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1. 发明申请

US20120299504A1 DISCHARGE LAMP LIGHTING APPARATUS 有权
标题翻译：放电灯照明设备
公开(公告)号：US20120299504A1
公开(公告)日：2012-11-29
申请号：US13477738
申请日：2012-05-22
申请人： Toru Kontani , Takashi Yamashita
发明人： Toru Kontani , Takashi Yamashita
IPC分类号： H01J61/06 , H05B41/16
CPC分类号： H01J61/0732 , H01J61/0735
摘要： In a discharge lamp lighting apparatus comprising a short arc type discharge lamp and a power supply unit, a relation of the natural frequency fe (Hz) of the electrodes, the ripple frequency fd (Hz) of the alternating current that is supplied to the discharge lamp, and the ripple power Pr (W) of the alternating current, satisfies a formula: Pr ≤  f e - f d  · ( - 0.13 × Vh Va + 3.0 ) , wherein the volume of the electrode head portion is represented as Vh and the volume of the segment of the electrode axis portion that projects into the arc tube is represented as Va. When the alternating current supplied to the discharge lamp satisfies the formula, it is possible to prevent or control damage in the electrode axis portion, since vibration produced in the electrodes during lighting of the discharge lamp is small even if the discharge lamp is lighted for a long time.
摘要翻译：在包括短弧型放电灯和电源单元的放电灯点亮装置中，电极的固有频率fe（Hz）的关系，提供给放电的交流电的纹波频率fd（Hz）灯和交流电的纹波功率Pr（W）满足下列公式：Pr≤attfe -fd·（ - 0.13×Vh Va + 3.0），其中电极头部分的体积表示为Vh，突出于电弧管的电极轴部分的段的体积表示为Va，当供给到放电灯的交流电满足公式时，可以防止或控制电极轴部的损伤，因为振动即使放电灯长时间点亮，放电灯点亮期间在电极中产生的电极也很小。

2. 发明授权

US08698411B2 Discharge lamp lighting apparatus 有权
标题翻译：放电灯照明装置
公开(公告)号：US08698411B2
公开(公告)日：2014-04-15
申请号：US13477738
申请日：2012-05-22
申请人： Toru Kontani , Takashi Yamashita
发明人： Toru Kontani , Takashi Yamashita
IPC分类号： H01J61/06 , H05B41/16
CPC分类号： H01J61/0732 , H01J61/0735
摘要： In a discharge lamp lighting apparatus comprising a short arc type discharge lamp and a power supply unit, a relation of the natural frequency fe (Hz) of the electrodes, the ripple frequency fd (Hz) of the alternating current that is supplied to the discharge lamp, and the ripple power Pr (W) of the alternating current, satisfies a formula: Pr ≤  f e - f d  · ( - 0.13 × Vh Va + 3.0 ) , wherein the volume of the electrode head portion is represented as Vh and the volume of the segment of the electrode axis portion that projects into the arc tube is represented as Va. When the alternating current supplied to the discharge lamp satisfies the formula, it is possible to prevent or control damage in the electrode axis portion, since vibration produced in the electrodes during lighting of the discharge lamp is small even if the discharge lamp is lighted for a long time.
摘要翻译：在包括短弧型放电灯和电源单元的放电灯点亮装置中，电极的固有频率fe（Hz）的关系，提供给放电的交流电的纹波频率fd（Hz）灯和交流电的纹波功率Pr（W）满足下列公式：Pr≤attfe -fd·（ - 0.13×Vh Va + 3.0），其中电极头部的体积表示为Vh，突出于电弧管的电极轴部分的段的体积表示为Va，当供给到放电灯的交流电满足公式时，可以防止或控制电极轴部的损伤，因为振动即使放电灯长时间点亮，放电灯点亮期间在电极中产生的电极也很小。

