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1. 发明授权

US07786330B2 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
公开(公告)号：US07786330B2
公开(公告)日：2010-08-31
申请号：US12379553
申请日：2009-02-24
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C37/04 , C07C41/26
CPC分类号： C07C39/27 , C07C41/16 , C07C41/26 , C07C43/225 , C07C43/23
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

2. 发明申请

US20090227817A1 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
标题翻译： 1,2-二烷氧基-3-氟苯的制备方法
公开(公告)号：US20090227817A1
公开(公告)日：2009-09-10
申请号：US12379553
申请日：2009-02-24
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C43/225 , C07C39/26
CPC分类号： C07C39/27 , C07C41/16 , C07C41/26 , C07C43/225 , C07C43/23
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
摘要翻译：本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业生产。

3. 发明授权

US07928268B2 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
标题翻译： 1,2-二烷氧基-3-氟苯的制备方法
公开(公告)号：US07928268B2
公开(公告)日：2011-04-19
申请号：US12805138
申请日：2010-07-14
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C41/01 , C07C43/205 , C07C39/24
CPC分类号： C07C41/16 , C07C37/00 , C07C37/02 , C07C41/01 , C07C41/26 , C07C43/23 , C07C39/27 , C07C43/225 , C07C39/245
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
摘要翻译：本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业化生产。

4. 发明申请

US20100286451A1 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
标题翻译： 1,2-二烷氧基-3-氟苯的制备方法
公开(公告)号：US20100286451A1
公开(公告)日：2010-11-11
申请号：US12805138
申请日：2010-07-14
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C41/01 , C07C43/23
CPC分类号： C07C41/16 , C07C37/00 , C07C37/02 , C07C41/01 , C07C41/26 , C07C43/23 , C07C39/27 , C07C43/225 , C07C39/245
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
摘要翻译：本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业生产。

5. 外观设计

USD1004162S1 Outdoor lamp 有权
公开(公告)号：USD1004162S1
公开(公告)日：2023-11-07
申请号：US29743460
申请日：2020-07-22
申请人： Bruce Pi , Wei Kang , Zhixiang Chen , Wei Zhang
设计人： Bruce Pi , Wei Kang , Zhixiang Chen , Wei Zhang
摘要： FIG. 1 is a perspective view of an outdoor lamp showing our new design.
FIG. 2 is a front elevation view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a left side elevation view thereof;
FIG. 5 is a right side elevation view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.

6. 发明申请

US20220110303A1 APPARATUS AND METHODS FOR EXPANDING AND COLLAPSING A ROD 有权
公开(公告)号：US20220110303A1
公开(公告)日：2022-04-14
申请号：US17067711
申请日：2020-10-11
申请人： Wei Zhang
发明人： Wei Zhang
IPC分类号： A01K87/02
摘要： Methods and apparatus for expanding a rod from a collapsed position to a formed position are disclosed. One such apparatus includes a plurality of segments for forming the body of the collapsible rod including with each segment coupled to each immediately adjacent segment of the plurality of segments. The apparatus may include a coupler for coupling each segment of the plurality of segments to each immediately adjacent segment of the plurality of segments. The coupler may stretch from a base segment to the tip of the apparatus and may be biased to apply a force to hold the plurality of segments in a formed position and to urge the plurality of segments into a formed position from a collapsed position. In the formed position, the plurality of segments may be aligned end-to-end to form a rod and in the collapsed position, the plurality of segments may be folded against each other such that cylindrical walls of each of the plurality of segments are positioned adjacent each other.

7. 发明申请

US20180295974A1 Convertible Bullet-proof Backpack 审中-公开
公开(公告)号：US20180295974A1
公开(公告)日：2018-10-18
申请号：US15731045
申请日：2017-04-12
申请人： Wei Zhang
发明人： Wei Zhang
IPC分类号： A45F4/02 , F41H1/02 , A45C15/00 , F41H5/08
CPC分类号： A45F4/02 , A45C3/001 , A45C7/0068 , A45C13/103 , A45C15/00 , A45F3/04 , A45F3/06 , F41H1/00 , F41H1/02 , F41H5/00 , F41H5/08
摘要： A convertible bullet-proof backpack and vest includes a body section divided into a front portion, a middle portion, and back portion. The middle portion has a head slot opening, and the front and back portions have respective sections of bullet-proof fabric integrated therein. A zipper runs around an outer perimeter of the front and back portions. In a backpack configuration, the front portion and the back portion fold toward each other and the zipper secures the outer perimeters of the front portion and the back portion together thereby forming a hollow backpack interior between them. In a bullet-proof vest configuration, the zipper is unzipped thereby allowing a user to insert their head through the head slot opening such that the front portion hangs in front of a torso of the user and the back portion hangs behind the torso of the user.

