reading the magnetic field strength, an ohmmeter (2), and a computer (5) for signal processing. As a result, a high-performance, inexpensive biochip reader can be provided without using an expensive laser or an expensive optical system, by employing a magnetic sensor and a disk driving mechanism generally used in a hard disk drive and the like.
摘要翻译：与荧光方法相比，本发明提供了一种用于读取生物芯片的高灵敏度，便宜的生物芯片读取器。生物芯片读取器设置有用于安装生物芯片（6）并以二维方式扫描生物芯片（6）的XY台（3），用于XY台的控制器（4），用于读取磁场强度，欧姆表（2）和用于信号处理的计算机（5）。结果，通过采用通常用于硬盘驱动器等中的磁传感器和盘驱动机构，可以提供高性能，廉价的生物芯片读取器，而不需要使用昂贵的激光器或昂贵的光学系统。

3. 发明授权

US06589740B2 Method and device for detecting hybridization reaction 失效
标题翻译：检测杂交反应的方法和装置
公开(公告)号：US06589740B2
公开(公告)日：2003-07-08
申请号：US09802804
申请日：2001-03-09
申请人： Motonao Nakao , Kenji Yamamoto , Junji Yoshii , Katsuya Mizuno
发明人： Motonao Nakao , Kenji Yamamoto , Junji Yoshii , Katsuya Mizuno
IPC分类号： C12Q168
CPC分类号： C12Q1/6837 , B01L7/52 , B01L2300/0819 , C12Q2563/107 , C12Q2527/107
摘要： The present invention detects and quantities only specific hybridization bindings. A biochip 10 which is spotted with a plurality of probe biopolymers is accommodated in a container 20 into which a washing solution is supplied from a liquid supplying unit 23. A heat block 31 controls the temperature of the biochip according to a predetermined time pattern. A pickup unit 55 picks up an image of the spot surface of the biochip at predetermined pickup intervals. The plurality of images picked up with the pickup unit are stored in a computer 40. By analyzing the images for individual spots, hybridization can be detected with high reliability for every spots without being influenced by optimal hybridization temperatures which differ depending upon the types of probes on the spots.
摘要翻译：本发明仅检测和量化特异性杂交结合。用多个探针生物聚合物点样的生物芯片10容纳在从液体供应单元23供应洗涤溶液的容器20中。加热块31根据预定的时间模式控制生物芯片的温度。拾取单元55以预定的取样间隔拾取生物芯片的光斑表面的图像。用拾取单元拾取的多个图像被存储在计算机40中。通过分析各个斑点的图像，可以以高可靠性检测每个斑点的杂交，而不受根据探针类型而不同的最佳杂交温度的影响在斑点上。

