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1. 发明申请

US20070134785A1 DNA Hybridization Device and Method 审中-公开
标题翻译： DNA杂交装置及方法
公开(公告)号：US20070134785A1
公开(公告)日：2007-06-14
申请号：US11622783
申请日：2007-01-12
申请人： Timothy Patno , Mark Fisher , George Kyaw Soe Maung Aye , Tom Westberg
发明人： Timothy Patno , Mark Fisher , George Kyaw Soe Maung Aye , Tom Westberg
IPC分类号： C12M1/34
CPC分类号： B01L3/50853 , B01L3/502 , B01L3/5055 , B01L3/5085 , B01L2200/026 , B01L2200/0689 , B01L2300/042 , B01L2300/0636 , B01L2300/0809 , B01L2300/0822 , B01L2300/0858
摘要： An apparatus and method for DNA hybridization is provided. The apparatus and method work in conjunction with a substrate comprising an upper surface having probes. The apparatus may comprise a material which abuts the substrate, with at least a portion of the material being pliable. The material and the substrate form a plurality of chambers, each chamber having a bottom including at least a portion of the upper surface, at least one sidewall, and an opening. The apparatus further comprises a mechanism for closing the openings of the chambers, thereby sealing the chambers.
摘要翻译：提供了用于DNA杂交的装置和方法。该装置和方法与包括具有探针的上表面的基底一起工作。该装置可以包括与基底邻接的材料，其中材料的至少一部分是柔韧的。材料和基底形成多个室，每个室具有包括上表面的至少一部分，至少一个侧壁和开口的底部。该装置还包括用于封闭腔室的开口的机构，从而密封腔室。

2. 发明授权

US07163823B2 DNA hybridization device and method 有权
标题翻译： DNA杂交装置及方法
公开(公告)号：US07163823B2
公开(公告)日：2007-01-16
申请号：US10352714
申请日：2003-01-27
申请人： Timothy Patno , Mark Fisher , George Kyaw Soe Maung , Tom Westberg
发明人： Timothy Patno , Mark Fisher , George Kyaw Soe Maung , Tom Westberg
IPC分类号： C12M3/00
CPC分类号： B01L3/50853 , B01L3/502 , B01L3/5055 , B01L3/5085 , B01L2200/026 , B01L2200/0689 , B01L2300/042 , B01L2300/0636 , B01L2300/0809 , B01L2300/0822 , B01L2300/0858
摘要： An apparatus and method for DNA hybridization is provided. The apparatus and method work in conjunction with a substrate comprising an upper surface having probes. The apparatus may comprise a material which abuts the substrate, with at least a portion of the material being pliable. The material and the substrate form a plurality of chambers, each chamber having a bottom including at least a portion of the upper surface, at least one sidewall, and an opening. The apparatus further comprises a mechanism for closing the openings of the chambers, thereby sealing the chambers.
摘要翻译：提供了用于DNA杂交的装置和方法。该装置和方法与包括具有探针的上表面的基底一起工作。该装置可以包括与基底邻接的材料，其中材料的至少一部分是柔韧的。材料和基底形成多个室，每个室具有包括上表面的至少一部分，至少一个侧壁和开口的底部。该装置还包括用于封闭腔室的开口的机构，从而密封腔室。

3. 发明申请

US20170364666A1 K-MER BASED STRAIN TYPING 审中-公开
公开(公告)号：US20170364666A1
公开(公告)日：2017-12-21
申请号：US15618843
申请日：2017-06-09
申请人： Mark Fisher , Keith Simmon
发明人： Mark Fisher , Keith Simmon
IPC分类号： G06F19/00 , G06F17/30
CPC分类号： G16C20/40 , G06F16/24575 , G16B30/10
摘要： At least one of the disclosed embodiments describes a computer system that enables efficient strain typing by comparing strain k-mer profiles to generate a strain typing relationship mapping. The system may include one or more processors, and one or more hardware storage devices with stored computer-executable instructions. The instructions may cause the computer system to receive a set of nucleotide sequence data. The nucleotide sequence data may include a plurality of nucleotide sequence data structures each corresponding to a separate microbial strain to be analyzed. For each nucleotide sequence data structure, a k-mer profile may be generated. K-mer profiles may be compared to determine a similarity score between the k-mer profiles, which may indicate a relationship mapping of the respective microbial strains corresponding to the k-mer profiles.

