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1. 发明授权

US06855122B1 Bloodless treating device 失效
标题翻译：无血治疗仪
公开(公告)号：US06855122B1
公开(公告)日：2005-02-15
申请号：US09913248
申请日：2000-02-09
申请人： Tomio Ohta , Tetsuya Miyatake , Yoshihiko Kinoshita
发明人： Tomio Ohta , Tetsuya Miyatake , Yoshihiko Kinoshita
IPC分类号： A61M1/36 , A61M37/00
CPC分类号： A61M1/3621
摘要： There is provided an apparatus which reduces a bleeding amount upon an operation.A bloodless treating apparatus used upon a surgical treatment of an objet comprises: (A) a fluid replacement supply unit which quantitatively supplies a fluid replacement into a blood vessel leading to the object (24); and (B) a fluid replacement withdrawing unit which quantitatively withdraws the fluid replacement having passed through the object (24) from a blood vessel coming from the object.
摘要翻译：提供了一种在手术时减少出血量的装置。一种用于对象的手术治疗的无血治疗装置包括：（A）液体替换供应单元，其将定量地将流体置换供给到通向对象的血管（24）; 以及（B）液体替换抽出单元，其从从所述物体的血管定量地取出已经通过所述物体（24）的液体置换装置。

2. 发明授权

US06626857B1 Extracorporeal circulation device and method for isolation temperature control method 有权
标题翻译：体外循环装置及隔离温度控制方法
公开(公告)号：US06626857B1
公开(公告)日：2003-09-30
申请号：US09856135
申请日：2001-07-23
申请人： Tomio Ohta , Tetsuya Miyatake , Yoshihiko Kinoshita , Tomoya Murakami
发明人： Tomio Ohta , Tetsuya Miyatake , Yoshihiko Kinoshita , Tomoya Murakami
IPC分类号： A61M3700
CPC分类号： A61M1/3455 , A61M1/3441 , A61M1/3458 , A61M1/369 , A61M2230/207
摘要： An extracorporeal circulation apparatus used for the selective temperature controlling method in which a temperature of an object is kept at a predetermined temperature, includes: (A) a fluid replacement supply unit which quantitatively supplies a fluid replacement of which temperature has been adjusted into a blood vessel; (B) a blood concentration unit which quantitatively withdraws blood diluted by the fluid replacement from a blood vessel and concentrates the withdrawn diluted blood; and (C) a blood supply unit which controls a temperature of the blood which has been concentrated and quantitatively supplies the concentrated blood into a blood vessel, the blood concentration unit comprising a diluted blood temperature sensor which measures a temperature of the withdrawn diluted blood, and the fluid replacement supply unit including a means which controls a temperature of the fluid replacement to be supplied based on a different extent between the measured diluted blood temperature and the predetermined temperature of the object.
摘要翻译：一种用于选择温度控制方法的体外循环装置，其中物体的温度保持在预定温度，包括：（A）液体替换供应单元，其将已经调节了温度的液体置换定量为血液容器;（B）血液浓度单元，其定量地从血管中取出由液体替换物稀释的血液，并浓缩取出的稀释血液; 和（C）血液供给单元，其对已经浓缩并定量地将浓缩血液供给到血管中的血液的温度进行控制，所述血液浓度单元包括测定取出的稀释血液的温度的稀释型血液温度传感器，并且所述流体置换供给单元包括基于所测量的稀释血液温度和所述物体的预定温度之间的不同程度控制要供应的所述流体置换的温度的装置。

