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1. 发明授权

US07025985B2 Dihydroxyphenyl compounds and glucoside compounds thereof 有权
标题翻译：二羟基苯基化合物及其葡糖苷化合物
公开(公告)号：US07025985B2
公开(公告)日：2006-04-11
申请号：US09946933
申请日：2001-09-05
申请人： Tomohiro Yokota , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
发明人： Tomohiro Yokota , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
IPC分类号： A61K47/00 , A61K31/19 , A61K31/70
CPC分类号： A23G3/36 , A23G4/06 , A23L33/10 , A23L33/30 , A61K8/347 , A61K8/60 , A61K8/602 , A61K31/05 , A61K31/12 , A61K31/7028 , A61Q19/02 , A61Q19/06 , C07H15/203
摘要： The present invention is a compound represented by the following formula (1) or (2): where one of R1 and R2 is hydrogen and the other one is hydrogen or glucose residue. The compound is effective for reforming obese constitution, suppressing or preventing obesity. It is also effective for skin whitening.
摘要翻译：本发明是由下式（1）或（2）表示的化合物：其中R 1和R 2中的一个是氢，另一个是氢或葡萄糖残渣。该化合物对于改变肥胖构成，抑制或预防肥胖有效。它也对皮肤美白有效。

2. 发明申请

US20090124561A1 DIHYDROXYPHENYL COMPOUNDS AND GLUCOSIDE COMPOUNDS THEREOF 有权
标题翻译：二羟基苯酚化合物及其葡糖苷化合物
公开(公告)号：US20090124561A1
公开(公告)日：2009-05-14
申请号：US12348849
申请日：2009-01-05
申请人： Tomohiro YOKOTA , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
发明人： Tomohiro YOKOTA , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
IPC分类号： A61K31/12 , A61K31/7004 , A61P17/00
CPC分类号： A23G3/36 , A23G4/06 , A23L33/10 , A23L33/30 , A61K8/347 , A61K8/60 , A61K8/602 , A61K31/05 , A61K31/12 , A61K31/7028 , A61Q19/02 , A61Q19/06 , C07H15/203
摘要： A skin cosmetic composition comprising the compound represented by the following formula (1): wherein R1 is hydrogen and R2 is hydrogen or glucose residue.
摘要翻译：一种皮肤化妆品组合物，其包含由下式（1）表示的化合物：其中R1是氢，R2是氢或葡萄糖残基。

3. 发明授权

US07879347B2 Dihydroxyphenyl compounds and glucoside compounds thereof 有权
标题翻译：二羟基苯基化合物及其葡糖苷化合物
公开(公告)号：US07879347B2
公开(公告)日：2011-02-01
申请号：US12348849
申请日：2009-01-05
申请人： Tomohiro Yokota , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
发明人： Tomohiro Yokota , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
IPC分类号： A61K8/02 , A61K31/19 , A61K31/70 , A01N37/10 , A01N43/04
CPC分类号： A23G3/36 , A23G4/06 , A23L33/10 , A23L33/30 , A61K8/347 , A61K8/60 , A61K8/602 , A61K31/05 , A61K31/12 , A61K31/7028 , A61Q19/02 , A61Q19/06 , C07H15/203
摘要： A skin cosmetic composition comprising the compound represented by the following formula (1): wherein R1 is hydrogen and R2 is hydrogen or glucose residue.
摘要翻译：一种皮肤化妆品组合物，其包含由下式（1）表示的化合物：其中R1是氢，R2是氢或葡萄糖残基。

4. 发明申请

US20060120978A1 Dihydroxyphenyl compounds and glucoside compounds thereof 审中-公开
标题翻译：二羟基苯基化合物及其葡糖苷化合物
公开(公告)号：US20060120978A1
公开(公告)日：2006-06-08
申请号：US11274565
申请日：2005-11-14
申请人： Tomohiro Yokota , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
发明人： Tomohiro Yokota , Shunsuke Yamazaki , Hiroko Nakatsugawa , Takeshi Ikemoto , Mariko Hara , Shintaro Inoue
IPC分类号： A61K8/60 , A61K8/35
CPC分类号： A23G3/36 , A23G4/06 , A23L33/10 , A23L33/30 , A61K8/347 , A61K8/60 , A61K8/602 , A61K31/05 , A61K31/12 , A61K31/7028 , A61Q19/02 , A61Q19/06 , C07H15/203
摘要： A skin cosmetic composition comprising the compound represented by the following formula (1): wherein R1 is hydrogen and R2 is hydrogen or glucose residue.
摘要翻译：一种皮肤化妆品组合物，其包含由下式（1）表示的化合物：其中R 1是氢，R 2是氢或葡萄糖残基。