4. 发明授权

US08241245B2 Co-axial catheter 有权
标题翻译：同轴导管
公开(公告)号：US08241245B2
公开(公告)日：2012-08-14
申请号：US10961706
申请日：2004-10-08
申请人： David F. Markel , Earl W. Voorhees, Jr. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
发明人： David F. Markel , Earl W. Voorhees, Jr. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/0014 , A61M25/0028 , A61M25/0045 , A61M25/0068 , A61M25/007 , A61M25/0097 , A61M25/0194 , A61M2025/0004 , A61M2025/0031 , A61M2025/0039 , A61M2025/0063 , Y10T29/49826
摘要： A co-axial catheter assembly including a first lumen having a first distal end and a first proximal end, and a second lumen having a second distal end and a second proximal end. The second lumen extends co-axially with the first lumen, wherein the second lumen is at least partially disposed within the first lumen and the second distal end extends distally of the first distal end. A catheter hub provides for fluid connections of the inner and outer lumens with respective extension tubes, and includes spacers that maintain the proximal end of the inner lumen concentrically within the proximal end of the outer lumen and the distal end of the inner lumen concentrically within the distal end of the outer lumen, respectively. Methods of manufacturing and of inserting the catheter are also disclosed.
摘要翻译：一种同轴导管组件，包括具有第一远端和第一近端的第一腔，以及具有第二远端和第二近端的第二腔。所述第二腔与所述第一腔同轴地延伸，其中所述第二腔至少部分地设置在所述第一腔内，并且所述第二远端在所述第一远端的远侧延伸。导管座提供内腔和外腔与相应的延伸管的流体连接，并且包括间隔件，其将内腔的近端同心地保持在外腔的近端内并且内腔的远端同心地保持在内腔内分别为外腔的远端。还公开了制造和插入导管的方法。

5. 发明授权

US07966493B2 Method of and system for determining if an electronic signature is necessary in order to commit a transaction to a database 有权
标题翻译：用于确定电子签名是否需要以便将交易提交到数据库的方法和系统
公开(公告)号：US07966493B2
公开(公告)日：2011-06-21
申请号：US10731623
申请日：2003-12-08
申请人： Srinivasulu Puri , Ravindra Akella , Savita Durgada , Mark Fisher , Hany Saleeb , Manish Gupta , William Stearns
发明人： Srinivasulu Puri , Ravindra Akella , Savita Durgada , Mark Fisher , Hany Saleeb , Manish Gupta , William Stearns
IPC分类号： H04L9/32
CPC分类号： G06F21/64 , G06F21/6227
摘要： A method of and system for intercepting a transaction instantiated by a database application to determine if an electronic signature is necessary to commit the transaction to the database is disclosed. In one embodiment the method comprises calling an application program interface to raise an event in response to a triggering action generated by the database application; initiating a workflow process that executes a rule to determine if an electronic signature is required to approve the transaction; and if execution of the rule results in a determination that an electronic signature is required for the transaction, instantiating a signature collection process. Some embodiments further comprise obtaining an electronic signature in response to the signature collection process and thereafter, verifying the electronic signature and updating a filed of the electronic record to indicate a valid signature was collected if the electronic signature is verified.
摘要翻译：公开了一种用于截取由数据库应用程序实例化的事务以确定电子签名是否需要将事务提交到数据库的方法和系统。在一个实施例中，该方法包括响应于由数据库应用产生的触发动作，调用应用程序接口来引发事件; 启动执行规则以确定电子签名是否需要批准交易的工作流程; 并且如果规则的执行导致对于交易需要电子签名的确定，则实例化签名收集处理。一些实施例还包括响应于签名收集过程获得电子签名，此后，如果电子签名被验证，则验证电子签名并更新电子记录的文件以指示有效的签名被收集。

