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1. 发明授权

US06871099B1 Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain 有权
标题翻译：用于脊髓刺激的完全可植入的微刺激作为慢性疼痛的治疗
公开(公告)号：US06871099B1
公开(公告)日：2005-03-22
申请号：US09929597
申请日：2001-08-13
申请人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann , Janusz A. Kuzma
发明人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann , Janusz A. Kuzma
IPC分类号： A61N1/34 , A61N1/18
CPC分类号： A61N1/36071
摘要： An implantable stimulator(s), small enough to be located near or within an area of the spine responsible for sensations in a region experiencing chronic pain uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, it necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：小到足以位于脊柱区域内的负责在慢性疼痛区域感觉的植入式刺激器使用诸如可再充电电池的电源/存储装置。这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。必要时，必须使用外部设备将数据传送到和/或从激励器传输，并传输电力。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。

2. 发明授权

US08214048B1 Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 有权
标题翻译：用于自主神经纤维刺激的完全植入式神经刺激器作为尿和肠功能障碍的治疗
公开(公告)号：US08214048B1
公开(公告)日：2012-07-03
申请号：US11373756
申请日：2006-03-10
申请人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann
发明人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/36007
摘要： An implantable stimulator(s), small enough to be located near or adjacent to an autonomic nerve(s) innervating urinary and/or gastrointestinal structures, uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, if necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：小到足以位于支配尿和/或胃肠结构的自主神经附近或邻近的可植入刺激器使用诸如可再充电电池的电源/存储装置。这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。必要时，如果需要，外部设备用于向刺激器传送数据和/或从刺激器传输数据。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。

3. 发明授权

US06941171B2 Implantable stimulator methods for treatment of incontinence and pain 有权
标题翻译：用于治疗失禁和疼痛的植入式刺激器方法
公开(公告)号：US06941171B2
公开(公告)日：2005-09-06
申请号：US09931804
申请日：2001-08-16
申请人： Carla M. Mann , Todd K. Whitehurst , James P. McGivern , Gerald E. Loeb , Frances J. R. Richmond
发明人： Carla M. Mann , Todd K. Whitehurst , James P. McGivern , Gerald E. Loeb , Frances J. R. Richmond
IPC分类号： A61N1/00 , A61N1/34 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/36017 , A61N1/36071 , A61N1/37205
摘要： A method and system for treatment of incontinence, urgency, frequency, and/or pelvic pain includes implantation of electrodes on a lead or the discharge portion of a catheter adjacent the perineal nerve(s) or tissue(s) to be stimulated. Stimulation pulses, either electrical or drug infusion pulses, are supplied by a stimulator implanted remotely, and through the lead or catheter, which is tunneled subcutaneously between the stimulator and stimulation site. For instance, the system and method reduce or eliminate the incidence of unintentional episodes of bladder emptying by stimulating nerve pathways that diminish involuntary bladder contractions, improve closure of the bladder outlet, and/or improve the long-term health of the urinary system by increasing bladder capacity and period between emptying. Moreover, the system and method allow a patient to be taught to receive one or more patterns of neural stimulation that can be prescribed by a physician and administered without continuous oversight by a clinical practitioner.
摘要翻译：用于治疗失禁，紧迫性，频率和/或骨盆疼痛的方法和系统包括将电极植入导联或导管的排出部分，邻近会阴神经或要刺激的组织。刺激脉冲（电或药物输注脉冲）由远程植入的刺激器和通过刺激器和刺激部位之间皮下隧道穿过的导联或导管提供。例如，该系统和方法通过刺激神经通路降低或消除膀胱排空的无意发作，从而减少无意识的膀胱收缩，改善膀胱出口的闭合，和/或通过增加泌尿系统的长期健康来改善膀胱容量和排空期间。此外，该系统和方法允许患者接受一种或多种神经刺激模式，其可由医师处方并由临床医师进行无持续监督。