5. 发明授权

US06686396B2 Noxious-insect repellent 失效
标题翻译：有害驱虫剂
公开(公告)号：US06686396B2
公开(公告)日：2004-02-03
申请号：US10057018
申请日：2002-01-24
申请人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
发明人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
IPC分类号： A01N3506
CPC分类号： A01N35/06 , A01N31/06 , Y10S424/10 , Y10S514/919 , A01N2300/00
摘要： Disclosed is a method of repelling noxious insects comprising the step of exposing said noxious insects to a composition containing from 0.1 to 90 wt. %, based on the total weight of the composition, of at least one of 2-(1-hydroxyalkyl) cycloalkanones represented by the following formula 11: wherein n is an integer of 3-10, R1 is hydrogen or a straight-chain saturated hydrocarbon radical having 1-6 carbon atoms; R2 is hydrogen or methyl group and Rm′ represents m′ of the same or different, straight-chain or branched, saturated or unsaturated, hydrocarbon radicals R which, as a substituent group, can be bonded to carbocyclic atoms; m′ is an integer of 0-8, provided that m′ should be at least 2 when n is at least 4 and both the R1and R2 are alkyl groups; the sum of the carbon atoms of Rm′ does not exceed 12; and, further, when n is 4, R may be an isopropylidene group which intramolecularly bridges between the third and sixth carbocyclic atoms.
摘要翻译：公开了一种排斥有害昆虫的方法，包括将所述有害昆虫暴露于含有0.1-90重量％％，基于组合物的总重量，由下式11表示的2-（1-羟基烷基）环烷酮中的至少一种：其中n为3-10的整数，R1为氢或直链饱和具有1-6个碳原子的烃基; R2是氢或甲基，Rm'表示相同或不同的直链或支链饱和或不饱和的烃基R的m'，其作为取代基可以键合到碳环原子上; m'为0-8的整数，条件是当n至少为4时m'至少为2，R 1和R 2均为烷基; Rm'的碳原子总数不超过12; 此外，当n为4时，R可以是在第三和第六碳环原子之间分子内桥接的异亚丙基。

6. 发明授权

US6130255A Noxious-insect repellent 失效
标题翻译：有害驱虫剂
公开(公告)号：US6130255A
公开(公告)日：2000-10-10
申请号：US635926
申请日：1996-11-06
申请人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
发明人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
IPC分类号： A01N31/06 , A01N35/06 , A01N31/04
CPC分类号： A01N35/06 , A01N31/06 , Y10S424/10 , Y10S514/919
摘要： Disclosed is a method of repelling noxious insects comprising the step of exposing said noxious insects to a composition containing from 0.1 to 90 wt. %, based on the total weight of the composition, of at least one of 2-(1-hydroxyalkyl)-cycloalkanols represented by the following formulae (2), (7) and (8): ##STR1## wherein R.sup.3 and R.sup.4 are independently a straight-chain or branched, saturated or unsaturated, hydrocarbon radical having 1-8 carbon atoms.
摘要翻译： PCT No.PCT / JP94 / 00885 Sec。 371日期：1996年11月6日 102（e）日期1996年11月6日PCT 1994年6月1日PCT被公开是一种排斥有害昆虫的方法，包括将所述有害昆虫暴露于含有0.1-90重量％基于组合物的总重量，由下式（2），（7）和（8）表示的2-（1-羟基烷基） - 环烷醇中的至少一种：其中R3和R4独立地为直链具有1-8个碳原子的链或支链，饱和或不饱和的烃基。

