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1. 发明申请

US20140203186A1 CHARGED PARTICLE BEAM IRRADIATION SYSTEM AND OPERATING METHOD OF CHARGED PARTICLE BEAM IRRADIATION SYSTEM 有权
标题翻译：充电颗粒光束辐射系统和充电颗粒光束辐射系统的工作方法
公开(公告)号：US20140203186A1
公开(公告)日：2014-07-24
申请号：US14238068
申请日：2011-08-31
申请人： Tomohisa Iwamoto , Kunio Moriyama , Hideaki Nishiuchi , Hideaki Nihongi
发明人： Tomohisa Iwamoto , Kunio Moriyama , Hideaki Nishiuchi , Hideaki Nihongi
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61N5/1075 , A61N5/1079 , A61N2005/1087 , H05H7/12 , H05H13/04 , H05H2007/008 , H05H2007/046
摘要： A charged particle beam irradiation system in which the energy, Bragg peak, and irradiation depth of a charged particle beam, with which a patient is to be irradiated, can be checked in real time just before actual irradiation. Just before the actual irradiation, by providing a high-speed steering magnet with 100% current, a checking beam is intentionally hit into a beam damper. By using a dosimeter and a dose measuring device in front thereof, extraction beam intensity is measured. By using a multi-layer beam monitor, a dose distribution thereof is measured. Accordingly, just before the actual irradiation, the energy, Bragg peak, and irradiation depth of the charged particle beam, with which the patient is to be irradiated, can be checked accurately and in real time. When the beam has a desired dose distribution as a result of checking, continuously, extraction control is performed.
摘要翻译：可以在实际照射之前实时检查其中要照射患者的带电粒子束的能量，布拉格峰和照射深度的带电粒子束照射系统。在实际照射之前，通过提供具有100％电流的高速转向磁体，有意地将检查光束撞到光束阻尼器中。通过使用前面的剂量计和剂量测量装置，测量提取束强度。通过使用多层光束监视器，测量其剂量分布。因此，在实际照射之前，可以准确，实时地检查与患者照射的带电粒子束的能量，布拉格峰和照射深度。当光束作为检查结果具有期望的剂量分布时，连续地执行提取控制。

2. 发明授权

US09199094B2 Charged particle beam irradiation system and operating method of charged particle beam irradiation system 有权
标题翻译：带电粒子束照射系统和带电粒子束照射系统的操作方法
公开(公告)号：US09199094B2
公开(公告)日：2015-12-01
申请号：US14238068
申请日：2011-08-31
申请人： Tomohisa Iwamoto , Kunio Moriyama , Hideaki Nishiuchi , Hideaki Nihongi
发明人： Tomohisa Iwamoto , Kunio Moriyama , Hideaki Nishiuchi , Hideaki Nihongi
IPC分类号： A61N5/00 , A61N5/10 , H05H7/12 , H05H13/04 , H05H7/00 , H05H7/04
CPC分类号： A61N5/1067 , A61N5/1075 , A61N5/1079 , A61N2005/1087 , H05H7/12 , H05H13/04 , H05H2007/008 , H05H2007/046
摘要： A charged particle beam irradiation system in which the energy, Bragg peak, and irradiation depth of a charged particle beam, with which a patient is to be irradiated, can be checked in real time just before actual irradiation. Just before the actual irradiation, by providing a high-speed steering magnet with 100% current, a checking beam is intentionally hit into a beam damper. By using a dosimeter and a dose measuring device in front thereof, extraction beam intensity is measured. By using a multi-layer beam monitor, a dose distribution thereof is measured. Accordingly, just before the actual irradiation, the energy, Bragg peak, and irradiation depth of the charged particle beam, with which the patient is to be irradiated, can be checked accurately and in real time. When the beam has a desired dose distribution as a result of checking, continuously, extraction control is performed.
摘要翻译：可以在实际照射之前实时检查其中要照射患者的带电粒子束的能量，布拉格峰和照射深度的带电粒子束照射系统。在实际照射之前，通过提供具有100％电流的高速转向磁体，有意地将检查光束撞到光束阻尼器中。通过使用前面的剂量计和剂量测量装置，测量提取束强度。通过使用多层光束监视器，测量其剂量分布。因此，在实际照射之前，可以准确，实时地检查与患者照射的带电粒子束的能量，布拉格峰和照射深度。当光束作为检查结果具有期望的剂量分布时，连续地执行提取控制。