3. 发明授权

US06336910B1 Extracorporeal circulation apparatus for selective cooling method 有权
标题翻译：用于选择性冷却方法的体外循环装置
公开(公告)号：US06336910B1
公开(公告)日：2002-01-08
申请号：US09187986
申请日：1998-11-09
申请人： Tomio Ohta , Takuichi Kobayashi
发明人： Tomio Ohta , Takuichi Kobayashi
IPC分类号： A61M3700
CPC分类号： A61M1/369 , A61F2007/126 , A61M2205/36 , A61M2205/3606 , Y10S128/03
摘要： An extracorporeal circulation apparatus capable of maintaining hypothermia for a prolonged period when used in the selective cooling method. The extracorporeal circulation apparatus used in the selective cooling method includes (1) a diluent supply unit for cooling a diluent and metering the diluent into a blood vessel; (2) a blood concentration unit for metering a diluted blood out from a blood vessel and concentrating the diluted blood thus drawn out by filtering the diluted blood; and (3) a blood supply unit for heating the concentrated blood and metering the concentrated blood into a blood vessel, wherein a flow rate of the injected diluent flow rate, Vd and a flow rate of a filtrate, Vb are so controlled that a relationship 0.1 Vd≦Vb≦Vd is maintained.
摘要翻译：一种体外循环装置，其能够在选择性冷却方法中使用时能够长时间保持低温。选择冷却方法中使用的体外循环装置包括（1）稀释剂供给单元，其用于冷却稀释剂并将稀释剂计量到血管 ; （2）用于从血管计量稀释的血液的血液浓缩单元，并且通过过滤稀释的血液浓缩由此抽出的稀释血液; 和（3）用于加热浓缩血液并将浓缩血液计量到血管中的血液供应单元，其中注入的稀释剂流量Vd和滤液的流量Vb的流量被控制为使得关系保持0.1 Vd <= Vb <= Vd。

4. 发明授权

US4567890A Pair of bipolar diathermy forceps for surgery 失效
标题翻译：一对双极性透热镊子用于手术
公开(公告)号：US4567890A
公开(公告)日：1986-02-04
申请号：US638562
申请日：1984-08-07
申请人： Tomio Ohta , Noboru Funatsu
发明人： Tomio Ohta , Noboru Funatsu
IPC分类号： A61B18/12 , A61B17/30 , A61B18/14 , A61M3/02 , A61B17/36
CPC分类号： A61B18/1442 , A61B17/30 , A61B2217/007 , A61M3/0279
摘要： A pair of bipolar diathermy forceps used for surgery having two arms electrically insulated from each other and adapted to keep opening their tips usually, comprising a tube which extends toward the inside tips of the arms and which is mounted along a groove, the said groove is provided on either or both of the arms, an elongate section which follows the said groove, an operational section inserted between two arms whereby a hole of the tube is open, when the said arms are closed and is closed when they are open, and a pouring section of physiological saline which is connected to the end of the tube. Irrigation is started when the arms are closed and is stopped when they are open automatically. When the tissue is held by the tips of arms and supplied with the current, the coagulation is caused by the high frequency conducted, whereby the control of hemorrhage is completed. The frequent saline irrigation of the work area in microsurgery and the dilution of a little bleeding can be obtained.
摘要翻译：一对用于手术的双极性透热镊子，其具有彼此电绝缘并且适于通常保持开口的手臂，包括朝向臂的内部尖端延伸并且沿着凹槽安装的管，所述凹槽是设置在所述臂中的一个或两个上，与所述凹槽相邻的细长部分，插入在两个臂之间的操作部分，其中当所述臂闭合并且当所述臂打开时关闭时，所述管的孔打开，并且生理盐水的浇注部分连接到管的端部。当手臂关闭并在自动打开时停止灌溉。当组织被手臂的尖端保持并且被提供电流时，由高频传导引起凝血，由此完成出血控制。显微手术中工作区频繁的盐水灌洗和稀释少许出血。