8. 发明申请

US20180177625A1 APPARATUS AND METHOD FOR TREATING MALE IMPOTENCE 审中-公开
公开(公告)号：US20180177625A1
公开(公告)日：2018-06-28
申请号：US15820401
申请日：2017-11-21
申请人： Wei Zhang
发明人： Wei Zhang
IPC分类号： A61F5/41
CPC分类号： A61F5/41 , A61F2005/411
摘要： The present invention strategically utilizes the sturdiness of thin wires enwrapped inside a thick layer of soft material such as silicone rubber which is smoother and softer than human tissue. Therefore, the device doesn't cause any damage or side effect and feels comfortable to user. The exposure of skin is 90% or higher, therefore solves the lack of sensation issue faced by prior art devices. The device is hard and yet flexible, the side walls or double bars are positioned toward ventral side of the device so that it is pleasing to the eye during use in addition to feeling good by the user.

9. 发明授权

US09574001B2 Humanized single-chain antibody against beta 3 integrin for the treatment and prevention of metastasis 有权
标题翻译：针对β3整联蛋白的人源化单链抗体用于治疗和预防转移
公开(公告)号：US09574001B2
公开(公告)日：2017-02-21
申请号：US13958145
申请日：2013-08-02
申请人： Thomas M. Wisniewski , Wei Zhang , Suying Dang
发明人： Thomas M. Wisniewski , Wei Zhang , Suying Dang
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2848 , A61K2039/505 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to methods inhibiting tumor metastasis and treating cancer in a subject that involve administering to the subject an antibody which recognizes GPIIIa49-66, under conditions effective to inhibit tumor metastasis and/or treat cancer in the subject.
摘要翻译：本发明涉及在受试者中抑制肿瘤转移和治疗癌症的方法，所述方法包括在有效抑制肿瘤转移和/或治疗受试者的癌症的条件下向受试者施用识别GPIIIa49-66的抗体。

10. 发明授权

US09478746B2 Electron donor-fullerene conjugated molecules for organic photovoltaic cells 有权
标题翻译：用于有机光伏电池的电子供体 - 富勒烯共轭分子
公开(公告)号：US09478746B2
公开(公告)日：2016-10-25
申请号：US13911351
申请日：2013-06-06
申请人： Xiong Gong , Stephen Z. D. Cheng , Wei Zhang
发明人： Xiong Gong , Stephen Z. D. Cheng , Wei Zhang
IPC分类号： H01L51/00 , H01L51/42
CPC分类号： H01L51/0047 , H01L51/0037 , H01L51/0043 , H01L51/0077 , H01L51/4253 , H01L2251/308 , Y02E10/549
摘要： A photovoltaic cell has an active area formed electron donor-fullerene conjugated molecules. The electron donor is formed of a polymer, which is conjugated with an electron acceptor, such as fullerene. By conjugating the fullerene, such as C60, with electron donor moieties, such as that of the polymer, double channels are formed therebetween, whereby one channel provides hole transport and the other channel provides electron transport. As a result, the electronic coupling between the fullerene and the electron donor moiety leads to increased short-circuit current density (Jsc) and increased open-circuit voltage (Voc), resulting in high power conversion efficacy (PCE) in the solar cell.
摘要翻译：光伏电池具有形成的电子供体 - 富勒烯共轭分子的有源区。电子给体由与电子受体（例如富勒烯）共轭的聚合物形成。通过将诸如C60的富勒烯与诸如聚合物的电子供体部分共轭，在其间形成双通道，由此一个通道提供空穴传输，另一个通道提供电子传输。结果，富勒烯和电子给体部分之间的电子耦合导致短路电流密度（Jsc）增加和开路电压（Voc）增加，导致太阳能电池中的高功率转换效率（PCE）。

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