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1. 发明授权

US07652025B2 Remedies for sepsis 失效
标题翻译：败血症的治疗方法
公开(公告)号：US07652025B2
公开(公告)日：2010-01-26
申请号：US10477062
申请日：2002-05-08
申请人： Tomohiko Suzuki , Hideaki Inada , Yoshitaka Yoshizawa , Kuniaki Kawamura , Toshiaki Tanaka
发明人： Tomohiko Suzuki , Hideaki Inada , Yoshitaka Yoshizawa , Kuniaki Kawamura , Toshiaki Tanaka
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/40 , A61K31/485 , A61K38/00 , C07D489/08 , C07K5/1016
摘要： A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid κ receptor agonist compound such as (−)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid κ receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.
摘要翻译：公开了脓毒症和伴随脓毒症的各种症状的治疗剂（例如脓毒性休克，弥散性血管内凝血综合征，成人呼吸窘迫综合征和多器官功能障碍）。根据本发明的败血症治疗剂包括作为有效成分的阿片样物质κ受体激动剂化合物，例如（ - ） - 17-（环丙基甲基）-3,14β-二羟基-4,5α-环氧-6β-[N-甲基（3-呋喃基）丙烯酰胺]氧化物衍生物。阿片样物质κ受体激动剂化合物可以原样或以通过将化合物与已知的药学上可接受的酸，载体或载体口服或胃肠外混合制备的药物组合物的形式进行给药。

2. 发明申请

US20060094741A1 Remedies for neuropathic pain and model animals of neuropathic pain 有权
标题翻译：神经性疼痛和模型动物的神经性疼痛的补救措施
公开(公告)号：US20060094741A1
公开(公告)日：2006-05-04
申请号：US11206489
申请日：2005-08-18
申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
发明人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
IPC分类号： A61K31/4745 , A61K49/00 , C07D471/04
CPC分类号： A61K31/485 , A61K31/4745 , C07D489/08
摘要： The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要翻译：本发明涉及神经性疼痛治疗剂，其含有作为活性成分的通式（I）表示的化合物或其药理学上可接受的酸加成盐：（其中R 1，R 2， R 2，R 3，R 4，R 5，R 6，R 6， A +和B B具有与说明书中描述的那些相同的定义）和通过给予（+） - 4a-（3- 羟基苯基）-2-甲基-1,2,3,4,4a，5,12,12a-八氢 - 反 - 喹啉并[2,3-g]异喹啉。本发明使得可以进行神经性疼痛的药物治疗。也可以评价化合物对神经性疼痛的治疗作用。

3. 发明授权

US08637539B2 Remedies for neuropathic pain and model animals of neuropathic pain 有权
标题翻译：神经性疼痛和模型动物的神经性疼痛的补救措施
公开(公告)号：US08637539B2
公开(公告)日：2014-01-28
申请号：US11206489
申请日：2005-08-18
申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
发明人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/485 , A61K31/4745 , C07D489/08
摘要： The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要翻译：本发明涉及神经性疼痛治疗剂，其含有作为活性成分的通式（I）表示的化合物或其药理学上可接受的酸加成盐：（其中R1，R2，R3，R4，R5，R6， R7，R8，A和B具有与说明书中描述的定义相同的定义）和通过给予（+） - 4a-（3-羟基苯基）-2-甲基-1,2,3,4 ，4a，5,12,12a-八氢 - 反 - 喹啉并[2,3-g]异喹啉。本发明使得可以进行神经性疼痛的药物治疗。也可以评价化合物对神经性疼痛的治疗效果。

4. 发明申请

US20130310414A1 THERAPEUTIC OR PROPHYLACTIC AGENT FOR CACHEXIA 有权
标题翻译： CACHEXIA的治疗或预防剂
公开(公告)号：US20130310414A1
公开(公告)日：2013-11-21
申请号：US13982578
申请日：2012-01-30
申请人： Tomohiko Suzuki , Yoshitaka Yoshizawa , Mikito Hirakata
发明人： Tomohiko Suzuki , Yoshitaka Yoshizawa , Mikito Hirakata
IPC分类号： A61K31/485
CPC分类号： A61K31/485
摘要： A therapeutic or prophylactic agent for cachexia includes as an effective ingredient a compound having a specified morphinan skeleton represented by a compound of the following structure: or a pharmacologically acceptable acid addition salt thereof.
摘要翻译：用于恶病质的治疗或预防剂包括具有由以下结构的化合物表示的特定吗啡喃骨架的化合物作为有效成分：或其药理学上可接受的酸加成盐。

5. 发明授权

US09006262B2 Therapeutic or prophylactic agent for cachexia 有权
标题翻译：恶病质的治疗或预防剂
公开(公告)号：US09006262B2
公开(公告)日：2015-04-14
申请号：US13982578
申请日：2012-01-30
申请人： Tomohiko Suzuki , Yoshitaka Yoshizawa , Mikito Hirakata
发明人： Tomohiko Suzuki , Yoshitaka Yoshizawa , Mikito Hirakata
IPC分类号： A61K31/44 , A61K31/485
CPC分类号： A61K31/485
摘要： A therapeutic or prophylactic agent for cachexia includes as an effective ingredient a compound having a specified morphinan skeleton represented by a compound of the following structure: or a pharmacologically acceptable acid addition salt thereof.
摘要翻译：用于恶病质的治疗或预防剂包括具有由以下结构的化合物表示的特定吗啡喃骨架的化合物作为有效成分：或其药理学上可接受的酸加成盐。

