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1. 发明申请

US20060152708A1 Multiparametric detection in a fluidic microsystem 审中-公开
标题翻译：流体微系统中的多参数检测
公开(公告)号：US20060152708A1
公开(公告)日：2006-07-13
申请号：US10544423
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.
摘要翻译：公开了一种用于测量移动通过流体微系统的颗粒的性质的方法，所述颗粒悬浮在液体中。根据本发明的方法，首先在第一测试台（11）测量特定颗粒的第一参数。然后在与第一测试站（11）在空间上分离的第二测试站（12）以与第一测量的间隔的间隔测量颗粒的第二参数，并且以相关方式联合评估第一和第二参数，第一和第二参数是测试颗粒的不同性质的特征。评估包括第一和第二参数与预定预期值的比较。根据比较的结果，对测试的颗粒进行另一测量或操作。还公开了被设计用于实施本发明方法的流体微系统。

2. 发明申请

US20060139638A1 Multiparametric cell identification and sorting method and associated device 审中-公开
标题翻译：多参数细胞识别和分选方法及相关装置
公开(公告)号：US20060139638A1
公开(公告)日：2006-06-29
申请号：US10544463
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Rudiger Meyer
IPC分类号： G01N21/00 , G01N21/64 , G01N15/02
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： The invention relates to an method of analysing biological particles, in particular to be conducted in a cell sorter, with following steps: placing the particles to be analysed into a carrier flow, carrying out a first analysis of the particles moving with the carrier flow, selecting at least one particle in dependence on the result of the first analysis, carrying out a second analysis of the selected particle in a decelerated condition. Furthermore, the invention comprises a corresponding analysis device.
摘要翻译：本发明涉及一种分析生物颗粒的方法，特别是在细胞分选器中进行分析，其步骤如下：将要分析的颗粒放入载体流中，对载体流动的颗粒进行第一次分析，根据第一次分析的结果选择至少一个粒子，在减速条件下进行所选粒子的第二次分析。此外，本发明包括相应的分析装置。

3. 发明申请

US20060012167A1 Device and method for coupling lines to fluidic microsystems 失效
标题翻译：将线耦合到流体微系统的装置和方法
公开(公告)号：US20060012167A1
公开(公告)日：2006-01-19
申请号：US10509190
申请日：2003-03-25
申请人： Torsten Muller , Annette Pfennig , Stephen Shirley , Stefan Hummel , Martin Reichel
发明人： Torsten Muller , Annette Pfennig , Stephen Shirley , Stefan Hummel , Martin Reichel
IPC分类号： F16L41/00
CPC分类号： F16L37/05
摘要： A coupling device (100), particularly for liquid-tight coupling of at least one liquid line (10) to a fluidic system (20), is described, which comprises: at least one sealing device (30), which is implemented to receive an end region (11) of the liquid line (10) and has a first sealing surface (31) for placement on an external surface (22) of the fluidic system in such a way that the end of the liquid line (10) is laterally enclosed by the first sealing surface (31) and points toward an opening (23) in the external surface (22), and a clamping device (40), using which the sealing device (30) may be pressed against the fluidic system (20), so that the first sealing surface (31) produces a liquid-tight connection with the external surface (22).
摘要翻译：描述了一种尤其用于至少一条液体管线（10）与流体系统（20）的液密耦合的联接装置（100），其包括：至少一个密封装置（30），其被实施为接收液体管线（10）的端部区域（11），并且具有用于放置在流体系统的外表面（22）上的第一密封表面（31），使得液体管线（10）的端部为由第一密封表面（31）横向包围并指向外表面（22）中的开口（23）的夹紧装置（40），密封装置（30）可以被压靠流体系统 20），使得第一密封表面（31）产生与外表面（22）的液密连接。

