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1. 发明申请

US20110212027A1 RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的放射性加热
公开(公告)号：US20110212027A1
公开(公告)日：2011-09-01
申请号：US13055227
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Alan J. Fenn , William L. Neeley , Robert S. Langer
发明人： Todd R. Hoare , Daniel S. Kohane , Alan J. Fenn , William L. Neeley , Robert S. Langer
IPC分类号： A61K49/00 , A61K47/30 , C08F20/56
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32 , C08G73/0266 , C08L79/02
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna, such as a microwave receive antenna may be used to focus microwave and/or radiofrequency radiation on an article. For instance, the receive antenna may focus microwave and/or radiofrequency radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器（例如使用微波辐射或其它形式的辐射，例如射频辐射）从制品中释放可释放物质的系统和方法。这样的系统和方法可用于例如生物应用（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于辐射如微波和/或射频辐射可能导致材料温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，诸如微波接收天线的接收天线可用于将微波和/或射频辐射聚焦在物品上。例如，接收天线可以将微波和/或射频辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

2. 发明申请

US20200146740A1 Thermodilatation and Thermocompression to Facilitate Targeted Cluster Tissue Ablation and Immune Response 审中-公开
公开(公告)号：US20200146740A1
公开(公告)日：2020-05-14
申请号：US16186317
申请日：2018-11-09
申请人： William W. Jow , John Mon , Stuart E. Katz , Alan J. Fenn
发明人： William W. Jow , John Mon , Stuart E. Katz , Alan J. Fenn
IPC分类号： A61B18/04 , A61B18/02 , A61B18/18
摘要： Method for treatment of the body with localized energy application in combination with other treatments to facilitate cluster tissue ablation and increase immune response including a method of treatment of a localized treatment area of a body including injection, IV or otherwise to entrap and/saturate a localized treatment area to be used singularly or in combination with: a high electric conductive material comprising a saline solution, hypertonic saline solution, a solution with metallic compounds, metals, nanoparticles, gel, polymers, high-polarity molecules, peptides, liposomes to treat and cause preferential heating and effect secondary conductive heating from cluster sites to adjacent tissues using external or intracavitary energy applicators.

3. 发明授权

US06768925B2 Method for improved safety in externally focused microwave thermotherapy for treating breast cancer 有权
标题翻译：改善外部聚焦微波热疗法治疗乳腺癌的安全性的方法
公开(公告)号：US06768925B2
公开(公告)日：2004-07-27
申请号：US10195455
申请日：2002-07-16
申请人： Alan J. Fenn , John Mon , Dennis Smith
发明人： Alan J. Fenn , John Mon , Dennis Smith
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method and apparatus that increases safety when employing externally focused adaptive phased array microwave thermotherapy (hyperthermia) for breast cancer treatment include microwave absorbing pads and metallic shielding to prevent undesired or stray surface tissue heating and to cushion the breast from mechanical pressure during breast compression. The microwave absorbing pads are attached on the top of the microwave waveguide thermotherapy applicators and on top of the breast compression paddles. A metallic-shielding strip mounted across the top portion of the microwave applicator aperture acts to block microwave radiation from illuminating the base of the breast and chest wall area. The patient treatment table utilizes a metallic shield to shield the body from stray microwave radiation. Combined E-field and temperature sensors within a single catheter are used to require only a single minimally invasive skin entry point for E-field focusing and measurement of the tumor temperature. Breast compression is maintained for a period of time following microwave-induced heating to accumulate additional equivalent thermal dose. Treatments incorporating the safety improvements include thermotherapy for early-stage breast carcinomas, locally advanced breast cancer, ductal carcinoma in-situ, and benign breast lesions.
摘要翻译：使用外部聚焦的自适应相控阵微波热疗法（热疗）用于乳腺癌治疗的方法和装置包括微波吸收垫和金属屏蔽物，以防止不期望的或杂散的表面组织加热并且在乳房压缩期间使乳房缓冲乳房的机械压力。微波吸收垫连接在微波波导热疗器施加器的顶部并且在乳房压缩桨的顶部。安装在微波加工器孔的顶部的金属屏蔽条用于阻止微波辐射照射乳房和胸壁区域的基部。患者治疗台使用金属屏蔽来屏蔽身体免受杂散微波辐射。单个导管内的组合电场和温度传感器仅用于仅需要单个微创皮肤入口点进行电场聚焦和测量肿瘤温度。乳房压缩在微波诱导加热后保持一段时间，以累积额外的等效热剂量。结合安全改善的治疗包括早期乳腺癌的热疗，局部晚期乳腺癌，原位导管癌和良性乳腺病变。

