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1. 发明申请

US20070218003A1 Truncated Dance, Dance Complex And Method Of Using These 有权
标题翻译：截断的舞蹈，舞蹈复合体和使用这些的方法
公开(公告)号：US20070218003A1
公开(公告)日：2007-09-20
申请号：US10594339
申请日：2005-03-04
申请人： Tomoyuki Nakamura , Maretoshi Hirai
发明人： Tomoyuki Nakamura , Maretoshi Hirai
IPC分类号： C12N15/09 , A61K38/46 , A61K45/00 , A61K48/00 , A61P11/00 , A61P17/00 , A61P17/02 , C12P21/08 , C12Q1/37 , G01N33/556 , G01N33/53 , G01N33/50 , G01N33/15 , C12Q1/26 , C12N9/64 , A61P43/00 , A61P9/00 , A61P9/10 , C07K14/47 , C07K16/18
CPC分类号： C07K14/475 , A61K38/00 , C07K16/22 , G01N33/573
摘要： The present invention provides a screening method that enables the development of a pharmaceutical of a new mechanism of action allowing the regulation of the formation of elastic fibers, and various means necessary for the method. More specifically, the present invention provides a polypeptide obtained by cleaving DANCE and a polynucleotide that encodes the same; a method of cleaving DANCE; an antibody against a polypeptide obtained by cleaving DANCE; a method of measuring the amount of DANCE cleaved and a kit therefor; a DANCE mutant and a polynucleotide that encodes the same; various DANCE complexes and methods of preparing the same; a screening method for a substance capable of regulating the activity of DANCE or a DANCE-specific protease, and the substance obtained thereby; a regulator of the formation of elastic fibers; and a kit comprising at least DANCE and a polynucleotide that encodes the same, and the like.
摘要翻译：本发明提供一种筛选方法，其能够开发能够调节弹性纤维形成的新作用机理的药物以及该方法所需的各种手段。更具体地，本发明提供了通过切割DANCE和编码该多肽的多核苷酸获得的多肽; 一种切割DANCE的方法; 通过切割DANCE获得的针对多肽的抗体; 测量DANCE切割量的方法及其用途; DANCE突变体和编码它的多核苷酸; 各种DANCE复合物及其制备方法; 能够调节DANCE或DANCE特异性蛋白酶活性的物质的筛选方法及由此获得的物质; 形成弹性纤维的调节器; 和至少包含DANCE的试剂盒和编码该试剂的多核苷酸等。

2. 发明授权

US07906616B2 Truncated DANCE, DANCE complex and method of using these 有权
标题翻译：截断DANCE，DANCE复合体及其使用方法
公开(公告)号：US07906616B2
公开(公告)日：2011-03-15
申请号：US10594339
申请日：2005-03-04
申请人： Tomoyuki Nakamura , Maretoshi Hirai
发明人： Tomoyuki Nakamura , Maretoshi Hirai
IPC分类号： C07K14/00
CPC分类号： C07K14/475 , A61K38/00 , C07K16/22 , G01N33/573
摘要： A method of screening for a medicine capable of regulating generation of elastic fibrous tissue; and various means that are requisite for the method. In particular, the invention includes a polypeptide obtained by cleaving DANCE and a polynucleotide coding for the polypeptide; a method of cleaving DANCE; an antibody against the polypeptide obtained by cleaving DANCE; a method of measuring the amount of DANCE cleavage and a kit therefore; a DANCE variant and its polynucleotide; various DANCE complexes and a method of preparing such; a method of screening for a substance capable of regulating DANCE or a DANCE-specific protease, and a substance obtained by such screening method; an agent for regulating generation of elastic fibrous tissue; and a kit with DANCE and a polynucleotide coding for the same.
摘要翻译：一种筛选能够调节弹性纤维组织产生的药物的方法; 以及该方法所必需的各种手段。特别地，本发明包括通过切割DANCE而获得的多肽和编码该多肽的多核苷酸; 一种切割DANCE的方法; 通过切割DANCE获得的针对多肽的抗体; 因此测量DANCE切割量的一种方法; DANCE变体及其多核苷酸; 各种DANCE复合物及其制备方法; 筛选能够调节DANCE或DANCE特异性蛋白酶的物质的方法和通过该筛选方法获得的物质; 用于调节弹性纤维组织的产生的试剂; 以及带有DANCE的试剂盒和编码该试剂盒的多核苷酸。