7. 发明授权

US06576247B1 Sustained-release aromatic and method of detecting micro-organism by using the same 有权
标题翻译：持续释放芳香剂及其使用方法检测微生物
公开(公告)号：US06576247B1
公开(公告)日：2003-06-10
申请号：US08849421
申请日：1999-03-08
申请人： Takeshi Ikemoto , Hiroko Nakatsugawa , Bun-ichi Okabe , Kazuo Ogino , Jun-ichi Matsui , Minoru Iwamoto , Akira Fujita , Masayoshi Inui
发明人： Takeshi Ikemoto , Hiroko Nakatsugawa , Bun-ichi Okabe , Kazuo Ogino , Jun-ichi Matsui , Minoru Iwamoto , Akira Fujita , Masayoshi Inui
IPC分类号： A61K700
CPC分类号： C12Q1/04 , A61K8/37 , A61K8/602 , A61K2800/57 , A61Q7/00 , A61Q13/00 , A61Q15/00
摘要： The present invention provides a sustained-release aromatic, characterized in that the aromatic comprises at least one perfume derivative as an active component selected from glycosides of perfumes, phosphoric acid ester derivatives of perfumes, amino acid derivatives of perfumes and carboxylic acid derivatives of perfumes, and contains no enzyme or acid which decomposes the perfume derivative, wherein the perfume derivative is decomposed by bacteria usually present on the skin or yeast to release a perfume component to exhibit aroma. The present invention also provides a method for the detection of micro-organisms using the aforesaid sustained-release aromatic. As the sustained-release aromatic of the present invention releases a perfume component only when it is decomposed by micro-organisms such as bacteria usually present on the skin or yeast, the amount of perfumes to be used can be extremely reduced. The sustained-release aromatic of the present invention is also excellent in keeping aroma. The stability with the passage of time of the sustained-release aromatic of the present invention is much better than that of the prior art because the perfume component is contained in the form of derivative. The sustained-release aromatic of the present invention is useful for applications on the skin, head skin or hair of human beings or animals, on clothes, or in drinks and foods, or as an indicator for detecting micro-organisms.
摘要翻译：本发明提供一种持续释放芳香族物质，其特征在于该芳香剂包含至少一种作为活性成分的香料衍生物，其选自香料糖苷，香料的磷酸酯衍生物，香料的氨基酸衍生物和香料的羧酸衍生物，并且不含有分解香料衍生物的酶或酸，其中香料衍生物由通常存在于皮肤或酵母上的细菌分解以释放香料组分以显示香味。本发明还提供了使用上述缓释芳香族物检测微生物的方法。作为本发明的持续释放性芳香族物质，只有当通过微生物如通常存在于皮肤或酵母上的细菌分解时才释放香料成分，所以可以极大地减少使用的香料量。本发明的持续释放芳香剂在保持香气的同时也是优异的。由于香料成分以衍生物形式包含，所以本发明的持续释放芳香族物质的稳定性比现有技术更好。本发明的持续释放的芳香剂可用于人或动物的皮肤，头皮或头发，衣服或饮料和食品中的应用，或用作检测微生物的指示剂。

8. 发明授权

US06531143B1 &agr;-hydroxy fatty acid derivatives and external compositions containing the same 有权
标题翻译： α-羟基脂肪酸衍生物和含有它们的外用组合物
公开(公告)号：US06531143B1
公开(公告)日：2003-03-11
申请号：US09701532
申请日：2000-11-28
申请人： Masafumi Yakumaru , Hiroko Nakatsugawa , Yoshiko Iwamoto , Takeshi Ikemoto
发明人： Masafumi Yakumaru , Hiroko Nakatsugawa , Yoshiko Iwamoto , Takeshi Ikemoto
IPC分类号： A01N3702
CPC分类号： A61K8/37 , A61K9/0014 , A61K47/14 , A61K2800/75 , A61Q1/06 , A61Q5/02 , A61Q19/00 , C07C69/675
摘要： An oily base, which has excellent stability, a low melting point and does not irritate the skin and an external composition which contains the oily base. The present invention is directed to an alpha-hydroxy fatty acid derivatives represented by the general formula (1): wherein R1 represents a straight-chain or branched alkyl group having 10 to 24 carbon atoms, R2 represents a straight-chain or branched alkyl group having 1 to 31 carbon atoms, and R3 represents a straight-chain or branched alkyl group having 11 to 31 carbon atoms, and an external composition contains at least one of the derivatives.
摘要翻译：油性基质，具有优异的稳定性，低熔点，不刺激皮肤，含有油性基质的外用组合物。本发明涉及由通式（1）表示的α-羟基脂肪酸衍生物：其中R1表示碳原子数为10〜24的直链或支链烷基，R2表示直链或支链烷基具有1至31个碳原子，R 3表示具有11至31个碳原子的直链或支链烷基，外部组合物含有至少一种衍生物。

