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1. 发明授权

US08554315B2 Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device 有权
标题翻译：使用可植入医疗装置识别和/或评估心律失常的方法
公开(公告)号：US08554315B2
公开(公告)日：2013-10-08
申请号：US13099547
申请日：2011-05-03
申请人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadnais
发明人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadnais
IPC分类号： A61B5/0452
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译：一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。此外，可以针对每个存储间隔的一个被监视的参数确定中值。在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。

2. 发明申请

US20110208078A1 METHODS OF IDENTIFYING AND/OR ASSESSING CARDIAC ARRHYTHMIAS USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗器械鉴别和/或评估心脏病的方法
公开(公告)号：US20110208078A1
公开(公告)日：2011-08-25
申请号：US13099547
申请日：2011-05-03
申请人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadnais
发明人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadnais
IPC分类号： A61B5/0452
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译：一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。此外，可以针对每个存储间隔的一个被监视的参数确定中值。在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。

3. 发明授权

US07937137B2 Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device 有权
标题翻译：使用可植入医疗装置识别和/或评估心律失常的方法
公开(公告)号：US07937137B2
公开(公告)日：2011-05-03
申请号：US11342397
申请日：2006-01-30
申请人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadneis
发明人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom , Susan C. Vadneis
IPC分类号： A61B5/0452
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译：一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。此外，可以针对每个存储间隔的一个被监视的参数确定中值。在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。

4. 发明授权

US07988635B2 Methods for detecting and monitoring sleep disordered breathing using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测和监测睡眠无序呼吸的方法
公开(公告)号：US07988635B2
公开(公告)日：2011-08-02
申请号：US12346290
申请日：2008-12-30
申请人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom
发明人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

5. 发明授权

US07488291B2 Methods for detecting and monitoring sleep disordered breathing using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测和监测睡眠无序呼吸的方法
公开(公告)号：US07488291B2
公开(公告)日：2009-02-10
申请号：US11237354
申请日：2005-09-28
申请人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom
发明人： Yong K. Cho , Tommy D. Bennett , Barbro M. Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

6. 发明授权

US07704209B2 Method and apparatus for continuous pulse contour cardiac output 有权
标题翻译：连续脉搏轮廓心输出量的方法和装置
公开(公告)号：US07704209B2
公开(公告)日：2010-04-27
申请号：US12369377
申请日：2009-02-11
申请人： Tommy D. Bennett , Robert T. Taepke, II , Barbro M. Kjellstrom
发明人： Tommy D. Bennett , Robert T. Taepke, II , Barbro M. Kjellstrom
IPC分类号： A61B5/00
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
摘要翻译：提供了一种用于感测心电图（EGM）信号和心室压力信号以及使用感测的EGM和感测的压力信号来估计行程量（SV）的系统和方法。可以从估计的SV和从EGM信号确定的心率计算心输出量的量度。感测到的心室压力信号和感测到的EGM信号用于导出标记点，例如估计的肺舒张压，平均肺动脉压，右心室压力峰值（RVP）和用于计算区域或脉冲轮廓积分。脉冲轮廓积分用于估计SV。估计的肺舒张压，平均肺动脉压和从估计的SV计算的CO可用于计算肺血管阻力。

7. 发明申请

US20090209876A1 Method and apparatus for continuous pulse contour cardiac output 有权
公开(公告)号：US20090209876A1
公开(公告)日：2009-08-20
申请号：US12369377
申请日：2009-02-11
申请人： Tommy D. Bennett , Robert T. Taepke, II , Barbro M. Kjellstrom
发明人： Tommy D. Bennett , Robert T. Taepke, II , Barbro M. Kjellstrom
IPC分类号： A61B5/0402 , A61B5/02
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.

8. 发明授权

US07507208B2 Method and apparatus for continuous pulse contour cardiac output 有权
标题翻译：连续脉搏轮廓心输出量的方法和装置
公开(公告)号：US07507208B2
公开(公告)日：2009-03-24
申请号：US12124847
申请日：2008-05-21
申请人： Tommy D. Bennett , Robert T. Taepke, II , Barbro M. Kjellstrom
发明人： Tommy D. Bennett , Robert T. Taepke, II , Barbro M. Kjellstrom
IPC分类号： A61B5/00
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
摘要翻译：提供了一种用于感测心电图（EGM）信号和心室压力信号以及使用感测的EGM和感测的压力信号来估计行程量（SV）的系统和方法。可以从估计的SV和从EGM信号确定的心率计算心输出量的量度。感测到的心室压力信号和感测到的EGM信号用于导出标记点，例如估计的肺舒张压，平均肺动脉压，右心室压力峰值（RVP）和用于计算区域或脉冲轮廓积分。脉冲轮廓积分用于估计SV。估计的肺舒张压，平均肺动脉压和从估计的SV计算的CO可用于计算肺血管阻力。

9. 发明授权

US08594790B2 System and method for monitoring a ventricular pressure index to predict worsening heart failure 有权
标题翻译：用于监测心室压力指数以预测心脏衰竭恶化的系统和方法
公开(公告)号：US08594790B2
公开(公告)日：2013-11-26
申请号：US11045571
申请日：2005-01-27
申请人： Barbro M. Kjellstrom , Tommy D. Bennett
发明人： Barbro M. Kjellstrom , Tommy D. Bennett
IPC分类号： A61N1/365 , A61B5/021
CPC分类号： A61N1/36564
摘要： A medical device monitors a patient to predict worsening heart failure. An input circuit of the medical device receives a pressure signal representative of a pressure sensed within a ventricle of the patient's heart as a function of time. A processor derives from the pressure signal a ventricular pressure index for a ventricular contraction based upon pressures in the ventricle. The processor then provides an output based upon the ventricular pressure index.
摘要翻译：医疗设备监测患者以预测恶化的心力衰竭。医疗装置的输入电路作为时间的函数接收表示患者心脏的心室内感测到的压力的压力信号。处理器根据压力信号得出基于心室压力的心室收缩的心室压力指数。然后处理器基于心室压力指数提供输出。

10. 发明申请

US20090171220A1 METHODS FOR DETECTING AND MONITORING SLEEP DISORDERED BREATHING USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗器械检测和监测睡眠障碍性呼吸的方法
公开(公告)号：US20090171220A1
公开(公告)日：2009-07-02
申请号：US12346290
申请日：2008-12-30
申请人： Yong Kyun Cho , Tommy D. Bennett , Barbro M. Kjellstrom
发明人： Yong Kyun Cho , Tommy D. Bennett , Barbro M. Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

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