3. 发明授权

US09074175B2 Method of regenerating elastic fiber with the use of dance or factor enhancing the expression thereof 有权
标题翻译：使用舞蹈或增强其表达的因子再生弹性纤维的方法
公开(公告)号：US09074175B2
公开(公告)日：2015-07-07
申请号：US11815690
申请日：2006-01-23
申请人： Tomoyuki Nakamura , Maretoshi Hirai
发明人： Tomoyuki Nakamura , Maretoshi Hirai
IPC分类号： C12N5/07 , C12N5/00 , A61L27/50 , A61L27/60 , C07K14/78
CPC分类号： C12N5/0031 , A61L27/507 , A61L27/60 , C07K14/78 , C12N5/0037 , C12N2501/15 , C12N2501/58 , C12N2501/998
摘要： The present invention provides a technique for conveniently and efficiently regenerating elastic fiber retaining a normal structure, and a technique enabling preparation of an artificial tissue comprising elastic fiber (for example, artificial skin, artificial blood vessels) that can be transplanted to humans. Specifically, the invention provides a method of producing elastic fiber, comprising culturing (for example, culturing in serum-free medium) cells having the capability of regenerating elastic fiber in the presence of DANCE and/or fibulin-4; artificial elastic fiber comprising DANCE and/or fibulin-4; an elastic fiber regenerating agent; a serum-free medium comprising DANCE and/or fibulin-4; and cells having the capability of regenerating elastic fiber, transfected with at least one of a DANCE expression vector, a fibulin-4 expression vector and a DANCE inducing factor expression vector, and the like.
摘要翻译：本发明提供一种方便有效地再生保持正常结构的弹性纤维的技术，以及能够制备能够移植到人体上的弹性纤维（例如人造皮肤，人造血管）的人造组织的技术。具体地说，本发明提供弹性纤维的制造方法，其特征在于，在DANCE和/或纤维蛋白-4的存在下，培养（例如培养无血清培养基）具有再生弹性纤维能力的细胞; 包含DANCE和/或纤维蛋白-4的人造弹性纤维; 弹性纤维再生剂; 包含DANCE和/或纤维蛋白-4的无血清培养基; 具有再生弹性纤维能力的细胞，用DANCE表达载体，纤维蛋白-4表达载体和DANCE诱导因子表达载体中的至少一种转染。

4. 发明申请

US20090012273A1 Method of Regenerating Elastic Fiber with the Use of Dance or Factor Enhancing the Expression Thereof 有权
标题翻译：使用舞蹈或增强其表达的因素再生弹性纤维的方法
公开(公告)号：US20090012273A1
公开(公告)日：2009-01-08
申请号：US11815690
申请日：2006-01-23
申请人： Tomoyuki Nakamura , Maretoshi Hirai
发明人： Tomoyuki Nakamura , Maretoshi Hirai
IPC分类号： C07K14/435 , C12N5/06 , C12P21/02
CPC分类号： C12N5/0031 , A61L27/507 , A61L27/60 , C07K14/78 , C12N5/0037 , C12N2501/15 , C12N2501/58 , C12N2501/998
摘要： The present invention provides a technique for conveniently and efficiently regenerating elastic fiber retaining a normal structure, and a technique enabling preparation of an artificial tissue comprising elastic fiber (for example, artificial skin, artificial blood vessels) that can be transplanted to humans. Specifically, the invention provides a method of producing elastic fiber, comprising culturing (for example, culturing in serum-free medium) cells having the capability of regenerating elastic fiber in the presence of DANCE and/or fibulin-4; artificial elastic fiber comprising DANCE and/or fibulin-4; an elastic fiber regenerating agent; a serum-free medium comprising DANCE and/or fibulin-4; and cells having the capability of regenerating elastic fiber, transfected with at least one of a DANCE expression vector, a fibulin-4 expression vector and a DANCE inducing factor expression vector, and the like.
摘要翻译：本发明提供一种方便有效地再生保持正常结构的弹性纤维的技术，以及能够制备能够移植到人体上的弹性纤维（例如人造皮肤，人造血管）的人造组织的技术。具体地说，本发明提供弹性纤维的制造方法，其特征在于，在DANCE和/或纤维蛋白-4的存在下，培养（例如培养无血清培养基）具有再生弹性纤维能力的细胞; 包含DANCE和/或纤维蛋白-4的人造弹性纤维; 弹性纤维再生剂; 包含DANCE和/或纤维蛋白-4的无血清培养基; 具有再生弹性纤维能力的细胞，用DANCE表达载体，纤维蛋白-4表达载体和DANCE诱导因子表达载体中的至少一种转染。