4. 发明授权

US4493644A Device for measuring and scraping operations in the field of prestorative dentistry 失效
标题翻译：预测性牙科领域的测量和刮削作业装置
公开(公告)号：US4493644A
公开(公告)日：1985-01-15
申请号：US548000
申请日：1983-11-02
申请人： Minoru Ai , Akira Manabe , Yoshimasa Igarashi , Katsuya Mizuno
发明人： Minoru Ai , Akira Manabe , Yoshimasa Igarashi , Katsuya Mizuno
IPC分类号： A61C13/003 , A61C13/38 , A61C19/04 , A61C19/055 , G01B5/24 , A61C3/00
CPC分类号： G01B5/24 , A61C19/055
摘要： An improved device for measuring an inclination angle of the tapered surface of a plaster die duplicated from the prepared tooth in the field of restorative dentistry is disclosed. The device is used also for scraping operation for the was pattern. It includes a turnable tool holding plate which is turnably held in a slot formed on the lower part of a core so as to turn about a support shaft. A rotary ring with its lower end face cut to a predetermined inclination angle, for instance, 7 degrees is rotatably fitted onto the core in such a manner that the lower inclined face comes in contact with the upper faces of wing-shaped lateral projections of the tool holding plate with a transversely extending shaft disposed therebetween. The transversely extending shaft is inserted through the tool holding plate at the same inclination angle as that of the lower inclined end face of the rotary ring so that its axis intersects with the axis of the support shaft. When a tool on the tool holding plate is to be inclined, a lock ring is loosened and the rotary ring is rotated by an operator's hand. When the rotary ring is rotated by 90 degrees, the tool is caused to incline by 7 degrees. When it is further rotated by 180 degrees, the tool is inclined by 14 degrees. A number of calibration lines are impressed over the peripheral surface of the rotary ring.
摘要翻译：公开了一种改进的装置，用于测量在修复牙科领域从制备的牙齿复制的石膏模具的锥形表面的倾斜角度。该设备也用于刮擦操作的模式。它包括可转动的工具夹持板，其可转动地保持在形成在芯的下部上的槽中，以围绕支撑轴转动。将其下端面切割成例如7度的预定倾斜角度的旋转环可旋转地装配到芯上，使得下倾斜面与翼形横向突起的上表面接触工具保持板，其间设置有横向延伸的轴。横向延伸的轴以与旋转环的下倾斜端面相同的倾斜角度插入工具夹持板，使得其轴线与支撑轴的轴线相交。当工具夹板上的工具倾斜时，松开锁定环并且操作者的手旋转旋转环。当旋转环旋转90度时，使工具倾斜7度。当进一步旋转180度时，刀具倾斜14度。在旋转环的圆周表面上印有多条校准线。

5. 发明授权

US06994965B2 Method for displaying results of hybridization experiment 失效
公开(公告)号：US06994965B2
公开(公告)日：2006-02-07
申请号：US09808407
申请日：2001-03-14
申请人： Takuro Tamura , Noriyuki Yamamoto , Nobuaki Suzuki , Katsuya Mizuno
发明人： Takuro Tamura , Noriyuki Yamamoto , Nobuaki Suzuki , Katsuya Mizuno
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G06F19/26 , G06F19/20
摘要： In a method for verifying the accuracy of hybridization experiments in which a plurality of probe biopolymers are hybridized to sample biopolymers, information concerning the hybridization level for each of the probe biopolymers obtained from the hybridization experiment is displayed together with similarity scores representing the similarities between base sequences of the respective probe biopolymers.

6. 发明授权

US06690461B1 Method for displaying microarray information 失效
标题翻译：显示微阵列信息的方法
公开(公告)号：US06690461B1
公开(公告)日：2004-02-10
申请号：US09806249
申请日：2001-03-27
申请人： Takuro Tamura , Jyunji Yoshii , Katsuya Mizuno
发明人： Takuro Tamura , Jyunji Yoshii , Katsuya Mizuno
IPC分类号： G10J330
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , C12Q2545/101
摘要： A method for displaying microarray information by which unknown but useful information is extracted from a mass amount of sample information obtained with microarrays. Luminescent intensity information of sample spots obtained with the microarrays is standardized for each microarray and displayed as a graph as a difference from the standardized luminescent intensity of a sample spot of interest. Accordingly, information can be compared without being influenced by a difference of experiment status between the microarrays or a difference of physical properties between the samples. A three-dimensional graph is displayed by sorting the set of samples and the set of microarrays to which the sample spots belong, under predetermined conditions, and assigning the set of sorted samples and the set of sorted microarrays to X-axis and Y-axis, and the accumulated luminescence intensity to Z-axis.
摘要翻译：一种用于显示微阵列信息的方法，通过其从由微阵列获得的大量样本信息中提取未知但有用的信息。对于每个微阵列，用微阵列获得的样品点的发光强度信息被标准化，并且作为与所关注的样品斑点的标准发光强度的差异显示为图。因此，可以比较信息而不受微阵列之间的实验状态的差异或样品之间的物理性质的差异的影响。通过在预定条件下对样本点所属的样本集和微阵列组进行排序，并将分类样本集合和分类微阵列组分配给X轴和Y轴来显示三维图形，和Z轴的累积发光强度。

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