3. 发明申请

US20090184263A1 Charged Particle Beam Irradiation System 有权
标题翻译：带电粒子束照射系统
公开(公告)号：US20090184263A1
公开(公告)日：2009-07-23
申请号：US12336592
申请日：2008-12-17
申请人： Kunio Moriyama , Takahide Nakayama , Hideaki Nishiuchi
发明人： Kunio Moriyama , Takahide Nakayama , Hideaki Nishiuchi
IPC分类号： A61N5/00
CPC分类号： H05H7/04 , A61N5/1077 , A61N2005/1087 , H05H2007/046
摘要： A charged particle beam irradiation system comprises a high-speed steerer (beam dump device) 100 disposed in a course of a beam transport line 4 through which an ion beam is extracted from a charged-particle beam generator 1. The beam dump device 100 is provided with dose monitoring devices 105, 106 for measuring a dose of an ion beam applied to a beam dump 104 so that the intensity of the ion beam can be measured without transporting the ion beam to irradiation nozzles 15A through 15D. Thus, the system is capable of adjusting the intensity of an ion beam extracted from a synchrotron without operating each component of a beam transport line, and an irradiation nozzle.
摘要翻译：带电粒子束照射系统包括设置在束输送线4的过程中的高速搅拌器（束流装置）100，通过该高速搅拌器离子束从带电粒子束发生器1中提取离子束。束流装置100是设置有用于测量施加到光束倾倒器104的离子束的剂量的剂量监测装置105,106，使得可以测量离子束的强度而不将离子束传送到照射喷嘴15A至15D。因此，该系统能够调节从同步加速器提取的离子束的强度，而不必操作光束输送线的每个部件和照射喷嘴。

4. 发明授权

US07875868B2 Charged particle beam irradiation system 有权
标题翻译：带电粒子束照射系统
公开(公告)号：US07875868B2
公开(公告)日：2011-01-25
申请号：US12336592
申请日：2008-12-17
申请人： Kunio Moriyama , Takahide Nakayama , Hideaki Nishiuchi
发明人： Kunio Moriyama , Takahide Nakayama , Hideaki Nishiuchi
IPC分类号： A61N5/00
CPC分类号： H05H7/04 , A61N5/1077 , A61N2005/1087 , H05H2007/046
摘要： A charged particle beam irradiation system comprises a high-speed steerer (beam dump device) 100 disposed in a course of a beam transport line 4 through which an ion beam is extracted from a charged-particle beam generator 1. The beam dump device 100 is provided with dose monitoring devices 105, 106 for measuring a dose of an ion beam applied to a beam dump 104 so that the intensity of the ion beam can be measured without transporting the ion beam to irradiation nozzles 15A through 15D. Thus, the system is capable of adjusting the intensity of an ion beam extracted from a synchrotron without operating each component of a beam transport line, and an irradiation nozzle.
摘要翻译：带电粒子束照射系统包括设置在束输送线4的过程中的高速搅拌器（束流装置）100，通过该高速搅拌器离子束从带电粒子束发生器1中提取离子束。束流装置100是设置有用于测量施加到光束倾倒器104的离子束的剂量的剂量监测装置105,106，使得可以测量离子束的强度而不将离子束传送到照射喷嘴15A至15D。因此，该系统能够调节从同步加速器提取的离子束的强度，而不必操作光束输送线的每个部件和照射喷嘴。

5. 发明授权

US07012267B2 Particle beam therapy system 有权
公开(公告)号：US07012267B2
公开(公告)日：2006-03-14
申请号：US10790850
申请日：2004-03-03
申请人： Kunio Moriyama , Akihiko Maeda , Yoshikatsu Yasue , Takahide Nakayama
发明人： Kunio Moriyama , Akihiko Maeda , Yoshikatsu Yasue , Takahide Nakayama
IPC分类号： A61N5/10
CPC分类号： A61N5/1079 , A61N5/10 , A61N2005/1087
摘要： A first manual input device for inputting an irradiation ready state is provided in each treatment room or a control room formed corresponding to the treatment room. A safety device confirms that preparations for generation of an ion beam in an accelerator are completed and preparations for transport of the ion beam in a beam transport system for introducing the ion beam to an irradiation unit in the treatment room selected in response to a ready signal from the first manual input device are completed, followed by outputting ready information. A ready state display unit for displaying the ready information is provided. In the treatment room or the control room, a second manual input device is provided for inputting an irradiation start instruction when the ready information is displayed by the ready state display unit.