4. 发明申请

US20060198766A1 Docking device for a fluidic microsystem 审中-公开
标题翻译：流体微系统的对接装置
公开(公告)号：US20060198766A1
公开(公告)日：2006-09-07
申请号：US10556095
申请日：2004-05-10
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig
IPC分类号： B01L9/00
CPC分类号： B01L9/523 , B01J2219/00804 , B01J2219/0081 , B01L9/52 , B01L13/02 , B01L2200/025 , B01L2200/027 , B01L2200/028
摘要： The invention relates to a docking device (100) for retaining a fluidic microsystem (10), comprising a base plate (20) and a retaining frame (30), movable relative to the base plate (20) and used to fasten the microsystem (10) on the base plate (20). The retaining frame (30) is adapted to detachably receive the microsystem (10) and can be detached from the base plate (20) together with the microsystem (10). The device is also provided with a clamping device (40) with which the microsystem (10) on the retaining frame (30) can be pushed against the base plate (20). The invention also relates to methods for operating a fluidic microsystem (10) using said docking device (100).
摘要翻译：本发明涉及一种用于保持流体微系统（10）的对接装置（100），其包括可相对于基板（20）移动并用于紧固微系统（20）的基板（20）和保持框架（30） 10）在基板（20）上。保持框架（30）适于可拆卸地接收微系统（10）并且可以与微系统（10）一起从基板（20）拆下。该装置还设置有夹紧装置（40），保持框架（30）上的微系统（10）可以通过该夹紧装置推靠在基板（20）上。本发明还涉及使用所述对接装置（100）操作流体微系统（10）的方法。

5. 发明申请

US20070111298A1 Sample depositing device for a cell sorter 审中-公开
标题翻译：细胞分选机的样品沉积装置
公开(公告)号：US20070111298A1
公开(公告)日：2007-05-17
申请号：US10556140
申请日：2004-05-10
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig
IPC分类号： C12M3/00
CPC分类号： B01L3/50851 , B01L3/0241 , B01L2300/046 , G01N2015/149 , G01N2035/0424
摘要： The invention relates to a sample depositing device, particularly for a cell sorter, comprising a sample supply (38, 39) for supplying samples to be deposited and comprising a sample storage element (36) for storing the samples. Said sample storage element (36) has a number of sample containers for storing the samples separately. The invention provides that the sample storage element (36) is mounted in a displaceable manner in order to select a sample container whereas the sample supply (38, 39) is stationary.
摘要翻译：本发明涉及一种样品沉积装置，特别是用于细胞分选机的样品沉积装置，其包括用于提供待沉积样品的样品供应源（38,39），并包括用于储存样品的样品存储元件（36）。所述样品存储元件（36）具有用于分别存储样品的多个样品容器。本发明提供了样品存储元件（36）以可移位的方式安装，以便选择样品容器，而样品供应（38,39）是静止的。

6. 发明申请

US20060115890A1 Particle injector for a cell sorter 失效
公开(公告)号：US20060115890A1
公开(公告)日：2006-06-01
申请号：US10556017
申请日：2004-05-10
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig
IPC分类号： C12M1/34
CPC分类号： G01N15/1404 , G01N2015/1409 , G01N2015/1413 , G01N2015/1418
摘要： The invention relates to a particle injector for introducing particles into a carrier flow of a microfluidic system, especially for injecting biological cells into the carrier flow of a cell sorter. The particle injector includes an inlet for receiving the carrier flow, an outlet for discharging the carrier flow including the introduced particles, a carrier flow channel which connects the inlet to the outlet, and an injection channel flowing into the carrier flow channel for introducing the particles into the carrier flow. The inventive particle injector is characterized in that the carrier flow channel has substantially no dead volume.

7. 发明授权

US07510685B2 Particle injector for a cell sorter 失效
标题翻译：细胞分选机的颗粒注射器
公开(公告)号：US07510685B2
公开(公告)日：2009-03-31
申请号：US10556017
申请日：2004-05-10
申请人： Torsten Müller , Stefan Hummel , Annette Pfennig
发明人： Torsten Müller , Stefan Hummel , Annette Pfennig
IPC分类号： B01L3/00
CPC分类号： G01N15/1404 , G01N2015/1409 , G01N2015/1413 , G01N2015/1418
摘要： The invention relates to a particle injector for introducing particles into a carrier flow of a microfluidic system, especially for injecting biological cells into the carrier flow of a cell sorter. The particle injector includes an inlet for receiving the carrier flow, an outlet for discharging the carrier flow including the introduced particles, a carrier flow channel which connects the inlet to the outlet, and an injection channel flowing into the carrier flow channel for introducing the particles into the carrier flow. The inventive particle injector is characterized in that the carrier flow channel has substantially no dead volume.
摘要翻译：本发明涉及一种用于将颗粒引入微流体系统的载体流中的颗粒注入器，特别是用于将生物细胞注入到细胞分选器的载体流中。颗粒注射器包括用于接收载体流的入口，用于排出包括引入的颗粒的载体流的出口，将入口连接到出口的载体流动通道和流入载体流动通道中以引入颗粒的注入通道进入载体流。本发明的颗粒注射器的特征在于载体流动通道基本上没有死体积。

