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1. 发明授权

US08241245B2 Co-axial catheter 有权
标题翻译：同轴导管
公开(公告)号：US08241245B2
公开(公告)日：2012-08-14
申请号：US10961706
申请日：2004-10-08
申请人： David F. Markel , Earl W. Voorhees, Jr. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
发明人： David F. Markel , Earl W. Voorhees, Jr. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/0014 , A61M25/0028 , A61M25/0045 , A61M25/0068 , A61M25/007 , A61M25/0097 , A61M25/0194 , A61M2025/0004 , A61M2025/0031 , A61M2025/0039 , A61M2025/0063 , Y10T29/49826
摘要： A co-axial catheter assembly including a first lumen having a first distal end and a first proximal end, and a second lumen having a second distal end and a second proximal end. The second lumen extends co-axially with the first lumen, wherein the second lumen is at least partially disposed within the first lumen and the second distal end extends distally of the first distal end. A catheter hub provides for fluid connections of the inner and outer lumens with respective extension tubes, and includes spacers that maintain the proximal end of the inner lumen concentrically within the proximal end of the outer lumen and the distal end of the inner lumen concentrically within the distal end of the outer lumen, respectively. Methods of manufacturing and of inserting the catheter are also disclosed.
摘要翻译：一种同轴导管组件，包括具有第一远端和第一近端的第一腔，以及具有第二远端和第二近端的第二腔。所述第二腔与所述第一腔同轴地延伸，其中所述第二腔至少部分地设置在所述第一腔内，并且所述第二远端在所述第一远端的远侧延伸。导管座提供内腔和外腔与相应的延伸管的流体连接，并且包括间隔件，其将内腔的近端同心地保持在外腔的近端内并且内腔的远端同心地保持在内腔内分别为外腔的远端。还公开了制造和插入导管的方法。

2. 发明申请

US20100043196A1 METHOD OF MAKING A CO-AXIAL CATHETER 有权
标题翻译：制造同轴导管的方法
公开(公告)号：US20100043196A1
公开(公告)日：2010-02-25
申请号：US12611991
申请日：2009-11-04
申请人： David F. Markel , Earl W. Voorhees, JR. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
发明人： David F. Markel , Earl W. Voorhees, JR. , Anthony J. Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
IPC分类号： B23P17/04 , B29C43/18
CPC分类号： A61M25/0014 , A61M25/0028 , A61M25/0045 , A61M25/0068 , A61M25/007 , A61M25/0097 , A61M25/0194 , A61M2025/0004 , A61M2025/0031 , A61M2025/0039 , A61M2025/0063 , Y10T29/49826
摘要： A co-axial catheter assembly (100), including a first lumen (110) having a first distal end (114) and a first proximal end (112), and a second lumen (120) having a second distal end (124) and a second proximal end (122). The second lumen (120) extends co-axially with the first lumen (110), wherein the second lumen is at least partially disposed within the first lumen and the second distal end extends distally of the first distal end. A method of manufacturing the catheter is also disclosed.
摘要翻译：包括具有第一远端（114）和第一近端（112）的第一腔（110）和具有第二远端（124）的第二腔（120）的同轴导管组件（100）第二近端（122）。所述第二腔（120）与所述第一腔（110）同轴地延伸，其中所述第二腔至少部分地设置在所述第一腔内，并且所述第二远端延伸到所述第一远端的远侧。还公开了制造导管的方法。