3. 发明申请

US20090131666A1 ACYLAMINOPIPERIDINE COMPOUND 失效
标题翻译： ACYLAMINOPIPERIDINE化合物
公开(公告)号：US20090131666A1
公开(公告)日：2009-05-21
申请号：US12294145
申请日：2007-03-23
申请人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
发明人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D487/04
摘要： [Problem] To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like. [Means for Resolution] An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C1-C6 alkylene, R1: phenyl which may be substituted, etc., R2: —H or C1-C6 alkyl, R3: —H, C1-C6 alkyl or C3-C8 cycloalkyl, R4: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].
摘要翻译： [问题]提供具有优异活性以调节CCR4或TARC和/或MDC功能的化合物，并可用于预防和/或治疗各种炎性疾病，过敏性疾病，自身免疫性疾病等。 [解决方法]由式（I）表示的酰氨基哌啶化合物或其药学上可接受的盐。 [式中的符号表示以下含义： A：单键或C1-C6亚烷基，R1：可被取代的苯基等，R2：-H或C1-C6烷基，R3：-H，C1-C6烷基或C3-C8环烷基，R4：吡咯烷 -2-基，其可以被取代等，D：苯环或吡唑环]。

4. 发明申请

US20090042856A1 PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的吡咯烷酮衍生物
公开(公告)号：US20090042856A1
公开(公告)日：2009-02-12
申请号：US12063766
申请日：2006-08-31
申请人： Hitoshi Yamazaki , Chiyoshi Kasahara , Hirokazu Kubota , Toru Kontani , Toru Asano , Hidekazu Mizuhara , Masaharu Yokomoto , Keiji Misumi , Tomohiko Kinoshita
发明人： Hitoshi Yamazaki , Chiyoshi Kasahara , Hirokazu Kubota , Toru Kontani , Toru Asano , Hidekazu Mizuhara , Masaharu Yokomoto , Keiji Misumi , Tomohiko Kinoshita
IPC分类号： A61K31/519 , A61P25/00 , C07D487/04 , C07D487/10 , C07D491/20 , C07D471/20 , A61K31/527 , C07D498/04 , A61K31/553 , A61K31/5383 , A61K31/5377 , A61K31/5025
CPC分类号： C07D487/04
摘要： A pyridazinone derivative compound shown by the following formula (I): wherein R1 is selected from hydrogen, etc.; R2 is selected from substituted or unsubstituted aryl, etc.; R3 is hydrogen, etc.; p is 0, 1 or 2; R4 and R5, are each hydrogen, etc.; R6 and R7, are taken together to form a group of the formula: wherein R8 is hydrogen; X is selected from oxygen, etc; R10 is selected from hydrogen, etc.; R11 is selected from hydrogen, etc.; R12 is selected from hydrogen, etc.; R13 is selected from hydrogen, etc.; R14 is selected from hydrogen, etc.; m and n are each 0, 1, or 2, or a pharmaceutically acceptable salt thereof, which is useful as a medicament.
摘要翻译：由下式（I）表示的哒嗪酮衍生物化合物：其中R1选自氢等; R2选自取代或未取代的芳基等; R3是氢等; p为0,1或2; R4和R5各自为氢等; R6和R7一起形成下式的基团：其中R8是氢; X选自氧等; R10选自氢等; R11选自氢等; R12选自氢等; R13选自氢等; R14选自氢等; m和n各自为0,1或2，或其药学上可接受的盐，其可用作药物。

5. 发明申请

US20050032855A1 Tetrahydro-2H-thiopyran-4-carboxamide derivative 有权
公开(公告)号：US20050032855A1
公开(公告)日：2005-02-10
申请号：US10912232
申请日：2004-08-06
申请人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
发明人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61P31/22 , C07D335/02 , C07D413/12 , A61K31/4245 , A61K31/422 , C07D413/02
CPC分类号： C07D335/02 , C07D413/12
摘要： A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

