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1. 发明申请

US20100216788A1 FUSED HETEROCYCLIC COMPOUND 审中-公开
标题翻译：熔融杂环化合物
公开(公告)号：US20100216788A1
公开(公告)日：2010-08-26
申请号：US12095543
申请日：2006-12-01
申请人： Tomoyasu Ishikawa , Kazuhiro Miwa , Masaki Seto , Hiroshi Banno , Youichi Kawakita
发明人： Tomoyasu Ishikawa , Kazuhiro Miwa , Masaki Seto , Hiroshi Banno , Youichi Kawakita
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/519 , C07D413/14 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound represented by the formula: wherein R1a is a hydrogen atom, R2a is a C1-6 alkyl group substituted by a group represented by —NR6a—CO—(CH2)n—SO2— optionally halogenated C1-4 alkyl wherein n is an integer of 1 to 4, R6a is a hydrogen atom or a C1-4 alkyl group, and —(CH2)n— is optionally substituted by C1-4 alkyl, R3a is a hydrogen atom or a C1-6 alkyl group, R4a is a halogen atom or a C1-6 alkyl group, R5a is a halogen atom or a C1-6 alkyl group, and Xa is a hydrogen atom or a halogen atom, or a salt thereof. The compound of the present invention has a superior tyrosine kinase inhibitory action, is highly safe, and is sufficiently satisfactory as a pharmaceutical product.
摘要翻译：本发明提供由下式表示的化合物：其中R1a是氢原子，R2a是被-NR6a-CO-（CH2）n-SO2-代表的基团取代的C1-6烷基，任选被卤代的C 1-4烷基其中n为1〜4的整数，R6a为氢原子或C1-4烷基， - （CH2）n-为C1-4烷基，R3a为氢原子或C1-6烷基基团，R 4a是卤素原子或C 1-6烷基，R 5a是卤素原子或C 1-6烷基，X a是氢原子或卤素原子或其盐。本发明的化合物具有优异的酪氨酸激酶抑制作用，是高度安全的，并且作为药物产品足够令人满意。

2. 发明申请

US20100004238A1 FUSED HETEROCYCLIC COMPOUND 审中-公开
标题翻译：熔融杂环化合物
公开(公告)号：US20100004238A1
公开(公告)日：2010-01-07
申请号：US12518596
申请日：2007-12-11
申请人： Tomoyasu Ishikawa , Hiroshi Banno , Youichi Kawakita , Tomohiro Ohashi , Osamu Kurasawa
发明人： Tomoyasu Ishikawa , Hiroshi Banno , Youichi Kawakita , Tomohiro Ohashi , Osamu Kurasawa
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/519 , A61K31/4985
CPC分类号： C07D487/04
摘要： The present invention provides a fused heterocyclic compound having a tyrosine kinase inhibitory action, which is represented by the formula: wherein R1 is a hydrogen atom, a halogen atom, or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom; R2 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to each other to form an optionally substituted ring structure; R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to the carbon atom on ring A to form an optionally substituted ring structure; ring A is an optionally substituted benzene ring; and ring B is (i) an optionally substituted fused ring, or (ii) a pyridine ring having optionally substituted carbamoyl (the pyridine ring is optionally further substituted).
摘要翻译：本发明提供具有酪氨酸激酶抑制作用的稠合杂环化合物，其由下式表示：其中R1是氢原子，卤原子或经由碳原子，氮原子或氧键键合的任意取代的基团原子; R2是氢原子，或通过碳原子或硫原子键合的任选取代的基团，或者R 1和R 2，或R 2和R 3相互结合形成任选取代的环结构; R3是氢原子或任选取代的脂族烃基，或R3任选地键合到环A上的碳原子上以形成任选取代的环结构; 环A是任选取代的苯环; 和环B是（i）任选取代的稠合环，或（ii）具有任选取代的氨基甲酰基的吡啶环（吡啶环任选进一步被取代）。