3. 发明申请

US20050080398A1 Co-axial tapered catheter 有权
标题翻译：同轴锥形导管
公开(公告)号：US20050080398A1
公开(公告)日：2005-04-14
申请号：US10961706
申请日：2004-10-08
申请人： David Markel , Earl Voorhees , J. Raulerson , Anthony Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
发明人： David Markel , Earl Voorhees , J. Raulerson , Anthony Madison , Timothy Schweikert , Mahase Nardeo , Mark Fisher
IPC分类号： A61M20060101 , A61M25/00 , A61M31/00
CPC分类号： A61M25/0014 , A61M25/0028 , A61M25/0045 , A61M25/0068 , A61M25/007 , A61M25/0097 , A61M25/0194 , A61M2025/0004 , A61M2025/0031 , A61M2025/0039 , A61M2025/0063 , Y10T29/49826
摘要： A co-axial catheter is disclosed. The catheter includes a first lumen having a first distal end, a first proximal end, and a longitudinal axis extending therethrough. The catheter further includes a second lumen having a second distal end and a second proximal end. The second lumen extends co-axially with the first lumen, wherein the second lumen is at least partially disposed within the first lumen. The second distal end extends distally of the first distal end. The second distal end includes a distal tip and a bulbous projection disposed between the distal tip and the first distal end. A method of manufacturing and of inserting the catheter is also disclosed.
摘要翻译：公开了一种同轴导管。导管包括具有第一远端，第一近端和延伸穿过其的纵轴的第一腔。导管还包括具有第二远端和第二近端的第二腔。第二腔与第一腔同轴地延伸，其中第二腔至少部分地设置在第一腔内。第二远端在第一远端的远端延伸。第二远端包括远侧末端和设置在远侧末端和第一远端之间的球形突起。还公开了制造和插入导管的方法。

4. 发明申请

US20070265597A1 Catheter Tunneler adapter 有权
标题翻译：导管接头适配器
公开(公告)号：US20070265597A1
公开(公告)日：2007-11-15
申请号：US11825633
申请日：2007-07-06
申请人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Wall , Kevin Sanford , Rodger Lyle
发明人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Wall , Kevin Sanford , Rodger Lyle
IPC分类号： A61M25/18
CPC分类号： A61B17/3415 , A61B2017/320044 , A61M25/0194 , A61M39/1011
摘要： An adapter assembly (120) for connecting a catheter assembly (50,52) to a tunneler (110) having a generally tubular body (122) having a first end (124), a second end (126) and a longitudinal axis (128) extending therethrough between the first end and the second end. The first end (124) of the adapter is constructed to engage the proximal end (114) of a trocar (110). The second end (126) of the adapter is constructed to releasably engage at least one catheter lumen (50,52). A slider (140) is disposed about the adapter (120) and is longitudinally slidable along the adapter. When the slider (140) is slid towards the second end (126) of the adapter, the slider engages a plurality of legs (134a-134d) on the adapter and biases the plurality of legs toward each other and the longitudinal axis of the adapter. A method of subcutaneously tunneling a catheter using the adapter assembly is also described that comprises inserting a catheter into a patient, connecting the proximal end of a trocar to the adapter assembly, releasably restraining at least one lumen of the catheter in the adapter, and tunneling the assembly.
摘要翻译：一种用于将导管组件（50,52）连接到具有大体管状体（122）的导管组件（120）的适配器组件（120），其具有第一端（124），第二端（126）和纵轴（128 ）在第一端和第二端之间延伸通过。适配器的第一端（124）构造成接合套管针（110）的近端（114）。适配器的第二端（126）构造成可释放地接合至少一个导管内腔（50,52）。滑块（140）围绕适配器（120）设置并且可沿适配器纵向滑动。当滑块（140）朝向适配器的第二端（126）滑动时，滑块与适配器上的多个支腿（134a-134d）接合并且将多个支腿朝向彼此偏置，并且纵向轴线适配器。还描述了使用适配器组件皮下隧穿导管的方法，其包括将导管插入患者体内，将套针针的近端连接到适配器组件，可释放地约束适配器中的导管的至少一个内腔，以及隧道大会。