6. 发明授权

US06949543B2 Amide derivative 失效
标题翻译：酰胺衍生物
公开(公告)号：US06949543B2
公开(公告)日：2005-09-27
申请号：US10416371
申请日：2001-11-08
申请人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Yoji Miyazaki , Hiroshi Suzuki , Eiichi Nakai , Shunji Kageyama
发明人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Yoji Miyazaki , Hiroshi Suzuki , Eiichi Nakai , Shunji Kageyama
IPC分类号： A61K8/42 , A61P31/22 , C07D277/40 , C07D277/62 , C07D277/64 , C07D277/74 , C07D417/12 , C07D417/14 , A61K31/426
CPC分类号： C07D277/74 , C07D277/40 , C07D277/62 , C07D277/64 , C07D417/12 , C07D417/14
摘要： The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4-yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of amido group. Since said amide derivative has excellent anti-herpesvirus action, it is useful as medicaments and antiviral agents, particularly as preventive or therapeutic agents for various diseases accompanied by Herpesviridae virus infections, illustratively, varicella (chickenpox) accompanied by varicella zoster virus infection, shingles accompanied by the recurrent infection of latent varicella zoster virus, labial herpes and herpes encephalitis accompanied by HSV-1 infection, genital herpes accompanied by HSV-2 and the like various herpesvirus infections.
摘要翻译：本发明涉及一种新颖的酰胺衍生物，其是具有芳基或杂芳基作为芳族环基的特征的N - （{[4-（取代的噻唑-4-基）苯基]氨基甲酰基}甲基）直接取代在氨基的N原子上。由于所述酰胺衍生物具有优异的抗疱疹病毒作用，因此可用作药物和抗病毒剂，特别是作为伴随疱疹病毒科病毒感染的各种疾病的预防或治疗剂，例如伴随水痘带状疱疹病毒感染的水痘（水痘），带状疱疹伴随由于潜伏性水痘带状疱疹病毒的复发感染，伴有HSV-1感染的唇疱疹和疱疹性脑炎，伴有HSV-2的生殖器疱疹等各种疱疹病毒感染。

7. 发明授权

US5643931A Bisoxadiazolidine derivative 失效
标题翻译：双恶二唑烷衍生物
公开(公告)号：US5643931A
公开(公告)日：1997-07-01
申请号：US537907
申请日：1995-10-26
申请人： Kunihiro Niigata , Takumi Takahashi , Tatsuya Maruyama , Takayuki Suzuki , Kyoichi Maeno , Kenichi Onda , Toru Kontani , Osamu Noshiro , Reiko Koike , Akiyoshi Shimaya , Jun Irie
发明人： Kunihiro Niigata , Takumi Takahashi , Tatsuya Maruyama , Takayuki Suzuki , Kyoichi Maeno , Kenichi Onda , Toru Kontani , Osamu Noshiro , Reiko Koike , Akiyoshi Shimaya , Jun Irie
IPC分类号： C07D271/06 , A61K31/4166 , A61K31/44 , A61P3/10 , C07D271/07 , C07D413/14 , A61K31/41
CPC分类号： C07D271/07 , C07D413/14
摘要： A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. ##STR1## each represents a phenylene groupL:(1) an oxygen,(2) a ##STR2## (3) a --S(O).sub.n --, (4) a --CO--,(5) a ##STR3## (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.
摘要翻译： PCT No.PCT / JP94 / 00696 Sec。 371 1995年10月26日第 102（e）日期1995年10月26日PCT 1994年4月26日PCT PCT。公开号WO94 / 25448 日期：1994年11月10日由以下通式（I）表示的双恶唑烷二酮衍生物或其药学上可接受的盐，其可用作胰岛素敏感性增加药物及其药物组合物。（I）各自表示亚苯基L：（1）氧，（2）a（S）a -S（O）n - ，（4）-CO-，（（5）可以分别用氧原子和/或硫原子间隔的亚烷基或亚烯基。

