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1. 发明授权

US5298482A Method for promoting plant growth using 5-aminolevulinic acid or a salt thereof 失效
标题翻译：使用5-氨基乙酰丙酸或其盐促进植物生长的方法
公开(公告)号：US5298482A
公开(公告)日：1994-03-29
申请号：US881705
申请日：1992-05-12
申请人： Tohru Tanaka , Kiyoshi Takahashi , Yasushi Hotta , Yasutomo Takeuchi , Makoto Konnai
发明人： Tohru Tanaka , Kiyoshi Takahashi , Yasushi Hotta , Yasutomo Takeuchi , Makoto Konnai
IPC分类号： A01N37/44
CPC分类号： A01N37/44
摘要： A method for treating plants with a plant growth promoter comprising 5-aminolevulinic acid or a salt thereof as an active ingredient. This treatment method is effective in enhancing the photosynthetic activity of a plant, enhancing its ability to absorb CO.sub.2, suppressing its respiration, increasing its chlorophyll content and promoting its growth. As a result, the treatment greatly contributes to the promotion of rooting, the reduction of lodging, an increase in yield, an improvement in cold resistance, maintenance of freshness, an improvement and maintenance of green color, the growth of good seedlings, the promotion of organs, an increase in tillers, a shortening of the time required for growth, a relief of chemical damage and an increase in the rooting ratio in, for example, cutting.
摘要翻译：用植物生长促进剂处理植物的方法，其包含5-氨基乙酰丙酸或其盐作为活性成分。这种处理方法对于提高植物的光合活性，提高其吸收CO2的能力，抑制其呼吸，增加叶绿素含量，促进其生长有效。因此，处理有助于促进生根，减少倒伏，提高产量，提高耐寒性，保持新鲜度，改善和保持绿色，良好的幼苗生长，促进的器官，分蘖的增加，生长所需时间的缩短，化学损害的缓解以及例如切割中生根比的增加。

2. 发明授权

US5661111A Method for improving plant salt-tolerance 失效
标题翻译：提高植物耐盐性的方法
公开(公告)号：US5661111A
公开(公告)日：1997-08-26
申请号：US561702
申请日：1995-11-22
申请人： Hitoshi Kuramochi , Makoto Konnai , Tohru Tanaka , Yasushi Hotta
发明人： Hitoshi Kuramochi , Makoto Konnai , Tohru Tanaka , Yasushi Hotta
IPC分类号： A01N37/44 , A01N37/46 , A01N55/02 , A01N63/00 , A01N63/02 , H01N43/36 , H01N37/44 , H01N37/46
CPC分类号： A01N63/02 , A01N37/44 , A01N37/46 , A01N55/02
摘要： A method for improving plant salt-tolerance is described, which comprises treating a plant with an active ingredient comprising at least one compound selected from the group consisting of 5-aminolevulinic acid, a derivative of 5-aminolevulinic acid, a salt of 5-aminolevulinic acid, a salt of derivatives of 5-aminolevulinic acid, and hemins. Furthermore, a salt-tolerant plant is described, wherein the plant is treated with the above-described active ingredient. Moreover, a method for causing recovery of a salt-damaged plant is described, comprising administering the above-described active ingredient to a salt-damaged plant.
摘要翻译：描述了一种改善植物耐盐性的方法，其包括用活性成分处理植物，所述活性成分包含至少一种选自5-氨基乙酰丙酸，5-氨基乙酰丙酸衍生物，5-氨基乙酰丙酸盐酸，5-氨基乙酰丙酸衍生物的盐和血红素。此外，描述了耐盐植物，其中用上述活性成分处理植物。此外，描述了一种引起盐受损植物回收的方法，包括将上述活性成分施用于盐受损植物。

3. 发明授权

US5733770A 5-aminolevulinic acid producing microorganism and process for producing 5-aminolevulinic acid 失效
标题翻译： 5-氨基乙酰丙酸生产微生物和生产5-氨基乙酰丙酸的方法
公开(公告)号：US5733770A
公开(公告)日：1998-03-31
申请号：US575818
申请日：1995-12-20
申请人： Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
发明人： Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
IPC分类号： C12P13/00 , C12N1/20
CPC分类号： C12P13/005 , C12R1/01 , C12R1/19 , C12R1/38 , C12R1/85 , Y10S435/822
摘要： A microorganism that produces 5-aminolevulinic acid, wherein the microorganism has a 5-aminolevulinic acid dehydratase variant having a reduced inhibitor constant for a 5-aminolevulinic acid dehydratate inhibitor. A microorganism that produces 5-aminolevulinic acid, wherein the microorganism is a photosynthetic bacterium that produces 5-aminolevulinic acid without light irradiation. A progess for producing 5-aminolevulinic acid comprising the step of culturing a microorganism that produces 5-aminolevulinic acid in a culture medium under at least one condition selected from the group consisting of (a) less than 1 ppm of dissolved oxygen concentration in the culture medium, (b) from -180 to 50 mV of oxidation-reduction potential in the culture medium, and (c) from 5.times.10.sup.-9 to (KrM-2.times.10.sup.-8) (mol of O.sub.2 /ml.multidot.min.multidot.cell) of cellular respiration rate, wherein KrM represents the maximum cellular respiration rate when oxygen is supplied in an excess quantity.
摘要翻译：一种产生5-氨基乙酰丙酸的微生物，其中微生物具有5-氨基乙酰丙酸脱水抑制剂的抑制剂常数降低的5-氨基乙酰丙酸脱水酶变体。产生5-氨基乙酰丙酸的微生物，其中所述微生物是不照射光而产生5-氨基乙酰丙酸的光合细菌。一种用于生产5-氨基乙酰丙酸的方法，包括在选自以下的至少一种条件下培养在培养基中产生5-氨基乙酰丙酸的微生物的步骤：（a）在培养物中小于1ppm的溶解氧浓度培养基中，（b）在培养基中的-180至50mV的氧化还原电位，和（c）5×10 -9至（KrM-2×10 -8）（摩尔的O 2 / ml×Min×细胞）的细胞呼吸速率，其中当以超量供给氧气时，KrM表示最大的细胞呼吸速率。

