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1. 发明授权

US08244355B2 Method and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous system 有权
标题翻译：提供受试者自主神经系统调节的诊断指标和治疗的方法和装置
公开(公告)号：US08244355B2
公开(公告)日：2012-08-14
申请号：US10977073
申请日：2004-10-29
申请人： Tommy D. Bennett , Edwin G. Duffin , Barbro Kjellstrom
发明人： Tommy D. Bennett , Edwin G. Duffin , Barbro Kjellstrom
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/4035 , A61B5/7239 , A61N1/36535 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/3702
摘要： A system and method are provided for determining an index of autonomic nervous system (ANS) or sympathetic nervous system (SNS) activity for use in patient monitoring or therapy delivery control. An ANS or SNS index is calculated as a function of multiple monitored physiological variables that strongly correlate to changes in autonomic or sympathetic tone. These ANS-influenced variables are derived from selected hemodynamic and/or electrical signals and may include variables relating to any of: the maximum rate of pressure rise (dP/dtmax), the maximum rate of pressure decline (dP/dtmin), pulse pressure (PP), pre-ejection time interval (PEI) and/or systolic time interval (STI), heart rate (HR), heart rate variability (HRV), and baro-reflex gain. Changes in the ANS or SNS index may be used to automatically adjust a device delivered therapy.
摘要翻译：提供了一种用于确定用于患者监测或治疗递送控制的自主神经系统（ANS）或交感神经系统（SNS）活动指数的系统和方法。 ANS或SNS指数被计算为与自主神经或交感神经紧张度变化密切相关的多个被监测的生理变量的函数。这些受ANS影响的变量来源于选定的血液动力学和/或电信号，并且可以包括与以下任何相关的变量：压力升高的最大速率（dP / dtmax），压力下降的最大速率（dP / dtmin），脉压（PP），预喷射时间间隔（PEI）和/或收缩期间隔（STI），心率（HR），心率变异性（HRV）和压力反射增益。可以使用ANS或SNS指数的变化来自动调整设备传递的治疗。

2. 发明授权

US06915157B2 Implantable medical device for assessing heart failure state from Mechanical Pulsus Alternans 有权
标题翻译：用于评估机械Pulsus Alternans的心力衰竭状态的可植入医疗装置
公开(公告)号：US06915157B2
公开(公告)日：2005-07-05
申请号：US10368278
申请日：2003-02-18
申请人： Tommy D. Bennett , Lawrence J. Mulligan , Edwin G. Duffin , Robert C. Hamlen , Wael Abo-Auda
发明人： Tommy D. Bennett , Lawrence J. Mulligan , Edwin G. Duffin , Robert C. Hamlen , Wael Abo-Auda
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/0245 , A61B5/0452 , A61B5/04
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/0215 , A61B5/0245 , A61B5/0452
摘要： An implantable heart monitor (IHM) implanted in a patient's body having electrogram (EGM) sense electrodes coupled with EGM sense circuitry to generate sense events upon detection of cardiac depolarizations and a blood pressure measurement transducer disposed in a heart chamber and coupled with blood pressure measurement circuitry operates to assess heart failure state as a function of mechanical pulsus alternans (MPA). MPA episodes are detected, and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.
摘要翻译：一种植入式心脏监测器（IHM），其植入患者体内，其具有与EGM感测电路耦合的电描记图（EGM）感测电极，以便在检测到心脏去极化时产生感测事件，以及设置在心室中的血压测量换能器，并与血压测量结合电路用于评估作为机械脉动交替（MPA）的函数的心力衰竭状态。检测到MPA发作，MPA发作的MPA特征单独使用或作为HF状态的诊断标记使用。 MPA情节数据集可以存储在与时间和日期戳相关联的存储器中。可以比较或绘制在一段时间内收集的一系列MPA数据集中的每个MPA数据集的MPA特性，以确定指示HF状态变化的趋势是否可辨别。

3. 发明授权

US08702604B2 Detection of waveform artifact 有权
标题翻译：检测波形伪影
公开(公告)号：US08702604B2
公开(公告)日：2014-04-22
申请号：US13017307
申请日：2011-01-31
申请人： Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett
发明人： Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译：包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。使用生理传感器在患者中感测到信号波形，并且识别与感测波形相关联的基准点。使用基准点建立点值。响应于建立的点值和建立的阈值检测信号伪像，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。

