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1. 发明授权

US08527034B2 Image derived input function for PET lung assessment 有权
标题翻译：用于PET肺评估的图像导出输入功能
公开(公告)号：US08527034B2
公开(公告)日：2013-09-03
申请号：US11775915
申请日：2007-07-11
申请人： Tobias Schroder , Marcos F. Vidal Melo , Guido Musch , Robert Scott Harris , Jose G. Venegas , Tilo Winkler
发明人： Tobias Schroder , Marcos F. Vidal Melo , Guido Musch , Robert Scott Harris , Jose G. Venegas , Tilo Winkler
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B5/08 , A61B6/037
摘要： An input function indicative of a time-activity curve in pulmonary arterial plasma is produced from a series of PET image frames in lieu of manual blood sampling. Two manually acquired blood samples are input along with pixel values of a blood pool region of interest (ROI) in the PET image frames into a two-parameter model of the ROI's time-activity curve. In an iterative process the model converges to accurately indicate the amount of 18F-FDG tracer in the arterial blood. Pulmonary uptake of the tracer is assessed with the PET image frames and the calculated input function.
摘要翻译：一系列PET图像帧代替手动血液取样产生指示肺动脉血浆中的时间 - 活动曲线的输入函数。将两个手动获取的血液样本与PET图像帧中的感兴趣的血池区域（ROI）的像素值一起输入到ROI的时间 - 活动曲线的双参数模型中。在迭代过程中，模型收敛以精确指示动脉血中18F-FDG示踪剂的量。使用PET图像帧和计算的输入函数评估示踪剂的肺部摄取。

2. 发明申请

US20090018438A1 Image Derived Input Function For PET Lung Assessment 有权
标题翻译：用于PET肺部评估的图像导出输入功能
公开(公告)号：US20090018438A1
公开(公告)日：2009-01-15
申请号：US11775915
申请日：2007-07-11
申请人： Tobias Schroder , Marcos F. Vidal Melo , Guido Musch , Robert Scott Harris , Jose G. Venegas , Tilo Winkler
发明人： Tobias Schroder , Marcos F. Vidal Melo , Guido Musch , Robert Scott Harris , Jose G. Venegas , Tilo Winkler
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B5/08 , A61B6/037
摘要： An input function indicative of a time-activity curve in pulmonary arterial plasma is produced from a series of PET image frames in lieu of manual blood sampling. Two manually acquired blood samples are input along with pixel values of a blood pool region of interest (ROI) in the PET image frames into a two-parameter model of the ROI's time-activity curve. In an iterative process the model converges to accurately indicate the amount of 18F-FDG tracer in the arterial blood. Pulmonary uptake of the tracer is assessed with the PET image frames and the calculated input function.
摘要翻译：一系列PET图像帧代替手动血液取样产生指示肺动脉血浆中的时间 - 活动曲线的输入函数。将两个手动获取的血液样本与PET图像帧中的感兴趣的血池区域（ROI）的像素值一起输入到ROI的时间 - 活动曲线的双参数模型中。在迭代过程中，模型收敛以精确指示动脉血中18F-FDG示踪剂的量。使用PET图像帧和计算的输入函数评估示踪剂的肺部摄取。

3. 发明授权

US08137302B2 Methods and systems for occluding collateral flow channels in the lung 有权
标题翻译：阻塞肺部旁路通道的方法和系统
公开(公告)号：US08137302B2
公开(公告)日：2012-03-20
申请号：US11684950
申请日：2007-03-12
申请人： Nikolai Aljuri , Jose G. Venegas , Ajit Nair , Rodney C. Perkins
发明人： Nikolai Aljuri , Jose G. Venegas , Ajit Nair , Rodney C. Perkins
IPC分类号： A61M16/00
CPC分类号： A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0479 , A61M16/0486 , A61M2202/0208 , A61M2202/025 , A61M2202/0275 , A61M2202/0283 , A61M2202/064
摘要： The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.
摘要翻译：相邻肺段之间的侧向流动通过阻塞具有颗粒的侧支流动通道而闭塞。从一个肺段通过中间纤维隔膜中的流动通道建立气流，并通过相邻的肺段排出。携带在气流中的颗粒变成滞留在侧流通道中以最终阻止流动。