4. 发明授权

US06735474B1 Implantable stimulator system and method for treatment of incontinence and pain 有权
标题翻译：植入式刺激器系统和治疗失禁和疼痛的方法
公开(公告)号：US06735474B1
公开(公告)日：2004-05-11
申请号：US09642979
申请日：2000-08-18
申请人： Gerald E. Loeb , Francis J. R. Richmond , Carla M. Mann , Michael A. Faltys , Todd K. Whitehurst , James P. McGivern
发明人： Gerald E. Loeb , Francis J. R. Richmond , Carla M. Mann , Michael A. Faltys , Todd K. Whitehurst , James P. McGivern
IPC分类号： A61N136
CPC分类号： A61N1/36007 , A61N1/36071 , A61N1/37205
摘要： A method and system for treatment of incontinence and/or pelvic pain includes the injection or laparoscopic implantation of one or more battery- or radio frequency-powered microstimulators (10) beneath the skin of the perineum and/or adjacent the tibial nerve. The devices are programmed using radio-frequency control via an external controller (20, 30)) that can be used by a physician to produce patterns of output stimulation pulses judged to be efficacious by appropriate clinical testing to diminish symptoms. The stimulation program is retained in the microstimulator device (10) or external controller (20) and is transmitted when commanded to start and stop by a signal from the patient or caregiver. The system and method reduce the incidence of unintentional episodes of bladder emptying by stimulating nerve pathways (8) that diminish involuntary bladder contractions, improve closure of the bladder outlet, and/or improve the long-term health of the urinary system by increasing bladder capacity and period between emptying. The incidence of fecal incontinence is similarly reduced or eliminated. Furthermore, the system and method reduce or eliminate the incidence of pelvic pain by chronically stimulating nerve pathways that derive from the sacral roots using a miniature implantable neurostimulator that can be implanted with a minimal surgical procedure. Moreover, the system and method allow a patient to be taught to receive one or more patterns of neural stimulation that can be prescribed by a physician and administered without continuous oversight by a clinical practitioner.
摘要翻译：用于治疗失禁和/或骨盆疼痛的方法和系统包括在会阴皮肤和/或邻近胫神经之下的一个或多个电池或射频激励微刺激器（10）的注射或腹腔镜植入。所述装置通过外部控制器（20,30）使用射频控制进行编程，所述外部控制器（20,30））可由医生用来产生通过适当的临床测试判断为有效的输出刺激脉冲的模式以减少症状。刺激程序被保留在微型刺激器装置（10）或外部控制器（20）中，并且在命令通过来自患者或看护者的信号启动和停止时被传送。该系统和方法通过刺激神经通路（8）减少膀胱排空的无意发作的发生率（8），通过增加膀胱容量来减少非自愿膀胱收缩，改善膀胱出口闭合和/或改善泌尿系统的长期健康和排空之间的时期。大便失禁的发生率同样减少或消除。此外，该系统和方法通过使用可以以最小外科手术植入的微型可植入神经刺激器来减少或消除由骶根引起的长期刺激神经通路的盆腔疼痛的发生。此外，该系统和方法允许患者接受一种或多种神经刺激模式，其可由医师处方并由临床医师进行无持续监督。

5. 发明授权

US08588917B2 Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 失效
标题翻译：用于自主神经纤维刺激的完全植入式神经刺激器作为尿和肠功能障碍的治疗
公开(公告)号：US08588917B2
公开(公告)日：2013-11-19
申请号：US13493753
申请日：2012-06-11
申请人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann
发明人： Todd K. Whitehurst , James P. McGivern , Carla M. Mann
IPC分类号： A61N1/00 , A61B5/103
CPC分类号： A61N1/36007
摘要： An implantable stimulator(s), small enough to be located near or adjacent to an autonomic nerve(s) innervating urinary and/or gastrointestinal structures, uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, if necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：小到足以位于支配尿和/或胃肠结构的自主神经附近或邻近的可植入刺激器使用诸如可再充电电池的电源/存储装置。这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。必要时，如果需要，外部设备用于向刺激器传送数据和/或从刺激器传输数据。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。

