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1. 发明授权

US5348879A Cell stretching method 失效
标题翻译：细胞拉伸法
公开(公告)号：US5348879A
公开(公告)日：1994-09-20
申请号：US20267
申请日：1993-02-19
申请人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , Wright John D. , Jose G. Venegas
发明人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , Wright John D. , Jose G. Venegas
IPC分类号： C12M3/00 , C12N5/06 , C12Q1/02
CPC分类号： C12M35/04
摘要： Disclosed is a method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subject in vivo. The method utilizes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively nonuniformly applied.
摘要翻译：公开了一种赋予细胞的活体培养物的方法，所述双轴机械力近似于细胞在体内受到的机械力。该方法利用位移施加器，其可被致动以接触和拉伸其上安装有活细胞培养物的膜。膜的拉伸赋予细胞双轴机械力。这些力可以均匀地施加到细胞，或者它们可以选择性地不均匀地施加。

2. 发明授权

US5217899A Cell stretching apparatus 失效
标题翻译：细胞伸展装置
公开(公告)号：US5217899A
公开(公告)日：1993-06-08
申请号：US572683
申请日：1990-08-24
申请人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , John D. Wright , Jose G. Venegas
发明人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , John D. Wright , Jose G. Venegas
IPC分类号： C12M3/00
CPC分类号： C12M35/04
摘要： Disclosed is an apparatus and method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subjected in vivo. The apparatus includes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively non-uniformly applied.
摘要翻译：公开了一种用于赋予细胞的活体培养的装置和方法，所述双轴机械力近似于细胞在体内受到的机械力。该装置包括位移施加器，其可被致动以接触和拉伸其上安装有活细胞培养物的膜。膜的拉伸赋予细胞双轴机械力。这些力可以均匀地施加到细胞，或者它们可以选择性地不均匀地施加。

3. 发明授权

US08197494B2 Medical device position guidance system with wireless connectivity between a noninvasive device and an invasive device 有权
标题翻译：医疗设备位置引导系统，在无创设备和侵入性设备之间具有无线连接
公开(公告)号：US08197494B2
公开(公告)日：2012-06-12
申请号：US11530385
申请日：2006-09-08
申请人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella, Jr. , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
发明人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella, Jr. , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
IPC分类号： A61B19/00
CPC分类号： A61B5/06 , A61B5/061 , A61B5/062 , A61B5/065 , A61B5/07
摘要： A medical device position guidance system having a noninvasive medical device communicable with an invasive medical device. The system provides outputs useful to assess the position of an invasive medical device in an animal, such as a human. A magnetic field is used to gather information about the position of the invasive device. Radio waves are used to communicate this information between the noninvasive device and the invasive device.
摘要翻译：一种医疗装置位置引导系统，其具有可与侵入性医疗装置通信的无创医疗装置。该系统提供有用的评估在诸如人类的动物中的侵入性医疗装置的位置的输出。使用磁场来收集关于侵入性装置的位置的信息。无线电波用于在无创设备和侵入性设备之间传送该信息。

4. 发明授权

US09687174B2 Medical device position guidance system with wireless connectivity between a noninvasive and an invasive device 有权
公开(公告)号：US09687174B2
公开(公告)日：2017-06-27
申请号：US13472588
申请日：2012-05-16
申请人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella, Jr. , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
发明人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella, Jr. , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
IPC分类号： A61B5/06 , A61B5/07
CPC分类号： A61B5/06 , A61B5/061 , A61B5/062 , A61B5/065 , A61B5/07
摘要： A medical device position guidance system having a noninvasive medical device communicable with an invasive medical device. The system provides outputs useful to assess the position of an invasive medical device in an animal, such as a human. A magnetic field is used to gather information about the position of the invasive device. Radio waves are used to communicate this information between the noninvasive device and the invasive device.