4. 发明授权

US5489572A Methods for reducing nitrate nitrogen and oxalic acids contents nin plants 失效
标题翻译：减少植物硝酸盐氮和草酸含量的方法
公开(公告)号：US5489572A
公开(公告)日：1996-02-06
申请号：US292024
申请日：1994-08-18
申请人： Ryuji Yoshida , Tohru Tanaka , Yasushi Hotta
发明人： Ryuji Yoshida , Tohru Tanaka , Yasushi Hotta
IPC分类号： A01N37/44
CPC分类号： A01N37/44 , Y02P60/218
摘要： Methods for reducing nitrate nitrogen and oxalic acid contents in plants, each of which comprises applying 5-aminolevulinic acid, a salt thereof or a mixture thereof. Nitrate nitrogen and oxalic acid contents in plants having high nitrate nitrogen and oxalic acid contents can be reduced effectively and easily.
摘要翻译：减少植物中硝酸盐氮和草酸含量的方法，每种方法包括施用5-氨基乙酰丙酸，其盐或其混合物。硝酸盐氮和草酸含量高的植物中的氮和草酸含量可以有效降低。

5. 发明授权

US5763235A 5-aminolevulinic acid producing microorganism and process for producing 5-aminolevulinic acid 失效
标题翻译： 5-氨基乙酰丙酸生产微生物和生产5-氨基乙酰丙酸的方法
公开(公告)号：US5763235A
公开(公告)日：1998-06-09
申请号：US813088
申请日：1997-03-07
申请人： Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
发明人： Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
IPC分类号： C12P13/00
CPC分类号： C12P13/005 , C12R1/01 , C12R1/19 , C12R1/38 , C12R1/85 , Y10S435/822
摘要： A microorganism that produces 5-aminolevulinic acid, wherein the microorganism has a 5-aminolevulinic acid dehydratase variant having a reduced inhibitor constant for a 5-aminolevulinic acid dehydratase inhibitor. A microorganism that produces 5-aminolevulinic acid, wherein the microorganism is a photosynthetic bacterium that produces 5-aminolevulinic acid without light irradiation. A process for producing 5-aminolevulinic acid comprising the step of culturing a microorganism that produces 5-aminolevulinic acid in a culture medium under at least one condition selected from the group consisting of (a) less than 1 ppm of dissolved oxygen concentration in the culture medium, (b) from -180 to 50 mV of oxidation-reduction potential in the culture medium, and (c from 5.times.10.sup.-9 to (KrM-2.times.10.sup.-8) (mol of O.sub.2 /ml.multidot.min.cndot.cell) of cellular respiration rate, wherein KrM represents the maximum cellular respiration rate when oxygen is supplied in an excess quantity.
摘要翻译：一种产生5-氨基乙酰丙酸的微生物，其中微生物具有5-氨基乙酰丙酸脱水酶抑制剂的抑制剂常数降低的5-氨基乙酰丙酸脱水酶变体。产生5-氨基乙酰丙酸的微生物，其中所述微生物是不照射光而产生5-氨基乙酰丙酸的光合细菌。一种生产5-氨基乙酰丙酸的方法，包括在选自以下的至少一种条件下培养在培养基中产生5-氨基乙酰丙酸的微生物的步骤：（a）在培养物中小于1ppm的溶解氧浓度培养基中，（b）培养基中-180至50mV的氧化还原电位，和（c从5×10 -9至（KrM-2×10 -8）（O 2 / ml×Mincell）的细胞呼吸速率，其中KrM表示当以超量供应氧气时的最大细胞呼吸速率。