9. 发明授权

US06677384B1 Noxious-insect repellent 失效
标题翻译：有害驱虫剂
公开(公告)号：US06677384B1
公开(公告)日：2004-01-13
申请号：US09492667
申请日：2000-01-27
申请人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
发明人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
IPC分类号： A01N3106
CPC分类号： A01N35/06 , A01N31/06 , Y10S424/10 , Y10S514/919 , A01N2300/00
摘要： Disclosed is a method of repelling noxious insects comprising the step of exposing said noxious insects to a composition containing from 0.1 to 90 wt. %, based on the total weight of the composition, of at least one of 2-(1-hydroxyalkyl)cycloalkanols represented by the following formulae (1), (5) and (6): wherein n is an integer of 3-10, R1 is hydrogen or a straight-chain saturated hydrocarbon radical having 1-6 carbon atoms; R2 is hydrogen or a methyl group; Rm represents m of the same or different, straight-chain or branched, saturated or unsaturated, hydrocarbon radicals R which, as a substituent group, can be bonded to carbocyclic atoms; m is an integer of 0-8, provided that m is at least one when either one of R1 or R2 is an alkyl group and m is at least 2 when both R1 and R2 are alkyl groups; the sum of the carbon atoms of Rm does not exceed 8, wherein when n is 4, R is optionally an isopropylidene group which intramolecularly bridges between the third and sixth carbocyclic atoms.
摘要翻译：公开了一种排斥有害昆虫的方法，包括将所述有害昆虫暴露于含有0.1-90重量％基于组合物的总重量的由下式（1），（5）和（6）表示的2-（1-羟基烷基）环烷醇中的至少一种：其中n是3-10的整数 R 1是氢或具有1-6个碳原子的直链饱和烃基; R 2是氢或甲基; Rm表示相同或不同的直链或支链的饱和或不饱和的烃基R的m，其作为取代基可以键合到碳环原子上; m为0-8的整数，条件是当R 1或R 2中的任一个为烷基时，m为至少一个，当R 1和R 2均为2时，m为至少2个是烷基; Rm的碳原子总数不超过8，其中当n为4时，R任选为在第三和第六碳环原子之间分子内桥接的异亚丙基。

10. 发明授权

US06372804B1 Noxious-insect repellent 失效
标题翻译：有害驱虫剂
公开(公告)号：US06372804B1
公开(公告)日：2002-04-16
申请号：US09492351
申请日：2000-01-27
申请人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
发明人： Takeshi Ikemoto , Hiroyuki Nishio , Hiroko Nakatsugawa
IPC分类号： A01N3106
CPC分类号： A01N35/06 , A01N31/06 , Y10S424/10 , Y10S514/919 , A01N2300/00
摘要： Disclosed is a method of repelling noxious insects comprising the step of exposing said noxious insects to a composition containing from 0.1 to 90 wt. %, based on the total weight of the composition, of at least one of 2-(1-hydroxyalkyl)cycloalkanols represented by the following formulae (9) and (10): wherein R4 is a straight-chain or branched, saturated or unsaturated, hydrocarbon radical having 1-8 carbon atoms and R5 and R6 are hydrogens or lower alkyl groups having at most 3 carbon atoms and the sum of the carbon atoms of R5 and R6 is 0-3.
摘要翻译：公开了一种排斥有害昆虫的方法，包括将所述有害昆虫暴露于含有0.1-90重量％基于组合物的总重量的由下式（9）和（10）表示的2-（1-羟基烷基）环烷醇中的至少一种：其中R 4是直链或支链，饱和或不饱和的具有1-8个碳原子的烃基和R 5和R 6是具有至多3个碳原子的氢或低级烷基，并且R 5和R 6的碳原子之和为0-3。

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