4. 发明授权

US07833220B2 Method and apparatus treating tissue adjacent a bodily conduit with thermocompression and drugs 有权
标题翻译：用热压和药物处理身体导管附近的组织的方法和装置
公开(公告)号：US07833220B2
公开(公告)日：2010-11-16
申请号：US10504302
申请日：2003-02-19
申请人： John Mon , Alan J. Fenn
发明人： John Mon , Alan J. Fenn
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00023 , A61B2018/00214 , A61B2018/00285 , A61B2018/00547 , A61B2018/046 , A61K9/0004 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61N5/045 , A61N7/022 , Y10S436/829 , Y10S514/866 , Y10T428/2984
摘要： A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
摘要翻译：一种使用热疗法在身体导管附近处理组织的方法和装置（100），同时防止由于水肿导致的身体导管的障碍，包括将药物包封在热敏载体（例如脂质体）内部的区域内的待处理组织。由能量发射源（110）产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分。此外，由能量发射源（110）产生的热激活热敏载体以激活封装药物的释放，并且药物靶向待加热的组织。能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

5. 发明授权

US06788977B2 System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumor 有权
标题翻译：用于加热前列腺以治疗和预防前列腺肿瘤的生长和扩散的系统和方法
公开(公告)号：US06788977B2
公开(公告)日：2004-09-07
申请号：US10247747
申请日：2002-09-20
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B8/06 , A61B8/12 , A61B18/1815 , A61B18/24 , A61B2017/00022 , A61B2017/00092 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/1861 , A61B2090/378 , A61M25/04 , A61M25/1011 , A61M29/02 , A61M2205/3368 , A61N5/04 , A61N5/045 , A61N7/02 , A61N2005/067
摘要： Improvements in safety and efficacy for externally focused adaptive phased array microwave thermotherapy (hyperthermia) for treatment of cancer and benign conditions of an organ or an appendage are described. In order to reduce blood flow thereby accumulating additional equivalent thermal dose following the step of heating an organ or appendage by irradiating microwaves at the organ or appendage, the step of compressing the organ or appendage following the heating step is added to thermotherapy treatment. In a preferred embodiment, the organ is the prostate and periodic prostate compression is employed to reduce the prostate blood flow thereby allowing chemotherapy, thermosensitive liposome-encapsulated chemotherapy, or gene therapy to accumulate in the prostate region during thermotherapy. Doppler ultrasound imaging may be used to measure tumor blood flow rate and then serve as real-time feedback to assist in adjusting the amount of balloon catheter inflation and to assess damage to the tumor vasculature during the treatment.
摘要翻译：描述了用于治疗癌症和器官或附属物的良性状态的外部聚焦的自适应相控阵微波热疗法（高热）的安全性和功效的改进。为了减少血液流动，从而在通过在器官或附属物上照射微波加热器官或附属物的步骤后积累额外的等效热剂量，将加热步骤后的器官或附属物压缩的步骤加入到热疗法中。在优选的实施方案中，器官是前列腺，并且使用周期性前列腺压缩来减少前列腺血流量，从而允许化学疗法，热敏脂质体包封的化学疗法或基因治疗在热疗期间在前列腺区积累。多普勒超声成像可用于测量肿瘤血流速率，然后作为实时反馈，以协助调整球囊导管充气量，并评估治疗期间对肿瘤脉管系统的损伤。