8. 发明授权

US08378573B2 High pressure discharge lamp 有权
标题翻译：高压放电灯
公开(公告)号：US08378573B2
公开(公告)日：2013-02-19
申请号：US12628452
申请日：2009-12-01
申请人： Toru Kontani , Kazuhiro Goto
发明人： Toru Kontani , Kazuhiro Goto
IPC分类号： H01J17/18 , H01J17/04
CPC分类号： H01J61/0732 , H01J61/86
摘要： A high pressure discharge lamp has an electric discharge container with sealing portions formed at both ends of a light emission section, and electrodes made of tungsten. The electrode has a base end which is buried in the sealing portion. Tips of the electrodes face each other in the light emission section. Purity of the tungsten is 99.99% or more. The electrode has a large diameter portion formed at the tip of the electrode and an axis portion whose diameter is smaller than that of the large diameter portion. A part of a surface of the large diameter portion has a concavo-convex structure where a portion having grooves in a circumference direction and a portion having no groove are asymmetrically formed with respect to an axis of the electrode.
摘要翻译：高压放电灯具有形成在发光部的两端的密封部以及由钨构成的电极的放电容器。电极具有埋在密封部分中的基端。在发光部分中电极的尖端彼此面对。钨的纯度为99.99％以上。电极具有形成在电极前端的大直径部分和直径小于大直径部分直径的轴部分。大直径部分的表面的一部分具有凹凸结构，其中在圆周方向具有凹槽的部分和不具有凹槽的部分相对于电极的轴线不对称地形成。

9. 发明申请

US20100105658A1 AZA-BRIDGED-RING COMPOUND 有权
标题翻译： AZA-BRIDGED-RING化合物
公开(公告)号：US20100105658A1
公开(公告)日：2010-04-29
申请号：US12524758
申请日：2008-02-07
申请人： Shinya Nagashima , Toru Kontani , Hiroshi Nagata , Yuji Matsushima , Hisao Hamaguchi , Tadatsura Koshika
发明人： Shinya Nagashima , Toru Kontani , Hiroshi Nagata , Yuji Matsushima , Hisao Hamaguchi , Tadatsura Koshika
IPC分类号： A61K31/439 , C07D453/02 , C07D223/14 , A61K31/55 , A61P29/00
CPC分类号： C07D453/02 , C07D471/18
摘要： [Problems] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.[Means for Solving Problems] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.
摘要翻译： [问题]提供对毒蕈碱M3受体具有拮抗作用的化合物，并且可用作炎性疾病如慢性阻塞性肺病（COPD），哮喘的预防和/或治疗剂的活性成分喜欢。解决问题的手段本发明人研究了对毒蕈碱性M3受体的结合具有拮抗作用的化合物，并且已经发现，氮杂桥环化合物或其盐对其有拮抗作用结合毒蕈碱M3受体，从而完成本发明。本发明的氮杂桥环化合物对毒蕈碱性M3受体的结合具有拮抗作用，可用作炎性疾病如慢性阻塞性肺疾病（COPD）的预防和/或治疗剂，，哮喘等。

10. 发明授权

US07790884B2 Acylaminopiperidine compound 失效
标题翻译：酰胺基哌啶化合物
公开(公告)号：US07790884B2
公开(公告)日：2010-09-07
申请号：US12294145
申请日：2007-03-23
申请人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
发明人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
IPC分类号： C07D473/34
CPC分类号： C07D401/04 , C07D401/14 , C07D487/04
摘要： To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like.An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C1-C6 alkylene, R1: phenyl which may be substituted, etc., R2: —H or C1-C6 alkyl, R3: —H, C1-C6 alkyl or C3-C8 cycloalkyl, R4: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].
摘要翻译：提供具有优异活性以调节CCR4或TARC和/或MDC功能的化合物，并可用于预防和/或治疗各种炎性疾病，过敏性疾病，自身免疫性疾病等。由式（I）表示的酰氨基哌啶化合物或其药学上可接受的盐。 [式中的符号表示以下含义： A：单键或C1-C6亚烷基，R1：可被取代的苯基等，R2：-H或C1-C6烷基，R3：-H，C1-C6烷基或C3-C8环烷基，R4：吡咯烷 -2-基，其可以被取代等，D：苯环或吡唑环]。

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