5. 发明申请

US20060030827A1 Luer cleaner 有权
标题翻译： Luer清洁剂
公开(公告)号：US20060030827A1
公开(公告)日：2006-02-09
申请号：US11180142
申请日：2005-07-13
申请人： J. Raulerson , Timothy Schweikert , William Wall , Mark Fisher
发明人： J. Raulerson , Timothy Schweikert , William Wall , Mark Fisher
IPC分类号： A61M25/00
CPC分类号： A61M39/16 , A61M39/162 , A61M2025/0019 , A61M2039/1033
摘要： A luer cleaner (100) including a generally hollow body (112) having an open first end (104), a closed second end (106), and a longitudinal axis extending therethrough between the first end and the second end. The first end (104) is sized to receive therein a luer connector (190) proximal end and includes a plurality of bristles (134) extending generally toward the longitudinal axis sufficiently to engage the outer surfaces of the luer proximal end disposed therein. The second end comprises a compressible reservoir (166) containing a fluid (168), wherein, when the second end is compressed, the fluid is transmitted from the reservoir toward the first end through passageways to wet the luer proximal end. A method for cleaning luer connectors is also disclosed.
摘要翻译：路厄尔清洁器（100）包括具有敞开的第一端（104）的大致中空的本体（112），封闭的第二端（106）和在第一端和第二端之间延伸穿过的纵向轴线。第一端（104）的尺寸被设计成在其中容纳路厄尔连接器（190）近端，并且包括大致朝向纵向轴线延伸的多个刷毛（134），其足以接合设置在其中的鲁尔近端的外表面。第二端包括容纳流体（168）的可压缩储存器（166），其中当第二端被压缩时，流体通过通道从储存器传递到第一端以润湿路厄近端。还公开了一种用于清洁鲁尔连接器的方法。

6. 发明授权

US08105313B2 Method of using a catheter tunneler adapter 有权
标题翻译：使用导管隧道适配器的方法
公开(公告)号：US08105313B2
公开(公告)日：2012-01-31
申请号：US11825633
申请日：2007-07-06
申请人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Shaun Wall , Kevin Sanford , Rodger Lyle
发明人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Shaun Wall , Kevin Sanford , Rodger Lyle
IPC分类号： A61M39/00
CPC分类号： A61B17/3415 , A61B2017/320044 , A61M25/0194 , A61M39/1011
摘要： An adapter assembly (120) for connecting a catheter assembly (50,52) to a tunneler (110) having a generally tubular body (122) having a first end (124), a second end (126) and a longitudinal axis (128) extending therethrough between the first end and the second end. The first end (124) of the adapter is constructed to engage the proximal end (114) of a trocar (110). The second end (126) of the adapter is constructed to releasably engage at least one catheter lumen (50,52). A slider (140) is disposed about the adapter (120) and is longitudinally slidable along the adapter. When the slider (140) is slid towards the second end (126) of the adapter, the slider engages a plurality of legs (134a-134d) on the adapter and biases the plurality of legs toward each other and the longitudinal axis of the adapter. A method of subcutaneously tunneling a catheter using the adapter assembly is also described that comprises inserting a catheter into a patient, connecting the proximal end of a trocar to the adapter assembly, releasably restraining at least one lumen of the catheter in the adapter, and tunneling the assembly.
摘要翻译：一种用于将导管组件（50,52）连接到具有大体管状体（122）的导管组件（120）的适配器组件（120），其具有第一端（124），第二端（126）和纵轴（128 ）在第一端和第二端之间延伸通过。适配器的第一端（124）构造成接合套管针（110）的近端（114）。适配器的第二端（126）构造成可释放地接合至少一个导管内腔（50,52）。滑块（140）围绕适配器（120）设置并且可沿适配器纵向滑动。当滑块（140）朝向适配器的第二端（126）滑动时，滑块接合适配器上的多个支腿（134a-134d），并且将多个支腿朝向彼此偏置，并且适配器的纵向轴线。还描述了使用适配器组件皮下隧穿导管的方法，其包括将导管插入患者体内，将套针针的近端连接到适配器组件，可释放地约束适配器中的导管的至少一个内腔，以及隧道大会。