6. 发明申请

US20100263468A1 CRANK ARM WITH STRAIN AMPLIFIER 有权
标题翻译：起重臂与应变放大器
公开(公告)号：US20100263468A1
公开(公告)日：2010-10-21
申请号：US12667859
申请日：2008-06-30
申请人： Mark Fisher , Leslie James Wills
发明人： Mark Fisher , Leslie James Wills
IPC分类号： B62M3/00 , G05G1/04 , G01L1/22 , B23P6/00
CPC分类号： G01L5/161 , A63B22/0046 , A63B22/0605 , A63B2220/51 , B62K2207/00 , B62M3/00 , G01L1/225 , G01L3/242 , G01L5/225
摘要： A crank arm (200) includes a mechanical ring amplifier (232), having a cavity and a connecting bridge (140), to amplify the radial strain exerted on the crank arm by a rider. Strain sensors (234, 235) are positioned to detect the amplified radial strain. The crank arm (200) may include further strain sensors (228, 229) adapted to detect tangential strain on the crank arm, allowing both the tangential and radial forces exerted by a bicycle rider to be measured. The crank arm (200) may also comprise means for adjusting the position of a pedal axle relative to the crank arm, via the loosening, rotation and retightening of a carrier disc held by the crank arm, where the carrier disc has an eccentrically mounted aperture for holding the pedal axle.
摘要翻译：曲柄臂（200）包括具有空腔和连接桥（140）的机械环形放大器（232），用于放大乘员施加在曲柄臂上的径向应变。定位应变传感器（234,235）以检测放大的径向应变。曲柄臂（200）可以包括适于检测曲柄臂上的切向应变的另外的应变传感器（228,229），从而允许测量骑自行车骑手施加的切向力和径向力。曲柄臂（200）还可以包括用于通过由曲柄臂保持的承载盘的松动，旋转和重新紧固来调节踏板轴相对于曲柄臂的位置的装置，其中承载盘具有偏心安装的孔用于握住踏板轴。

7. 发明授权

US07708513B2 Binding elements and plurality of binding elements particularly suited for automated processes 有权
标题翻译：绑定元件和多个特别适用于自动化过程的绑定元件
公开(公告)号：US07708513B2
公开(公告)日：2010-05-04
申请号：US11462532
申请日：2006-08-04
申请人： Mark Fisher , Peter Hotkowski , Marc Kullberg , Samuel Amdahl , Frank Todaro
发明人： Mark Fisher , Peter Hotkowski , Marc Kullberg , Samuel Amdahl , Frank Todaro
IPC分类号： B42B5/06 , B42B9/00 , B42F13/06 , B42F13/08 , A44B1/04 , A44B11/25 , A44B17/00 , B42F1/00
CPC分类号： B42B5/08 , B42B5/10 , B42F13/02 , Y10T24/20 , Y10T24/207
摘要： A plurality of binding elements, each of a substantially uniform thickness, the fingers being looped over and coupled to the spine such that the inner surface of the fingers is disposed against the inner surface of the spine by an adhesive when assembled. In an embodiment, at least a portion of the outer surface of the binding element is resistant to a more permanent attachment to the adhesive such that the plurality may be stacked together, and successively decoupled or removed for insertion into a stack. The binding elements may include score lines or bends in the fingers to provide a rounded closed loop structure; optional gussets in the bends inhibit straightening of the fingers. The fingers optionally include variations in cross-section along the length to relieve certain stresses to inhibit the looped finger. The binding elements optionally include structure for facilitating interaction with an automating binding process.
摘要翻译：多个结合元件，每个具有基本均匀的厚度，手指环绕并联接到脊柱，使得当组装时，指状物的内表面通过粘合剂抵靠脊柱的内表面设置。在一个实施例中，装订元件的外表面的至少一部分抵抗对粘合剂的更永久的附着，使得多个可以堆叠在一起，并且连续地解耦或移除以插入到堆叠中。绑定元件可以包括手指中的刻痕线或弯曲以提供圆形闭环结构; 弯曲中的可选角撑板可以抑制手指的矫直。手指可选地包括沿着长度的横截面的变化以减轻某些应力以抑制环形手指。绑定元件可选地包括用于促进与自动化绑定过程的交互的结构。

8. 发明申请

US20100043196A1 METHOD OF MAKING A CO-AXIAL CATHETER 有权
标题翻译：制造同轴导管的方法
公开(公告)号：US20100043196A1
公开(公告)日：2010-02-25
申请号：US12611991
申请日：2009-11-04
申请人： David F. Markel , Earl W. Voorhees, JR. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
发明人： David F. Markel , Earl W. Voorhees, JR. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
IPC分类号： B23P17/04 , B29C43/18
CPC分类号： A61M25/0014 , A61M25/0028 , A61M25/0045 , A61M25/0068 , A61M25/007 , A61M25/0097 , A61M25/0194 , A61M2025/0004 , A61M2025/0031 , A61M2025/0039 , A61M2025/0063 , Y10T29/49826
摘要： A co-axial catheter assembly (100), including a first lumen (110) having a first distal end (114) and a first proximal end (112), and a second lumen (120) having a second distal end (124) and a second proximal end (122). The second lumen (120) extends co-axially with the first lumen (110), wherein the second lumen is at least partially disposed within the first lumen and the second distal end extends distally of the first distal end. A method of manufacturing the catheter is also disclosed.
摘要翻译：包括具有第一远端（114）和第一近端（112）的第一腔（110）和具有第二远端（124）的第二腔（120）的同轴导管组件（100）第二近端（122）。所述第二腔（120）与所述第一腔（110）同轴地延伸，其中所述第二腔至少部分地设置在所述第一腔内，并且所述第二远端延伸到所述第一远端的远侧。还公开了制造导管的方法。