5. 发明授权

US5576324A Quinoline derivatives or salt thereof and remedy for cardiac diseases containing the same 失效
标题翻译：喹啉衍生物或其盐和含有其的心脏疾病的治疗药物
公开(公告)号：US5576324A
公开(公告)日：1996-11-19
申请号：US325270
申请日：1994-10-27
申请人： Yoshinori Kyotani , Tadaaki Ohgiya , Tsutomu Toma , Yuji Kurihara , Takahiro Kitamura , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Hiromichi Shigyo , Tomio Ohta , Mitsuo Kawada , Yasumi Uchida
发明人： Yoshinori Kyotani , Tadaaki Ohgiya , Tsutomu Toma , Yuji Kurihara , Takahiro Kitamura , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Hiromichi Shigyo , Tomio Ohta , Mitsuo Kawada , Yasumi Uchida
IPC分类号： C07D491/04 , C07D491/048 , C07D491/056 , A61K31/44
CPC分类号： C07D491/04
摘要： A quinoline derivative represented by general formula (1), a medicinally acceptable salt thereof, and a remedy for cardiac diseases containing the same: ##STR1## [wherein ring A represents a furan, dihydrofuran or dioxolane ring, and R.sup.1 represents an aminoalkyl group].The compound (1) has a positively inotropic effect on myocardia and an antiarrhythmic effect, and can dilate blood vessels without extremely increasing the heart rate. Therefore, a remedy for cardiac diseases containing the same as the active ingredient is remarkably useful for treating cardiac insufficiency, arrhythmia, and so forth.
摘要翻译： PCT No.PCT / JP93 / 00566 Sec。 371日期：1994年10月27日 102（e）日期1994年10月27日PCT提交1993年4月28日PCT公布。公开号WO93 / 22317 日本特公昭日1993年11月11日由通式（1）表示的喹啉衍生物及其药学上可接受的盐以及含有该喹啉衍生物的心脏病的药物：其中环A表示呋喃，二氢呋喃或二氧戊环，R1表示氨基烷基]。化合物（1）对心肌具有正性变力作用，具有抗心律失常作用，能够扩张血管而不会极大地提高心率。因此，含有与活性成分相同的心脏病的治疗对于治疗心功能不全，心律失常等是非常有用的。

6. 发明授权

US4737506A Anti-arteriosclerotic pyridyl or imidazolyl derivatives of carbonyloxyalkyl hantzsch esters 失效
标题翻译：羧基烷基羟胺酯的抗动脉硬化吡啶基或咪唑基衍生物
公开(公告)号：US4737506A
公开(公告)日：1988-04-12
申请号：US851134
申请日：1986-04-07
申请人： Noboru Shimizu , Hiroyuki Ishiwata , Tomio Ohta , Hiroshi Ishihama , Yasumi Uchida
发明人： Noboru Shimizu , Hiroyuki Ishiwata , Tomio Ohta , Hiroshi Ishihama , Yasumi Uchida
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4427 , A61K31/455 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , C07D211/90 , C07D401/14
CPC分类号： C07D211/90
摘要： This invention relates to a 1,4-dihydropyridine-3,5-dicarboxylate derivative represented by the following general formula (I): ##STR1## wherein R means an imidazolyl or pyridyl group, R.sub.1 denotes a hydrogen or halogen atom or a nitro or trifluoromethyl group, R.sub.2 is a lower alkyl group, X is CH or N, A means a lower alkylene group, ##STR2## B being a lower alkylene or O-lower alkylene group, ##STR3## R.sub.4 being a hydrogen atom or lower alkyl group, or ##STR4## m denotes a number of 1-3, and n stands for 1 or 2. The derivative has vasodilative effects, hyperkinemic effects, platelet aggregation inhibitory effects, thromboxane A.sub.2 formation inhibitory effects and so on, and are hence useful as a pharmaceutical product such as vasodilator, antihypertensive, antithrombotic agent, antiarteriosclerotic agent or the like.
摘要翻译： PCT No.PCT / JP85 / 00449 Sec。一九八六年四月七日 102（e）日期1986年4月7日PCT提交1985年8月12日PCT公布。公开号WO86 / 01206 PCT 日本特愿1986年2月27日。本发明涉及由以下通式（I）表示的1,4-二氢吡啶-3,5-二羧酸酯衍生物：其中R表示咪唑基或吡啶基，R1 表示氢或卤素原子或硝基或三氟甲基，R 2为低级烷基，X为CH或N，A表示低级亚烷基，B为低级亚烷基或O-低级亚烷基，IMA图 > R4是氢原子或低级烷基，或者表示1-3个数，n代表1或2.该衍生物具有血管扩张作用，超动力作用，血小板聚集抑制作用，血栓素A2形成抑制效果等，因此可用作药物产品如血管扩张剂，抗高血压剂，抗血栓形成剂，抗动脉硬化剂等。