5. 发明申请

US20150088378A1 ROAD SURFACE CONDITION ESTIMATING APPARATUS 有权
标题翻译：道路表面条件估算装置
公开(公告)号：US20150088378A1
公开(公告)日：2015-03-26
申请号：US14388158
申请日：2012-03-29
申请人： Haruhiko Sugai , Tomoyuki Nakamura
发明人： Haruhiko Sugai , Tomoyuki Nakamura
IPC分类号： B60G17/0165 , B60W40/06 , B60W10/22 , B60G17/018
CPC分类号： B60G17/0165 , B60G17/018 , B60G17/0182 , B60G2400/82 , B60G2400/821 , B60G2401/142 , B60G2500/10 , B60G2500/20 , B60W10/22 , B60W40/06 , B60W2420/42
摘要： A camera takes an image or images of a region including a vehicle (vehicle-in-front) running in front of a driver's own vehicle. A wheel information acquiring unit acquires the positional information of a wheel or wheels of the vehicle-in-front in the image taken by the camera. More specifically, the boundary between the wheels of the vehicle-in-front and the road surface. The processing for detecting the boundary is done by use of the difference in the brightness between the wheels and the road surface of the vehicle-in-front. A camera attitude correcting unit corrects the detected boundary by use of a self-calibration function, and a road surface condition estimating unit estimates the conditions of the road surface on which the vehicle-in-front is traveling.
摘要翻译：相机拍摄包括在驾驶员本身的车辆前方行驶的车辆（车前）的区域的图像或图像。轮信息获取单元获取由相机拍摄的图像中的前方车辆的车轮或车轮的位置信息。更具体地说，前后车轮与路面之间的边界。用于检测边界的处理通过使用车轮与前方车辆的路面之间的亮度的差异来完成。相机姿态校正单元通过使用自校准功能校正检测到的边界，并且路面状态估计单元估计前方行驶的路面的状况。

6. 发明授权

US08395882B2 Dielectric ceramic and multilayer ceramic capacitor 有权
标题翻译：介质陶瓷和多层陶瓷电容器
公开(公告)号：US08395882B2
公开(公告)日：2013-03-12
申请号：US12844040
申请日：2010-07-27
申请人： Hironori Suzuki , Hideyasu Onishi , Kazuo Muto , Tomoyuki Nakamura
发明人： Hironori Suzuki , Hideyasu Onishi , Kazuo Muto , Tomoyuki Nakamura
IPC分类号： H01G4/06 , C04B35/00
CPC分类号： C04B35/468 , C04B35/49 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3262 , C04B2235/3281 , C04B2235/3418 , C04B2235/6025 , C04B2235/652 , C04B2235/6582 , C04B2235/6584 , C04B2235/6588 , C04B2235/761 , H01B3/12 , H01G4/1227 , H01G4/30 , Y10T156/10
摘要： In a dielectric ceramic having crystal grains and containing a perovskite in which the A site contains Ba and the B site contains Ti. as a main component, the crystal orientations are aligned in substantially the same direction within the crystal grains. Some of Ba may be replaced with Ca and/or Sr, and some of Ti may be replaced with Zr and/pr Hf. This achieves a dielectric ceramic which has a high dielectric constant and has favorable AC electric field characteristics in which the change in dielectric constant is small even with changes in applied electric field.
摘要翻译：在具有晶粒并含有A位置含有Ba且B位含有Ti的钙钛矿的电介质陶瓷中。作为主要成分，晶体取向在晶粒内基本相同的方向排列。一些Ba可以被Ca和/或Sr替代，并且一些Ti可以被Zr和/ pr Hf替代。这实现了具有高介电常数并且具有良好的AC电场特性的介电陶瓷，其中即使施加电场的变化，介电常数的变化也很小。

