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    • 5. 发明申请
    • GAME THEORY MODEL FOR PATROLLING AN AREA THAT ACCOUNTS FOR DYNAMIC UNCERTAINTY
    • 用于计算动态不确定性帐户的游戏理论模型
    • US20140279818A1
    • 2014-09-18
    • US14216449
    • 2014-03-17
    • Albert Xin JiangZhengyu YinChao ZhangMilind TambeSarit Kraus
    • Albert Xin JiangZhengyu YinChao ZhangMilind TambeSarit Kraus
    • G06N5/04
    • G06N5/048G06N7/005G06Q10/047
    • Game theory models may be used for producing a strategy and schedule for patrolling an area like a rail transportation system. In some instances, the model may account for events that cause a patrol unit to deviate from a patrol schedule and route. For example, a patrol schedule may be generated for one or more patrol units using a Bayesian Stackelberg game theory model based on a map of the public transportation system, a schedule of the transports, a list of the one or more patrolling units, a probability distribution for the occurrence of the passenger not paying to ride the transports, a list of the one or more possible events that would delay the patrol units, and a probability distribution for the occurrence of the one or more possible events that would delay the patrolling units represented by a Markov-decision process.
    • 游戏理论模型可用于制定巡视像铁路运输系统这样的区域的战略和时间表。 在某些情况下,该模型可能会导致巡视单位偏离巡逻进度和路线的事件。 例如,可以使用基于公共交通系统的地图,运输时间表,一个或多个巡逻单元的列表,一个或多个巡逻单元的列表,使用贝叶斯Stackelberg游戏理论模型来生成针对一个或多个巡逻单元的巡逻时间表 分配用于不支付乘坐运输工具的乘客的发生,将延迟巡逻单位的一个或多个可能的事件的列表,以及发生一个或多个可能的事件的概率分布,这些事件将延迟巡逻单位 由马尔科夫决定过程代表。
    • 7. 发明授权
    • Selective serine/threonine kinase inhibitors
    • 选择性丝氨酸/苏氨酸激酶抑制剂
    • US08748601B2
    • 2014-06-10
    • US12088059
    • 2006-09-26
    • Jack TauntonMichael CohenKevan ShokatChao Zhang
    • Jack TauntonMichael CohenKevan ShokatChao Zhang
    • C07D487/00C07D411/02C07D487/04
    • C07D487/04C07D239/42C07D403/06C07D487/14C07D519/00
    • Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
    • 在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使本身或细胞或受试者中的激酶与抑制有效量的具有由两个或更多个的杂环核心结构组成的化合物接触来实现 含有至少一个氮环原子的稠环,以及能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电取代基。 优选的化合物包括具有这样的亲电子取代基的某些吡咯并嘧啶和羟吲哚,以及任选的能够与位于激酶的关守位置的苏氨酸或更小残基相互作用的芳族或杂芳族取代基。 缺乏这种半胱氨酸残基的激酶可以被改造或修饰,使得它们能够被这种化合物抑制,通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其它氨基酸残基。
    • 8. 发明授权
    • Compounds and methods for kinase modulation, and indications therefor
    • 用于激酶调节的化合物和方法及其适应症
    • US08673928B2
    • 2014-03-18
    • US12949741
    • 2010-11-18
    • Prabha N. IbrahimWayne SpevakHanna ChoSongyuan ShiChao ZhangYing Zhang
    • Prabha N. IbrahimWayne SpevakHanna ChoSongyuan ShiChao ZhangYing Zhang
    • C07D487/04A61K31/519A61P25/28A61P25/16A61P35/00A61P37/06A61P31/18
    • C07D487/04A61K31/437A61K31/519A61K31/5377C07D401/04C07D403/04C07D471/04
    • and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds of Formula (I) or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease.
    • 及其盐,其制剂,其缀合物,其衍生物,其形式及用途。 在某些方面和实施方案中,所述式(I)化合物或其盐,其制剂,其缀合物,其衍生物,其形式在至少一种Raf蛋白激酶上具有活性。 在某些方面和实施方案中,所述化合物在抑制Ras突变细胞系的增殖中是有活性的。 还描述了其用于治疗疾病和病症的方法,包括与B-Raf V600E突变蛋白激酶(包括黑素瘤,神经胶质瘤,多形性成胶质细胞瘤,纤维细胞性星形细胞瘤,结肠直肠癌,甲状腺癌,肺癌,卵巢)的活动相关的疾病和病症 癌症,前列腺癌,肝癌,胆囊癌,胃肠道间质瘤,胆道癌和胆管癌。 还描述了其用于治疗疾病和病症的方法,包括与c-Raf-1蛋白激酶的活性相关的疾病和病症,包括急性疼痛,慢性疼痛或多囊肾病。
    • 9. 发明申请
    • METHOD AND APPARATUS FOR MEMORY DUMP PROCESSING AND A MEMORY DUMP SYSTEM
    • 用于存储器处理和记忆体系统的方法和装置
    • US20120304019A1
    • 2012-11-29
    • US13340342
    • 2011-12-29
    • Jun LiChao Zhang
    • Jun LiChao Zhang
    • G06F11/34
    • G06F11/0778G06F11/3037
    • The present application provides a method, an apparatus and a system for memory dump processing. The method comprises: invoking a first set of processing units to process a first stage of memory dump processing for each of memory blocks; invoking each set of processing units other than the first set of processing units to process a subsequent processing stage after completing the first stage respectively, to write the memory blocks into a storage device. The technical solutions provided in the present application enable processing each stage for each of the memory blocks in a pipeline manner, avoid instantaneous peak flow of disk I/O transmission and improve memory dump performance.
    • 本申请提供了一种用于存储器转储处理的方法,装置和系统。 该方法包括:调用第一组处理单元来处理每个存储块的第一级存储器转储处理; 调用除第一组处理单元之外的每组处理单元以分别在完成第一阶段之后处理后续处理阶段,以将存储块写入存储设备。 本申请中提供的技术方案使得能够以流水线的方式处理每个存储器块的每个级,从而避免磁盘I / O传输的瞬时峰值流动并提高存储器转储性能。