3. 发明授权

US07507740B2 Fused heterocyclic compound 失效
标题翻译：稠合杂环化合物
公开(公告)号：US07507740B2
公开(公告)日：2009-03-24
申请号：US10592812
申请日：2005-06-01
申请人： Tomoyasu Ishikawa , Hiroshi Banno , Masaki Seto
发明人： Tomoyasu Ishikawa , Hiroshi Banno , Masaki Seto
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04 , C07D487/16
摘要： The present invention relates to a compound represented by the formula: wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1—, —O—, —S—, —SO—, —SO2— or —CHR3— wherein R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to A to form an optionally substituted ring structure, R1 is a hydrogen atom or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom, R2 is a hydrogen atom or optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to form an optionally substituted ring structure, or a salt thereof, and a tyrosine kinase inhibitor or an agent for the prophylaxis or treatment of cancer, which contains this compound or a prodrug thereof.
摘要翻译：本发明涉及由下式表示的化合物：其中W是C（R 1）或N，每个A是任选取代的芳基或杂芳基，X 1是-NR 3 -Y 1 - ， - O - ， - ，-SO-，-SO 2 - 或-CHR 3 - ，其中R 3是氢原子或任选取代的脂族烃基，或R 3任选地键合到A上以形成任选取代的环结构，R 1是氢原子或任选被取代的通过碳原子，氮原子或氧原子键合的基团，R 2是氢原子或经由碳原子或硫原子键合的任选取代的基团，或R 1和R 2，或R 2和R 3可任选地键合形成任选地取代的环结构或其盐，以及含有该化合物或其前药的酪氨酸激酶抑制剂或用于预防或治疗癌症的药剂。

4. 发明授权

US08178543B2 Bi- and tricyclic fused pyrimidines as tyrosine kinase inhibitors 失效
标题翻译：双 - 和三环稠合嘧啶作为酪氨酸激酶抑制剂
公开(公告)号：US08178543B2
公开(公告)日：2012-05-15
申请号：US12172631
申请日：2008-07-14
申请人： Tomoyasu Ishikawa , Hiroshi Banno , Masaki Seto
发明人： Tomoyasu Ishikawa , Hiroshi Banno , Masaki Seto
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , C07D487/16
摘要： The present invention relates to a compound represented by the formula: wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1—, —O—, —S—, —SO—, —SO2— or —CHR3— wherein R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to A to form an optionally substituted ring structure, R1 is a hydrogen atom or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom, R2 is a hydrogen atom or optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to form an optionally substituted ring structure, or a salt thereof, and a tyrosine kinase inhibitor or an agent for the prophylaxis or treatment of cancer, which contains this compound or a prodrug thereof.
摘要翻译：本发明涉及由下式表示的化合物：其中W是C（R 1）或N，每个A是任选取代的芳基或杂芳基，X 1是-NR 3 -Y 1 - ， - O - ， - ，-SO-，-SO 2 - 或-CHR 3 - ，其中R 3是氢原子或任选取代的脂族烃基，或R 3任选地键合到A上以形成任选取代的环结构，R 1是氢原子或任选被取代的通过碳原子，氮原子或氧原子键合的基团，R 2是氢原子或经由碳原子或硫原子键合的任选取代的基团，或R 1和R 2，或R 2和R 3可任选地键合形成任选地取代的环结构或其盐，以及含有该化合物或其前药的酪氨酸激酶抑制剂或用于预防或治疗癌症的药剂。