7. 发明申请

US20130059710A1 HEAT SEAL BAR MOUNTING APPARATUS OF PLASTIC BAG MAKING MACHINE 有权
标题翻译：塑料袋制袋机热密封条安装装置
公开(公告)号：US20130059710A1
公开(公告)日：2013-03-07
申请号：US13590519
申请日：2012-08-21
申请人： Mikio Totani , Tomoyuki Nakamura
发明人： Mikio Totani , Tomoyuki Nakamura
IPC分类号： B31B1/64
CPC分类号： B29C65/18 , B29C66/43 , B29C66/8122 , B29C66/81264 , B29C66/8167 , B29C66/81821 , B29C66/8511 , F16B21/09 , B29K2905/02
摘要： It is intended to mount and remove the heat seal bar 2 without difficulty. A receiving recess 7 formed in the heat seal bar 2 while an insert 8 is received in and fixed to the receiving recess 7. A tension pin 16 is supported by the heater unit 1, inserted into the adjacent recess 11 and then inserted into the axial groove 9 through the axial opening 10. An actuator is provided at the heater unit 1, the tension pin 16 being pulled and moved axially thereof by the actuator 19 so that the head 17 should be engaged with the inward protrusion 18. The tension pin 16 and the insert 8 cooperate with each other to mount the heat seal bar 2 on the heater unit 1.
摘要翻译：旨在不用困难地安装和移除热封条2。形成在热封条2中的接收凹部7，同时插入件8被接收并固定到容纳凹槽7中。张紧销16由加热器单元1支撑，插入相邻的凹部11中，然后插入到轴向凹槽9通过轴向开口10.致动器设置在加热器单元1处，张紧销16被致动器19沿轴向拉动并移动，使得头部17应与向内突出部18接合。张紧销16 并且插入件8相互配合以将热封条2安装在加热器单元1上。

8. 发明授权

US08248754B2 Dielectric ceramic, method for producing dielectric ceramic, and monolithic ceramic capacitor 有权
标题翻译：电介质陶瓷，制造电介质陶瓷的方法和单片陶瓷电容器
公开(公告)号：US08248754B2
公开(公告)日：2012-08-21
申请号：US12540743
申请日：2009-08-13
申请人： Tomonori Muraki , Tomoyuki Nakamura , Makoto Matsuda , Hironori Suzuki , Takehisa Sasabayashi , Masayuki Ishihara , Akihiro Shiota
发明人： Tomonori Muraki , Tomoyuki Nakamura , Makoto Matsuda , Hironori Suzuki , Takehisa Sasabayashi , Masayuki Ishihara , Akihiro Shiota
IPC分类号： H01G4/06 , C04B35/00
CPC分类号： C04B35/4682 , B82Y30/00 , C04B2235/3203 , C04B2235/3206 , C04B2235/3208 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3229 , C04B2235/3239 , C04B2235/3262 , C04B2235/3418 , C04B2235/5445 , C04B2235/5454 , C04B2235/5481 , C04B2235/6582 , C04B2235/6584 , C04B2235/6588 , C04B2235/781 , C04B2235/784 , C04B2235/785 , C04B2235/79 , H01G4/1227 , H01G4/30 , Y10T29/435
摘要： A dielectric ceramic contains a barium titanate and Li. In the dielectric ceramic, the following inequalities are satisfied: 0.5≦e≦6.0, 0.06
摘要翻译：介电陶瓷含有钛酸钡和Li。在电介质陶瓷中，满足以下不等式：0.5＆nlE; e＆nlE; 6.0,0.06