4. 发明授权

US08585604B2 Integrated patient care 有权
标题翻译：综合病人护理
公开(公告)号：US08585604B2
公开(公告)日：2013-11-19
申请号：US12915992
申请日：2010-10-29
申请人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
发明人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
IPC分类号： A61B5/02
CPC分类号： G06F19/3481 , A61B5/0022 , A61B5/021 , A61B5/0215 , A61B5/0537 , A61B5/11 , A61B5/4836 , A61B5/4878 , A61B5/743 , A61B5/7435 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H40/63 , G16H50/20
摘要： A therapy regimen, e.g., a contingent medication prescription, may be created and automatically distributed to a patient via an integrated patient care system. A clinician may create therapy instructions by at least associating patient conditions with one or more therapy regimens, e.g., medication prescriptions. In some examples, the integrated patient care system may present historical condition data to the clinician to aid the clinician with creating and/or updating the therapy instructions specific to the patient. A therapy module of the integrated patient care system may use the therapy instructions to automatically select a therapy regimen from the therapy instructions based on a patient condition detected based on a sensed physiological parameter. The physiological parameter of the patient may be sensed by an implanted or external sensor. In some examples, the therapy regimen can be presented to the patient according to a predetermined schedule or in response to the detected condition.
摘要翻译：可以创建治疗方案，例如或有药物处方，并通过综合的患者护理系统自动分配给患者。临床医生可以通过至少将患者状况与一种或多种治疗方案（例如药物处方）相关联来产生治疗指导。在一些示例中，综合的患者护理系统可向临床医生呈现历史状态数据，以帮助临床医生创建和/或更新患者特有的治疗指导。综合患者护理系统的治疗模块可以使用治疗指令根据基于检测到的生理参数检测到的患者状况从治疗指令中自动选择治疗方案。患者的生理参数可以通过植入或外部传感器来感测。在一些实例中，治疗方案可以根据预定的时间表或响应于检测到的病症呈现给患者。

5. 发明授权

US08554315B2 Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device 有权
标题翻译：使用可植入医疗装置识别和/或评估心律失常的方法
公开(公告)号：US08554315B2
公开(公告)日：2013-10-08
申请号：US13099547
申请日：2011-05-03
申请人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadnais
发明人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadnais
IPC分类号： A61B5/0452
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译：一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。此外，可以针对每个存储间隔的一个被监视的参数确定中值。在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。

6. 发明授权

US08372013B2 Method and apparatus for determining a respiration parameter in a medical device 有权
标题翻译：用于确定医疗装置中的呼吸参数的方法和装置
公开(公告)号：US08372013B2
公开(公告)日：2013-02-12
申请号：US12262285
申请日：2008-10-31
申请人： Maneesh Shrivastav , Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling
发明人： Maneesh Shrivastav , Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling
IPC分类号： A61B5/0205 , A61B5/08
CPC分类号： A61B5/6846 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0816 , A61B5/4818 , A61N1/36514 , A61N1/3702 , A61N1/37258
摘要： A method of determining a respiration parameter in a medical device in which pressure signals are sensed to generate corresponding sample points, and a breath detection threshold is continuously adjusted in response to the generated sample points to generate a current adjusted breath detection threshold. A current generated sample point is compared to the current adjusted breath detection threshold, and the continuous adjusting of the breath detection threshold is suspended and the breath detection threshold is equal to the most current adjusted breath detection threshold generated prior to the suspending in response to the comparing. A next sample point, generated subsequent to the suspending, is compared to the set breath detection threshold, and the respiration parameter is determined in response to the comparing of a next sample point to the set breath detection threshold.
摘要翻译：一种确定医疗装置中的呼吸参数的方法，其中感测压力信号以产生相应的采样点，并且响应于所产生的采样点连续地调整呼吸检测阈值以产生当前调节的呼吸检测阈值。将当前生成的采样点与当前调节的呼吸检测阈值进行比较，并且暂停呼吸检测阈值的连续调整，并且呼吸检测阈值等于响应于该呼吸检测阈值之前产生的最新调整的呼吸检测阈值比较。将在悬挂之后产生的下一采样点与设定的呼吸检测阈值进行比较，并且响应于下一采样点与设定的呼吸检测阈值的比较来确定呼吸参数。

7. 发明授权

US08202223B2 Method and apparatus for determining respiratory effort in a medical device 有权
标题翻译：用于确定医疗装置中的呼吸力的方法和装置
公开(公告)号：US08202223B2
公开(公告)日：2012-06-19
申请号：US12262320
申请日：2008-10-31
申请人： Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Maneesh Shrivastav , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling , Robert A. Corey
发明人： Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Maneesh Shrivastav , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling , Robert A. Corey
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/6846 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0816 , A61B5/4818 , A61N1/36514 , A61N1/3702 , A61N1/37258
摘要： A method of determining respiratory effort in a medical device in which pressure signals are sensed to generate corresponding sample points, an inspiration and an expiration are detected in response to the sensed pressure signals, a breath is detected in response to the detected inspiration and the detected expiration, and the respiratory effort is determined in response to the detected breath.
摘要翻译：一种在医疗装置中确定呼吸力的方法，其中响应于检测到的压力信号检测压力信号以产生相应的采样点，吸气和呼气，响应于检测到的吸气和检测到的呼吸被检测到呼吸到期，并且响应于检测到的呼吸来确定呼吸努力。