6. 发明授权

US08637837B2 Charged particle irradiation system and method for controlling the same 有权
标题翻译：带电粒子照射系统及其控制方法
公开(公告)号：US08637837B2
公开(公告)日：2014-01-28
申请号：US12892225
申请日：2010-09-28
申请人： Takayoshi Natori , Kunio Moriyama , Koji Matsuda
发明人： Takayoshi Natori , Kunio Moriyama , Koji Matsuda
IPC分类号： G21G5/00
CPC分类号： A61N5/1048 , A61N5/1037 , A61N5/1043 , A61N5/1064 , A61N2005/1087
摘要： A beam extraction process (interruption and restart) is appropriately performed when a failure occurs during irradiation of a spot group. A charged particle irradiation system includes a synchrotron 12 and a scanning irradiation unit 15 that scans an ion beam extracted from the synchrotron over a subject. The extraction of the ion beam from the synchrotron is stopped on the basis of a beam extraction stop command. Scanning magnets 5A and 5B are controlled to change a point (spot) to be irradiated with the ion beam, while the extraction of the ion beam is stopped. The extraction of the ion beam from the synchrotron is restarted after the change of the spot to be irradiated. When a relatively minor failure in which continuous irradiation would be possible occurs during irradiation of a certain spot with the beam, the extraction of the beam is not immediately stopped.
摘要翻译：当点组的照射期间发生故障时，适当地执行光束提取处理（中断和重新启动）。带电粒子照射系统包括同步加速器12和扫描照射单元15，扫描照射单元15扫描从对象上的同步加速器提取的离子束。基于光束提取停止命令停止来自同步加速器的离子束的提取。在停止提取离子束的同时，控制扫描磁体5A和5B来改变要用离子束照射的点（点）。离子束从同步加速器的提取在被照射点改变后重新开始。当在用光束照射某一点时可能发生连续照射的相对较小的故障，则梁的提取不会立即停止。

7. 发明授权

US07709818B2 Particle beam irradiation apparatus and particle beam irradiation method 有权
标题翻译：粒子束照射装置和粒子束照射方法
公开(公告)号：US07709818B2
公开(公告)日：2010-05-04
申请号：US11239073
申请日：2005-09-30
申请人： Koji Matsuda , Kazuo Hiramoto , Kunio Moriyama
发明人： Koji Matsuda , Kazuo Hiramoto , Kunio Moriyama
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/1043 , A61N5/1079 , A61N2005/1074 , A61N2005/1087
摘要： To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes: a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.
摘要翻译：为了确保照射精度和安全性，即使使用采用不同的照射方式的照射装置，在此公开了一种带电粒子束照射被照射靶的带电粒子束照射装置，包括：带电粒子束发生器，用于产生带电粒子梁; 被动散射照射装置和扫描照射装置，用于向照射目标照射带电粒子束; 用于将从带电粒子束发生器提取的带电粒子束传送到两个照射装置中的一个的光束传输系统; 以及根据所选择的照射装置采用的照射方法修改带电粒子束发生器的工作参数的中央控制器。

8. 发明授权

US07692168B2 Device and method for outputting charged particle beam 有权
标题翻译：用于输出带电粒子束的装置和方法
公开(公告)号：US07692168B2
公开(公告)日：2010-04-06
申请号：US11774085
申请日：2007-07-06
申请人： Kunio Moriyama , Noriaki Ouchi , Masahiro Tadokoro , Hisataka Fujimaki
发明人： Kunio Moriyama , Noriaki Ouchi , Masahiro Tadokoro , Hisataka Fujimaki
IPC分类号： A61N5/10
CPC分类号： H05H7/12 , A61N5/1048 , A61N2005/1087
摘要： The present invention improves the accuracy of therapy by checking in real time whether an spread-out Bragg peak (SOBP) width agrees with a desired width during irradiation with a beam. The device for outputting a charged particle beam includes a charged particle beam generator 1 including a synchrotron 4; a range modulation device such as a range modulation wheel (RMW) 28 which forms a Bragg peak of an ion beam extracted from this charged particle beam generator 1; an irradiation device 16 which is located in the direction of ion beam propagation of this RMW device 28 and includes a dose monitor 31 for detecting a dose of the ion beam; and an SOBP width calculation device 73 which calculates ion beam Bragg peak formed by the RMW device 28 based on a detection value of the dose monitor 31.
摘要翻译：本发明通过实时检查展开的布拉格峰（SOBP）宽度是否与用束照射期间的期望宽度一致而提高了治疗的准确性。用于输出带电粒子束的装置包括：包括同步加速器4的带电粒子束发生器1; 范围调制装置，例如形成从该带电粒子束发生器1提取的离子束的布拉格峰的范围调制轮（RMW）28; 照射装置16，其位于该RMW装置28的离子束传播方向上，并包括用于检测离子束剂量的剂量监测器31; 以及SOBP宽度计算装置73，其基于剂量监视器31的检测值计算由RMW装置28形成的离子束布拉格峰。

