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1. 发明授权

US09222090B2 RNA interference target for treating AIDS 有权
标题翻译：治疗艾滋病的RNA干扰目标
公开(公告)号：US09222090B2
公开(公告)日：2015-12-29
申请号：US13584319
申请日：2012-08-13
申请人： Tong Cheng , Tao Zhang , Yali Zhang , Ji Miao , Jun Zhang , Ningshao Xia
发明人： Tong Cheng , Tao Zhang , Yali Zhang , Ji Miao , Jun Zhang , Ningshao Xia
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/1132 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The RNAi target sequences, which could be used for treating AIDS through targeting HIV. Based on the target sequences, recombinant expression vectors, packaging vectors and cells were constructed, which express siRNA and/or miRNA and/or ribozyme and/or antisense oligonucleotide for targeting HIV. And the applications of said recombinant expression vectors, packaging vectors and cells in preparing medicament for treating AIDS.
摘要翻译： RNAi靶序列，可用于通过靶向HIV来治疗艾滋病。基于靶序列，构建重组表达载体，包装载体和细胞，其表达用于靶向HIV的siRNA和/或miRNA和/或核酶和/或反义寡核苷酸。以及所述重组表达载体，包装载体和细胞在制备用于治疗AIDS的药物中的应用。

2. 发明申请

US20110243904A1 RNA INTERFERENCE TARGET FOR TREATING AIDS 审中-公开
标题翻译：用于治疗艾滋病的RNA干扰目标
公开(公告)号：US20110243904A1
公开(公告)日：2011-10-06
申请号：US12602005
申请日：2008-06-02
申请人： Tong Cheng , Tao Zhang , Yali Zhang , Ji Miao , Jun Zhang , Ningshao Xia
发明人： Tong Cheng , Tao Zhang , Yali Zhang , Ji Miao , Jun Zhang , Ningshao Xia
IPC分类号： A61K48/00 , C07H21/04 , C12N15/63 , C07H21/02 , C12N15/85 , C12N5/10 , C12N1/00 , A61K31/713 , A61K31/7088 , A61K35/12 , A61P31/18
CPC分类号： C12N15/1132 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to RNA interference target sequence targeting HIV for the treatment of AIDS. Based on the target sequence, recombinant expression vectors, packaging vectors and cells were constructed, which express a siRNA and/or a miRNA and/or a ribozyme and/or an antisense oligonucleotide targeting HIV. Also provided is the use of the recombinant expression vectors, packaging vectors and recombinant cells in the manufacture of a medicament for the treatment of AIDS.
摘要翻译：本发明涉及靶向用于治疗AIDS的HIV的RNA干扰靶序列。基于靶序列，构建重组表达载体，包装载体和细胞，其表达siRNA和/或miRNA和/或靶向HIV的核酶和/或反义寡核苷酸。还提供了重组表达载体，包装载体和重组细胞在制备用于治疗AIDS的药物中的用途。

3. 发明申请

US20100286451A1 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
标题翻译： 1,2-二烷氧基-3-氟苯的制备方法
公开(公告)号：US20100286451A1
公开(公告)日：2010-11-11
申请号：US12805138
申请日：2010-07-14
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C41/01 , C07C43/23
CPC分类号： C07C41/16 , C07C37/00 , C07C37/02 , C07C41/01 , C07C41/26 , C07C43/23 , C07C39/27 , C07C43/225 , C07C39/245
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
摘要翻译：本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业生产。

4. 发明授权

US08080747B2 Mechanical interlock between two electrical devices 有权
标题翻译：两个电气设备之间的机械互锁
公开(公告)号：US08080747B2
公开(公告)日：2011-12-20
申请号：US12526781
申请日：2008-02-04
申请人： Haiyuan Wang , Yali Zhang
发明人： Haiyuan Wang , Yali Zhang
IPC分类号： H01H1/20
CPC分类号： H01H50/323 , H01H9/26 , H01H50/04 , H01H50/546 , H01H2009/265
摘要： A low voltage electrical appliance having a mechanical interlock means comprises at least two contactors, wherein every contactor includes a base (11, 21), a support (12, 22), a top cover (4) and a contact holding sliding part (13, 23) in the base. Two contactors which are arranged in parallel both have one mechanical interlock means, which includes an interlocking element (3). The shaft of the interlocking element (3) may rotate in the slot of the base (11, 21). By the swinging of the interlocking element (3), a tang of the interlocking element (3) extends into the locking aperture of the contact holding sliding part, thereby preventing the energization action of the contact holding sliding part.
摘要翻译：具有机械互锁装置的低压电器包括至少两个接触器，其中每个接触器包括基座（11,21），支撑件（12,22），顶盖（4）和接触保持滑动部件（13），23）在基地。平行布置的两个接触器具有一个机械互锁装置，其包括互锁元件（3）。互锁元件（3）的轴可以在基座（11,21）的槽中旋转。通过互锁元件（3）的摆动，互锁元件（3）的柄脚延伸到触点保持滑动部分的锁定孔中，从而防止触点保持滑动部分的通电动作。