9. 发明申请

US20120121965A1 SECONDARY BATTERY, BATTERY UNIT, AND BATTERY MODULE 有权
标题翻译：二次电池，电池组和电池模块
公开(公告)号：US20120121965A1
公开(公告)日：2012-05-17
申请号：US13293738
申请日：2011-11-10
申请人： Tetsuya Makino , Hiroshi Takabayashi , Tomoyuki Nakamura , Kunihiko Hayashi , Yosuke Konishi , Akira Sasaki , Akira Saito
发明人： Tetsuya Makino , Hiroshi Takabayashi , Tomoyuki Nakamura , Kunihiko Hayashi , Yosuke Konishi , Akira Sasaki , Akira Saito
IPC分类号： H01M2/06 , H01M2/10 , H01M4/64
CPC分类号： H01M2/22 , H01M4/70 , H01M2004/021 , H01M2220/30
摘要： There is provided a secondary battery including a battery device that has a thickness of 3 to 20 mm, and a battery discharge capacity of 3 to 50 Ah, and an exterior material that packages the battery device. The battery device includes a positive electrode that has a positive electrode current collector and a positive electrode active material layer, a negative electrode that has a negative electrode current collector and a negative electrode active material layer, a separator that is interposed between the positive electrode and the negative electrode that are alternately laminated, a positive electrode tab that is electrically connected to a positive electrode current collector exposed portion and is led-out to the outside of the exterior material, and a negative electrode tab that is electrically connected to a negative electrode current collector exposed portion and is led-out to the outside of the exterior material.
摘要翻译：提供一种二次电池，其包括厚度为3〜20mm，电池放电容量为3〜50Ah的电池装置以及封装电池装置的外部材料。电池装置包括具有正极集电体和正极活性物质层的正极，负极集电体和负极活性物质层的负极，夹在正极和正极活性物质层之间的隔膜交替层叠的负极，与正极集电体露出部分电连接并被引出到外部材料的外部的正极片，以及与负极电连接的负极片集电器露出部分，并被引出到外部材料的外部。

10. 发明申请

US20120033344A1 DIELECTRIC CERAMIC AND LAMINATED CERAMIC CAPACITOR 有权
标题翻译：电介质陶瓷和层压陶瓷电容器
公开(公告)号：US20120033344A1
公开(公告)日：2012-02-09
申请号：US13195147
申请日：2011-08-01
申请人： Tomoyuki Nakamura
发明人： Tomoyuki Nakamura
IPC分类号： H01G4/12 , C04B35/468
CPC分类号： H01G4/1227 , C04B35/4682 , C04B37/006 , C04B2235/3203 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3217 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3229 , C04B2235/3232 , C04B2235/3239 , C04B2235/3241 , C04B2235/3244 , C04B2235/3256 , C04B2235/3258 , C04B2235/3272 , C04B2235/3275 , C04B2235/3279 , C04B2235/3427 , C04B2237/123 , C04B2237/346
摘要： A dielectric ceramic and a laminated ceramic capacitor using the dielectric ceramic are achieved which provide favorable thermal shock resistance without damaging properties or characteristics such as dielectric properties, insulation properties, temperature characteristics, and characteristics in high temperature loading, even when the dielectric layers are reduced in thickness and the number of stacked layers increased. The dielectric ceramic contains, as its main constituent, a barium titanate based compound represented by the general formula ABO3, and a crystalline oxide containing Al, Mg, and Si is present as secondary phase grains in the dielectric ceramic.
摘要翻译：实现了使用电介质陶瓷的电介质陶瓷和层压陶瓷电容器，即使当电介质层减少时，其也提供良好的耐热冲击性而不损坏诸如介电性能，绝缘性能，温度特性和高温负载特性的特性或特性厚度和堆叠层数增加。电介质陶瓷作为其主要成分含有由通式ABO 3表示的钛酸钡系化合物，在电介质陶瓷中作为二相晶粒存在含有Al，Mg，Si的结晶性氧化物。

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