9. 发明申请

US20060022152A1 Particle beam therapy system and control system for particle beam therapy 审中-公开
标题翻译：粒子束治疗系统和粒子束治疗控制系统
公开(公告)号：US20060022152A1
公开(公告)日：2006-02-02
申请号：US11188642
申请日：2005-07-26
申请人： Takayoshi Natori , Kunio Moriyama , Kazumune Sakai , Takahide Nakayama
发明人： Takayoshi Natori , Kunio Moriyama , Kazumune Sakai , Takahide Nakayama
IPC分类号： G21G4/00
CPC分类号： A61N5/1079 , A61N5/10 , A61N2005/1087
摘要： A particle beam therapy system comprises a charged particle beam generator for generating a charged particle beam, two or more treatment rooms provided with respective irradiation devices for irradiating the charged particle beam, a beam line for transporting the charged particle beam extracted from the charged particle beam generator to the irradiation device in selected one of the two or more treatment rooms, a beam detection processing/control unit for monitoring a beam state of the charged particle beam in one of the two or more irradiation devices, and a selector for switchably selecting one of the irradiation devices which is to be monitored by the beam detection processing/control unit. The selector is controlled such that the selector establishes connection with the irradiation device in the selected one treatment room to which the charged particle beam is transported through the beam line. The system configuration can be simplified while maintaining the operation efficiency.
摘要翻译：粒子束治疗系统包括用于产生带电粒子束的带电粒子束发生器，设置有用于照射带电粒子束的各个照射装置的两个或更多个治疗室，用于输送从带电粒子束提取的带电粒子束的束线发生器到两个或更多个处理室中选定的一个中的照射装置;用于监测两个或更多个照射装置之一中的带电粒子束的束状态的光束检测处理/控制单元，以及用于可选择地选择一个由光束检测处理/控制单元监视的照射装置。控制选择器使得选择器与所选择的一个处理室中的照射装置建立连接，通过束线将带电粒子束传送到该处理室。可以简化系统配置，同时保持运行效率。

10. 发明授权

US07397054B2 Particle beam therapy system and control system for particle beam therapy 有权
标题翻译：粒子束治疗系统和粒子束治疗控制系统
公开(公告)号：US07397054B2
公开(公告)日：2008-07-08
申请号：US11602489
申请日：2006-11-21
申请人： Takayoshi Natori , Kunio Moriyama , Kazumune Sakai , Takahide Nakayama
发明人： Takayoshi Natori , Kunio Moriyama , Kazumune Sakai , Takahide Nakayama
IPC分类号： A61N5/00 , A61N5/10 , G21G1/00
CPC分类号： A61N5/1079 , A61N5/10 , A61N2005/1087
摘要： A particle beam therapy system comprises a charged particle beam generator for generating a charged particle beam, two or more treatment rooms provided with respective irradiation devices for irradiating the charged particle beam, a beam line for transporting the charged particle beam extracted from the charged particle beam generator to the irradiation device in selected one of the two or more treatment rooms, a beam detection processing/control unit for monitoring a beam state of the charged particle beam in one of the two or more irradiation devices, and a selector for switchably selecting one of the irradiation devices which is to be monitored by the beam detection processing/control unit. The selector is controlled such that the selector establishes connection with the irradiation device in the selected one treatment room to which the charged particle beam is transported through the beam line. The system configuration can be simplified while maintaining the operation efficiency.
摘要翻译：粒子束治疗系统包括用于产生带电粒子束的带电粒子束发生器，设置有用于照射带电粒子束的各个照射装置的两个或更多个治疗室，用于输送从带电粒子束提取的带电粒子束的束线发生器到两个或更多个处理室中选定的一个中的照射装置;用于监测两个或更多个照射装置之一中的带电粒子束的束状态的光束检测处理/控制单元，以及用于可选择地选择一个由光束检测处理/控制单元监视的照射装置。控制选择器使得选择器与所选择的一个处理室中的照射装置建立连接，通过束线将带电粒子束传送到该处理室。可以简化系统配置，同时保持运行效率。

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