5. 发明申请

US20080097475A1 MEDICAL DEVICE POSITION GUIDANCE SYSTEM WITH WIRELESS CONNECTIVITY BETWEEN A NONINVASIVE DEVICE AND AN INVASIVE DEVICE 有权
标题翻译：医疗器械位置指导系统与无创装置与入侵装置之间的无线连接
公开(公告)号：US20080097475A1
公开(公告)日：2008-04-24
申请号：US11530385
申请日：2006-09-08
申请人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
发明人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
IPC分类号： A61B19/00 , A61M5/00
CPC分类号： A61B5/06 , A61B5/061 , A61B5/062 , A61B5/065 , A61B5/07
摘要： A medical device position guidance system having a noninvasive medical device communicable with an invasive medical device. The system provides outputs useful to assess the position of an invasive medical device in an animal, such as a human. A magnetic field is used to gather information about the position of the invasive device. Radio waves are used to communicate this information between the noninvasive device and the invasive device.
摘要翻译：一种医疗装置位置引导系统，其具有可与侵入性医疗装置通信的无创医疗装置。该系统提供有用的评估在诸如人类的动物中的侵入性医疗装置的位置的输出。使用磁场来收集关于侵入性装置的位置的信息。无线电波用于在无创设备和侵入性设备之间传送该信息。

6. 发明申请

US20120226148A1 MEDICAL DEVICE POSITION GUIDANCE SYSTEM WITH WIRELESS CONNECTIVITY BETWEEN A NONINVASIVE AND AN INVASIVE DEVICE 有权
标题翻译：医疗器械位置指导系统与非侵入性和入侵设备之间的无线连接
公开(公告)号：US20120226148A1
公开(公告)日：2012-09-06
申请号：US13472588
申请日：2012-05-16
申请人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella, JR. , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
发明人： David S. Jaggi , Donald A. Kay , Joseph P. Killam , Salvatore Manzella, JR. , King Y. Moy , David K. Platt , Shawn G. Purnell , Alan R. Shapiro , Michael C. Shaughnessy , Mark C. Witt , Christopher Zachara
IPC分类号： A61M25/095 , A61B6/00
CPC分类号： A61B5/06 , A61B5/061 , A61B5/062 , A61B5/065 , A61B5/07
摘要： A medical device position guidance system having a noninvasive medical device communicable with an invasive medical device. The system provides outputs useful to assess the position of an invasive medical device in an animal, such as a human. A magnetic field is used to gather information about the position of the invasive device. Radio waves are used to communicate this information between the noninvasive device and the invasive device.
摘要翻译：一种医疗装置位置引导系统，其具有可与侵入性医疗装置通信的无创医疗装置。该系统提供有用的评估在诸如人类的动物中的侵入性医疗装置的位置的输出。使用磁场来收集关于侵入性装置的位置的信息。无线电波用于在无创设备和侵入性设备之间传送该信息。

7. 发明授权

US5425367A Catheter depth, position and orientation location system 失效
标题翻译：导管深度，位置和方向定位系统
公开(公告)号：US5425367A
公开(公告)日：1995-06-20
申请号：US755024
申请日：1991-09-04
申请人： Alan R. Shapiro , Donald A. Kay , Clair L. Strohl, Jr.
发明人： Alan R. Shapiro , Donald A. Kay , Clair L. Strohl, Jr.
IPC分类号： A61M25/00 , A61B5/06 , A61B19/00 , A61M25/095 , G01V3/10 , A61B5/05
CPC分类号： G01V3/105 , A61B5/06 , A61B2034/107 , A61B2034/2051 , A61B2090/3958 , A61B34/20 , H01F2005/027
摘要： A system for externally locating the depth and orientation of a catheter in tissue with an external probe which generates a virtual rotating magnetic field. The catheter includes an inductive coil for developing an induced signal in response to the virtual rotating magnetic field. An indicating device such as a light bar display or digital readout indicates the strength of the induced signal for locating, independently of the relative angular orientation of the probe and the catheter, the depth in the tissue of the catheter.
摘要翻译：用于外部定位导管在组织中的深度和取向的系统，该外部探针产生虚拟的旋转磁场。导管包括用于响应于虚拟旋转磁场显影感应信号的感应线圈。诸如光条显示器或数字读出器之类的指示装置指示用于定位的感应信号的强度，与探针和导管的相对角度取向无关，即导管组织中的深度。