7. 发明申请

US20050027282A1 Catheter tunneler adapter 有权
标题翻译：导管隧道适配器
公开(公告)号：US20050027282A1
公开(公告)日：2005-02-03
申请号：US10889816
申请日：2004-07-13
申请人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Wall , Kevin Sanford , Rodger Lyle
发明人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Wall , Kevin Sanford , Rodger Lyle
IPC分类号： A61B17/34 , A61M20060101 , A61M25/00 , A61M25/18 , A61M39/10
CPC分类号： A61B17/3415 , A61B2017/320044 , A61M25/0194 , A61M39/1011
摘要： An adapter assembly for connecting a catheter assembly to a tunneler is disclosed. The adapter assembly has a generally tubular body having a first end, a second end and a longitudinal axis extending therethrough between the first end and the second end. The first end of the adapter is constructed to engage the proximal end of a trocar. The second end of the adapter is constructed to releasably engage at least one catheter lumen. A slider is disposed about the adapter and is longitudinally slidable along the adapter. When the slider is slid towards the second end of the adapter, the slider engages a plurality of legs on the adapter. The slider biases the plurality of legs toward each other and the longitudinal axis of the adapter. A method of subcutaneously tunneling a catheter using the adapter assembly is also described. The method comprises inserting a catheter into a patient, connecting the proximal end of a trocar to the adapter assembly, releasably restraining at least one lumen of the catheter in the adapter, and tunneling the assembly.
摘要翻译：公开了一种用于将导管组件连接到隧道器的适配器组件。适配器组件具有大致管状体，其具有在第一端和第二端之间延伸穿过其的第一端，第二端和纵向轴线。适配器的第一端构造成接合套管针的近端。适配器的第二端构造成可释放地接合至少一个导管内腔。滑块围绕适配器设置并且可沿着适配器纵向滑动。当滑块朝向适配器的第二端滑动时，滑块接合适配器上的多个腿。滑块朝向彼此和适配器的纵向轴线偏压多个腿。还描述了使用适配器组件皮下隧道导管的方法。该方法包括将导管插入患者体内，将套管针的近端连接到适配器组件，可释放地约束适配器中的导管的至少一个内腔，并且将组件穿透。

8. 发明授权

US08100884B2 Catheter tunneler adapter 有权
标题翻译：导管隧道适配器
公开(公告)号：US08100884B2
公开(公告)日：2012-01-24
申请号：US10889816
申请日：2004-07-13
申请人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Shaun Wall , Kevin Sanford , Rodger Lyle
发明人： Timothy Schweikert , Mark Fisher , Angela Wentling , W. Shaun Wall , Kevin Sanford , Rodger Lyle
IPC分类号： A61M39/00
CPC分类号： A61B17/3415 , A61B2017/320044 , A61M25/0194 , A61M39/1011
摘要： An adapter assembly (120) for connecting a catheter assembly (50,52) to a tunneler (110) having a generally tubular body (122) having a first end (124), a second end (126) and a longitudinal axis ( )128 extending therethrough between the first end and the second end. The first end (124) of the adapter is constructed to engage the proximal end (114) of a trocar (110). The second end (126) of the adapter is constructed to releasably engage at least one catheter lumen (50,52). A slider (140) is disposed about the adapter (120) and is longitudinally slidable along the adapter. When the slider (140) is slid towards the second end (126) of the adapter, the slider engages a plurality of legs (134a-134d) on the adapter and biases the plurality of legs toward each other and the longitudinal axis of the adapter. A method of subcutaneously tunneling a catheter using the adapter assembly is also described that comprises inserting a catheter into a patient, connecting the proximal end of a trocar to the adapter assembly, releasably restraining at least one lumen of the catheter in the adapter, and tunneling the assembly.
摘要翻译：一种用于将导管组件（50,52）连接到具有具有第一端（124），第二端（126）和纵轴（））的大致管状体（122）的隧道（110）的适配器组件（120） 128在第一端和第二端之间延伸穿过。适配器的第一端（124）构造成接合套管针（110）的近端（114）。适配器的第二端（126）构造成可释放地接合至少一个导管内腔（50,52）。滑块（140）围绕适配器（120）设置并且可沿适配器纵向滑动。当滑块（140）朝向适配器的第二端（126）滑动时，滑块接合适配器上的多个支腿（134a-134d），并且将多个支腿朝向彼此偏置，并且适配器的纵向轴线。还描述了使用适配器组件皮下隧穿导管的方法，其包括将导管插入患者体内，将套针针的近端连接到适配器组件，可释放地约束适配器中的导管的至少一个内腔，以及隧道大会。