6. 发明授权

US06342377B1 Microorganisms producing 5-aminolevulinic acid and processes for producing 5-aminolevulinic acid by using the same 有权
标题翻译：生产5-氨基乙酰丙酸的微生物及使用该5-氨基乙酰丙酸的方法
公开(公告)号：US06342377B1
公开(公告)日：2002-01-29
申请号：US09424671
申请日：2000-02-28
申请人： Seiji Nishikawa , Tohru Tanaka , Tomomi Kaminaga , Kikuo Watanabe , Nobuya Miyachi , Keitaro Watanabe , Yasushi Hotta
发明人： Seiji Nishikawa , Tohru Tanaka , Tomomi Kaminaga , Kikuo Watanabe , Nobuya Miyachi , Keitaro Watanabe , Yasushi Hotta
IPC分类号： C12P1300
CPC分类号： C12N9/1029 , C12P13/005
摘要： Microorganisms producing 5-aminolevulinic acid which show a 5-aminolevulinic acid synthetase activity of 2 to 7 (nmol/min/mg protein) under aerobic culture conditions with a dissolved oxygen concentration of 0.70 to 6.60 ppm; a process for producing 5-aminolevulinic acid characterized by culturing one or more microorganisms and harvesting 5-aminolevulinic acid from the obtained culture; a process for producing 5-aminolevulinic acid characterized by culturing 5-aminolevulinic acid-producing microorganisms in a medium containing 5 to 500 &mgr;M of iron components; and a method for culturing 5-aminolevulinic acid-producing microorganisms.
摘要翻译：产生5-氨基乙酰丙酸的微生物，其在需氧培养条件下，溶解氧浓度为0.70至6.60ppm，显示5-7个氨基乙酰丙酸合成酶活性为2至7（nmol / min / mg蛋白）; 一种生产5-氨基乙酰丙酸的方法，其特征在于培养一种或多种微生物并从所得培养物中收获5-氨基乙酰丙酸; 一种生产5-氨基乙酰丙酸的方法，其特征在于在含有5-500微米铁成分的培养基中培养5-氨基乙酰丙酸生产微生物; 以及培养5-氨基乙酰丙酸生产微生物的方法。

7. 发明授权

US5318788A Method for improving pigmentation of rind of apple 失效
标题翻译：改善苹果皮肤色素沉着的方法
公开(公告)号：US5318788A
公开(公告)日：1994-06-07
申请号：US151264
申请日：1993-11-12
申请人： Kiyoshi Yokota , Tohru Tanaka , Yasushi Hotta
发明人： Kiyoshi Yokota , Tohru Tanaka , Yasushi Hotta
IPC分类号： A01G7/00 , A01G7/06 , A01N37/44 , A23L1/272
CPC分类号： A01N37/44 , A01G7/06
摘要： A method for improving pigmentation of the rind of anthocyanin-containing apples comprising treating fruit-bearing apple trees or apples before or after harvesting with an effective amount of an agent which comprises 5-aminolevulinic acid, a salt thereof or a mixture thereof as an active component.
摘要翻译：一种用于改善含花青素的苹果皮的色素沉着的方法，包括用有效量的包含5-氨基乙酰丙酸，其盐或其混合物作为活性物质的试剂在收获之前或之后处理果实的苹果树或苹果零件。

8. 发明授权

US09474770B2 Prophylactic agent and/or therapeutic agent for sepsis 有权
标题翻译：脓毒症的预防剂和/或治疗剂
公开(公告)号：US09474770B2
公开(公告)日：2016-10-25
申请号：US14237407
申请日：2012-08-10
申请人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
发明人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
IPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
CPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.
摘要翻译：本发明提供了可用于预防和治疗败血症的败血症治疗药物。制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁。 ALA的优选实例包括ALA; 各种ALA的酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。

9. 发明授权

US09012502B2 Cancer heat therapy-enhancing agent 有权
标题翻译：癌症热疗增强剂
公开(公告)号：US09012502B2
公开(公告)日：2015-04-21
申请号：US13820303
申请日：2011-09-12
申请人： Taku Chibazakura , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
发明人： Taku Chibazakura , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
IPC分类号： A61K31/221 , C07C229/22 , A61K31/197
CPC分类号： C07C229/22 , A61K31/197
摘要： Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): R2R1NCH2COCH2CH2COR3 (1) [wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.
摘要翻译：提供了不与光动力疗法结合的癌症热疗的增强剂。通过使用作为癌症热疗的增强剂，可以通过使用由式（1）表示的5-氨基乙酰丙酸获得癌症治疗：R2R1NCH2COCH2CH2COR3（1）[其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基）或其盐。

10. 发明申请

US20140186464A1 PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR SEPSIS 有权
标题翻译：预防剂和/或治疗剂
公开(公告)号：US20140186464A1
公开(公告)日：2014-07-03
申请号：US14237407
申请日：2012-08-10
申请人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
发明人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
IPC分类号： A61K33/26 , A61K45/06 , A61K31/197
CPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.
摘要翻译：本发明提供了可用于预防和治疗败血症的败血症治疗药物。制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁。 ALA的优选实例包括ALA; 各种ALA的酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。

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