9. 发明申请

US20090005499A1 Silicone Resin Film, Method of Preparing Same, and Nanomaterial-Filled Silicone Composition 审中-公开
标题翻译：硅树脂膜，其制备方法和纳米填充硅酮组合物
公开(公告)号：US20090005499A1
公开(公告)日：2009-01-01
申请号：US12087074
申请日：2007-01-10
申请人： Mark Fisher , Bizhong Zhu
发明人： Mark Fisher , Bizhong Zhu
IPC分类号： C08J3/28
CPC分类号： C08J5/18 , C08G77/12 , C08G77/20 , C08J2383/04 , C08K3/046 , C08K7/06 , C09D183/04 , C08L83/00
摘要： A method of preparing a silicone resin film comprising coating a release liner with a nanomaterial-filled silicone composition comprising (i) a hydrosilylation-curable silicone composition comprising a silicone resin and a photoactivated hydrosilylation catalyst and (ii) a carbon nanomaterial, and exposing the coating to radiation having a wavelength of from 150 to 800 nm at a dosage sufficient to cure the silicone resin; a silicone resin film prepared according to the preceding method; and a nanomaterial-filled silicone composition.
摘要翻译：一种制备有机硅树脂膜的方法，其包括用纳米材料填充的硅氧烷组合物涂覆剥离衬垫，所述硅氧烷组合物包含（i）含硅树脂和光活化氢化硅烷化催化剂的氢化硅烷化可固化的有机硅组合物和（ii）碳纳米材料，以足以固化硅树脂的剂量涂覆波长为150至800nm的辐射; 根据前述方法制备的有机硅树脂膜; 和纳米材料填充的硅氧烷组合物。

10. 发明申请

US20070265597A1 Catheter Tunneler adapter 有权
标题翻译：导管接头适配器
公开(公告)号：US20070265597A1
公开(公告)日：2007-11-15
申请号：US11825633
申请日：2007-07-06
申请人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Wall , Kevin Sanford , Rodger Lyle
发明人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Wall , Kevin Sanford , Rodger Lyle
IPC分类号： A61M25/18
CPC分类号： A61B17/3415 , A61B2017/320044 , A61M25/0194 , A61M39/1011
摘要： An adapter assembly (120) for connecting a catheter assembly (50,52) to a tunneler (110) having a generally tubular body (122) having a first end (124), a second end (126) and a longitudinal axis (128) extending therethrough between the first end and the second end. The first end (124) of the adapter is constructed to engage the proximal end (114) of a trocar (110). The second end (126) of the adapter is constructed to releasably engage at least one catheter lumen (50,52). A slider (140) is disposed about the adapter (120) and is longitudinally slidable along the adapter. When the slider (140) is slid towards the second end (126) of the adapter, the slider engages a plurality of legs (134a-134d) on the adapter and biases the plurality of legs toward each other and the longitudinal axis of the adapter. A method of subcutaneously tunneling a catheter using the adapter assembly is also described that comprises inserting a catheter into a patient, connecting the proximal end of a trocar to the adapter assembly, releasably restraining at least one lumen of the catheter in the adapter, and tunneling the assembly.
摘要翻译：一种用于将导管组件（50,52）连接到具有大体管状体（122）的导管组件（120）的适配器组件（120），其具有第一端（124），第二端（126）和纵轴（128 ）在第一端和第二端之间延伸通过。适配器的第一端（124）构造成接合套管针（110）的近端（114）。适配器的第二端（126）构造成可释放地接合至少一个导管内腔（50,52）。滑块（140）围绕适配器（120）设置并且可沿适配器纵向滑动。当滑块（140）朝向适配器的第二端（126）滑动时，滑块与适配器上的多个支腿（134a-134d）接合并且将多个支腿朝向彼此偏置，并且纵向轴线适配器。还描述了使用适配器组件皮下隧穿导管的方法，其包括将导管插入患者体内，将套针针的近端连接到适配器组件，可释放地约束适配器中的导管的至少一个内腔，以及隧道大会。

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