5. 发明申请

US20070244132A1 Fused Heterocyclic Compound 失效
标题翻译：熔融杂环化合物
公开(公告)号：US20070244132A1
公开(公告)日：2007-10-18
申请号：US10592812
申请日：2005-06-01
申请人： Tomoyasu Ishikawa , Takahiko Taniguchi , Hiroshi Banno , Masaki Seto
发明人： Tomoyasu Ishikawa , Takahiko Taniguchi , Hiroshi Banno , Masaki Seto
IPC分类号： A61K31/519 , A61K31/517 , A61P35/00 , A61P43/00 , C07D239/70
CPC分类号： C07D487/04 , C07D487/16
摘要： The present invention relates to a compound represented by the formula: wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1—, —O—, —S—, —SO—, —SO2— or —CHR3— wherein R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to A to form an optionally substituted ring structure, R1 is a hydrogen atom or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom, R2 is a hydrogen atom or optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to form an optionally substituted ring structure, or a salt thereof, and a tyrosine kinase inhibitor or an agent for the prophylaxis or treatment of cancer, which contains this compound or a prodrug thereof.
摘要翻译：本发明涉及由下式表示的化合物：其中W是C（R 1）或N，每个A是任选取代的芳基或杂芳基，X 1， -O - ， - S - ， - SO - ， - SO 2 - 或 - CHR 3 - 其中R 3是氢原子或任选取代的脂族烃基，或R 3任选地与A键合，形成任选取代的环结构，R 1是氢原子或经由碳原子，氮原子或氧原子键合的任选取代的基团，R 2是氢原子或通过碳原子或硫原子键合的任选取代的基团，或R 1和R 2，R 2，R 2和R 2， 3任选地键合以形成任选取代的环结构，或其盐，和酪氨酸激酶抑制剂或用于预防或治疗癌症的试剂，其含有该化合物或产物 g。

6. 发明授权

US08791803B2 Abnormality detection apparatus 有权
标题翻译：异常检测装置
公开(公告)号：US08791803B2
公开(公告)日：2014-07-29
申请号：US13112248
申请日：2011-05-20
申请人： Tomoyasu Ishikawa
发明人： Tomoyasu Ishikawa
IPC分类号： B60Q1/00
CPC分类号： G01M15/042 , G07C5/0816
摘要： An abnormality detection apparatus has: an abnormality detection portion that detects at least one of an abnormality of a vehicle and an abnormality of an in-vehicle device based on an output of the in-vehicle device that indicates a state of a vehicle; an environmental drive condition information obtaining portion that obtains information regarding an environmental drive condition that affects the output of the in-vehicle device; and an abnormality detection criteria changing portion that changes an abnormality detection criteria used by the abnormality detecting portion based on the environmental drive condition information obtained by the environmental drive condition information obtaining portion.
摘要翻译：异常检测装置具有：异常检测部，其基于表示车辆的状态的车载装置的输出，检测车辆的异常和车内装置的异常中的至少一个; 获取关于影响车载装置的输出的环境驱动条件的信息的环境驱动条件信息获取部; 以及异常检测基准变更部，其根据由环境驱动条件信息获取部获得的环境驱动条件信息，改变异常检测部所使用的异常检测标准。

7. 发明申请

US20100250061A1 VEHICLE CONTROL DEVICE 审中-公开
标题翻译：车辆控制装置
公开(公告)号：US20100250061A1
公开(公告)日：2010-09-30
申请号：US12741999
申请日：2009-01-15
申请人： Naoki Toyofuku , Tomoyasu Ishikawa
发明人： Naoki Toyofuku , Tomoyasu Ishikawa
IPC分类号： G06F7/00
CPC分类号： G07C5/085
摘要： A vehicle control device includes a control unit controlling an in-vehicle device and a status information acquisition unit acquiring status information of a vehicle and output the acquired status information to the control unit. In the vehicle control device, the control unit specifies a failure-cause-verification information to be used for verifying a cause of a failure from among the status information acquired by the status information acquisition unit, the failure-cause-verification information being specified by using a timing when a predetermined fail-safe control is started as a reference, the timing being determined based on the status information acquired by the status information acquisition unit, and the control unit stores the specified failure-cause-verification information in a predetermined storage medium.
摘要翻译：车辆控制装置包括控制车内装置的控制单元和获取车辆的状态信息的状态信息获取单元，并将所获取的状态信息输出到控制单元。在车辆控制装置中，控制单元从由状态信息获取单元获取的状态信息中指定用于验证故障原因的故障原因验证信息，故障原因验证信息由当以预定的故障安全控制开始作为参考的定时时，基于由状态信息获取单元获取的状态信息来确定定时，并且控制单元将指定的故障原因验证信息存储在预定存储器中。