8. 发明授权

US4272190A Optical measuring system 失效
标题翻译：光学测量系统
公开(公告)号：US4272190A
公开(公告)日：1981-06-09
申请号：US933465
申请日：1978-08-14
申请人： Alan R. Shapiro
发明人： Alan R. Shapiro
IPC分类号： G01M11/02 , G01B9/00
CPC分类号： G01M11/0235
摘要： Automatic test equipment for determining the optical properties of a test object is described. A highly collimated test beam of approximately one millimeter diameter is directed through the test object, is reflected, and passes through the test object a second time. The test beam source may be a laser and spatial filter, or equivalent. The reflected beam intensity and the exit point and return slope angle at which this beam leaves the test object are accurately measured to determine the optical characteristics of the test object. In one described embodiment, the exit point is determined by moving a knife edge to a point where half the light is blocked. The angle is determined by focusing the reflected beam and determining the position of the focal point, i.e. image height, by means of a pinhole mounted on a three axis micrometer platform. The light transmitted through the pinhole is detected by a light sensitive diode or equivalent. The entrance point of the test beam is determined by a mirror driven by a micrometer. A computer may be used to automatically drive all the micrometer scans and print out a numerical analysis of the optical properties of the test object. A second embodiment requires the test object to be located two focal lengths from an off-axis paraboloid mirror. A pinhole is located at the focal plane to determine the slope and a means for determining the beam position is located at the conjugate plane to measure the height of the exit beam. The second embodiment is more easily automated since the image height can be measured directly by any one of several electrical devices.
摘要翻译：描述了用于确定测试对象的光学性质的自动测试设备。大约一毫米直径的高度准直的测试光束被引导通过测试对象，被反射，并经过测试对象第二次。测试光束源可以是激光和空间滤波器或等效物。准确地测量反射光束强度以及该光束离开测试对象的出射点和返回倾斜角，以确定测试对象的光学特性。在一个所描述的实施例中，出口点是通过将刀刃移动到一半的光被阻挡的点来确定的。通过聚焦反射光束并通过安装在三轴测微平台上的针孔来确定焦点的位置即图像高度来确定角度。通过针孔传输的光由光敏二极管或等效物检测。测试光束的入射点由用千分尺驱动的镜子确定。计算机可用于自动驱动所有千分尺扫描并打印出测试对象的光学性质的数值分析。第二实施例要求测试对象从离轴抛物面镜位于两个焦距处。针孔位于焦平面以确定斜率，并且用于确定光束位置的装置位于共轭平面处以测量出射光束的高度。第二实施例更容易自动化，因为图像高度可以由几个电气设备中的任何一个直接测量。