5. 发明申请

US20090227817A1 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
标题翻译： 1,2-二烷氧基-3-氟苯的制备方法
公开(公告)号：US20090227817A1
公开(公告)日：2009-09-10
申请号：US12379553
申请日：2009-02-24
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C43/225 , C07C39/26
CPC分类号： C07C39/27 , C07C41/16 , C07C41/26 , C07C43/225 , C07C43/23
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
摘要翻译：本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业生产。

6. 发明授权

US07786330B2 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
公开(公告)号：US07786330B2
公开(公告)日：2010-08-31
申请号：US12379553
申请日：2009-02-24
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C37/04 , C07C41/26
CPC分类号： C07C39/27 , C07C41/16 , C07C41/26 , C07C43/225 , C07C43/23
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

7. 发明申请

US20100044192A1 Low Voltage Apparatus Having Mechanical Interlocking Means 有权
标题翻译：具有机械联锁装置的低压装置
公开(公告)号：US20100044192A1
公开(公告)日：2010-02-25
申请号：US12526781
申请日：2008-02-04
申请人： Haiyuan Wang , Yali Zhang
发明人： Haiyuan Wang , Yali Zhang
IPC分类号： H01H9/26
CPC分类号： H01H50/323 , H01H9/26 , H01H50/04 , H01H50/546 , H01H2009/265
摘要： A low voltage electrical appliance having a mechanical interlock means comprises at least two contactors, wherein every contactor includes a base (11, 21), a support (12, 22), a top cover (4) and a contact holding sliding part (13, 23) in the base. Two contactors which are arranged in parallel both have one mechanical interlock means, which includes an interlocking element (3). The shaft of the interlocking element (3) may rotate in the slot of the base (11, 21). By the swinging of the interlocking element (3), a tang of the interlocking element (3) extends into the locking aperture of the contact holding sliding part, thereby preventing the energization action of the contact holding sliding part.
摘要翻译：具有机械互锁装置的低压电器包括至少两个接触器，其中每个接触器包括基座（11,21），支撑件（12,22），顶盖（4）和接触保持滑动部件（13），23）在基地。平行布置的两个接触器具有一个机械互锁装置，其包括互锁元件（3）。互锁元件（3）的轴可以在基座（11,21）的槽中旋转。通过互锁元件（3）的摆动，互锁元件（3）的柄脚延伸到触点保持滑动部分的锁定孔中，从而防止触点保持滑动部分的通电动作。

8. 发明授权

US07928268B2 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
标题翻译： 1,2-二烷氧基-3-氟苯的制备方法
公开(公告)号：US07928268B2
公开(公告)日：2011-04-19
申请号：US12805138
申请日：2010-07-14
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C41/01 , C07C43/205 , C07C39/24
CPC分类号： C07C41/16 , C07C37/00 , C07C37/02 , C07C41/01 , C07C41/26 , C07C43/23 , C07C39/27 , C07C43/225 , C07C39/245
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
摘要翻译：本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业化生产。

9. 发明申请

US20060236528A1 Non-aqueous electrolytic solution 审中-公开
标题翻译：非水电解液
公开(公告)号：US20060236528A1
公开(公告)日：2006-10-26
申请号：US11196782
申请日：2005-08-03
申请人： Wu Xu , Zhongyi Deng , Yali Zhang , Pascal Bolomey
发明人： Wu Xu , Zhongyi Deng , Yali Zhang , Pascal Bolomey
IPC分类号： H01M10/04 , H01M10/40 , H01M4/50 , H01M4/58 , H01M4/52
CPC分类号： H01M10/0525 , H01M4/131 , H01M4/133 , H01M10/0568 , H01M10/4235 , Y10T29/49108
摘要： The use of lithium bis(oxalato)borate (LiBOB) as an additive in a lithium secondary battery provides improved battery performance such as long life, high capacity retention, and protection against overcharging.
摘要翻译：在锂二次电池中使用双（草酸）硼酸锂（LiBOB）作为添加剂提供了改善的电池性能，例如寿命长，高容量保持和防止过充电。

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