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1. 发明授权

US07675624B2 Portable and cartridge-based surface plasmon resonance sensing systems 有权
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US07675624B2
公开(公告)日：2010-03-09
申请号：US11398964
申请日：2006-04-05
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

2. 发明申请

US20100284012A1 Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems 审中-公开
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US20100284012A1
公开(公告)日：2010-11-11
申请号：US12699377
申请日：2010-02-03
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

3. 发明授权

US08174700B2 Portable and cartridge-based surface plasmon resonance sensing systems 有权
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US08174700B2
公开(公告)日：2012-05-08
申请号：US13016788
申请日：2011-01-28
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/00
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

4. 发明申请

US20110128548A1 Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems 有权
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US20110128548A1
公开(公告)日：2011-06-02
申请号：US13016788
申请日：2011-01-28
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

5. 发明申请

US20100128269A1 MINIATURIZED SURFACE PLASMON RESONANCE IMAGING SYSTEM 审中-公开
标题翻译： MINIATURIZED表面质子共振成像系统
公开(公告)号：US20100128269A1
公开(公告)日：2010-05-27
申请号：US12304986
申请日：2007-06-18
申请人： Timothy M. Chinowsky , Kyle S. Johnston , Michael S. Grow
发明人： Timothy M. Chinowsky , Kyle S. Johnston , Michael S. Grow
IPC分类号： G01N21/55 , G01J4/00 , G06K9/00
CPC分类号： G01N21/553
摘要： A miniaturized Surface Plasmon Resonance (SPR) imaging system (20) is provided, which includes a light source (21), a sensor substrate (26c) arranged to receive light at an incident angle from the light source, and a detector (31) for detecting an image from the sensor substrate. The system further includes a folded light path structure (23) arranged between the light source and the detector. The folded light path structure includes the sensor substrate (26c), and is configured so as to receive the light from the light source, to redirect the received light to be incident on the sensor substrate (26c) at the incident angle (first redirection), and to further redirect the light reflected from the sensor substrate (26c) toward the detector (second redirection). The folded light path structure allows for a minimal instrumentation footprint, which in turn allows for the construction of a miniaturized, hand-portable SPR imaging system.
摘要翻译：提供了一种小型化的表面等离子体共振（SPR）成像系统（20），其包括光源（21），被布置为接收来自光源的入射角的光的传感器基板（26c）和检测器（31）用于检测来自传感器基板的图像。该系统还包括布置在光源和检测器之间的折叠光路结构（23）。折叠光路结构包括传感器基板（26c），并被配置为接收来自光源的光，以以入射角（第一重定向）入射到传感器基板（26c）上的接收光重定向，并且进一步将从传感器基板（26c）反射的光朝向检测器（第二重定向）重定向。折叠的光路结构允许最小的仪表占地面积，这又允许构造小型化的手提式SPR成像系统。

6. 发明授权

US06782470B1 Operand queues for streaming data: A processor register file extension 有权
标题翻译：流数据操作数队列：处理器寄存器文件扩展名
公开(公告)号：US06782470B1
公开(公告)日：2004-08-24
申请号：US09706899
申请日：2000-11-06
申请人： Stefan G. Berg , Michael S. Grow , Weiyun Sun , Donglok Kim , Yongmin Kim
发明人： Stefan G. Berg , Michael S. Grow , Weiyun Sun , Donglok Kim , Yongmin Kim
IPC分类号： G06F934
CPC分类号： G06F9/30141 , G06F9/30098 , G06F9/30134 , G06F9/3824 , G06F9/3828
摘要： The register file of a processor includes embedded operand queues. The configuration of the register file into registers and operand queues is defined dynamically by a computer program. The programmer determines the trade-off between the number and size of the operand queue(s) versus the number of registers used for the program. The programmer partitions a portion of the registers into one or more operand queues. A given queue occupies a consecutive set of registers, although multiple queues need not occupy consecutive registers. An additional address bit is included to distinguish operand queue addresses from register addresses. Queue state logic tracks status information for each queue, including a header pointer, tail pointer, start address, end address and number of vacancies value. The program sets the locations and depth of a given operand queue within the register file.
摘要翻译：处理器的寄存器文件包括嵌入的操作数队列。寄存器文件到寄存器和操作数队列中的配置由计算机程序动态定义。程序员确定操作数队列的数量和大小与程序使用的寄存器数之间的权衡。编程器将一部分寄存器分成一个或多个操作数队列。给定的队列占用连续的一组寄存器，尽管多个队列不需要占用连续的寄存器。包括一个额外的地址位来区分操作数队列地址与寄存器地址。队列状态逻辑跟踪每个队列的状态信息，包括头指针，尾指针，起始地址，结束地址和空位数值。程序设置寄存器文件中给定操作数队列的位置和深度。

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