8. 发明授权

US07475916B2 Device and method for coupling lines to fluidic microsystems 失效
标题翻译：将线耦合到流体微系统的装置和方法
公开(公告)号：US07475916B2
公开(公告)日：2009-01-13
申请号：US10509190
申请日：2003-03-25
申请人： Torsten Müller , Annette Pfennig , Stephen Shirley , Stefan Hummel , Martin Reichel
发明人： Torsten Müller , Annette Pfennig , Stephen Shirley , Stefan Hummel , Martin Reichel
IPC分类号： F16L25/00 , F16L35/00
CPC分类号： F16L37/05
摘要： A coupling device (100), particularly for liquid-tight coupling of at least one liquid line (10) to a fluidic system (20), is described, which comprises: at least one sealing device (30), which is implemented to receive an end region (11) of the liquid line (10) and has a first sealing surface (31) for placement on an external surface (22) of the fluidic system in such a way that the end of the liquid line (10) is laterally enclosed by the first sealing surface (31) and points toward an opening (23) in the external surface (22), and a clamping device (40), using which the sealing device (30) may be pressed against the fluidic system (20), so that the first sealing surface (31) produces a liquid-tight connection with the external surface (22).
摘要翻译：描述了一种尤其用于至少一条液体管线（10）与流体系统（20）的液密耦合的联接装置（100），其包括：至少一个密封装置（30），其被实施为接收液体管线（10）的端部区域（11），并且具有用于放置在流体系统的外表面（22）上的第一密封表面（31），使得液体管线（10）的端部为由第一密封表面（31）横向包围并指向外表面（22）中的开口（23）的夹紧装置（40），密封装置（30）可以被压靠流体系统 20），使得第一密封表面（31）产生与外表面（22）的液密连接。

9. 发明授权

US07262843B2 Method and device for correcting for the size and/or shape of a measuring volume in a chemical and/or biological sample 有权
标题翻译：用于校正化学和/或生物样品中的测量体积的尺寸和/或形状的方法和装置
公开(公告)号：US07262843B2
公开(公告)日：2007-08-28
申请号：US10496589
申请日：2002-11-19
申请人： Stefan Hummel
发明人： Stefan Hummel
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G01N21/6452 , G01N2021/6463 , G01N2021/6478 , G01N2021/6482
摘要： In a method for correcting for the size and/or shape of a measuring volume (18)in a chemical and/or biological sample (14), especially in fluorescence spectroscopy, a measuring volume (18) located within the sample (14) is imaged to a detector means (44), using observing optics (32). The imaging is effected through a sample carrier w all (16) of a sample carrier (12) containing the sample (14). In the next step, the thickness of the sample carrier wall (16) is automatically determined. Thereafter, at least one lens (28) is shifted automatically along an optical axis of the observing optics (32) to correct for the size and/or shape of the measuring volume (18) as a function of the thickness of the sample carrier wall (16).
摘要翻译：在用于校正化学和/或生物样品（14）中的测量体积（18）的尺寸和/或形状的方法中，特别是在荧光光谱学中，位于样品（14）内的测量体积（18）是使用观察光学器件（32）成像到检测器装置（44）。通过样品载体w（包含样品（14））的样品载体（12）的全部（16）进行成像。在下一步骤中，自动确定样品载体壁（16）的厚度。此后，至少一个透镜（28）沿着观察光学器件（32）的光轴自动移位，以根据样品载体壁的厚度来校正测量体积（18）的尺寸和/或形状（16）。

10. 发明授权

US07226134B2 Method for stabilizing the driving state of a utility vehicle combination 有权
标题翻译：稳定多用途车组合的驾驶状态的方法
公开(公告)号：US07226134B2
公开(公告)日：2007-06-05
申请号：US10488997
申请日：2002-09-06
申请人： Matthias Horn , Stefan Hummel , Falk Hecker , Ulrich Guecker
发明人： Matthias Horn , Stefan Hummel , Falk Hecker , Ulrich Guecker
IPC分类号： B60T7/20
CPC分类号： B60T8/1708 , B60T8/1755
摘要： According to the invention, the driving stability of a utility vehicle combination, which is comprised of a towing vehicle and of a towed vehicle, is monitored (3-5) when the towed vehicle is braked. In the event of an unstable driving state, the vehicle combination is stabilized by effecting a cyclic or clocked reduction of the towed vehicle brake pressure (6).
摘要翻译：根据本发明，当牵引车辆被制动时，监视由牵引车辆和牵引车辆组成的多用途车组合的驾驶稳定性（3-5）。在不稳定的驾驶状态的情况下，车辆组合通过执行拖车车辆制动压力（6）的循环或时钟减少来稳定。

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