9. 发明授权

US5645065A Catheter depth, position and orientation location system 失效
标题翻译：导管深度，位置和方向定位系统
公开(公告)号：US5645065A
公开(公告)日：1997-07-08
申请号：US420020
申请日：1995-04-11
申请人： Alan R. Shapiro , Donald A. Kay
发明人： Alan R. Shapiro , Donald A. Kay
IPC分类号： A61M25/00 , A61B5/06 , A61B19/00 , A61M25/095 , G01V3/10 , A61B5/05
CPC分类号： A61B5/06 , G01V3/105 , A61B2034/107 , A61B2034/2051 , A61B2090/062 , A61B2090/3958 , A61B34/20 , A61B34/25 , H01F2005/027
摘要： A system for externally locating a sensor in tissue, comprising an external probe including at least first and second electromagnetic output coils with non-parallel longitudinal axes; and output coil driver for alternately energizing the first and second output coils, for generating a time-varying magnetic field which penetrates the patient's skin; a sensor coil, having a longitudinal axis, for developing an induced electrical voltage in response to the time-varying magnetic field; a distance determinator, responsive to the induced voltage from the sensor coil, for determining from the induced voltage, the distance between the output coils and the sensor coil, independently of the relative angle, in a horizontal plane, between the sensor coil longitudinal axis, and the longitudinal axes of the output coils; and a direction determinator for determining and displaying the direction, in the horizontal plane, in which the sensor coil longitudinal axis is pointing.
摘要翻译：一种用于将传感器外部定位在组织中的系统，包括至少包括具有非平行纵向轴线的第一和第二电磁输出线圈的外部探头; 以及输出线圈驱动器，用于交替地激励第一和第二输出线圈，用于产生穿透患者皮肤的时变磁场; 传感器线圈，具有纵向轴线，用于响应于时变磁场而产生感应电压; 响应于来自传感器线圈的感应电压的距离确定器，用于根据感应电压确定输出线圈和传感器线圈之间的距离，独立于水平平面中在传感器线圈纵向轴线与传感器线圈之间的相对角度，和输出线圈的纵向轴线; 以及用于确定和显示传感器线圈纵向轴指向的水平面中的方向的方向确定器。

10. 发明授权

US4905698A Method and apparatus for catheter location determination 失效
标题翻译：用于导管位置确定的方法和装置
公开(公告)号：US4905698A
公开(公告)日：1990-03-06
申请号：US243689
申请日：1988-09-13
申请人： Clair L. Strohl, Jr. , Michael C. Ferragamo , Donald A. Kay , Alan R. Shapiro , Gary R. Whipple
发明人： Clair L. Strohl, Jr. , Michael C. Ferragamo , Donald A. Kay , Alan R. Shapiro , Gary R. Whipple
IPC分类号： A61B5/06 , A61M25/00 , A61M25/095
CPC分类号： A61B5/06
摘要： A method and apparatus (10) for determining accurately the location of the tip (14) of a catheter (16) inside biological tissue is disclosed including a locator (34) having a coil (38) wound axially on a core (36) and a detector (12) in the form of a coil (28) wound on a core (24) removably positionable within catheter (16) adjacent the tip (14). A controller (20) generates AC current to coil (38) to produce an electromagnetic field and compares it with the output voltage developed in coil ( b 28) when the locator (34) comes within close physical proximity to detecetor (12). Locator (34) includes an amber LED indicator (42) which is energized when the locator (34) is behind the detector (12) and the monitored output voltage is in phase with the generated alternating current and includes a red LED indicator (44) which is energized when the locator (34) is beyond the detector (12) and the monitored output voltage is 180.degree. out of phase with the generated alternating current. The controller (20) includes a beeper (48) which provides an audible indicator when energization changes between the indicators (42, 44).
摘要翻译：公开了一种用于准确地确定生物组织内的导管（16）的尖端（14）的位置的方法和装置（10），包括定位器（34），该定位器具有轴向地卷绕在芯部（36）上的线圈（38）卷绕在芯子（24）上的线圈（28）形式的检测器（12），其可拆卸地定位在邻近尖端（14）的导管（16）内。控制器（20）产生交流电流到线圈（38）以产生电磁场，并且当定位器（34）进入与物体接近检测器（12）时，与线圈（28）中产生的输出电压进行比较。定位器（34）包括琥珀色LED指示器（42），当定位器（34）位于检测器（12）后面时被激励，并且所监视的输出电压与产生的交流电流同相并且包括红色LED指示器（44）当定位器（34）超出检测器（12）并且所监视的输出电压与产生的交流电流相差180°时，其被通电。控制器（20）包括蜂鸣器（48），当在指示器（42,44）之间通电时，提供可听指示器。

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