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1. 发明授权

US08934968B2 Neurostimulation and coronary artery disease treatment 有权
标题翻译：神经刺激和冠状动脉疾病治疗
公开(公告)号：US08934968B2
公开(公告)日：2015-01-13
申请号：US11779769
申请日：2007-07-18
申请人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/362 , A61N1/36 , A61M5/142
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译：用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。

2. 发明授权

US06970741B1 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US06970741B1
公开(公告)日：2005-11-29
申请号：US10246554
申请日：2002-09-17
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
IPC分类号： A61M5/00 , A61M5/142 , A61M5/172 , A61N1/00 , A61N1/30 , A61N1/32
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

3. 发明授权

US07481759B2 Systems and methods for treatment of coronary artery disease 失效
标题翻译：用于治疗冠状动脉疾病的系统和方法
公开(公告)号：US07481759B2
公开(公告)日：2009-01-27
申请号：US10211463
申请日：2002-08-02
申请人： Todd K. Whitehurst , James P McGivern , Kelly H McClure , Mark R. Stultz
发明人： Todd K. Whitehurst , James P McGivern , Kelly H McClure , Mark R. Stultz
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： Methods and systems for treatment of coronary artery disease (CAD) include implantation of the discharge portion(s) of a catheter and, optionally, electrodes on a lead, near the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, the aorta, the left ventricle, the left atrium, and/or the pulmonary veins, among other locations. Disclosed treatments include drugs used for acute treatment of CAD, for chronic treatment of CAD, to promote angiogenesis, and/or as AGE Crosslink Breakers, among other drugs. For instance, the systems and methods reduce or eliminate the incidence of CAD and related morbidities, improve symptoms resulting from CAD, and/or improve cardiac blood flow, cardiac function, and patient quality of life.
摘要翻译：用于治疗冠状动脉疾病（CAD）的方法和系统包括将导管的放电部分和可选地在导线上的电极植入，以被刺激的组织附近。刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。刺激部位包括冠状动脉，主动脉，左心室，左心房和/或肺静脉等。公开的治疗包括用于急性治疗CAD，用于慢性CAD治疗，促进血管发生的药物和/或作为AGE交联断裂剂等药物。例如，系统和方法可减少或消除CAD和相关疾病的发生率，改善由CAD引起的症状和/或改善心脏血流量，心脏功能和患者生活质量。

4. 发明申请

US20100331807A1 TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION 有权
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US20100331807A1
公开(公告)日：2010-12-30
申请号：US12873170
申请日：2010-08-31
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.
摘要翻译：用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

5. 发明授权

US08401634B2 Treatment of movement disorders by brain stimulation 有权
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US08401634B2
公开(公告)日：2013-03-19
申请号：US12873170
申请日：2010-08-31
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.
摘要翻译：用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

6. 发明授权

US08301248B1 Sequenced and simultaneous stimulation for treating congestive heart failure 有权
标题翻译：有序和同时刺激治疗充血性心力衰竭
公开(公告)号：US08301248B1
公开(公告)日：2012-10-30
申请号：US12163803
申请日：2008-06-27
申请人： James R. Thacker , Kelly H. McClure , Todd K. Whitehurst
发明人： James R. Thacker , Kelly H. McClure , Todd K. Whitehurst
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A patient's ejection fraction is maximized through simultaneous sensing and stimulating across multiple electrodes. In one exemplary embodiment, a catheter or lead having multiple electrodes connected to a pulse generator is used. The pulse generator provides individual current control of the stimulus applied to each electrode, and further includes the ability to sense intrinsic and evoked depolarization through multiple electrodes. In another exemplary embodiment, a multiplicity of individual implantable microstimulators, each having its own current source and/or sensor and electrodes, cooperate in concert to provide multi-site stimulation and sensing.
摘要翻译：患者的射血分数通过同时感测和刺激跨多个电极而最大化。在一个示例性实施例中，使用具有连接到脉冲发生器的多个电极的导管或引线。脉冲发生器提供对施加到每个电极的刺激的单独电流控制，并且还包括通过多个电极感测固有和诱发去极化的能力。在另一个示例性实施例中，多个单独的可植入微型激励器（各自具有其自身的电流源和/或传感器和电极）协同协作以提供多位点刺激和感测。