9. 发明申请

US20170364666A1 K-MER BASED STRAIN TYPING 审中-公开
公开(公告)号：US20170364666A1
公开(公告)日：2017-12-21
申请号：US15618843
申请日：2017-06-09
申请人： Mark Fisher , Keith Simmon
发明人： Mark Fisher , Keith Simmon
IPC分类号： G06F19/00 , G06F17/30
CPC分类号： G16C20/40 , G06F16/24575 , G16B30/10
摘要： At least one of the disclosed embodiments describes a computer system that enables efficient strain typing by comparing strain k-mer profiles to generate a strain typing relationship mapping. The system may include one or more processors, and one or more hardware storage devices with stored computer-executable instructions. The instructions may cause the computer system to receive a set of nucleotide sequence data. The nucleotide sequence data may include a plurality of nucleotide sequence data structures each corresponding to a separate microbial strain to be analyzed. For each nucleotide sequence data structure, a k-mer profile may be generated. K-mer profiles may be compared to determine a similarity score between the k-mer profiles, which may indicate a relationship mapping of the respective microbial strains corresponding to the k-mer profiles.

10. 发明授权

US07966493B2 Method of and system for determining if an electronic signature is necessary in order to commit a transaction to a database 有权
标题翻译：用于确定电子签名是否需要以便将交易提交到数据库的方法和系统
公开(公告)号：US07966493B2
公开(公告)日：2011-06-21
申请号：US10731623
申请日：2003-12-08
申请人： Srinivasulu Puri , Ravindra Akella , Savita Durgada , Mark Fisher , Hany Saleeb , Manish Gupta , William Stearns
发明人： Srinivasulu Puri , Ravindra Akella , Savita Durgada , Mark Fisher , Hany Saleeb , Manish Gupta , William Stearns
IPC分类号： H04L9/32
CPC分类号： G06F21/64 , G06F21/6227
摘要： A method of and system for intercepting a transaction instantiated by a database application to determine if an electronic signature is necessary to commit the transaction to the database is disclosed. In one embodiment the method comprises calling an application program interface to raise an event in response to a triggering action generated by the database application; initiating a workflow process that executes a rule to determine if an electronic signature is required to approve the transaction; and if execution of the rule results in a determination that an electronic signature is required for the transaction, instantiating a signature collection process. Some embodiments further comprise obtaining an electronic signature in response to the signature collection process and thereafter, verifying the electronic signature and updating a filed of the electronic record to indicate a valid signature was collected if the electronic signature is verified.
摘要翻译：公开了一种用于截取由数据库应用程序实例化的事务以确定电子签名是否需要将事务提交到数据库的方法和系统。在一个实施例中，该方法包括响应于由数据库应用产生的触发动作，调用应用程序接口来引发事件; 启动执行规则以确定电子签名是否需要批准交易的工作流程; 并且如果规则的执行导致对于交易需要电子签名的确定，则实例化签名收集处理。一些实施例还包括响应于签名收集过程获得电子签名，此后，如果电子签名被验证，则验证电子签名并更新电子记录的文件以指示有效的签名被收集。

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