6. 发明授权

US08725971B2 Storage apparatus and method for controlling storage apparatus involving snapshots 失效
标题翻译：用于控制涉及快照的存储装置的存储装置和方法
公开(公告)号：US08725971B2
公开(公告)日：2014-05-13
申请号：US13394045
申请日：2012-02-20
申请人： Yasuaki Nakamura , Tomohiko Suzuki , Tetsuya Abe , Akemi Sanada
发明人： Yasuaki Nakamura , Tomohiko Suzuki , Tetsuya Abe , Akemi Sanada
IPC分类号： G06F13/00
CPC分类号： G06F3/061 , G06F3/0653 , G06F3/0689 , G06F11/3409 , G06F11/3485
摘要： A drop in the access performance to a source volume is prevented by executing various control methods according to the snapshot usage method. A storage apparatus comprises one or more storage devices which provide storage areas; and a controller which creates a logical volume in the storage area provided by the one or more storage devices, and which reads and writes data from/to the logical volume according to a request from a host, wherein the controller acquires one or more snapshots which are data images at certain time points of the logical volume, wherein the controller determines whether the logical volume is subject to abrupt load fluctuations on the basis of performance information of the logical volume and the snapshots, and wherein, if the logical volume is subject to abrupt load fluctuations, the controller executes predetermined control processing according to usage cases of the snapshots.
摘要翻译：通过根据快照使用方法执行各种控制方法来防止对源卷的访问性能的下降。存储装置包括提供存储区域的一个或多个存储装置; 以及控制器，其在由所述一个或多个存储设备提供的存储区域中创建逻辑卷，并且根据来自主机的请求从/向所述逻辑卷读取和写入数据，其中所述控制器获取一个或多个快照，是逻辑卷的特定时间点的数据图像，其中控制器基于逻辑卷和快照的性能信息来确定逻辑卷是否受到突然的负载波动，并且其中，如果逻辑卷经受突然的负载波动，控制器根据快照的使用情况执行预定的控制处理。

7. 发明申请

US20070174694A1 Data recovery method for computer system 失效
标题翻译：计算机系统的数据恢复方法
公开(公告)号：US20070174694A1
公开(公告)日：2007-07-26
申请号：US11340280
申请日：2006-01-25
申请人： Masayuki Yamamoto , Masayasu Asano , Takashi Oeda , Tomohiko Suzuki
发明人： Masayuki Yamamoto , Masayasu Asano , Takashi Oeda , Tomohiko Suzuki
IPC分类号： G06F11/00
CPC分类号： G06F11/1456 , G06F11/1469 , G06F11/1471
摘要： To reduce a burden imposed on a system administrator in restore operation, there is provided a computer system including at least one storage system, at least one host computer, and a management computer, in which: the storage system includes: a first processor; a first memory; and a disk drive; the host computer includes: a second processor; and a second memory; the management computer includes: a third processor; and a third memory; the second processor executes plurality of applications; the first processor and the second processor create check points to be used to maintain consistency of data at predetermined timing for the respective applications; and a third processor obtains recovery conditions, which are conditions for a check point to be used for a recovery, and identifies a check point, which satisfies the obtained conditions, from the created check points for the respective applications.
摘要翻译：为了减少在还原操作中对系统管理员的负担，提供了一种包括至少一个存储系统，至少一个主计算机和管理计算机的计算机系统，其中：所述存储系统包括：第一处理器; 第一个记忆; 和磁盘驱动器; 所述主计算机包括：第二处理器; 和第二存储器; 管理计算机包括：第三处理器; 和第三存储器; 第二处理器执行多个应用; 第一处理器和第二处理器创建检查点以用于在各个应用的预定定时保持数据的一致性; 并且第三处理器获得作为用于恢复的检查点的条件的恢复条件，并且从针对各个应用的创建的检查点识别满足获得的条件的检查点。