4. 发明授权

US5217899A Cell stretching apparatus 失效
标题翻译：细胞伸展装置
公开(公告)号：US5217899A
公开(公告)日：1993-06-08
申请号：US572683
申请日：1990-08-24
申请人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , John D. Wright , Jose G. Venegas
发明人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , John D. Wright , Jose G. Venegas
IPC分类号： C12M3/00
CPC分类号： C12M35/04
摘要： Disclosed is an apparatus and method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subjected in vivo. The apparatus includes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively non-uniformly applied.
摘要翻译：公开了一种用于赋予细胞的活体培养的装置和方法，所述双轴机械力近似于细胞在体内受到的机械力。该装置包括位移施加器，其可被致动以接触和拉伸其上安装有活细胞培养物的膜。膜的拉伸赋予细胞双轴机械力。这些力可以均匀地施加到细胞，或者它们可以选择性地不均匀地施加。

5. 发明授权

US4155356A Respiration assisting apparatus and method 失效
标题翻译：呼吸辅助装置及方法
公开(公告)号：US4155356A
公开(公告)日：1979-05-22
申请号：US764865
申请日：1977-02-02
申请人： Jose G. Venegas
发明人： Jose G. Venegas
IPC分类号： A61M16/00
CPC分类号： A61M16/00 , A61M16/0006 , A61M16/0009 , A61M16/0075 , A61M2230/04
摘要： Process and apparatus for assisting expiration of respiratory gas from the lungs and/or assisting pulmonary blood circulation. The apparatus comprises means for generating a series of pressure pulses and means for transmitting the pressure pulses to air passageways in the lungs through respiratory gas. The generating means can comprise a solenoid controlled pump, a solenoid controlled valve, or a reflector means for directing pulses into the lungs. The transmitting means preferable comprises a tube for placement in the trachea. The frequency, amplitude, and shape of the pressure waves are controlled to outwardly displace walls of collapsed air passageways in the lungs, to maintain the outward displacement, and to generate a pumping action to assist in respiration. Wave characteristics may be controlled manually or modulated by signals derived from an electrocardiogram and/or a pleural pressure sensing means.
摘要翻译：用于辅助来自肺的呼吸气体呼气和/或辅助肺血液循环的方法和装置。该装置包括用于产生一系列压力脉冲的装置和用于通过呼吸气体将压力脉冲传送到肺中的空气通道的装置。发电装置可以包括电磁控制泵，电磁控制阀或用于将脉冲引导到肺中的反射器装置。发送装置优选包括用于放置在气管中的管。压力波的频率，振幅和形状被控制为向外移动肺中的塌陷空气通道的壁，以保持向外的位移，并产生泵送作用以辅助呼吸。波特征可以手动控制或者由来自心电图和/或胸膜压力感测装置的信号调制。

6. 发明申请

US20080228130A1 METHODS AND SYSTEMS FOR OCCLUDING COLLATERAL FLOW CHANNELS IN THE LUNG 有权
标题翻译：在肺内阻断阴道流通道的方法和系统
公开(公告)号：US20080228130A1
公开(公告)日：2008-09-18
申请号：US11684950
申请日：2007-03-12
申请人： Nikolai Aljuri , Jose G. Venegas , Ajit Nair , Rodney C. Perkins
发明人： Nikolai Aljuri , Jose G. Venegas , Ajit Nair , Rodney C. Perkins
IPC分类号： A61M16/00
CPC分类号： A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0479 , A61M16/0486 , A61M2202/0208 , A61M2202/025 , A61M2202/0275 , A61M2202/0283 , A61M2202/064
摘要： The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.
摘要翻译：相邻肺段之间的侧向流动通过阻塞具有颗粒的侧支流动通道而闭塞。从一个肺段通过中间纤维隔膜中的流动通道建立气流，并通过相邻的肺段排出。携带在气流中的颗粒变成滞留在侧流通道中以最终阻止流动。

7. 发明授权

US5348879A Cell stretching method 失效
标题翻译：细胞拉伸法
公开(公告)号：US5348879A
公开(公告)日：1994-09-20
申请号：US20267
申请日：1993-02-19
申请人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , Wright John D. , Jose G. Venegas
发明人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , Wright John D. , Jose G. Venegas
IPC分类号： C12M3/00 , C12N5/06 , C12Q1/02
CPC分类号： C12M35/04
摘要： Disclosed is a method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subject in vivo. The method utilizes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively nonuniformly applied.
摘要翻译：公开了一种赋予细胞的活体培养物的方法，所述双轴机械力近似于细胞在体内受到的机械力。该方法利用位移施加器，其可被致动以接触和拉伸其上安装有活细胞培养物的膜。膜的拉伸赋予细胞双轴机械力。这些力可以均匀地施加到细胞，或者它们可以选择性地不均匀地施加。

