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1. 发明申请

US20110212163A1 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：磁力加热用于药物输送和其他应用
公开(公告)号：US20110212163A1
公开(公告)日：2011-09-01
申请号：US13055195
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
发明人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
IPC分类号： A61K47/02 , A61K9/127
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/00
摘要： The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.
摘要翻译：本发明一般涉及使用外部触发器（例如磁场）从制品中释放化合物的系统和方法。本发明的一个方面通常涉及含有易磁化物质的制品。将易磁感应材料暴露于诸如振荡磁场的磁场可能导致敏感材料的温度升高。在一些实施方案中，可以使用这种温度升高来引起药物或其它可释放材料从制品中的释放。例如，药物可以包含在与易感材料热连通的热敏材料中，或者药物可以包含在外壳内，该外壳至少部分地由热敏材料隔热与易感材料的通讯。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过在受试者内植入制品，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

2. 发明申请

US20110212027A1 RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的放射性加热
公开(公告)号：US20110212027A1
公开(公告)日：2011-09-01
申请号：US13055227
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Alan J. Fenn , William L. Neeley , Robert S. Langer
发明人： Todd R. Hoare , Daniel S. Kohane , Alan J. Fenn , William L. Neeley , Robert S. Langer
IPC分类号： A61K49/00 , A61K47/30 , C08F20/56
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32 , C08G73/0266 , C08L79/02
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna, such as a microwave receive antenna may be used to focus microwave and/or radiofrequency radiation on an article. For instance, the receive antenna may focus microwave and/or radiofrequency radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器（例如使用微波辐射或其它形式的辐射，例如射频辐射）从制品中释放可释放物质的系统和方法。这样的系统和方法可用于例如生物应用（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于辐射如微波和/或射频辐射可能导致材料温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，诸如微波接收天线的接收天线可用于将微波和/或射频辐射聚焦在物品上。例如，接收天线可以将微波和/或射频辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

3. 发明申请

US20110166060A1 TYMPANIC MEMBRANE PERMEATING EAR DROPS AND USES THEREOF 有权
标题翻译：透明膜渗透油墨及其用途
公开(公告)号：US20110166060A1
公开(公告)日：2011-07-07
申请号：US12993358
申请日：2009-05-19
申请人： Emmanuel John Simons , Todd R. Hoare , Daniel S. Kohane , Robert S. Langer
发明人： Emmanuel John Simons , Todd R. Hoare , Daniel S. Kohane , Robert S. Langer
IPC分类号： A61K38/12 , A61K31/7048 , A61K31/60 , A61K31/573 , A61K31/57 , A61K31/545 , A61K31/546 , A61K31/5415 , A61K31/5383 , A61K31/497 , A61K31/496 , A61K31/505 , A61K31/437 , A61K31/445 , A61K31/4402 , A61K31/421 , A61K31/42 , A61K31/407 , A61K31/38 , A61K31/245 , A61K31/192 , A61K31/18 , A61K31/165 , A61P27/16
CPC分类号： A61K9/0046 , A61K47/48023 , A61K47/48046 , A61K47/4823 , A61K47/48784 , A61K47/54 , A61K47/543 , A61K47/61 , A61K47/6903 , Y10S514/817
摘要： The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
摘要翻译：本发明提供了用于在完整鼓膜上非侵入性递送治疗剂的组合物和方法。例如，组合物包括渗透促进剂，其增加穿过鼓膜的治疗剂（例如抗生素）的通量。这样的组合物特别可用于治疗中耳炎。另外，组合物可以包括在一些实施方案中形成持续释放储存器的持续释放剂，其一旦施用于患者就位。