8. 发明授权

US08152730B2 Method for continuous baroreflex sensitivity measurement 有权
标题翻译：连续压力反射灵敏度测量方法
公开(公告)号：US08152730B2
公开(公告)日：2012-04-10
申请号：US13013465
申请日：2011-01-25
申请人： Yong K. Cho , Tommy D. Bennett
发明人： Yong K. Cho , Tommy D. Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0816 , A61B5/7285 , A61N1/3627 , A61N1/36521 , A61N1/368
摘要： A medical device and method for determining baroreflex sensitivity (BRS) based on one or more respiration cycles. The BRS determination may be performed continuously based on measurements of heart rate, blood pressure, and respiration cycles.
摘要翻译：一种用于根据一个或多个呼吸周期来确定压力反射灵敏度（BRS）的医疗装置和方法。可以基于心率，血压和呼吸周期的测量来连续进行BRS测定。

9. 发明申请

US20100217135A1 METHOD AND SYSTEM FOR INTERPRETING HEMODYNAMIC DATA INCORPORATING PATIENT POSTURE INFORMATION 审中-公开
标题翻译：用于解释患有病人信息的血液动力学数据的方法和系统
公开(公告)号：US20100217135A1
公开(公告)日：2010-08-26
申请号：US12714850
申请日：2010-03-01
申请人： Yong K. Cho , Yongduk Cho , Tommy D. Bennett , Mustafa Karamanoglu
发明人： Yong K. Cho , Yongduk Cho , Tommy D. Bennett , Mustafa Karamanoglu
IPC分类号： A61B5/021 , A61B5/103
CPC分类号： A61N1/3702 , A61N1/36535 , A61N1/36542
摘要： Systems and methods for improving hemodynamic data interpretation by accounting for the effects of patient posture is disclosed. In certain embodiments, a posture signal is acquired and used to categorize hemodynamic data according to posture to facilitate distinguishing posture-related changes in acquired hemodynamic data from those due to pathophysiologic changes. Posture information may be used to normalize data acquired in various postures to facilitate interpretation of such data. Baseline measurements of hemodynamic data acquired in various postures may also be used to subsequently detect changes in patient posture without the need for an implanted posture sensor.
摘要翻译：公开了通过考虑患者姿势的影响来改善血液动力学数据解释的系统和方法。在某些实施例中，获取姿势信号并用于根据姿势对血液动力学数据进行分类，以便于将所获得的血液动力学数据中的姿势相关变化与由于病理生理变化引起的姿势相关的变化区分开。姿势信息可以用于对在各种姿势中获取的数据进行归一化，以便于解释这些数据。在各种姿势中获取的血液动力学数据的基线测量也可用于随后检测患者姿势的变化，而不需要植入的姿势传感器。

10. 发明申请

US20100076322A1 METHOD AND APPARATUS FOR DETERMINING A RESPIRATION PARAMETER IN A MEDICAL DEVICE 有权
标题翻译：用于确定医疗装置中呼吸参数的方法和装置
公开(公告)号：US20100076322A1
公开(公告)日：2010-03-25
申请号：US12262285
申请日：2008-10-31
申请人： Maneesh A. Shrivastav , Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling
发明人： Maneesh A. Shrivastav , Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling
IPC分类号： A61B5/0205 , A61B5/08
CPC分类号： A61B5/6846 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0816 , A61B5/4818 , A61N1/36514 , A61N1/3702 , A61N1/37258
摘要： A method of determining a respiration parameter in a medical device in which pressure signals are sensed to generate corresponding sample points, and a breath detection threshold is continuously adjusted in response to the generated sample points to generate a current adjusted breath detection threshold. A current generated sample point is compared to the current adjusted breath detection threshold, and the continuous adjusting of the breath detection threshold is suspended and the breath detection threshold is equal to the most current adjusted breath detection threshold generated prior to the suspending in response to the comparing. A next sample point, generated subsequent to the suspending, is compared to the set breath detection threshold, and the respiration parameter is determined in response to the comparing of a next sample point to the set breath detection threshold.
摘要翻译：一种确定医疗装置中的呼吸参数的方法，其中感测压力信号以产生相应的采样点，并且响应于所产生的采样点连续地调整呼吸检测阈值以产生当前调节的呼吸检测阈值。将当前生成的采样点与当前调节的呼吸检测阈值进行比较，并且暂停呼吸检测阈值的连续调整，并且呼吸检测阈值等于响应于该呼吸检测阈值之前产生的最新调整的呼吸检测阈值比较。将在悬挂之后产生的下一采样点与设定的呼吸检测阈值进行比较，并且响应于下一采样点与设定的呼吸检测阈值的比较来确定呼吸参数。

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