7. 发明授权

US5510366A Indole derivatives, salts thereof, and congestive heart failure therapeutic agents comprising the same 失效
标题翻译：吲哚衍生物，其盐，以及包含其的充血性心力衰竭治疗剂
公开(公告)号：US5510366A
公开(公告)日：1996-04-23
申请号：US330670
申请日：1994-10-28
申请人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
发明人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
IPC分类号： C07D491/04 , C07D491/048 , A61K31/40 , C07D491/056
CPC分类号： C07D491/04
摘要： An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
摘要翻译：由式（1）表示的吲哚衍生物，本文R10为氢或低级烷基，虚线可以任选存在，R 1 -R 9表示各种取代基。化合物（1）对心肌呈现正性肌力作用，抗心律失常作用和血管舒张作用而不增加心率。包含该化合物作为有效成分的心脏治疗剂对于治疗心力衰竭和心律失常是非常有效的。

8. 发明授权

US5389630A Diamine compound and brain protecting agent containing the same 失效
标题翻译：二胺化合物和含有相同的脑保护剂
公开(公告)号：US5389630A
公开(公告)日：1995-02-14
申请号：US966142
申请日：1993-01-22
申请人： Seiichi Sato , Kiyoshi Kawamura , Yoshio Takahashi , Koichiro Watanabe , Sadahiro Shimizu , Tomio Ohta
发明人： Seiichi Sato , Kiyoshi Kawamura , Yoshio Takahashi , Koichiro Watanabe , Sadahiro Shimizu , Tomio Ohta
IPC分类号： A61K31/135 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/22 , A61K31/24 , A61K31/245 , A61K31/25 , A61K31/255 , A61K31/27 , A61K31/4164 , A61K31/495 , A61K31/55 , A61K31/551 , A61P25/28 , C07C211/09 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/49 , C07C235/50 , C07C237/04 , C07C271/28 , C07C275/28 , C07C275/34 , C07C309/65 , C07C311/18 , C07C311/29 , C07C311/41 , C07C327/26 , C07C327/28 , C07C327/30 , C07C327/32 , C07C327/34 , C07C327/36 , C07D243/08 , C07D295/04 , C07D295/06 , C07D295/08 , C07D295/12 , C07D295/13 , C07D295/14
CPC分类号： C07D295/13 , C07C211/27 , C07C211/49 , C07C237/04 , C07C271/28 , C07C275/34 , C07C311/29 , C07C327/30
摘要： Diamine compounds of formula (I) or an addition salt thereof are provided: ##STR1## These compounds have an excellent cerebral protective action, are very safe, and exhibit a strong action when orally administered, and therefore, medicines containing such compounds are effective for treating disorders caused by cerebral hemorrhage, cerebral infarction, subarachnoid hemorrhage, transient ischemic attack, cerebrovascular disorders and the like, or preventing progress of such disorders.
摘要翻译： PCT No.PCT / JP90 / 00970 Sec。 371日期：1993年1月22日 102（e）日期1993年1月22日PCT提交1990年7月30日PCT公布。出版物WO92 / 02487 （I）的二胺化合物或其加成盐提供：（I）这些化合物具有优异的脑保护作用，非常安全，并且在口服给药时表现出强烈的作用，因此，含有这些化合物的药物对于治疗由脑出血，脑梗塞，蛛网膜下腔出血，短暂性脑缺血发作，脑血管障碍等引起的疾病或预防这些障碍的进展是有效的。

9. 发明授权

US4960883A Piperazines and homopiperazines 失效
标题翻译：哌嗪和高哌嗪
公开(公告)号：US4960883A
公开(公告)日：1990-10-02
申请号：US310683
申请日：1989-02-15
申请人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
发明人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
IPC分类号： C07D295/18 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/55 , A61P9/00 , C07D217/02 , C07D243/08 , C07D295/192 , C07D295/22 , C07D295/26
CPC分类号： C07D295/192 , C07D217/02 , C07D295/26
摘要： A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group,and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.

10. 发明授权

US4948892A Sulfonamid compound useful for treating cardiovascular disorders 失效
标题翻译：用于治疗心血管疾病的磺酰胺类化合物
公开(公告)号：US4948892A
公开(公告)日：1990-08-14
申请号：US310684
申请日：1989-02-15
申请人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
发明人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
IPC分类号： C07D295/12 , A61K31/495 , A61P9/00 , C07D213/74 , C07D213/75 , C07D241/04 , C07D295/13
CPC分类号： C07D213/74 , C07D295/13
摘要： A sulfonamide compound represented by the following formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralykyl group; R.sup.5 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R.sup.6 and R.sup.7 are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8,and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.

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