8. 发明授权

US5854423A Apparatus and method for assessment of visco-elasticity and shear adherence strength properties of blood clots 失效
标题翻译：用于评估血块粘弹性和剪切粘附强度性质的装置和方法
公开(公告)号：US5854423A
公开(公告)日：1998-12-29
申请号：US820149
申请日：1997-03-19
申请人： Jose G. Venegas
发明人： Jose G. Venegas
IPC分类号： G01N11/04 , G01N11/16 , G01N33/49 , G01N33/86 , G01N11/00 , C12Q1/56
CPC分类号： G01N11/167 , G01N11/04 , G01N33/86 , G01N33/4905
摘要： The present invention, a thrombo visco-elastogram (TVE), measures the changes in blood elastic and viscous properties in the magnitude and phase of the hydro-dynamic impedance of a tubular blood sample as the thrombus is formed. The present invention is an apparatus and method for assessment of visco-elasticity and shear adherence strength properties of blood clots. An apparatus for practicing the invention includes a tubular conduit connected to a fluid-filled cylindrical chamber and a fluid-filled reservoir, a piezo-electric bender attached to the fluid-filled cylindrical chamber, which creates a volume variation in the fluid-filled cylindrical chamber, a fluid source capable of injecting a fluid into the tubular conduit, a blood source capable of injecting blood into the tubular conduit, and a microprocessor to supply a sinusoidal wave form or limited band frequency content signal to the piezo-electric bender and record and analyze resulting pressure signals. A method for practicing the invention measures the viscosity and elastic shear modulus of a blood sample over time obtaining the average and maximum viscosity and shear modulus for the blood sample as it clots, and further includes applying a forcing signal, which displaces the clotted blood sample, while measuring the applied pressure for clot dislodgement from the walls of the test section. The adherence strength properties of the blood clot are calculated.
摘要翻译：本发明的血栓粘弹性图（TVE）测量形成血栓时管状血液样品的水动力学阻抗的大小和相位的血液弹性和粘性特性的变化。本发明是用于评估血块的粘弹性和剪切粘附强度性质的装置和方法。用于实施本发明的装置包括连接到流体填充的圆柱形室和流体填充的储存器的管状导管，附接到流体填充的圆柱形室的压电弯曲器，其产生流体填充圆柱形的体积变化腔室，能够将流体注射到管状导管中的流体源，能够将血液注入管状导管中的血液源，以及向压电弯曲器提供正弦波形或有限频带内容信号的微处理器，并且记录并分析所得到的压力信号。实施本发明的方法随着时间的推移测量血液样品的粘度和弹性剪切模量，获得血液样品凝块时的平均和最大粘度和剪切模量，并且还包括施加强迫信号，其移动凝血血样，同时测量从测试部分的壁移除凝块的施加压力。计算血块的粘附强度性质。

9. 发明授权

US5026348A Apparatus and method for the detection of IV catheter obstruction and extravasation 失效
标题翻译：用于检测IV导管阻塞和外渗的装置和方法
公开(公告)号：US5026348A
公开(公告)日：1991-06-25
申请号：US203280
申请日：1988-06-06
申请人： Jose G. Venegas
发明人： Jose G. Venegas
IPC分类号： A61M5/168
CPC分类号： A61M5/16859 , Y10S128/13
摘要： An in-line fluid conduit condition analyzer which includes a chamber placed in the conduit flow path and having one wall forming a piezoceramic bender that varies the chamber volume (or pressure) according to a predetermined waveform or noise spectrum and an associated piezoceramic pressure or displacement sensor. The time derivative of the displacement or the pressure are analyzed under computer control to identify conduit abnormalities. In particular application to intravenous fluid administration to patients, the system is capable of distinguishing a number of abnormalities including cathether obstruction, catheter needle out of the vein, catheter needle into the vein, as well as fluid bubble presence or conduit disconnection.
摘要翻译：一种在线流体导管条件分析器，其包括放置在导管流动路径中的腔室，并且具有形成压电陶瓷弯曲机的一个壁，其根据预定的波形或噪声谱以及相关的压电陶瓷压力或位移改变腔体积（或压力）传感器。在计算机控制下分析位移或压力的时间导数以识别导管异常。特别是对静脉注射给患者的应用，该系统能够区分许多异常，包括导管阻塞，静脉导管针，导管针入静脉，以及流体气泡存在或导管断开。

10. 发明授权

US10953169B2 Systems and methods for reverse pressure pulse therapy delivery 有权
公开(公告)号：US10953169B2
公开(公告)日：2021-03-23
申请号：US15037434
申请日：2014-11-19
申请人： Elliot E. Greenblatt , Jose G. Venegas
发明人： Elliot E. Greenblatt , Jose G. Venegas
IPC分类号： A61M15/00 , A61M16/00 , A61M16/14 , A61M11/00 , A61M11/02
摘要： A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir.

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