6. 发明授权

US06522932B1 Implantable, expandable, multicontact electrodes and tools for use therewith 有权
标题翻译：可植入，可扩展的多电极电极和工具
公开(公告)号：US06522932B1
公开(公告)日：2003-02-18
申请号：US09783237
申请日：2001-02-13
申请人： Janusz A. Kuzma , Carla M. Mann
发明人： Janusz A. Kuzma , Carla M. Mann
IPC分类号： A61N105
CPC分类号： A61N1/05 , A61N1/0553
摘要： A paddle-type electrode or electrode array is implantable like a percutaneously inserted lead, i.e., without requiring major surgery, and once implanted, expands to provide a platform for many electrode configurations. The electrode array is provided on a flexible, foldable, subcarrier or substrate. Such subcarrier or substrate folds or compresses during implantation, thereby facilitating its insertion using percutaneous implantation techniques and tools. Once implanted, such subcarrier or substrate expands, thereby placing the electrodes in a desired spaced-apart positional relationship, and thus achieving a desired electrode array configuration. A steering stylet may be accommodated in a lumen provided in the subcarrier or substrate. Insertion tools useful with such electrode arrays include a needle with an oblong cross-section, which accommodates the dimensions of the folded array, and also accommodates other electrode arrays that are not necessarily folded.
摘要翻译：桨状电极或电极阵列可植入如经皮插入的引线，即不需要大量手术，并且一旦植入，扩张以提供用于许多电极构造的平台。电极阵列设置在柔性，可折叠的副载波或衬底上。这样的子载波或衬底在植入期间折叠或压缩，从而便于其使用经皮植入技术和工具的插入。一旦植入，这样的副载波或衬底就会膨胀，从而将电极放置在所希望的间隔开的位置关系中，从而实现所需的电极阵列构型。转向探针可以容纳在设置在子载波或基板中的内腔中。与这种电极阵列有用的插入工具包括具有长方形横截面的针，其适应折叠阵列的尺寸，并且还容纳不一定折叠的其它电极阵列。

7. 发明授权

US06205361B1 Implantable expandable multicontact electrodes 有权
标题翻译：可植入的可扩展多电极电极
公开(公告)号：US06205361B1
公开(公告)日：2001-03-20
申请号：US09239927
申请日：1999-01-28
申请人： Janusz A. Kuzma , Carla M. Mann
发明人： Janusz A. Kuzma , Carla M. Mann
IPC分类号： A61N105
CPC分类号： A61N1/05 , A61N1/0553
摘要： A paddle-type electrode or electrode array is implantable like a percutaneously inserted lead, i.e., without requiring major surgery, but once inserted, expands to provide a platform for many electrode configurations. The electrode array is provided on a flexible, foldable, subcarrier or substrate. Such subcarrier or substrate is folded, or compressed. during implantation, thereby facilitating its insertion using simple, well-known percutaneous implantation techniques. Once implanted, such subcarrier or substrate expands, thereby placing the electrodes in a desired spaced-apart positional relationship, and thus achieving a desired electrode array configuration. A memory element is used within the subcarrier or substrate which causes the electrode array to expand or unfold to a desired unfolded or expanded state after it has been implanted while in a folded up or compressed state. Further, the electrode array includes a membrane as an integral part thereof that prevents ingrowth of tissue inside the electrode array, thereby facilitating repositioning, removal, and/or reinsertion of the electrode array, as required.
摘要翻译：桨状电极或电极阵列可植入如经皮插入的引线，即不需要大量手术，但一旦插入，则扩张以提供许多电极构造的平台。电极阵列设置在柔性，可折叠的副载波或衬底上。这样的副载波或基板被折叠或压缩。在植入期间，从而通过使用简单的公知的经皮植入技术便于其插入。一旦植入，这样的副载波或衬底就会膨胀，从而将电极放置在所希望的间隔开的位置关系中，从而实现所需的电极阵列构型。在子载波或衬底内使用存储元件，其使得电极阵列在折叠或压缩状态下被植入之后扩展或展开到期望的展开或展开状态。此外，电极阵列包括作为其整体部分的膜，其防止组织在电极阵列内部的向内生长，从而有助于根据需要重新定位，去除和/或重新插入电极阵列。

8. 发明授权

US06658302B1 Insertion needle for use with implantable, expandable, multicontact electrodes 失效
标题翻译：插入针用于可植入，可扩张，多电极电极
公开(公告)号：US06658302B1
公开(公告)日：2003-12-02
申请号：US10188168
申请日：2002-07-01
申请人： Janusz A. Kuzma , Carla M. Mann
发明人： Janusz A. Kuzma , Carla M. Mann
IPC分类号： A61N105
CPC分类号： A61N1/0553 , A61N1/05 , A61N1/0558
摘要： An insertion needle facilitates the implantation of an electrode array carried on a flexible, foldable or compressible, subcarrier or substrate. Such subcarrier or substrate folds or compresses during implantation, thereby facilitating its insertion using the insertion needle. Once implanted, such subcarrier or substrate expands, thereby placing the electrodes in a desired spaced-apart positional relationship, and thus achieving a desired electrode array configuration. The insertion needle has a lumen with a non-circular cross-sectional shape, e.g., having a width greater than its height, to facilitate sliding the folded or compressed paddle-type electrode array therein, and further includes a longitudinal slit.
摘要翻译：插入针有助于植入在柔性，可折叠或可压缩的副载波或衬底上的电极阵列。这样的子载波或衬底在植入期间折叠或压缩，从而便于其使用插入针进行插入。一旦植入，这样的副载波或衬底就会膨胀，从而将电极放置在所希望的间隔开的位置关系中，从而实现所需的电极阵列构型。插入针具有具有非圆形横截面形状的内腔，例如具有大于其高度的宽度，以便于将折叠或压缩的桨式电极阵列滑入其中，并且还包括纵向狭缝。