8. 发明申请

US20090163563A1 Phorboxazole Compounds and Methods of Their Preparation 审中-公开
标题翻译： Phorboxazole化合物及其制备方法
公开(公告)号：US20090163563A1
公开(公告)日：2009-06-25
申请号：US12325706
申请日：2008-12-01
申请人： Thomas M. Razler , Amos B. Smith, III , Jeffrey P. Ciavarri , Tomoyasu Hirose , Tomoyasu Ishikawa
发明人： Thomas M. Razler , Amos B. Smith, III , Jeffrey P. Ciavarri , Tomoyasu Hirose , Tomoyasu Ishikawa
IPC分类号： A61K31/424 , C07D498/22 , C12N5/02
CPC分类号： C07D498/22
摘要： Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division.
摘要翻译：公开了新型的大分子内酯，其制备方法，含有这些化合物的药物组合物及其制药方法。在某些实施方案中，大分子内酯化合物尤其可用于治疗各种癌症，诱导恶性细胞凋亡或抑制癌细胞分裂。

9. 发明授权

US08260488B2 Abnormality analysis system for vehicle and abnormality analysis method for vehicle 失效
标题翻译：车辆异常分析方法车辆异常分析方法
公开(公告)号：US08260488B2
公开(公告)日：2012-09-04
申请号：US12543902
申请日：2009-08-19
申请人： Tomoyasu Ishikawa , Toshiyuki Abe
发明人： Tomoyasu Ishikawa , Toshiyuki Abe
IPC分类号： G01M17/00 , G06F7/00 , G06F19/00
CPC分类号： G07C5/085 , G07C5/008
摘要： When an abnormality of a vehicle is detected based on a vehicle state value that indicates the vehicle state, an abnormality analysis system for the vehicle estimates a cause of the abnormality. The abnormality analysis system includes: a factor identifying information extraction unit that extracts factor identifying information which is used to identify a factor of the abnormality based on the vehicle state value; a database that contains data groups which correspond to respective categories of the factor identifying information and which store causes of abnormalities and vehicle state values at the time of occurrence of the abnormalities; and an abnormality cause estimation unit that executes a process for estimating the cause of the abnormality of the vehicle with the use of the data group that corresponds to the category of the factor identifying information extracted by the factor identifying information extraction unit.
摘要翻译：当基于指示车辆状态的车辆状态值检测到车辆的异常时，车辆的异常分析系统估计异常的原因。异常分析系统包括：因子识别信息提取单元，其根据车辆状态值提取用于识别异常因子的因子识别信息; 数据库，其包含对应于因子识别信息的各个类别的数据组，并且在异常发生时存储异常原因和车辆状态值; 以及异常原因估计单元，其使用与由因子识别信息提取单元提取的因子识别信息的类别对应的数据组来执行用于估计车辆的异常原因的处理。

10. 发明授权

US07889072B2 Failure information detection device, failure information detection system, server, and failure information detection method 有权
标题翻译：故障信息检测装置，故障信息检测系统，服务器和故障信息检测方法
公开(公告)号：US07889072B2
公开(公告)日：2011-02-15
申请号：US12208681
申请日：2008-09-11
申请人： Tomoyasu Ishikawa
发明人： Tomoyasu Ishikawa
IPC分类号： G08B1/08 , B60Q1/00 , G06F19/00 , G06F11/30 , G01M17/00 , G01R31/00
CPC分类号： G01S7/529 , G01S7/52004
摘要： A failure information detection device that detects abnormality of a vehicle-mounted device that is mounted in a vehicle has: an attachment detection portion that detects whether a first component part has been attached to the vehicle; an abnormality detection portion that detects abnormality of a second component part that is disposed on the first component part; and an abnormality information discernment portion that discerns that abnormality information regarding the abnormality is not based on a failure of the vehicle-mounted device if the attachment detection portion detects that the first component part has not been attached to the vehicle.
摘要翻译：一种检测安装在车辆中的车载装置的异常的故障信息检测装置具有：检测第一部件是否已经安装在车辆上的附件检测部; 异常检测部，其检测配置在所述第一部件上的第二部件的异常; 以及异常信息识别部，其在所述附着检测部检测到所述第一部件未附接到所述车辆的情况下，识别出所述异常的异常信息不是基于所述车载装置的故障。

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