8. 发明授权

US06512477B2 Detecting apparatus 有权
标题翻译：检测装置
公开(公告)号：US06512477B2
公开(公告)日：2003-01-28
申请号：US09973709
申请日：2001-10-11
申请人： Tomohiko Suzuki
发明人： Tomohiko Suzuki
IPC分类号： G01S704
CPC分类号： G01S7/10 , G01S7/062 , G01S7/22
摘要： While successively varying its orientation at specific intervals, a detecting apparatus transmits pulsed radio waves from an antenna (1), and data corresponding to input levels derived from one sweep are written in a primary memory (4). output values obtained in preceding signal processing operation are written in a secondary memory (9). A signal comparator circuit (7) determines current output values based on the input levels of the primary memory (4) and the preceding output values of the secondary memory (9) by reference to a table (8) and writes the current output values thus obtained in the secondary memory (9). The detecting apparatus causes display brilliance or color between a blip exhibiting large fluctuation in received signal strength and a blip exhibiting small fluctuation in received signal strength. Alternatively, the detecting apparatus causes the pattern of fluctuation in display brilliance or color according to fluctuation in received signal strength at the same point or at nearby points to vary from one transmit/receive cycle to another depending on whether the received signal strength has once exceeded a specified value or not.
摘要翻译：在以特定间隔连续地改变其取向的情况下，检测装置从天线（1）发送脉冲无线电波，并将与从一次扫描得到的输入电平对应的数据写入主存储器（4）。在先前信号处理操作中获得的输出值被写入辅助存储器（9）。信号比较器电路（7）通过参考表（8）基于主存储器（4）的输入电平和辅助存储器（9）的先前输出值来确定当前输出值，并且因此写入当前输出值在第二存储器（9）中获得。检测装置使接收信号强度的波动大的显示亮度或接收信号强度的波动小的blip之间的显示亮度或颜色。或者，检测装置根据接收信号强度是否一旦超过，根据接收信号强度的波动在同一点或附近点使显示亮度或颜色的波动图案从一个发送/接收周期变化到另一个发送/接收周期一个指定的值。

9. 发明申请

US20120297156A1 STORAGE SYSTEM AND CONTROLLING METHOD OF THE SAME 审中-公开
标题翻译：存储系统及其控制方法
公开(公告)号：US20120297156A1
公开(公告)日：2012-11-22
申请号：US13133095
申请日：2011-05-20
申请人： Tomohiko Suzuki , Keiichi Tezuka , Akitatsu Harada
发明人： Tomohiko Suzuki , Keiichi Tezuka , Akitatsu Harada
IPC分类号： G06F12/02 , G06F12/16
CPC分类号： G06F3/0647 , G06F3/0607 , G06F3/0649 , G06F3/067
摘要： A storage system comprising a first storage apparatus, a second storage apparatus, each storing data processed by an external apparatus, each of the first and second apparatuses including a pool of a plurality of unit physical storage areas for storing the data, the unit physical storage areas being classified into a plurality of storage tiers, a logical storage area in the first storage apparatus and the logical storage area in the second storage apparatus respectively including one or more of the storage tiers that are assigned to the respective logical storage areas, the storage system holding storage tier construction information of the first storage apparatus, and a data migration controller, when the data stored in the first storage apparatus are migrated to the second storage apparatus, transferring the storage tier construction information of the first storage apparatus to the second storage apparatus.
摘要翻译：一种存储系统，包括第一存储装置，第二存储装置，每个存储装置存储由外部装置处理的数据，所述第一和第二装置中的每一个包括用于存储数据的多个单位物理存储区域的池，所述单位物理存储分为多个存储层的区域，第一存储装置中的逻辑存储区域和第二存储装置中的逻辑存储区域，分别包括分配给各逻辑存储区域的一个或多个存储层，存储区系统保存第一存储装置的存储层构造信息和数据迁移控制器，当存储在第一存储装置中的数据被迁移到第二存储装置时，将第一存储装置的存储层构造信息传送到第二存储器仪器。

10. 发明授权

US07506117B2 Data recovery method for computer system 失效
标题翻译：计算机系统的数据恢复方法
公开(公告)号：US07506117B2
公开(公告)日：2009-03-17
申请号：US11340280
申请日：2006-01-25
申请人： Masayuki Yamamoto , Masayasu Asano , Takashi Oeda , Tomohiko Suzuki
发明人： Masayuki Yamamoto , Masayasu Asano , Takashi Oeda , Tomohiko Suzuki
IPC分类号： G06F12/16
CPC分类号： G06F11/1456 , G06F11/1469 , G06F11/1471
摘要： To reduce a burden imposed on a system administrator in restore operation, there is provided a computer system including at least one storage system, at least one host computer, and a management computer, in which: the storage system includes: a first processor; a first memory; and a disk drive; the host computer includes: a second processor; and a second memory; the management computer includes: a third processor; and a third memory; the second processor executes plurality of applications; the first processor and the second processor create check points to be used to maintain consistency of data at predetermined timing for the respective applications; and a third processor obtains recovery conditions, which are conditions for a check point to be used for a recovery, and identifies a check point, which satisfies the obtained conditions, from the created check points for the respective applications.
摘要翻译：为了减少在还原操作中对系统管理员的负担，提供了一种包括至少一个存储系统，至少一个主计算机和管理计算机的计算机系统，其中：所述存储系统包括：第一处理器; 第一个记忆; 和磁盘驱动器; 所述主计算机包括：第二处理器; 和第二存储器; 管理计算机包括：第三处理器; 和第三存储器; 第二处理器执行多个应用; 第一处理器和第二处理器创建检查点以用于在各个应用的预定定时保持数据的一致性; 并且第三处理器获得作为用于恢复的检查点的条件的恢复条件，并且从针对各个应用的创建的检查点识别满足获得的条件的检查点。

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