4. 发明授权

US08822410B2 Tympanic membrane permeating ear drops and uses thereof 有权
标题翻译：鼓膜渗透耳滴及其用途
公开(公告)号：US08822410B2
公开(公告)日：2014-09-02
申请号：US12993358
申请日：2009-05-19
申请人： Emmanuel John Simons , Todd R. Hoare , Daniel S. Kohane , Robert S. Langer
发明人： Emmanuel John Simons , Todd R. Hoare , Daniel S. Kohane , Robert S. Langer
IPC分类号： A61K38/12 , A61K31/7048 , A61K31/18 , A61P27/16 , A61K8/18 , A61K31/245 , A61K31/42 , A61K31/38 , A61K47/48 , A61K9/00
CPC分类号： A61K9/0046 , A61K47/48023 , A61K47/48046 , A61K47/4823 , A61K47/48784 , A61K47/54 , A61K47/543 , A61K47/61 , A61K47/6903 , Y10S514/817
摘要： The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
摘要翻译：本发明提供了用于在完整鼓膜上非侵入性递送治疗剂的组合物和方法。例如，组合物包括渗透促进剂，其增加穿过鼓膜的治疗剂（例如抗生素）的通量。这样的组合物特别可用于治疗中耳炎。另外，组合物可以包括在一些实施方案中形成持续释放储存器的持续释放剂，其一旦施用于患者就位。

5. 发明授权

US08414912B2 Contact lens drug delivery device 有权
标题翻译：隐形眼镜药物输送装置
公开(公告)号：US08414912B2
公开(公告)日：2013-04-09
申请号：US12636671
申请日：2009-12-11
申请人： Joseph B. Ciolino , Todd R. Hoare , Daniel S. Kohane
发明人： Joseph B. Ciolino , Todd R. Hoare , Daniel S. Kohane
IPC分类号： A61K9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K31/496 , G02C7/04 , Y02A50/411 , Y02A50/491
摘要： The present invention relates generally to devices and methods for administering one or more active agents to the eye of a human or animal patient in need thereof, and more particularly to devices for application to the cornea which release active agent to the eye in a controlled manner.
摘要翻译：本发明一般涉及向有需要的人或动物患者的眼睛施用一种或多种活性剂的装置和方法，更具体地涉及用于以受控方式将活性剂释放到眼睛的角膜的装置。

6. 发明申请

US20110230568A1 HEATING OF POLYMERS AND OTHER MATERIALS USING RADIATION FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：加热聚合物和其他材料，使用辐射进行药物递送和其他应用
公开(公告)号：US20110230568A1
公开(公告)日：2011-09-22
申请号：US13055177
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Jesus Santamaria Ramiro
发明人： Todd R. Hoare , Daniel S. Kohane , Jesus Santamaria Ramiro
IPC分类号： A61K47/30 , A61P35/00 , A61P25/00 , A61P3/10 , A61P9/00 , A61P37/06 , A61P29/00
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using infrared or near-infrared radiation. Such systems and methods may be useful, for example in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation-sensitive material to radiation such as infrared or near-infrared radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna may be used to focus infrared or near- infrared radiation on an article. For instance, the receive antenna may focus infrared or near-infrared radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器例如使用红外或近红外辐射从制品中释放可释放物质的系统和方法。这样的系统和方法可能是有用的，例如在生物应用中（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于诸如红外或近红外辐射的辐射可能导致材料的温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，接收天线可用于将红外或近红外辐射聚焦在物品上。例如，接收天线可以将红外或近红外辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

7. 发明申请

US20100239637A1 CONTACT LENS DRUG DELIVERY DEVICE 有权
标题翻译：联系人眼镜药物递送装置
公开(公告)号：US20100239637A1
公开(公告)日：2010-09-23
申请号：US12636671
申请日：2009-12-11
申请人： Joseph B. Ciolino , Todd R. Hoare , Daniel S. Kohane
发明人： Joseph B. Ciolino , Todd R. Hoare , Daniel S. Kohane
IPC分类号： A61K9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K31/496 , G02C7/04 , Y02A50/411 , Y02A50/491
摘要： The present invention relates generally to devices and methods for administering one or more active agents to the eye of a human or animal patient in need thereof, and more particularly to devices for application to the cornea which release active agent to the eye in a controlled manner.
摘要翻译：本发明一般涉及向有需要的人或动物患者的眼睛施用一种或多种活性剂的装置和方法，更具体地涉及用于以受控方式将活性剂释放到眼睛的角膜的装置。

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