7. 发明申请

US20080286327A1 THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY 失效
标题翻译： THOMBOLYSIS和CHRONIC抗凝治疗
公开(公告)号：US20080286327A1
公开(公告)日：2008-11-20
申请号：US11949752
申请日：2007-12-03
申请人： Todd K. Whitehurst , Kelly H. McClure , James R. Thacker
发明人： Todd K. Whitehurst , Kelly H. McClure , James R. Thacker
IPC分类号： A61K9/00 , A61K31/727 , A61K31/353 , A61K31/60 , A61K38/48
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a catheter, configuring one or more stimulation parameters to treat at least one of a myocardial infarction, a stroke, and a pulmonary embolism, programming the stimulator with the one or more stimulation parameters, delivering with the stimulator via the catheter at least one drug to at least one tissue in accordance with the one or more stimulation parameters, and limiting perfusion of the at least one tissue by delivering electrical stimulation with the stimulator via the at least one electrode to the at least one tissue.
摘要翻译：用心肌梗死，中风和肺栓塞中的至少一种治疗患者的方法和系统包括提供耦合到至少一个电极和导管的刺激器，配置一个或多个刺激参数以治疗下列中的至少一个：心肌梗塞，中风和肺栓塞，用一个或多个刺激参数对刺激器进行编程，根据该一个或多个刺激参数，通过导管将至少一种药物通过导管递送至至少一个组织，并限制通过将所述刺激器经由所述至少一个电极递送到所述至少一个组织的电刺激来灌注所述至少一个组织。

8. 发明授权

US08712547B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US08712547B2
公开(公告)日：2014-04-29
申请号：US13036278
申请日：2011-02-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： An implantable stimulation device includes a device body; at least one set of partitioned electrodes disposed on a portion of the device body and configured and arranged for application of electrical stimulation to adjacent tissue; and insulating material separating the partitioned electrodes from each other. Each set of partitioned electrodes includes a plurality of partitioned electrodes disposed around a circumference of the device body. The implantable stimulation device can be configured and arranged so that each of the partitioned electrodes is independently programmable.
摘要翻译：可植入刺激装置包括装置主体; 至少一组分隔电极，其设置在所述装置主体的一部分上，并被配置和布置成用于对相邻组织施加电刺激; 以及将分隔电极彼此分离的绝缘材料。每组分隔电极包括围绕装置主体的圆周设置的多个分隔电极。可植入式刺激装置可以被配置和布置成使得每个分隔电极可独立编程。

9. 发明授权

US08364278B2 Lead assembly for implantable microstimulator 有权
标题翻译：可植入微型激励器的导线组件
公开(公告)号：US08364278B2
公开(公告)日：2013-01-29
申请号：US10503281
申请日：2003-01-29
申请人： Anne M. Pianca , Todd K. Whitehurst , James P. McGivern
发明人： Anne M. Pianca , Todd K. Whitehurst , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： H01R43/16 , A61N1/05 , H01R13/5224 , Y10T29/49204
摘要： A lead assembly for a small implantable medical device connects a remote electrode to a microdevice and inhibits fluid ingress into the connection. Microdevices may provide either or both tissue stimulation and sensing. Known microdevices include spaced apart electrodes on the outer surface of the microdevice. The lead assembly includes an insulated lead including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode at the distal end of the lead and electrically connected to the at least one conductor, and a connector attached to the proximal end of the lead and adapted to be removably connectable to the microdevice. The connector includes at least one contact to electrically connect at least one device electrode on the microdevice to the at least one conductor. The lead assembly is configured to inhibit fluid ingress into the connector.
摘要翻译：用于小型可植入医疗装置的引导组件将远程电极连接到微型装置并且阻止流体进入连接。微器件可以提供组织刺激和感测之一或两者。已知的微器件在微器件的外表面上包括间隔开的电极。引线组件包括绝缘引线，其包括近端和远端，其间具有至少一个导体; 在所述引线的远端处的至少一个电极并且电连接到所述至少一个导体，以及连接到所述引线的近端并适于可移除地连接到所述微器件的连接器。所述连接器包括至少一个接触件，以将所述微器件上的至少一个器件电极电连接到所述至少一个导体。引线组件被配置为抑制流体进入连接器。

10. 发明授权

US06901296B1 Methods and systems for direct electrical current stimulation as a therapy for cancer and other neoplastic diseases 有权
标题翻译：直接电流刺激作为癌症和其他肿瘤疾病治疗的方法和系统
公开(公告)号：US06901296B1
公开(公告)日：2005-05-31
申请号：US10133768
申请日：2002-04-26
申请人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Janusz A. Kuzma
IPC分类号： A61N1/08 , A61N1/10 , A61N1/20 , A61N1/372
CPC分类号： A61N1/205 , A61N1/08 , A61N1/37205
摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue. The small stimulator provides means of stimulating a neoplasm with direct electrical current, such as relatively low-level direct current, without the need for external appliances during the stimulation session. The stimulator may be configured to be small enough to be implanted entirely within a neoplasm. Open- and closed-loop systems are disclosed.
摘要翻译：一个小的植入式刺激器包括至少两个用于向周围组织传递电刺激的电极。小的刺激器提供了用直接电流刺激肿瘤的手段，例如相对低的直流电流，而不需要在刺激期间的外部器具。刺激器可以被配置为足够小以完全植入肿瘤内。公开了开环和闭环系统。

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