9. 发明授权

US06415187B1 Implantable, expandable, multicontact electrodes and insertion needle for use therewith 有权
标题翻译：可植入，可扩张的多电极电极和插入针
公开(公告)号：US06415187B1
公开(公告)日：2002-07-02
申请号：US09778267
申请日：2001-02-07
申请人： Janusz A. Kuzma , Carla M. Mann
发明人： Janusz A. Kuzma , Carla M. Mann
IPC分类号： A61N105
CPC分类号： A61N1/0553 , A61N1/05 , A61N1/0558
摘要： A paddle-type electrode or electrode array is implantable like a percutaneously inserted lead, i.e., without requiring major surgery. Once implanted, the electrode array provides a platform for many electrode configurations. In a preferred embodiment, the electrode array is provided on a flexible, foldable or compressible, subcarrier or substrate. Such subcarrier or substrate folds or compresses during implantation, thereby facilitating its insertion using an insertion needle. Once implanted, such subcarrier or substrate expands, thereby placing the electrodes in a desired spaced-apart positional relationship, and thus achieving a desired electrode array configuration. The insertion needle has a lumen with a non-circular cross-sectional shape, e.g., having a width greater than its height, to facilitate sliding the folded or compressed paddle-type electrode array therein.
摘要翻译：桨状电极或电极阵列可植入如经皮插入的引线，即不需要大量手术。一旦植入，电极阵列为许多电极配置提供了平台。在优选实施例中，电极阵列设置在柔性，可折叠或可压缩的子载波或衬底上。这样的子载波或衬底在植入期间折叠或压缩，从而便于其使用插入针进行插入。一旦植入，这样的副载波或衬底就会膨胀，从而将电极放置在所希望的间隔开的位置关系中，从而实现所需的电极阵列构型。插入针具有非圆形横截面形状的内腔，例如具有大于其高度的宽度，以有助于将折叠或压缩的桨式电极阵列滑入其中。

10. 发明授权

US06605094B1 Integrated subcutaneous tunneling and carrying tool 有权
标题翻译：综合皮下隧道和携带工具
公开(公告)号：US06605094B1
公开(公告)日：2003-08-12
申请号：US09702422
申请日：2000-10-31
申请人： Carla M. Mann , Kenny K. Chinn
发明人： Carla M. Mann , Kenny K. Chinn
IPC分类号： A61B1900
CPC分类号： A61B17/3415 , A61B17/3401 , A61B2017/320044 , A61N1/0551
摘要： A subcutaneous tunneling and carrying tool has a handle, a rod, and a carrier. The tool is used in connection with the implantation of electrical stimulators within the body, and more particularly facilitates the surgical procedure in the connection of an electrode lead extension to the implantable stimulator when the electrode and stimulator may not be co-located. In one embodiment, tunneling is accomplished by a tip that also serves to connect the tool to a disposable carrier in which the lead extension connector is packaged. In another embodiment the carrier comprises a carrier body and a removable cover, wherein the carrier cover covers a carrier cavity during tunneling and includes a tunneling end, and the carrier cover is removed after tunneling to expose the carrier cavity, into which carrier cavity the electrode lead extension is inserted to carry back through the tunnel.
摘要翻译：皮下隧道和携带工具具有手柄，杆和载体。该工具用于在体内植入电刺激器，并且当电极和刺激器可能不位于同一位置时，更特别地便于将电极引线延伸部连接到可植入刺激器的外科手术。在一个实施例中，通过尖端实现隧道掘进，该尖端还用于将工具连接到一次性载体中，其中引线延伸连接器被封装在该一次性载体中。在另一个实施例中，载体包括载体主体和可移除盖，其中载体覆盖物在隧穿期间覆盖载体空腔并且包括隧道端，并且在隧穿之后移除载体盖以暴露载体腔，载体腔中的电极插入导线延长线穿过隧道。

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