6. 发明授权

US06477426B1 System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors 有权
公开(公告)号：US06477426B1
公开(公告)日：2002-11-05
申请号：US09597234
申请日：2000-06-20
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B8/06 , A61B8/12 , A61B18/1815 , A61B18/24 , A61B2017/00022 , A61B2017/00092 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/1861 , A61B2090/378 , A61M25/04 , A61M25/1011 , A61M29/02 , A61M2205/3368 , A61N5/04 , A61N5/045 , A61N7/02 , A61N2005/067
摘要： A system and method for safely heating cancerous and pre-cancerous conditions of the prostate, as well as benign and pre-benign lesions (any localized pathological change in the prostate tissue) by irradiation of the prostate tissue with coherent phased array or non-coherent energy is introduced. Microwave energy and prostate compression provide preferential heating of high-water content prostate carcinoma and benign cells in the prostate compared to the surrounding lower-water content normal prostate tissues and tissue surrounding the prostate. To coherently focus the energy, such as microwave energy, in the prostate, the patient's prostate can be compressed via a urethral and rectal balloon and either a single electric-field probe, inserted in the central portion of the prostate, or two noninvasive electric-field sensors on the urethral and rectal walls, can be used to measure a feedback signal to adjust the energy phase delivered to the applicators located in the urethra and in the rectum. The initial energy power delivered to the energy applicators is set to a desired value that is known to produce a desired increase in temperature in the prostate. Temperature feedback sensors are used to measure urethral and rectal wall temperatures during treatment to adjust the energy power delivered to the applicators to avoid overheating the urethral and rectal walls. The energy delivered to the applicators is monitored in real time during treatment, and the treatment is completed when a desired total energy dose has been administered. The system according to the invention can heat and destroy the prostate carcinoma and benign cells sufficiently in order to prevent prostate cancer and benign prostatic hyperplasia. The treatment is administered as a preventative for cancer and BPH, when a patient's PSA level is less than 4 and for BPH, when a patient's AUA Symptom Index scores less than 13.

7. 发明授权

US06470217B1 Method for heating ductal and glandular carcinomas and other breast lesions to perform thermal downsizing and a thermal lumpectomy 有权
公开(公告)号：US06470217B1
公开(公告)日：2002-10-22
申请号：US09548630
申请日：2000-04-13
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method for selectively heating cancerous conditions of the breast including invasive ductal carcinoma and invasive glandular lobular carcinoma, and pre-cancerous conditions of the breast including ductal carcinoma in-situ, lobular carcinoma in-situ, and intraductal hyperplasia, as well as benign lesions (any localized pathological change in the breast tissue) such as fibroadenomas and cysts by irradiation of the breast tissue with adaptive phased array focused microwave energy is introduced. Microwave energy provides preferential heating of high-water content breast tissues such as carcinomas, fibroadenomas, and cysts compared to the surrounding lower-water content normal breast tissues. To focus the microwave energy in the breast, the patient's breast can be compressed and a single electric-field probe, inserted in the central portion of the breast, or two noninvasive electric-field probes on opposite sides of the breast skin, can be used to measure a feedback signal to adjust the microwave phase delivered to waveguide applicators on opposite sides of the compressed breast tissue. The initial microwave power delivered to the microwave applicators is set to a desired value that is known to produce a desired increase in temperature in breast tumors. Temperature feedback sensors are used to measure skin temperatures during treatment to adjust the microwave power delivered to the waveguide applicators to avoid overheating the skin. The microwave energy delivered to the waveguide applicators is monitored in real time during treatment, and the treatment is completed when a desired total microwave energy dose has been administered. By heating and destroying the breast lesion sufficiently, lesions can be reduced in size and surrounding normal breast tissues are spared so that surgical mastectomy can be replaced with surgical lumpectomy or the lesions can be completely destroyed so that surgical mastectomy or lumpectomy is avoided.

