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1. 发明授权

US08614085B2 Yeast with increased butanol tolerance involving a multidrug efflux pump gene 有权
标题翻译：具有增加的丁醇耐受性的酵母涉及多药外排泵基因
公开(公告)号：US08614085B2
公开(公告)日：2013-12-24
申请号：US12711308
申请日：2010-02-24
申请人： Tina K. Van Dyk
发明人： Tina K. Van Dyk
IPC分类号： C12N1/15 , C12N1/19 , C12N15/00 , C12P7/16 , C07K14/00 , C07H21/00 , C12N9/00 , C12P21/00
CPC分类号： C12P7/16 , Y02E50/10
摘要： Increasing tolerance to butanol in yeast has been accomplished by decreasing activity of Pdr5p encoded by an endogenous PDR5 gene. A deletion mutation of the PDR5 gene led to improved growth yield in the presence of butanol. Yeast cells with reduced Pdr5p activity, or other multidrug resistance ATP-binding cassette transporter protein activity encoded by CDR1 or BFR1, and a butanol biosynthetic pathway may be used for improved butanol production.
摘要翻译：通过降低由内源性PDR5基因编码的Pdr5p的活性，可以增加对酵母中丁醇的耐受性。 PDR5基因的缺失突变导致丁醇存在下生长产量提高。可以使用具有降低的Pdr5p活性的酵母细胞或由CDR1或BFR1编码的其他多药耐药性ATP结合盒转运蛋白活性和丁醇生物合成途径来改善丁醇生产。

2. 发明授权

US08569036B2 Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid 有权
标题翻译：固定化的TAL生物催化剂用于生产对羟基肉桂酸
公开(公告)号：US08569036B2
公开(公告)日：2013-10-29
申请号：US11485575
申请日：2006-07-12
申请人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Tina K. Van Dyk , Robert J. Trotman
发明人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Tina K. Van Dyk , Robert J. Trotman
IPC分类号： C12N1/20 , C12N9/88 , C12P7/40 , C12P7/24 , C07H21/04
CPC分类号： C12N11/04 , C12N9/88 , C12N11/06 , C12N11/10 , C12P7/42 , Y02P20/588
摘要： TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
摘要翻译：使用低浓度戊二醛将TAL细胞生物催化剂固定在藻酸盐交联珠粒中。生物催化剂珠具有高度稳定的TAL活性和机械强度，使得它们在pHCA的生产中经受长时间的再循环。

3. 发明授权

US08222000B2 Recombinant bacteria having the ability to metabolize sucrose 有权
标题翻译：具有蔗糖代谢能力的重组细菌
公开(公告)号：US08222000B2
公开(公告)日：2012-07-17
申请号：US12960634
申请日：2010-12-06
申请人： Tina K. Van Dyk
发明人： Tina K. Van Dyk
IPC分类号： C12P21/06
CPC分类号： C12P7/18 , C12N15/52 , C12P7/20 , C12P7/42
摘要： Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.
摘要翻译：描述了能够代谢蔗糖的重组细菌。重组细菌在其基因组或至少一种重组构建体中包含：编码具有蔗糖转运蛋白活性的多肽的地衣芽孢杆菌ATCC 14580的核苷酸序列和编码具有蔗糖水解酶活性的多肽的地衣芽孢杆菌ATCC 14580的核苷酸序列。这些核苷酸序列各自可操作地连接到相同或不同的启动子。还描述了能够代谢蔗糖以产生甘油和/或甘油衍生产物如1,3-丙二醇和3-羟基丙酸的重组细菌。

4. 发明授权

US08518678B2 Strain comprising increased expression of a CFA coding region for butanol production 有权
标题翻译：包含增加用于丁醇生产的CFA编码区的表达的菌株
公开(公告)号：US08518678B2
公开(公告)日：2013-08-27
申请号：US12330534
申请日：2008-12-09
申请人： Dennis Flint , Robert A. Larossa , Vasantha Nagarajan , Tina K. Van Dyk , Rick W. Ye
发明人： Dennis Flint , Robert A. Larossa , Vasantha Nagarajan , Tina K. Van Dyk , Rick W. Ye
IPC分类号： C12P7/16 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P7/16 , C12N9/1007 , Y02E50/10
摘要： Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased butanol tolerance. Bacterial strains with increased cyclopropane fatty acid synthase and having a butanol biosynthetic pathway are useful for production of butanol.
摘要翻译：筛选不是天然丁醇生产者的脂肪酸饲养细菌增加膜环丙烷脂肪酸提供改善的丁醇耐受性。在酶底物存在下增加环丙烷脂肪酸合酶的表达，该酶底物是细胞内源的或进入细胞，提高了丁醇耐受性。具有增加的环丙烷脂肪酸合成酶并具有丁醇生物合成途径的细菌菌株可用于生产丁醇。

5. 发明授权

US08426173B2 Method for the production of 1-butanol 有权
标题翻译： 1-丁醇生产方法
公开(公告)号：US08426173B2
公开(公告)日：2013-04-23
申请号：US12110503
申请日：2008-04-28
申请人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
发明人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
IPC分类号： C12P7/16
CPC分类号： C12N15/74 , C12N15/70 , C12P7/16 , C12Y103/01038 , C12Y103/01044 , C12Y402/01017 , C12Y402/01055 , Y02E50/10
摘要： A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
摘要翻译：公开了通过使用微生物生产宿主发酵生产1-丁醇的方法。该方法在发酵过程中使用温度降低，导致生产主体对丁醇产物的更强的耐受性。

6. 发明申请

US20110144377A1 PROCESS FOR THE BIOLOGICAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID WITH HIGH YIELD 审中-公开
标题翻译：具有高生产力的3-羟基丙酸生物工艺
公开(公告)号：US20110144377A1
公开(公告)日：2011-06-16
申请号：US12815461
申请日：2010-06-15
申请人： Andrew C. Eliot , Tina K. Van Dyk
发明人： Andrew C. Eliot , Tina K. Van Dyk
IPC分类号： C12P7/42 , C12N1/20 , C07C59/01 , C07C59/40 , C07C55/08 , C07C69/52 , C07C69/34
CPC分类号： C12P7/42 , C12N9/0006 , C12N9/0008 , C12N9/16 , C12N9/88
摘要： The present invention provides a microorganism useful for biologically producing 3-hydroxypropionic acid from a fermentable carbon source. Further, the microorganism comprises disruptions in specified genes and alterations in the expression levels of specified genes that are useful in a higher yielding process to produce 3-hydroxypropionic acid, compositions comprising renewably sourced 3-hydroxypropionic acid provided by said microorganism, and industrial relevant products made using such renewably sourced 3-hydroxypropionic acid.
摘要翻译：本发明提供可用于从可发酵碳源生物学生产3-羟基丙酸的微生物。此外，微生物包含特定基因的破坏以及可用于产生3-羟基丙酸的较高产率过程的特定基因的表达水平的改变，包含由所述微生物提供的可再生来源的3-羟基丙酸的组合物和工业相关产品使用这种可再生来源的3-羟基丙酸制备。

7. 发明授权

US07384788B2 Regulator/promoter for tunable gene expression and metabolite sensing 失效
标题翻译：用于可调基因表达和代谢物检测的调节剂/启动子
公开(公告)号：US07384788B2
公开(公告)日：2008-06-10
申请号：US11165160
申请日：2005-06-23
申请人： Tina K. Van Dyk
发明人： Tina K. Van Dyk
IPC分类号： C12N15/74 , C12N1/20 , C12N15/63
CPC分类号： C12N15/70 , C07K14/245
摘要： A method for the facile and inexpensive inducible expression of heterologous genes has been discovered. The yhcS regulator gene has been found to be inducible by aromatic carboxylic acids and to alter the expression of operons in the LysR gene family, including the yhcRQP operon, common in enteric bacteria. Heterologous nucleic acid molecules placed under the control of yhcS responsive promoters may be overexpressed in response to the presence of inexpensive aromatic carboxylic acids.
摘要翻译：已经发现了易于且廉价地诱导表达异源基因的方法。已经发现yhcS调节基因可被芳香族羧酸诱导，并改变LysR基因家族中操纵子的表达，包括在肠细菌中常见的yhcRQP操纵子。置于yhcS响应性启动子控制下的异源核酸分子可以响应于廉价的芳族羧酸的存在而过表达。

8. 发明申请

US20080032371A1 Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid 有权
标题翻译：固定化的TAL生物催化剂用于生产对羟基肉桂酸
公开(公告)号：US20080032371A1
公开(公告)日：2008-02-07
申请号：US11485575
申请日：2006-07-12
申请人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Robert J. Trotman , Tina K. Van Dyk
发明人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Robert J. Trotman , Tina K. Van Dyk
IPC分类号： C12P7/24 , C12N11/10
CPC分类号： C12N11/04 , C12N9/88 , C12N11/06 , C12N11/10 , C12P7/42 , Y02P20/588
摘要： TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
摘要翻译：使用低浓度戊二醛将TAL细胞生物催化剂固定在藻酸盐交联珠粒中。生物催化剂珠具有高度稳定的TAL活性和机械强度，使得它们在pHCA的生产中经受长时间的再循环。

9. 发明授权

US08426174B2 Method for the production of 2-butanol 有权
标题翻译： 2-丁醇生产方法
公开(公告)号：US08426174B2
公开(公告)日：2013-04-23
申请号：US12110510
申请日：2008-04-28
申请人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
发明人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
IPC分类号： C12P7/16
CPC分类号： C12N15/63 , C12P7/16 , C12Q1/04 , C12Q3/00 , Y02E50/10
摘要： A method for the production of 2-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
摘要翻译：公开了通过使用微生物生产宿主发酵生产2-丁醇的方法。该方法在发酵过程中使用温度降低，导致生产主体对丁醇产物的更强的耐受性。

10. 发明申请

US20090203097A1 STRAIN FOR BUTANOL PRODUCTION 有权
标题翻译：用于丁醇生产的菌株
公开(公告)号：US20090203097A1
公开(公告)日：2009-08-13
申请号：US12330534
申请日：2008-12-09
申请人： DENNIS FLINT , Robert A. Larossa , Vasantha Nagarajan , Tina K. Van Dyk , Rick W. Ye
发明人： DENNIS FLINT , Robert A. Larossa , Vasantha Nagarajan , Tina K. Van Dyk , Rick W. Ye
IPC分类号： C12P7/16 , C12N1/21 , C12N15/87
CPC分类号： C12P7/16 , C12N9/1007 , Y02E50/10
摘要： Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased butanol tolerance. Bacterial strains with increased cyclopropane fatty acid synthase and having a butanol biosynthetic pathway are useful for production of butanol.
摘要翻译：筛选不是天然丁醇生产者的脂肪酸饲养细菌增加膜环丙烷脂肪酸提供改善的丁醇耐受性。在酶底物存在下增加环丙烷脂肪酸合酶的表达，该酶底物是细胞内源的或进入细胞，提高了丁醇耐受性。具有增加的环丙烷脂肪酸合成酶并具有丁醇生物合成途径的细菌菌株可用于生产丁醇。

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