8. 发明授权

US5540737A Minimally invasive monopole phased array hyperthermia applicators and method for treating breast carcinomas 失效
标题翻译：微创单极相控阵热疗仪及乳腺癌治疗方法
公开(公告)号：US5540737A
公开(公告)日：1996-07-30
申请号：US157928
申请日：1993-11-24
申请人： Alan J. Fenn
发明人： Alan J. Fenn
IPC分类号： A61N5/02 , A61N5/04 , A61N5/00
CPC分类号： A61N5/04 , A61N5/02
摘要： An RF hyperthermia applicator for inducing a temperature rise in a human female breast for treating carcinomas includes a waveguide applicator having an aperture and a phased-array of monopole electric field radiators coupled to a source of electric field energy for producing electric field radiation output from the waveguide through the aperture. Compression means is used for compressing a human breast to a predetermined thickness. The waveguide is positioned adjacent to the compression means such that the breast is positioned adjacent to the aperture and thereby receives electric field radiation from the waveguide. In another embodiment, at least two waveguide applicators are positioned on opposite sides of the compression means so that the compressed breast is positioned between the opposed apertures of the waveguides. An electric field probe is placed into a target within the breast to assist in focusing the electric field energy into the target.
摘要翻译：用于诱导人乳房乳房中温度升高以用于治疗癌症的RF热疗施加器包括具有孔径的波导施加器和耦合到电场能量源的单极电场辐射器的相控阵列，用于产生从波导通孔。压缩装置用于将人乳房压缩至预定厚度。波导定位成与压缩装置相邻，使得乳房定位成邻近孔径，从而接收来自波导的电场辐射。在另一个实施例中，至少两个波导管施加器位于压缩装置的相对侧上，使得压缩的乳房位于波导的相对的孔之间。将电场探针放置在乳房内的靶中，以帮助将电场能量聚焦到靶中。

9. 发明授权

US08749441B2 Simultaneous transmit and receive antenna system 有权
标题翻译：同时发射和接收天线系统
公开(公告)号：US08749441B2
公开(公告)日：2014-06-10
申请号：US13282700
申请日：2011-10-27
申请人： Alan J. Fenn , Peter T. Hurst , Jeffrey S. Herd , Kenneth E. Kolodziej , Leonard I. Parad , Hans Steyskal
发明人： Alan J. Fenn , Peter T. Hurst , Jeffrey S. Herd , Kenneth E. Kolodziej , Leonard I. Parad , Hans Steyskal
IPC分类号： H01Q9/16
CPC分类号： H01Q1/525 , H01Q21/20 , H01Q21/28
摘要： Described is a simultaneous transmit and receive antenna system having a ring array of transmit antenna elements and a receive antenna element disposed on an axis that is perpendicular to and passing through the center of the ring array. Alternatively, the ring array includes receive elements and a transmit antenna element is disposed on the axis perpendicular to the ring array. Opposite antenna elements in the ring array differ in phase by 180° so that a radiation pattern null occurs at the antenna element at the center of the ring array. Also included are at least one ground plane and an electrically-conductive cylinder disposed on the perpendicular axis inside the ring array to provide a high degree of isolation between the transmit and receive antenna elements. The system may be configured for wireless communications, for example, according to WIFI IEEE standard 802.11 or WIMAX IEEE standard 802.16.
摘要翻译：描述了具有发射天线元件的环阵列和设置在垂直于并穿过环阵列的中心的轴上的接收天线元件的同时发射和接收天线系统。或者，环阵列包括接收元件，并且发射天线元件设置在垂直于环阵列的轴上。环形阵列中的相对的天线元件的相位相差180°，使得在环阵列的中心处的天线元件处发生辐射图案零点。还包括设置在环阵列内的垂直轴上的至少一个接地平面和导电圆柱体，以在发射天线元件和接收天线元件之间提供高度隔离。该系统可以被配置用于无线通信，例如，根据WIFI IEEE标准802.11或WIMAX IEEE标准802.16。

10. 发明授权

US06725095B2 Thermotherapy method for treatment and prevention of cancer in male and female patients and cosmetic ablation of tissue 有权
标题翻译：男性和女性患者治疗和预防癌症的热疗方法和组织的化妆消融
公开(公告)号：US06725095B2
公开(公告)日：2004-04-20
申请号：US10270312
申请日：2002-10-15
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioning at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.
摘要翻译：用于治疗身体或器官的癌症或良性病症的方法使用能量选择性地照射身体组织。该方法包括以下步骤：监测邻近身体的皮肤表面的温度，将至少一个能量施加器定位在身体周围，将能量传递到至少一个能量施加器以选择性地用能量照射身体组织并且治疗癌症中的至少一种以及身体的良性状态，基于所监测的皮肤温度，调整在治疗期间被输送到至少一个能量施加器的功率水平，监测传送到至少一个能量施加器的能量，确定传递给所述至少一个能量施加器的总能量至少一个能量施加器，并且当所述至少一个能量施加器被递送到所述身体时，完成所述治疗。

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